EC: 2.7.11.1

non-specific serine/threonine protein kinase (ATP:protein phosphotransferase (non-specific))

enzyme lambda metabolic reaction experiment
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

ATP + Lys_Lys_Arg_Asn_Arg_Thr_Leu_Ser_Val -> ADP + Lys_Lys_Arg_Asn_Arg_Thr_Leu_Ser_phosphate_Val		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

Gly_Arg_Pro_Arg_Thr_Ser_Ser_Phe + ATP -> Gly_Arg_Pro_Arg_Thr_Ser_Ser_phosphate_Phe + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

Arg_Pro_Arg_Thr_Ser_Ser_Leu + ATP -> ADP + Arg_Pro_Arg_Thr_Ser_Ser_phosphate_Leu		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

ATP + Arg_Pro_Arg_Ala_Ser_Ser_Phe -> ADP + Arg_Pro_Arg_Ala_Ser_Ser_phosphate_Phe		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

ATP + Arg_Pro_Arg_Thr_Ser_Ser_Phe -> ADP + Arg_Pro_Arg_Thr_Ser_Ser_phosphate_Phe		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

Arg_Pro_Arg_Thr_Ser_Ser_Val + ATP -> ADP + Arg_Pro_Arg_Thr_Ser_Ser_phosphate_Val		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

Arg_Pro_Arg_Thr_Ser_Thr_Phe + ATP -> ADP + Arg_Pro_Arg_Thr_Ser_Thr_phosphate_Phe		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

Arg_Pro_Arg_Thr_Ser_Ser_Ala + ATP -> ADP + Arg_Pro_Arg_Thr_Ser_Ser_phosphate_Ala		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

ATP + Arg_Pro_Arg_Gly_Ser_Ser_Phe -> Arg_Pro_Arg_Gly_Ser_Ser_phosphate_Phe + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

ATP + Arg_Pro_Arg_Thr_Ser_Ser_Lys -> ADP + Arg_Pro_Arg_Thr_Ser_Ser_phosphate_Lys		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
uniprot:P31751 [non-specific serine/threonine protein kinase(Enzyme) wildtype activated His PKB beta]

ATP + Gly_Arg_Pro_Arg_Thr_Ser_Ser_Phe_Ala_Glu_Gly -> ADP + Gly_Arg_Pro_Arg_Thr_Ser_Ser_phosphate_Phe_Ala_Glu_Gly		 (( (Vmax * S) ) / (Km + S)) buffer: *
PH: 7
Temperature: 36
uniprot:Q9Y243 [non-specific serine/threonine protein kinase(Enzyme) wildtype activated GST PKB gamma]

Gly_Arg_Pro_Arg_Thr_Ser_Ser_Phe_Ala_Glu_Gly + ATP -> ADP + Gly_Arg_Pro_Arg_Thr_Ser_Ser_phosphate_Phe_Ala_Glu_Gly		 (( (Vmax * S) ) / (Km + S)) buffer: *
PH: 7
Temperature: 36
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

ATP + Gly_Arg_Pro_Arg_Thr_Ser_Ser_Phe_Ala_Glu_Gly -> ADP + Gly_Arg_Pro_Arg_Thr_Ser_Ser_phosphate_Phe_Ala_Glu_Gly		 (( (Vmax * S) ) / (Km + S)) buffer: *
PH: 7
Temperature: 36
uniprot:P31751 [non-specific serine/threonine protein kinase(Enzyme) wildtype activated His PKB beta]

Arg_Pro_Arg_Ala_Ala_Thr_Phe + ATP -> Arg_Pro_Arg_Ala_Ala_Thr_phosphate_Phe + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: *
PH: 7
Temperature: 36
uniprot:Q9Y243 [non-specific serine/threonine protein kinase(Enzyme) wildtype activated GST PKB gamma]

ATP + Arg_Pro_Arg_Ala_Ala_Thr_Phe -> Arg_Pro_Arg_Ala_Ala_Thr_phosphate_Phe + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: *
PH: 7
Temperature: 36
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

Arg_Pro_Arg_Ala_Ala_Thr_Phe + ATP -> ADP + Arg_Pro_Arg_Ala_Ala_Thr_phosphate_Phe		 (( (Vmax * S) ) / (Km + S)) buffer: *
PH: 7
Temperature: 36
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

ATP + Gly_Arg_Pro_Arg_Thr_Ser_Ser_Phe_Ala_Glu_Gly -> ADP + Gly_Arg_Pro_Arg_Thr_Ser_Ser_phosphate_Phe_Ala_Glu_Gly		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

ATP + Arg_Pro_Arg_Thr_Ala_Ser_Phe -> Arg_Pro_Arg_Thr_Ala_Ser_phosphate_Phe + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

ATP + Arg_Pro_Arg_Thr_Gly_Ser_Phe -> Arg_Pro_Arg_Thr_Gly_Ser_phosphate_Phe + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

ATP + Arg_Pro_Arg_Thr_Asn_Ser_Phe -> ADP + Arg_Pro_Arg_Thr_Asn_Ser_phosphate_Phe		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

ATP + Arg_Pro_Arg_Thr_Val_Ser_Phe -> Arg_Pro_Arg_Thr_Val_Ser_phosphate_Phe + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

ATP + Arg_Pro_Arg_Ala_Ala_Ser_Phe -> ADP + Arg_Pro_Arg_Ala_Ala_Ser_phosphate_Phe		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

Arg_Pro_Arg_Val_Ser_Ser_Phe + ATP -> Arg_Pro_Arg_Val_Ser_Ser_phosphate_Phe + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

Arg_Pro_Arg_Gly_Ala_Ser_Phe + ATP -> Arg_Pro_Arg_Gly_Ala_Ser_phosphate_Phe + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

ATP + Arg_Pro_Arg_Ala_Gly_Ser_Phe -> ADP + Arg_Pro_Arg_Ala_Gly_Ser_phosphate_Phe		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

Arg_Pro_Arg_Gly_Gly_Ser_Phe + ATP -> Arg_Pro_Arg_Gly_Gly_Ser_phosphate_Phe + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
- [non-specific serine/threonine protein kinase(Enzyme) wildtype]

ATP + CD98 -> ADP + CD98_phosphorylated		 (( (Vmax * A) ) / (Km + A)) buffer: 30 mM Tris-HCl, 1 mM EGTA, 150 mM NaCl, 50 mM KCl, 10 mM MgCl2, 100 µM Na3VO4, 100 µM NaF, 0.05% Triton X-100
PH: 7.6
Temperature: 30
uniprot:P67999 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

