Metabolism of vitamins and cofactors

Metabolites

Biotin

Formula: C10H16N2O3S (244.08815859999999)

CAS ID: 58-85-5

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen peroxide

Formula: H2O2 (34.0054792)

CAS ID: 7722-84-1

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

Nicotinamide-beta-riboside

Formula: C11H15N2O5 (255.098092)

CAS ID: 1341-23-7

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Pyridoxal

Formula: C8H9NO3 (167.0582404)

CAS ID: 66-72-8

Pyridoxamine

Formula: C8H12N2O2 (168.0898732)

CAS ID: 85-87-0

Pyridoxine

Formula: C8H11NO3 (169.0738896)

CAS ID: 65-23-6

Pyridoxine phosphate

Formula: C8H12NO6P (249.0402222)

CAS ID: 447-05-2

Thiamine

Formula: C12H17N4OS (265.1123012)

CAS ID: 70-16-6

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

Ubiquinol-10

Formula: C59H92O4 (864.6995231999999)

CAS ID: 5677-55-4

formate

Formula: CHO2 (44.997654600000004)

CAS ID: 71-47-6

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

4-hydroxybenzoate

Formula: C7H5O3 (137.023868)

CAS ID: 456-23-5

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
2.1.1.-
1.1.1.42 isocitrate dehydrogenase (NADP+) isocitrate:NADP+ oxidoreductase (decarboxylating)
1.14.15.45 4-hydroxy-3-polyprenylbenzoate 5-hydroxylase 4-hydroxy-3-all-trans-polyprenylbenzoate,ferredoxin:oxygen oxidoreductase (5-hydroxylating)
1.14.15.46 2-methoxy-6-polyprenylphenol 4-hydroxylase 2-methoxy-6-(all-trans-polyprenyl)phenol,ferredoxin:oxygen oxidoreductase (4-hydroxylating)
1.4.3.5 pyridoxal 5'-phosphate synthase pyridoxamine-5'-phosphate:oxygen oxidoreductase (deaminating)
1.5.1.3 dihydrofolate reductase 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
1.5.1.5 methylenetetrahydrofolate dehydrogenase (NADP+) 5,10-methylenetetrahydrofolate:NADP+ oxidoreductase
1.5.1.53 methylenetetrahydrofolate reductase (NADPH) 5-methyltetrahydrofolate:NADP+ oxidoreductase
1.6.2.4 NADPH-hemoprotein reductase NADPH:hemoprotein oxidoreductase
2.1.1.114 polyprenyldihydroxybenzoate methyltransferase S-adenosyl-L-methionine:3,4-dihydroxy-5-all-trans-polyprenylbenzoate 3-O-methyltransferase
2.1.1.201 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase S-adenosyl-L-methionine:2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol 5-C-methyltransferase
2.1.1.64 3-demethylubiquinol 3-O-methyltransferase S-adenosyl-L-methionine:3-hydroxy-2-methoxy-5-methyl-6-(all-trans-polyprenyl)-1,4-benzoquinol 3-O-methyltransferase
2.1.2.1 glycine hydroxymethyltransferase 5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase
2.4.2.19 nicotinate-nucleotide diphosphorylase (carboxylating) nicotinate-D-ribonucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating)
2.5.1.39 4-hydroxybenzoate polyprenyltransferase polyprenyl-diphosphate:4-hydroxybenzoate polyprenyltransferase
2.7.1.173 nicotinate riboside kinase ATP:beta-D-ribosylnicotinate 5-phosphotransferase
2.7.1.22 ribosylnicotinamide kinase ATP:N-ribosylnicotinamide 5'-phosphotransferase
2.7.1.23 NAD+ kinase ATP:NAD+ 2'-phosphotransferase
2.7.1.24 dephospho-CoA kinase ATP:3'-dephospho-CoA 3'-phosphotransferase
2.7.1.26 riboflavin kinase ATP:riboflavin 5'-phosphotransferase
2.7.1.33 pantothenate kinase ATP:(R)-pantothenate 4'-phosphotransferase
2.7.1.35 pyridoxal kinase ATP:pyridoxal 5'-phosphotransferase
2.7.6.2 thiamine diphosphokinase ATP:thiamine diphosphotransferase
2.7.7.2 FAD synthase ATP:FMN adenylyltransferase
2.7.7.3 pantetheine-phosphate adenylyltransferase ATP:pantetheine-4'-phosphate adenylyltransferase
2.8.1.7 cysteine desulfurase L-cysteine:acceptor sulfurtransferase
3.5.4.16 GTP cyclohydrolase I GTP 7,8-8,9-dihydrolase
3.5.4.9 methenyltetrahydrofolate cyclohydrolase 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)
3.6.1.22 NAD+ diphosphatase NAD+ phosphohydrolase
4.1.1.130 4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase 4-hydroxy-3-methoxy-5-all-trans-polyprenylbenzoate carboxy-lyase
4.2.1.93 ATP-dependent NAD(P)H-hydrate dehydratase (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ATP-hydrolysing; NADH-forming)
5.1.99.6 NAD(P)H-hydrate epimerase (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide 6-epimerase
6.3.2.17 tetrahydrofolate synthase tetrahydropteroyl-gamma-polyglutamate:L-glutamate gamma-ligase (ADP-forming)
6.3.2.5 phosphopantothenate-cysteine ligase (CTP) (R)-4'-phosphopantothenate:L-cysteine ligase
6.3.3.2 5-formyltetrahydrofolate cyclo-ligase 5-formyltetrahydrofolate cyclo-ligase (ADP-forming)
6.3.4.10 biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase biotin:apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming)
6.3.4.11 biotin-[methylcrotonoyl-CoA-carboxylase] ligase biotin:apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming)
6.3.4.14 biotin carboxylase [biotin carboxyl-carrier protein]-biotin-N6-L-lysine:hydrogencarbonate ligase (ADP-forming)
6.3.4.15 biotin-[biotin carboxyl-carrier protein] ligase biotin:apo-[carboxyl-carrier protein] ligase (AMP-forming)
6.3.4.3 formate-tetrahydrofolate ligase formate:tetrahydrofolate ligase (ADP-forming)
6.3.4.9 biotin-[methylmalonyl-CoA-carboxytransferase] ligase biotin:apo[methylmalonyl-CoA:pyruvate carboxytransferase] ligase (AMP-forming)
6.3.5.1 NAD+ synthase (glutamine-hydrolysing) deamido-NAD+:L-glutamine amido-ligase (AMP-forming)
6.4.1.1 pyruvate carboxylase pyruvate:carbon-dioxide ligase (ADP-forming)
6.4.1.2 acetyl-CoA carboxylase acetyl-CoA:hydrogencarbonate ligase (ADP-forming)


