BPL1 - Saccharomyces cerevisiae S288C
Biotin--protein ligase
> BPL1 - Saccharomyces cerevisiae S288C [Biotin--protein ligase]
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Metadata
Organism Source: 559292 - Saccharomyces cerevisiae S288C
EC Number: 6.3.4.- / 6.3.4.10 / 6.3.4.11 / 6.3.4.15 / 6.3.4.9
Cluster:
Registry Model:
Reactions
| reaction id | name | note |
|---|---|---|
| KEGG:R01074 | biotin:CoA ligase (AMP-forming); | first step of two-step reaction (R01075, R04562, R04563, R04582 or R04604) |
| KEGG:R04562 | biotin:apo-[acetyl-CoA:carbondioxide ligase (ADP-forming)] ligase (AMP-forming) | two-step reaction (see R01074 + R05145) |
| KEGG:R04563 | biotin:apo[methylmalonyl-CoA:pyruvate carboxyltransferase] ligase (AMP-forming) | two-step reaction (see R01074 + R05145) |
| KEGG:R04582 | biotin:apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] | two-step reaction (see R01074 + R05145) |
| KEGG:R04604 | biotin:apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming) | two-step reaction (see R01074 + R05145) |
| KEGG:R05145 | biotinyl-5'-AMP:apo-[carboxylase] ligase (AMP-forming) | general reaction (see R04562, R04563, R04582 and R04604) |
| BioCyc:BIOTINLIG-RXN | BCCP-L-lysine + BIOTIN + ATP --> PPI + AMP + BCCP-biotin-L-lysine + PROTON | |
| Rhea:RHEA:11205 | apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + biotin + ATP => holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + AMP + diphosphate + H+ | |
| Rhea:RHEA:11206 | holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + AMP + diphosphate + H+ => apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + biotin + ATP | |
| Rhea:RHEA:11207 | apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + biotin + ATP <=> holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + AMP + diphosphate + H+ | |
| Rhea:RHEA:11757 | biotin + L-lysyl-[protein] + ATP => N6-biotinyl-L-lysyl-[protein] + AMP + diphosphate + H+ | Multi-step reaction: RHEA:31115 + RHEA:59732 |
| Rhea:RHEA:11758 | N6-biotinyl-L-lysyl-[protein] + AMP + diphosphate + H+ => biotin + L-lysyl-[protein] + ATP | Multi-step reaction: RHEA:31115 + RHEA:59732 |
| Rhea:RHEA:11759 | biotin + L-lysyl-[protein] + ATP <=> N6-biotinyl-L-lysyl-[protein] + AMP + diphosphate + H+ | Multi-step reaction: RHEA:31115 + RHEA:59732 |
| Rhea:RHEA:23669 | apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + biotin + ATP => holo-[methylmalonyl-CoA:pyruvate carboxytransferase] + AMP + diphosphate + H+ | |
| Rhea:RHEA:23670 | holo-[methylmalonyl-CoA:pyruvate carboxytransferase] + AMP + diphosphate + H+ => apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + biotin + ATP | |
| Rhea:RHEA:23671 | apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + biotin + ATP <=> holo-[methylmalonyl-CoA:pyruvate carboxytransferase] + AMP + diphosphate + H+ | |
| Rhea:RHEA:24377 | apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + biotin + ATP => holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + AMP + diphosphate + H+ | |
| Rhea:RHEA:24378 | holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + AMP + diphosphate + H+ => apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + biotin + ATP | |
| Rhea:RHEA:24379 | apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + biotin + ATP <=> holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + AMP + diphosphate + H+ | |
| BioCyc:6.3.4.9-RXN | apo-Transcarboxylases + BIOTIN + ATP --> holo-Transcarboxylases + PPI + AMP | |
| BioCyc:6.3.4.10-RXN | ATP + BIOTIN + Apo-Propionyl-CoA-CO2-ligases --> AMP + PPI + Propionyl-CoA-CO2-ligases | |
| BioCyc:RXN-17368 | CPD-18779 + GLY + ATP --> CPD-18777 + ADP + Pi + 2 PROTON | |
| BioCyc:6.3.4.11-RXN | 3-methylcrotonoyl-CoA-carboxylase-lysine + BIOTIN + ATP --> Biotin-EC6-4-1-4 + PPI + AMP + PROTON | |
| BioCyc:RXN-12152 | GTP + CPD-13097 + L-ASPARTATE --> CPD-13099 + GDP + Pi + 2 PROTON |
Pathways
| pathway id | name |
|---|---|
| BioCyc:YEAST_PWY0-1264 | biotin-carboxyl carrier protein assembly |
| Reactome:R-SCE-1430728 | Metabolism |
| Reactome:R-SCE-196849 | Metabolism of water-soluble vitamins and cofactors |
| Reactome:R-SCE-196780 | Biotin transport and metabolism |
| Reactome:R-SCE-196854 | Metabolism of vitamins and cofactors |