ATP + Gly_Arg_Pro_Arg_Thr_Ser_Ser_Phe_Ala_Glu_Gly -> ADP + Gly_Arg_Pro_Arg_Thr_Ser_Ser_phosphate_Phe_Ala_Glu_Gly		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
- [non-specific serine/threonine protein kinase(Enzyme) wildtype]

ATP + Gly_Arg_Pro_Arg_Thr_Ser_Ser_Phe_Ala_Glu_Gly -> ADP + Gly_Arg_Pro_Arg_Thr_Ser_Ser_phosphate_Phe_Ala_Glu_Gly		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

Lys_Lys_Lys_Asn_Arg_Thr_Leu_Ser_Val_Ala + ATP -> ADP + Lys_Lys_Lys_Asn_Arg_Thr_Leu_Ser_phosphate_Val_Ala		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

Lys_Lys_Arg_Asn_Arg_Thr_Leu_Ser_Val_Ala + ATP -> Lys_Lys_Arg_Asn_Arg_Thr_Leu_Ser_phosphate_Val_Ala + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

Arg_Pro_Arg_Ala_Ala_Thr_Phe + ATP -> Arg_Pro_Arg_Ala_Ala_Thr_phosphate_Phe + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
uniprot:P67999 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

Arg_Pro_Arg_Thr_Ser_Thr_Phe + ATP -> ADP + Arg_Pro_Arg_Thr_Ser_Thr_phosphate_Phe		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
uniprot:P67999 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

ATP + Arg_Pro_Arg_Thr_Ser_Ser_Phe -> Arg_Pro_Arg_Thr_Ser_Ser_phosphate_Phe + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
- [non-specific serine/threonine protein kinase(Enzyme) wildtype]

Arg_Pro_Arg_Ala_Ala_Ser_Phe + ATP -> Arg_Pro_Arg_Ala_Ala_Ser_phosphate_Phe + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
- [non-specific serine/threonine protein kinase(Enzyme) wildtype]

Arg_Pro_Arg_Thr_Ser_Ser_Phe + ATP -> Arg_Pro_Arg_Thr_Ser_Ser_phosphate_Phe + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

Arg_Pro_Arg_Thr_Ser_Ser_Phe_Ala + ATP -> ADP + Arg_Pro_Arg_Thr_Ser_Ser_phosphate_Phe_Ala		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 0.1 mM EGTA, 0.1 % (v/v) 2-mercaptoethanol, 2.5 µM PKI, 10 mM magnesium acetate
PH: 7.5
Temperature: 30
uniprot:P31749 [ADP]

Peptide + ATP -> ADP + Phosphopeptide		 (( (Vmax * A) ) / (( (Km * (1 + (I / Ki))) ) + (A * (1 + (I / Ki))))) buffer: 20 mM Tris-HCl, 10 mM MgCl2, 1 mM DTT, 1 mM EGTA, 1 mM Na3VO4, 0.1% BSA
PH: 7.4
Temperature: 22
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype AKT1, His-tagged]

ATP + Peptide -> ADP + Phosphopeptide		 (( (Vmax * A) ) / (( (Km * (1 + (I / Ki))) ) + (A * (1 + (I / Ki))))) buffer: 20 mM Tris-HCl, 10 mM MgCl2, 1 mM DTT, 1 mM EGTA, 1 mM Na3VO4, 0.1% BSA
PH: 7.4
Temperature: 22
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype AKT1, His-tagged]

Peptide + ATP -> Phosphopeptide + ADP		 (( (Vmax * A) ) / (( (Km * (1 + (I / Ki))) ) + A)) buffer: 20 mM Tris-HCl, 10 mM MgCl2, 1 mM DTT, 1 mM EGTA, 1 mM Na3VO4, 0.1% BSA
PH: 7.4
Temperature: 22
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype AKT1, His-tagged]

ATP + Peptide -> Phosphopeptide + ADP		 (( (Vmax * A) ) / (( (Km * (1 + (I / Ki))) ) + (A * (1 + (I / Ki))))) buffer: 20 mM Tris-HCl, 10 mM MgCl2, 1 mM DTT, 1 mM EGTA, 1 mM Na3VO4, 0.1% BSA
PH: 7.4
Temperature: 22
uniprot:Q9Y243 [non-specific serine/threonine protein kinase(Enzyme) wildtype myr-AKT3-IP]

Peptide + ATP -> Phosphopeptide + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 10 mM MgCl2, 1 mM DTT, 1 mM EGTA, 1 mM Na3VO4, 0.1% BSA
PH: 7.4
Temperature: 22
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype myr-AKT1-IP]

ATP + Peptide -> Phosphopeptide + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 10 mM MgCl2, 1 mM DTT, 1 mM EGTA, 1 mM Na3VO4, 0.1% BSA
PH: 7.4
Temperature: 22
uniprot:P31751 [non-specific serine/threonine protein kinase(Enzyme) wildtype myr-AKT2-IP]

Peptide + ATP -> Phosphopeptide + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 10 mM MgCl2, 1 mM DTT, 1 mM EGTA, 1 mM Na3VO4, 0.1% BSA
PH: 7.4
Temperature: 22
uniprot:P31751 [non-specific serine/threonine protein kinase(Enzyme) wildtype myr-AKT2-IP]

ATP + Peptide -> Phosphopeptide + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 10 mM MgCl2, 1 mM DTT, 1 mM EGTA, 1 mM Na3VO4, 0.1% BSA
PH: 7.4
Temperature: 22
uniprot:Q9Y243 [non-specific serine/threonine protein kinase(Enzyme) wildtype myr-AKT3-IP]

Peptide + ATP -> ADP + Phosphopeptide		 (( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 10 mM MgCl2, 1 mM DTT, 1 mM EGTA, 1 mM Na3VO4, 0.1% BSA
PH: 7.4
Temperature: 22
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype AKT1, His-tagged]

ATP + Peptide -> ADP + Phosphopeptide		 (( (kcat * E) ) / (( (( (( (( (alpha * Ka) ) / A) ) + (( (alpha * Kb) ) / B)) ) + (( (( (( (alpha * Kia) ) * Kb) ) / A) ) * B)) ) + 1)) buffer: 20 mM Tris-HCl, 10 mM MgCl2, 1 mM DTT, 1 mM EGTA, 1 mM Na3VO4, 0.1% BSA
PH: 7.4
Temperature: 22
uniprot:Q9Y243 [non-specific serine/threonine protein kinase(Enzyme) wildtype AKT3, His-tagged]