Proteins

Protein ID name full name
O13525 COQ4 Ubiquinone biosynthesis protein COQ4, mitochondrial
P07245 ADE3 C-1-tetrahydrofolate synthase, cytoplasmic
P07807 DFR1 Dihydrofolate reductase
P11154 PYC1 Pyruvate carboxylase 1
P16603 NCP1 NADPH--cytochrome P450 reductase
P18900 COQ1 Hexaprenyl pyrophosphate synthase, mitochondrial
P21373 UTR1 NAD(+) kinase
P21954 IDP1 Isocitrate dehydrogenase [NADP], mitochondrial
P25374 NFS1 Cysteine desulfurase, mitochondrial
P27680 COQ3 Ubiquinone biosynthesis O-methyltransferase, mitochondrial
P27697 COQ8 Atypical kinase COQ8, mitochondrial
P32378 COQ2 4-hydroxybenzoate polyprenyltransferase, mitochondrial
P35202 THI80 Thiamine pyrophosphokinase
P36059 NNR2 ATP-dependent (S)-NAD(P)H-hydrate dehydratase
P37291 SHM2 Serine hydroxymethyltransferase, cytosolic
P38075 PDX3 Pyridoxamine 5'-phosphate oxidase
P38795 QNS1 Glutamine-dependent NAD(+) synthetase
P38820 UBA4 Adenylyltransferase and sulfurtransferase UBA4
P38913 FAD1 Flavin adenine dinucleotide synthase
P39988 BUD16 Putative pyridoxal kinase BUD16
P40099 FAU1 5-formyltetrahydrofolate cyclo-ligase
P40165 NNR1 NAD(P)H-hydrate epimerase
P40506 CAB2 Phosphopantothenate--cysteine ligase CAB2
P43619 BNA6 Nicotinate-nucleotide pyrophosphorylase [carboxylating]
P48445 BPL1 Biotin--protein ligase
P49017 COQ5 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
P51601 FOL2 GTP cyclohydrolase 1
P53128 MET13 Methylenetetrahydrofolate reductase 2
P53164 NPY1 NAD-capped RNA hydrolase NPY1
P53318 COQ6 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
P53332 CAB4 Phosphopantetheine adenylyltransferase
P53915 NRK1 Nicotinamide riboside kinase
Q00955 ACC1 Acetyl-CoA carboxylase
Q03778 FMN1 Riboflavin kinase
Q03941 CAB5 Dephospho-CoA kinase CAB5
Q04430 CAB1 Pantothenate kinase CAB1
Q08645 MET7 Folylpolyglutamate synthase