folate interconversions
Piper MD, Hong SP, Ball GE, Dawes IW. Regulation of the balance of one-carbon metabolism in Saccharomyces cerevisiae. J Biol Chem. 2000 Oct 06;275(40):30987–95. doi: 10.1074/jbc.m004248200. PMID: 10871621.; McNeil JB, Bognar AL, Pearlman RE. In Vivo Analysis of Folate Coenzymes and Their Compartmentation in Saccharomyces cerevisiae. 1996 Feb 01;142(2):371–81. doi: 10.1093/genetics/142.2.371.; Appling DR. Compartmentation of folate-mediated one-carbon metabolism in eukaryotes. FASEB J. 1991 Sep;5(12):2645–51. doi: 10.1096/fasebj.5.12.1916088. PMID: 1916088.; Shannon KW, Rabinowitz JC. Isolation and characterization of the Saccharomyces cerevisiae MIS1 gene encoding mitochondrial C1-tetrahydrofolate synthase. Journal of Biological Chemistry. 1988 Jun;263(16):7717–25. doi: 10.1016/s0021-9258(18)68558-8.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.4.4.2 | glycine dehydrogenase (aminomethyl-transferring) | glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating) | |
| 1.5.1.15 | methylenetetrahydrofolate dehydrogenase (NAD+) | 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase | |
| 1.5.1.20 | methylenetetrahydrofolate reductase [NAD(P)H] | 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase | |
| 1.5.1.3 | dihydrofolate reductase | 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase | |
| 1.5.1.5 | methylenetetrahydrofolate dehydrogenase (NADP+) | 5,10-methylenetetrahydrofolate:NADP+ oxidoreductase | |
| 1.5.1.53 | methylenetetrahydrofolate reductase (NADPH) | 5-methyltetrahydrofolate:NADP+ oxidoreductase | |
| 1.8.1.4 | dihydrolipoyl dehydrogenase | protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase | |
| 2.1.1.45 | thymidylate synthase | 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase | |
| 2.1.2.1 | glycine hydroxymethyltransferase | 5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase | |
| 2.1.2.10 | aminomethyltransferase | [protein]-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) | |
| 3.5.4.9 | methenyltetrahydrofolate cyclohydrolase | 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing) | |
| 6.3.4.3 | formate-tetrahydrofolate ligase | formate:tetrahydrofolate ligase (ADP-forming) |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P06785 | CDC21 | Thymidylate synthase |
| P07245 | ADE3 | C-1-tetrahydrofolate synthase, cytoplasmic |
| P07807 | DFR1 | Dihydrofolate reductase |
| P09440 | MIS1 | C-1-tetrahydrofolate synthase, mitochondrial |
| P09624 | LPD1 | Dihydrolipoyl dehydrogenase, mitochondrial |
| P37291 | SHM2 | Serine hydroxymethyltransferase, cytosolic |
| P37292 | SHM1 | Serine hydroxymethyltransferase, mitochondrial |
| P46151 | MET12 | Methylenetetrahydrofolate reductase 1 |
| P48015 | GCV1 | Aminomethyltransferase, mitochondrial |
| P49095 | GCV2 | Glycine dehydrogenase (decarboxylating), mitochondrial |
| P53128 | MET13 | Methylenetetrahydrofolate reductase 2 |
| Q02046 | MTD1 | Methylenetetrahydrofolate dehydrogenase [NAD(+)] |