ATP + Peptide -> Phosphopeptide + ADP		 (( (kcat * E) ) / (( (( (( (( (alpha * Ka) ) / A) ) + (( (alpha * Kb) ) / B)) ) + (( (( (( (alpha * Kia) ) * Kb) ) / A) ) * B)) ) + 1)) buffer: 20 mM Tris-HCl, 10 mM MgCl2, 1 mM DTT, 1 mM EGTA, 1 mM Na3VO4, 0.1% BSA
PH: 7.4
Temperature: 22
uniprot:P31751 [non-specific serine/threonine protein kinase(Enzyme) wildtype AKT2, His-tagged]

ATP + Peptide -> ADP + Phosphopeptide		 (( (kcat * E) ) / (( (( (( (( (alpha * Ka) ) / A) ) + (( (alpha * Kb) ) / B)) ) + (( (( (( (alpha * Kia) ) * Kb) ) / A) ) * B)) ) + 1)) buffer: 20 mM Tris-HCl, 10 mM MgCl2, 1 mM DTT, 1 mM EGTA, 1 mM Na3VO4, 0.1% BSA
PH: 7.4
Temperature: 22
uniprot:P31749 [non-specific serine/threonine protein kinase(Enzyme) wildtype myr-AKT1-IP]

Peptide + ATP -> ADP + Phosphopeptide		 (( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 10 mM MgCl2, 1 mM DTT, 1 mM EGTA, 1 mM Na3VO4, 0.1% BSA
PH: 7.4
Temperature: 22
- [PP2A]

S6K1 + Phosphate -> S6K1p		 (( (( (k20 * mTOR_Raptor) ) * (( (kto ^ nto) ) / (( (kto ^ nto) ) + (PP2A ^ nto)))) ) * S6K1) buffer: *
PH: 7
Temperature: 36
uniprot:P31749 [beta,gamma-Methylene ATP]

Peptide + ATP -> Phosphopeptide + ADP		 (( (Vmax * A) ) / (( (Km * (1 + (I / Ki))) ) + (A * (1 + (I / Ki))))) buffer: 20 mM Tris-HCl, 10 mM MgCl2, 1 mM DTT, 1 mM EGTA, 1 mM Na3VO4, 0.1% BSA
PH: 7.4
Temperature: 22
uniprot:P31749 [beta,gamma-Methylene ATP]

Peptide + ATP -> Phosphopeptide + ADP		 (( (Vmax * A) ) / (( (Km * (1 + (I / Ki))) ) + A)) buffer: 20 mM Tris-HCl, 10 mM MgCl2, 1 mM DTT, 1 mM EGTA, 1 mM Na3VO4, 0.1% BSA
PH: 7.4
Temperature: 22
uniprot:P31749 [Ala-peptide]

Peptide + ATP -> ADP + Phosphopeptide		 (( (Vmax * A) ) / (Km + (A * (1 + (I / Ki))))) buffer: 20 mM Tris-HCl, 10 mM MgCl2, 1 mM DTT, 1 mM EGTA, 1 mM Na3VO4, 0.1% BSA
PH: 7.4
Temperature: 22
uniprot:P31749 [Ala-peptide]

ATP + Peptide -> ADP + Phosphopeptide		 (( (Vmax * A) ) / (( (Km * (1 + (I / Ki))) ) + A)) buffer: 20 mM Tris-HCl, 10 mM MgCl2, 1 mM DTT, 1 mM EGTA, 1 mM Na3VO4, 0.1% BSA
PH: 7.4
Temperature: 22
uniprot:Q9Y243 [non-specific serine/threonine protein kinase(Enzyme) wildtype AKT3, His-tagged]

Peptide + ATP -> ADP + Phosphopeptide		 (( (Vmax * A) ) / (( (Km * (1 + (I / Ki))) ) + (A * (1 + (I / Ki))))) buffer: 20 mM Tris-HCl, 10 mM MgCl2, 1 mM DTT, 1 mM EGTA, 1 mM Na3VO4, 0.1% BSA
PH: 7.4
Temperature: 22
uniprot:P31751 [non-specific serine/threonine protein kinase(Enzyme) wildtype AKT2, His-tagged]

Peptide + ATP -> Phosphopeptide + ADP		 (( (Vmax * A) ) / (( (Km * (1 + (I / Ki))) ) + (A * (1 + (I / Ki))))) buffer: 20 mM Tris-HCl, 10 mM MgCl2, 1 mM DTT, 1 mM EGTA, 1 mM Na3VO4, 0.1% BSA
PH: 7.4
Temperature: 22
uniprot:Q9Y243 [non-specific serine/threonine protein kinase(Enzyme) wildtype AKT3, His-tagged]

ATP + Peptide -> ADP + Phosphopeptide		 (( (Vmax * A) ) / (( (Km * (1 + (I / Ki))) ) + A)) buffer: 20 mM Tris-HCl, 10 mM MgCl2, 1 mM DTT, 1 mM EGTA, 1 mM Na3VO4, 0.1% BSA
PH: 7.4
Temperature: 22
uniprot:P31751 [non-specific serine/threonine protein kinase(Enzyme) wildtype AKT2, His-tagged]

Peptide + ATP -> ADP + Phosphopeptide		 (( (Vmax * A) ) / (( (Km * (1 + (I / Ki))) ) + A)) buffer: 20 mM Tris-HCl, 10 mM MgCl2, 1 mM DTT, 1 mM EGTA, 1 mM Na3VO4, 0.1% BSA
PH: 7.4
Temperature: 22
uniprot:P48730 [non-specific serine/threonine protein kinase(Enzyme) mutant T44A delta317]

alpha_Casein + ATP -> ADP + phosphorylated_alpha_Casein		 (( (Vmax * B) ) / (Km_B + B)) buffer: 50 mM Hepes, 1 mM DTT, 1 mM MgCl2
PH: 7.5
Temperature: 25
uniprot:P48730 [non-specific serine/threonine protein kinase(Enzyme) wildtype delta317]

