ADE3 - Saccharomyces cerevisiae S288C

C-1-tetrahydrofolate synthase, cytoplasmic

Amino-acid biosynthesis ATP-binding Cytoplasm Direct protein sequencing Histidine biosynthesis Hydrolase Ligase Methionine biosynthesis Multifunctional enzyme NADP Nucleotide-binding Nucleus One-carbon metabolism Oxidoreductase Phosphoprotein Purine biosynthesis Reference proteome

Cytoplasm Nucleus
> ADE3 - Saccharomyces cerevisiae S288C [C-1-tetrahydrofolate synthase, cytoplasmic]
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统计信息
序列长度 0
疏水性残基 0
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Metadata

Organism Source: 559292 - Saccharomyces cerevisiae S288C
EC Number: 1.5.1.5 / 3.5.4.9 / 6.3.4.3
Cluster:
Registry Model:

Reactions

reaction id name note
KEGG:R00943 formate:tetrahydrofolate ligase (ADP-forming) Tetrahydrofolate + Formate + ATP <=> ADP + Orthophosphate + 10-Formyltetrahydrofolate
KEGG:R01220 5,10-methylenetetrahydrofolate:NADP+ oxidoreductase 5,10-Methylenetetrahydrofolate + NADP+ <=> 5,10-Methenyltetrahydrofolate + NADPH
KEGG:R01655 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing) 5,10-Methenyltetrahydrofolate + H2O <=> 10-Formyltetrahydrofolate + H+
BioCyc:FORMATETHFLIG-RXN THF-GLU-N + ATP + FORMATE --> FORMYL-THF-GLU-N + ADP + Pi
BioCyc:METHYLENETHFDEHYDROG-NADP-RXN METHYLENE-THF-GLU-N + NADP<=>5-10-METHENYL-THF-GLU-N + NADPH
BioCyc:METHENYLTHFCYCLOHYDRO-RXN 5-10-METHENYL-THF-GLU-N + WATER<=>FORMYL-THF-GLU-N + PROTON
Rhea:RHEA:20222 (6S)-5,6,7,8-tetrahydrofolate + formate + ATP => (6R)-10-formyltetrahydrofolate + ADP + phosphate
Rhea:RHEA:20223 (6R)-10-formyltetrahydrofolate + ADP + phosphate => (6S)-5,6,7,8-tetrahydrofolate + formate + ATP
Rhea:RHEA:20224 (6S)-5,6,7,8-tetrahydrofolate + formate + ATP <=> (6R)-10-formyltetrahydrofolate + ADP + phosphate
Rhea:RHEA:22813 (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP+ => (6R)-5,10-methenyltetrahydrofolate + NADPH
Rhea:RHEA:22814 (6R)-5,10-methenyltetrahydrofolate + NADPH => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP+
Rhea:RHEA:22815 (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP+ <=> (6R)-5,10-methenyltetrahydrofolate + NADPH
Rhea:RHEA:23701 (6R)-5,10-methenyltetrahydrofolate + H2O => (6R)-10-formyltetrahydrofolate + H+
Rhea:RHEA:23702 (6R)-10-formyltetrahydrofolate + H+ => (6R)-5,10-methenyltetrahydrofolate + H2O
Rhea:RHEA:23703 (6R)-5,10-methenyltetrahydrofolate + H2O <=> (6R)-10-formyltetrahydrofolate + H+

Pathways

pathway id name
BioCyc:YEAST_PWY3O-697 folate interconversions
BioCyc:YEAST_PWY-1722 formate assimilation into 5,10-methylenetetrahydrofolate
BioCyc:YEAST_PWY-2161 folate polyglutamylation
BioCyc:YEAST_PWY-2201 folate transformations
Reactome:R-SCE-1430728 Metabolism
Reactome:R-SCE-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-SCE-196854 Metabolism of vitamins and cofactors
Reactome:R-SCE-196757 Metabolism of folate and pterines