ATP + alpha_Casein -> phosphorylated_alpha_Casein + ADP		 (( (Vmax * B) ) / (Km_B + B)) buffer: 50 mM Hepes, 1 mM DTT, 1 mM MgCl2
PH: 7.5
Temperature: 25
uniprot:P48730 [non-specific serine/threonine protein kinase(Enzyme) mutant H46R delta317]

alpha_Casein + ATP -> phosphorylated_alpha_Casein + ADP		 (( (Vmax * B) ) / (Km_B + B)) buffer: 50 mM Hepes, 1 mM DTT, 1 mM MgCl2
PH: 7.5
Temperature: 25
- [non-specific serine/threonine protein kinase(Enzyme) wildtype]

cdc2k + ATP -> cdc2k_P + ADP		 (( (cell * C2) ) * k8notP) buffer: *
PH: 7
Temperature: 36
uniprot:P48730 [non-specific serine/threonine protein kinase(Enzyme) mutant H46R delta317]

PER2_peptide + ATP -> ADP + phosphorylated_PER2_peptide		 (( (Vmax * B) ) / (Km_B + B)) buffer: 50 mM Hepes, 1 mM DTT, 1 mM MgCl2
PH: 7.5
Temperature: 25
uniprot:P48730 [non-specific serine/threonine protein kinase(Enzyme) wildtype delta317]

PER2_peptide + ATP -> ADP + phosphorylated_PER2_peptide		 (( (Vmax * B) ) / (Km_B + B)) buffer: 50 mM Hepes, 1 mM DTT, 1 mM MgCl2
PH: 7.5
Temperature: 25
uniprot:P48730 [non-specific serine/threonine protein kinase(Enzyme) mutant T44A delta317]

alpha_Casein + ATP -> ADP + phosphorylated_alpha_Casein		 (( (Vmax * A) ) / (Km_A + A)) buffer: 50 mM Hepes, 1 mM DTT, 1 mM MgCl2
PH: 7.5
Temperature: 25
uniprot:P48730 [non-specific serine/threonine protein kinase(Enzyme) mutant T44A delta317]

ATP + PER2_peptide -> phosphorylated_PER2_peptide + ADP		 (( (Vmax * B) ) / (Km_B + B)) buffer: 50 mM Hepes, 1 mM DTT, 1 mM MgCl2
PH: 7.5
Temperature: 25
uniprot:P48730 [non-specific serine/threonine protein kinase(Enzyme) mutant H46R delta317]

alpha_Casein + ATP -> phosphorylated_alpha_Casein + ADP		 (( (Vmax * A) ) / (Km_A + A)) buffer: 50 mM Hepes, 1 mM DTT, 1 mM MgCl2
PH: 7.5
Temperature: 25
uniprot:P48730 [non-specific serine/threonine protein kinase(Enzyme) wildtype delta317]

ATP + alpha_Casein -> phosphorylated_alpha_Casein + ADP		 (( (Vmax * A) ) / (Km_A + A)) buffer: 50 mM Hepes, 1 mM DTT, 1 mM MgCl2
PH: 7.5
Temperature: 25
uniprot:O15530 [non-specific serine/threonine protein kinase(Enzyme) wildtype N-terminal middle T-tag]

Protein + ATP -> ADP + Phosphoprotein		 (( (( (( (( (E * kcat) ) * A) ) * B) ) / (alphaKm_A * Km_B)) ) / (( (( (1 + (A / Km_A)) ) + (B / Km_B)) ) + (( (( (A * B) ) / alphaKm_A) ) * Km_B))) buffer: 10 mM HEPES, 0.002% Brij-35, 0.2 mM EGTA, 5 mM MgCl2, 2 mM DTT
PH: 7.5
Temperature: 36
uniprot:Q9Y6E0 [Co2+]

ATP + Myelin_basic_protein -> ADP + phosphorylated_Myelin_basic_protein		 (( (Vmax * S) ) / (Km + S)) buffer: 40 mM PIPES
PH: 7
Temperature: 22
uniprot:Q9Y6E0 [Mg2+]

Myelin_basic_protein + ATP -> phosphorylated_Myelin_basic_protein + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 40 mM PIPES
PH: 7
Temperature: 22
uniprot:Q9Y6E0 [Mn2+]

ATP + Myelin_basic_protein -> ADP + phosphorylated_Myelin_basic_protein		 (( (Vmax * S) ) / (Km + S)) buffer: 40 mM PIPES
PH: 7
Temperature: 22
uniprot:Q6IQ55 [Mg2+]

ATP + Peptide -> ADP + Phosphopeptide		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris/HCl, 0.1 mM EGTA
PH: 7.5
Temperature: 30
uniprot:Q6IQ55 [Mg2+]

Peptide + ATP -> Phosphopeptide + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris/HCl, 0.1 mM EGTA
PH: 7.5
Temperature: 30
uniprot:Q6IQ55 [Mg2+]

ATP + Peptide -> Phosphopeptide + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris/HCl, 0.1 mM EGTA
PH: 7.5
Temperature: 30
uniprot:Q6IQ55 [Mg2+]

ATP + Peptide -> Phosphopeptide + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris/HCl, 0.1 mM EGTA
PH: 7.5
Temperature: 30
uniprot:Q6IQ55 [Mg2+]

ATP + Peptide -> ADP + Phosphopeptide		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris/HCl, 0.1 mM EGTA
PH: 7.5
Temperature: 30
uniprot:Q6IQ55 [Mg2+]

Peptide + ATP -> Phosphopeptide + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris/HCl, 0.1 mM EGTA
PH: 7.5
Temperature: 30
uniprot:Q6IQ55 [Mg2+]

Peptide + ATP -> ADP + Phosphopeptide		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris/HCl, 0.1 mM EGTA
PH: 7.5
Temperature: 30
uniprot:Q6IQ55 [Mg2+]

ATP + Peptide -> Phosphopeptide + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris/HCl, 0.1 mM EGTA
PH: 7.5
Temperature: 30
uniprot:Q6IQ55 [Mg2+]

Peptide + ATP -> Phosphopeptide + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris/HCl, 0.1 mM EGTA
PH: 7.5
Temperature: 30
uniprot:Q6IQ55 [Mg2+]

ATP + Peptide -> ADP + Phosphopeptide		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris/HCl, 0.1 mM EGTA
PH: 7.5
Temperature: 30
uniprot:Q6IQ55 [Mg2+]

ATP + Peptide -> ADP + Phosphopeptide		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris/HCl, 0.1 mM EGTA
PH: 7.5
Temperature: 30
uniprot:Q6IQ55 [Mg2+]

ATP + Peptide -> ADP + Phosphopeptide		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris/HCl, 0.1 mM EGTA
PH: 7.5
Temperature: 30
uniprot:Q6IQ55 [Mg2+]

ATP + Peptide -> Phosphopeptide + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris/HCl, 0.1 mM EGTA
PH: 7.5
Temperature: 30
uniprot:Q6IQ55 [Mg2+]

Peptide + ATP -> Phosphopeptide + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris/HCl, 0.1 mM EGTA
PH: 7.5
Temperature: 30
uniprot:Q6IQ55 [Mg2+]

ATP + Peptide -> Phosphopeptide + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris/HCl, 0.1 mM EGTA
PH: 7.5
Temperature: 30
uniprot:Q9Y6E0 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

ATP + Myelin_basic_protein -> phosphorylated_Myelin_basic_protein + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 40 mM PIPES
PH: 7
Temperature: 22
uniprot:Q1MX30 [Mg2+]

XA21K_intracellular_domain + ATP -> phosphorylated_XA21K_intracellular_domain + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM HEPES, 1 mM dithiothreitol
PH: 7.4
Temperature: 22
uniprot:Q9FIL7 [Calmodulin]

CRCK1 + ATP -> phosphorylated_CRCK1 + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 25 mM HEPES
PH: 7.5
Temperature: 25
uniprot:Q9FIL7 [Mg2+]

CRCK1 + ATP -> phosphorylated_CRCK1 + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 25 mM HEPES
PH: 7.5
Temperature: 25
uniprot:Q6IQ55 [Mg2+]

ATP + Peptide -> ADP + Phosphopeptide		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris/HCl, 0.1 mM EGTA
PH: 7.5
Temperature: 30
uniprot:Q6IQ55 [Mg2+]

Peptide + ATP -> Phosphopeptide + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris/HCl, 0.1 mM EGTA
PH: 7.5
Temperature: 30
uniprot:Q6IQ55 [Mg2+]

ATP + Peptide -> Phosphopeptide + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris/HCl, 0.1 mM EGTA
PH: 7.5
Temperature: 30
uniprot:Q6IQ55 [Mg2+]

ATP + Peptide -> Phosphopeptide + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris/HCl, 0.1 mM EGTA
PH: 7.5
Temperature: 30
uniprot:Q6IQ55 [Mg2+]

Peptide + ATP -> Phosphopeptide + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris/HCl, 0.1 mM EGTA
PH: 7.5
Temperature: 30
uniprot:Q6IQ55 [Mg2+]

ATP + Peptide -> Phosphopeptide + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris/HCl, 0.1 mM EGTA
PH: 7.5
Temperature: 30
uniprot:Q94AG2 [Mg2+]

L_Threonyl_AtSERK1 + ATP -> ADP + O_Phospho_L_threonyl_AtSERK1		 (( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris, 50 mM NaCl, 0.01 % Triton X-100, 1 mM dithiothreitol
PH: 7.5
Temperature: 30
uniprot:P80197 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

Fragmin_actin_complex + ATP -> Phospho_fragmin_actin_complex + ADP		 (( (Vmax * S2) ) / (Km + S2)) buffer: 30 mM HEPES-NaOH, 5 mM NaF, 10 mM ß-glycerophosphate, 0.1 mg/ml leupeptin, 1 mM DTT, 30 mM KCl, 6 mM MgCl2, 1 mM EGTA-Ca2+
PH: 7.2
Temperature: 25
uniprot:P80197 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

Fragmin_actin_complex + ATP -> Phospho_fragmin_actin_complex + ADP		 (( (Vmax * S1) ) / (Km + S1)) buffer: 30 mM HEPES-NaOH, 5 mM NaF, 10 mM ß-glycerophosphate, 0.1 mg/ml leupeptin, 1 mM DTT, 30 mM KCl, 6 mM MgCl2, 1 mM EGTA-Ca2+
PH: 7.2
Temperature: 25
- [non-specific serine/threonine protein kinase(Enzyme) wildtype]

Protein + ATP -> Phosphoprotein + ADP		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K229A/K230A/K232A]

ATP + Protein -> Phosphoprotein + ADP		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K229A]

Protein + ATP -> Phosphoprotein + ADP		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) wildtype]

ATP + Protein -> ADP + Phosphoprotein		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K232A]

ATP + Protein -> Phosphoprotein + ADP		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K230A]

Protein + ATP -> Phosphoprotein + ADP		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K230A]

Protein + ATP -> ADP + Phosphoprotein		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) wildtype]

Protein + ATP -> ADP + Phosphoprotein		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K229A]

Protein + ATP -> Phosphoprotein + ADP		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K229A/K230A/K232A]

Protein + ATP -> Phosphoprotein + ADP		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K229A/K230A/K232A]

ATP + Protein -> Phosphoprotein + ADP		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K232A]

ATP + Protein -> Phosphoprotein + ADP		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K229A]

ATP + Protein -> Phosphoprotein + ADP		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K230A]

ATP + Protein -> ADP + Phosphoprotein		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K232A]

ATP + Protein -> Phosphoprotein + ADP		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) wildtype]

Protein + ATP -> Phosphoprotein + ADP		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) wildtype]

ATP + Protein -> Phosphoprotein + ADP		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K229A]

Protein + ATP -> Phosphoprotein + ADP		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K232A]

ATP + Protein -> ADP + Phosphoprotein		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K230A]

Protein + ATP -> Phosphoprotein + ADP		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K229A/K230A/K232A]

ATP + Protein -> Phosphoprotein + ADP		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K230A]

Protein + ATP -> ADP + Phosphoprotein		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K229A/K230A/K232A]

Protein + ATP -> ADP + Phosphoprotein		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K232A]

ATP + Protein -> Phosphoprotein + ADP		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K229A]

Protein + ATP -> Phosphoprotein + ADP		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) wildtype]

Protein + ATP -> ADP + Phosphoprotein		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K229A]

Protein + ATP -> ADP + Phosphoprotein		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K230A]

ATP + Protein -> Phosphoprotein + ADP		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K229A/K230A/K232A]

Protein + ATP -> Phosphoprotein + ADP		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K232A]

ATP + Protein -> ADP + Phosphoprotein		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) wildtype]

Protein + ATP -> Phosphoprotein + ADP		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K232A]

Protein + ATP -> Phosphoprotein + ADP		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K230A]

Protein + ATP -> ADP + Phosphoprotein		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K229A]

Protein + ATP -> ADP + Phosphoprotein		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
- [non-specific serine/threonine protein kinase(Enzyme) mutant K229A/K230A/K232A]

ATP + Protein -> ADP + Phosphoprotein		 (( (V * A) ) / (Km + A)) buffer: 50 mM Tris/HCl, 10 mM MgCl2, 100 mM NaCl
PH: 7.5
Temperature: 37
uniprot:Q91ZN7 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

ATP + Protein_tyrosine -> ADP + Protein_tyrosine_phosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 20 mM Tris-HCl, 10 mM MgCl2, 1 mM MnCl2, 50 µM Na3VO4
PH: 7
Temperature: 30
uniprot:P10728 [non-specific serine/threonine protein kinase(Enzyme) wildtype]

ATP + SpoIIAA -> ADP + SpoIIAA_phosphorylated		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 50 mM KCl, 10 mM MgCl2, 1 mM DTT
PH: 7.5
Temperature: 21
uniprot:P10728 [non-specific serine/threonine protein kinase(Enzyme) mutant E104K]

ATP + SpoIIAA -> SpoIIAA_phosphorylated + ADP		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 50 mM Tris-HCl, 50 mM KCl, 10 mM MgCl2, 1 mM DTT
PH: 7.5
Temperature: 21
uniprot:Q9ZVR7 [Mg2+]

Ser/Thr_peptide + ATP -> phosphorylated_Ser/Thr_peptide + ADP		 (( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 0.2 mM DTT
PH: 7.5
Temperature: 36

Pathways

pathway id name
BioCyc:HUMAN_PWY66-400 glycolysis
BioCyc:HUMAN_PWY-6352 3-phosphoinositide biosynthesis
BioCyc:META_PWY-6352 3-phosphoinositide biosynthesis
BioCyc:META_ANAGLYCOLYSIS-PWY glycolysis III (from glucose)
BioCyc:ARA_PWY-6352 3-phosphoinositide biosynthesis
BioCyc:MOUSE_GLYCOLYSIS glycolysis I
BioCyc:MOUSE_PWY3DJ-1 cyclic AMP biosynthesis
BioCyc:MOUSE_PWY3DJ-219 PIP metabolism
BioCyc:MOUSE_GLUCONEO-PWY gluconeogenesis I
BioCyc:HUMAN_PWY66-399 gluconeogenesis
BioCyc:META_ANAEROFRUCAT-PWY homolactic fermentation
BioCyc:ARA_GLUCONEO-PWY gluconeogenesis I
BioCyc:MOUSE_PWY-6352 3-phosphoinositide biosynthesis
BioCyc:HUMAN_PWY66-407 superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
BioCyc:META_PWY66-399 gluconeogenesis III
BioCyc:YEAST_PWY-6352 3-phosphoinositide biosynthesis
BioCyc:ARA_PWY-6952 glycerophosphodiester degradation
BioCyc:MOUSE_P341-PWY glycolysis V (Pyrococcus)
BioCyc:SYNEL_PWY490-12 circadian clock oscillator KaiABC
BioCyc:HUMAN_PWY-6371 superpathway of inositol phosphate compounds
BioCyc:YEAST_PWY3O-242 phosphatidylinositol phosphate biosynthesis
BioCyc:ARA_PWY-561 superpathway of glyoxylate cycle and fatty acid degradation
BioCyc:MOUSE_ANAGLYCOLYSIS-PWY glycolysis III
PathBank:SMP0000837 Threonine Biosynthesis
Plant Reactome:R-OSA-9826798 Gravitropism under normal or artificial gravity environments
Plant Reactome:R-OSA-9928372 Root gravitropism
Plant Reactome:R-OSA-9916190 Root angle formation: elongation and curvature response
Plant Reactome:R-OSA-9766881 TF network involved in salinity response
Plant Reactome:R-OSA-9030769 Growth and developmental processes
Plant Reactome:R-OSA-9031670 Vegetative structure development
Plant Reactome:R-OSA-9640032 Root structure development
Plant Reactome:R-OSA-8932729 Responses to stimuli: abiotic stimuli and stresses
Plant Reactome:R-OSA-8934036 Long day regulated expression of florigens
Plant Reactome:R-OSA-9611432 Cell Death and immunity
Plant Reactome:R-OSA-9031669 Reproductive structure development
Plant Reactome:R-OSA-8934257 Transition from vegetative to reproductive shoot apical meristem
Plant Reactome:R-OSA-9639861 Development of root hair
Plant Reactome:R-OSA-9638808 Response to salinity
Plant Reactome:R-OSA-8934088 Inflorescence development
Plant Reactome:R-OSA-8986768 Anther and pollen development
Plant Reactome:R-OSA-9612650 Responses to stimuli: biotic stimuli and stresses
PlantCyc:ARA_PWY-6352 3-phosphoinositide biosynthesis
PlantCyc:ARA_GLUCONEO-PWY gluconeogenesis I
PlantCyc:ARA_PWY-561 superpathway of glyoxylate cycle and fatty acid degradation
Reactome:R-CEL-9639288 Amino acids regulate mTORC1
Reactome:R-RNO-9648025 EML4 and NUDC in mitotic spindle formation
Reactome:R-SPO-9612973 Autophagy
Reactome:R-DME-9663891 Selective autophagy
Reactome:R-SCE-9639288 Amino acids regulate mTORC1
Reactome:R-MMU-9639288 Amino acids regulate mTORC1
Reactome:R-HSA-9613354 Lipophagy
Reactome:R-HSA-9639288 Amino acids regulate mTORC1
Reactome:R-HSA-9607240 FLT3 Signaling
Reactome:R-HSA-9664565 Signaling by ERBB2 KD Mutants
Reactome:R-HSA-9635486 Infection with Mycobacterium tuberculosis
Reactome:R-HSA-9636667 Manipulation of host energy metabolism
Reactome:R-HSA-9610379 HCMV Late Events
Reactome:R-HSA-9648025 EML4 and NUDC in mitotic spindle formation
Reactome:R-RNO-9607240 FLT3 Signaling
Reactome:R-SPO-9639288 Amino acids regulate mTORC1
Reactome:R-DME-9607240 FLT3 Signaling
Reactome:R-DME-9639288 Amino acids regulate mTORC1
Reactome:R-DME-9612973 Autophagy
Reactome:R-DDI-9663891 Selective autophagy
Reactome:R-DDI-9648025 EML4 and NUDC in mitotic spindle formation
Reactome:R-MMU-9663891 Selective autophagy
Reactome:R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency
Reactome:R-HSA-9645460 ALPK1 signaling pathway
Reactome:R-HSA-9649948 Signaling downstream of RAS mutants
Reactome:R-HSA-9609690 HCMV Early Events
Reactome:R-CEL-9663891 Selective autophagy
Reactome:R-SSC-9612973 Autophagy
Reactome:R-RNO-9663891 Selective autophagy
Reactome:R-BTA-9607240 FLT3 Signaling
Reactome:R-DDI-9612973 Autophagy
Reactome:R-DDI-9639288 Amino acids regulate mTORC1
Reactome:R-SCE-9663891 Selective autophagy
Reactome:R-MMU-9607240 FLT3 Signaling
Reactome:R-MMU-9612973 Autophagy
Reactome:R-HSA-9663891 Selective autophagy
Reactome:R-HSA-1227990 Signaling by ERBB2 in Cancer
Reactome:R-HSA-9637690 Response of Mtb to phagocytosis
Reactome:R-HSA-9609646 HCMV Infection
Reactome:R-HSA-9645723 Diseases of programmed cell death
Reactome:R-CEL-9612973 Autophagy
Reactome:R-RNO-9639288 Amino acids regulate mTORC1
Reactome:R-RNO-9612973 Autophagy
Reactome:R-SPO-9663891 Selective autophagy
Reactome:R-SCE-9612973 Autophagy
Reactome:R-MMU-9645460 ALPK1 signaling pathway
Reactome:R-MMU-9648025 EML4 and NUDC in mitotic spindle formation
Reactome:R-HSA-9612973 Autophagy
Reactome:R-HSA-9648895 Response of EIF2AK1 (HRI) to heme deficiency
Reactome:R-HSA-9635465 Suppression of apoptosis
Reactome:R-GGA-9675108 Nervous system development
Reactome:R-DDI-9664873 Pexophagy
Reactome:R-MMU-9664873 Pexophagy
Reactome:R-DME-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases
Reactome:R-HSA-9669938 Signaling by KIT in disease
Reactome:R-HSA-9670439 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Reactome:R-HSA-9679506 SARS-CoV Infections
Reactome:R-HSA-9679191 Potential therapeutics for SARS
Reactome:R-HSA-9702518 STAT5 activation downstream of FLT3 ITD mutants
Reactome:R-HSA-9693928 Defective RIPK1-mediated regulated necrosis
Reactome:R-HSA-9694516 SARS-CoV-2 Infection
Reactome:R-HSA-9694635 Translation of Structural Proteins
Reactome:R-HSA-9686347 Microbial modulation of RIPK1-mediated regulated necrosis
Reactome:R-CEL-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-RNO-9711123 Cellular response to chemical stress
Reactome:R-DME-9711123 Cellular response to chemical stress
Reactome:R-DDI-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases
Reactome:R-HSA-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-HSA-9700206 Signaling by ALK in cancer
Reactome:R-BTA-9748784 Drug ADME
Reactome:R-CFA-9748787 Azathioprine ADME
Reactome:R-RNO-9748784 Drug ADME
Reactome:R-CEL-9759194 Nuclear events mediated by NFE2L2
Reactome:R-HSA-9772572 Early SARS-CoV-2 Infection Events
Reactome:R-HSA-9758274 Regulation of NF-kappa B signaling
Reactome:R-MMU-9759194 Nuclear events mediated by NFE2L2
Reactome:R-RNO-9755511 KEAP1-NFE2L2 pathway
Reactome:R-SSC-9755511 KEAP1-NFE2L2 pathway
Reactome:R-HSA-9692914 SARS-CoV-1-host interactions
Reactome:R-HSA-9824439 Bacterial Infection Pathways
Reactome:R-BTA-9833482 PKR-mediated signaling
Reactome:R-GGA-9732724 IFNG signaling activates MAPKs
Reactome:R-MMU-9732724 IFNG signaling activates MAPKs
Reactome:R-HSA-9861718 Regulation of pyruvate metabolism
Reactome:R-HSA-9856651 MITF-M-dependent gene expression
Reactome:R-MMU-9824878 Regulation of TBK1, IKK (IKBKE)-mediated activation of IRF3, IRF7
Reactome:R-MMU-9856649 Transcriptional and post-translational regulation of MITF-M expression and activity
Reactome:R-RNO-9856649 Transcriptional and post-translational regulation of MITF-M expression and activity
Reactome:R-SCE-9730414 MITF-M-regulated melanocyte development
Reactome:R-CEL-9675108 Nervous system development
Reactome:R-RNO-9031628 NGF-stimulated transcription
Reactome:R-DME-9664873 Pexophagy
Reactome:R-DDI-9675108 Nervous system development
Reactome:R-MMU-9675108 Nervous system development
Reactome:R-HSA-9675108 Nervous system development
Reactome:R-DDI-5213460 RIPK1-mediated regulated necrosis
Reactome:R-HSA-9679504 Translation of Replicase and Assembly of the Replication Transcription Complex
Reactome:R-HSA-9703648 Signaling by FLT3 ITD and TKD mutants
Reactome:R-RNO-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-SCE-9711097 Cellular response to starvation
Reactome:R-MMU-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-HSA-9711097 Cellular response to starvation
Reactome:R-CFA-9748784 Drug ADME
Reactome:R-HSA-9748787 Azathioprine ADME
Reactome:R-CEL-9755511 KEAP1-NFE2L2 pathway
Reactome:R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses
Reactome:R-HSA-9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Reactome:R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Reactome:R-MMU-9755511 KEAP1-NFE2L2 pathway
Reactome:R-RNO-9758274 Regulation of NF-kappa B signaling
Reactome:R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses
Reactome:R-MMU-9755088 Ribavirin ADME
Reactome:R-HSA-9821993 Replacement of protamines by nucleosomes in the male pronucleus
Reactome:R-RNO-9833482 PKR-mediated signaling
Reactome:R-HSA-9833109 Evasion by RSV of host interferon responses
Reactome:R-MMU-9840373 Cellular response to mitochondrial stress
Reactome:R-RNO-2562578 TRIF-mediated programmed cell death
Reactome:R-DME-9856649 Transcriptional and post-translational regulation of MITF-M expression and activity
Reactome:R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activity
Reactome:R-MMU-9730414 MITF-M-regulated melanocyte development
Reactome:R-RNO-9730414 MITF-M-regulated melanocyte development
Reactome:R-CEL-9031628 NGF-stimulated transcription
Reactome:R-HSA-9665348 Signaling by ERBB2 ECD mutants
Reactome:R-HSA-9664873 Pexophagy
Reactome:R-HSA-9678108 SARS-CoV-1 Infection
Reactome:R-HSA-9683701 Translation of Structural Proteins
Reactome:R-DDI-5675482 Regulation of necroptotic cell death
Reactome:R-HSA-9694631 Maturation of nucleoprotein
Reactome:R-CEL-9711123 Cellular response to chemical stress
Reactome:R-CEL-9711097 Cellular response to starvation
Reactome:R-SSC-9711123 Cellular response to chemical stress
Reactome:R-GGA-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-RNO-9711097 Cellular response to starvation
Reactome:R-DME-9711097 Cellular response to starvation
Reactome:R-DDI-9711097 Cellular response to starvation
Reactome:R-DDI-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-MMU-9711123 Cellular response to chemical stress
Reactome:R-DDI-2559586 DNA Damage/Telomere Stress Induced Senescence
Reactome:R-HSA-9725370 Signaling by ALK fusions and activated point mutants
Reactome:R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis
Reactome:R-BTA-9748787 Azathioprine ADME
Reactome:R-MMU-9748784 Drug ADME
Reactome:R-RNO-9748787 Azathioprine ADME
Reactome:R-BTA-9758274 Regulation of NF-kappa B signaling
Reactome:R-HSA-9772573 Late SARS-CoV-2 Infection Events
Reactome:R-HSA-9755511 KEAP1-NFE2L2 pathway
Reactome:R-MMU-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Reactome:R-RNO-9759194 Nuclear events mediated by NFE2L2
Reactome:R-SSC-9759194 Nuclear events mediated by NFE2L2
Reactome:R-BTA-9755088 Ribavirin ADME
Reactome:R-CFA-9755088 Ribavirin ADME
Reactome:R-HSA-9735871 SARS-CoV-1 targets host intracellular signalling and regulatory pathways
Reactome:R-HSA-9634815 Transcriptional Regulation by NPAS4
Reactome:R-HSA-9768919 NPAS4 regulates expression of target genes
Reactome:R-RNO-9755088 Ribavirin ADME
Reactome:R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells
Reactome:R-HSA-9824446 Viral Infection Pathways
Reactome:R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion
Reactome:R-HSA-9732724 IFNG signaling activates MAPKs
Reactome:R-HSA-9816359 Maternal to zygotic transition (MZT)
Reactome:R-MMU-9833482 PKR-mediated signaling
Reactome:R-HSA-9840373 Cellular response to mitochondrial stress
Reactome:R-RNO-9840373 Cellular response to mitochondrial stress
Reactome:R-CEL-9730414 MITF-M-regulated melanocyte development
Reactome:R-HSA-9828211 Regulation of TBK1, IKK -mediated activation of IRF3, IRF7 upon TLR3 ligation
Reactome:R-HSA-9842663 Signaling by LTK
Reactome:R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation
Reactome:R-SCE-9856649 Transcriptional and post-translational regulation of MITF-M expression and activity
Reactome:R-DRE-9031628 NGF-stimulated transcription
Reactome:R-GGA-9031628 NGF-stimulated transcription
Reactome:R-RNO-9675108 Nervous system development
Reactome:R-BTA-9675108 Nervous system development
Reactome:R-DME-9675108 Nervous system development
Reactome:R-MMU-9031628 NGF-stimulated transcription
Reactome:R-HSA-9031628 NGF-stimulated transcription
Reactome:R-DDI-5218859 Regulated Necrosis
Reactome:R-HSA-9683610 Maturation of nucleoprotein
Reactome:R-HSA-9682385 FLT3 signaling in disease
Reactome:R-HSA-9703465 Signaling by FLT3 fusion proteins
Reactome:R-HSA-9694676 Translation of Replicase and Assembly of the Replication Transcription Complex
Reactome:R-XTR-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-SPO-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-SPO-9711097 Cellular response to starvation
Reactome:R-BTA-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-DME-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-SCE-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-MMU-9711097 Cellular response to starvation
Reactome:R-HSA-9711123 Cellular response to chemical stress
Reactome:R-HSA-9748784 Drug ADME
Reactome:R-MMU-9748787 Azathioprine ADME
Reactome:R-DME-9755511 KEAP1-NFE2L2 pathway
Reactome:R-HSA-9705683 SARS-CoV-2-host interactions
Reactome:R-HSA-9759194 Nuclear events mediated by NFE2L2
Reactome:R-MMU-9758274 Regulation of NF-kappa B signaling
Reactome:R-RNO-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Reactome:R-HSA-9755088 Ribavirin ADME
Reactome:R-DME-9833482 PKR-mediated signaling
Reactome:R-HSA-9833482 PKR-mediated signaling
Reactome:R-RNO-9732724 IFNG signaling activates MAPKs
Reactome:R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway
Reactome:R-HSA-9833110 RSV-host interactions
Reactome:R-RNO-937041 IKK complex recruitment mediated by RIP1
Reactome:R-CEL-9856649 Transcriptional and post-translational regulation of MITF-M expression and activity
Reactome:R-DME-9730414 MITF-M-regulated melanocyte development
Reactome:R-HSA-9824878 Regulation of TBK1, IKK (IKBKE)-mediated activation of IRF3, IRF7
Reactome:R-HSA-9730414 MITF-M-regulated melanocyte development
Reactome:R-MMU-9861718 Regulation of pyruvate metabolism
Reactome:R-MMU-9842663 Signaling by LTK
Reactome:R-RNO-9842663 Signaling by LTK
Reactome:R-BTA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes
Reactome:R-BTA-9860931 Response of endothelial cells to shear stress
Reactome:R-CEL-9855142 Cellular responses to mechanical stimuli
Reactome:R-DME-9855142 Cellular responses to mechanical stimuli
Reactome:R-HSA-9865118 Diseases of branched-chain amino acid catabolism
Reactome:R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes
Reactome:R-HSA-9860276 SLC15A4:TASL-dependent IRF5 activation
Reactome:R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Reactome:R-MMU-9860931 Response of endothelial cells to shear stress
Reactome:R-RNO-9855142 Cellular responses to mechanical stimuli
Reactome:R-RNO-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes
Reactome:R-SCE-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Reactome:R-HSA-9909505 Modulation of host responses by IFN-stimulated genes
Reactome:R-MMU-9927354 ICOS co-stimulation
Reactome:R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
Reactome:R-HSA-9764265 Regulation of CDH1 Expression and Function
Reactome:R-BTA-9909615 Regulation of PD-L1(CD274) Post-translational modification
Reactome:R-HSA-9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274)
Reactome:R-MMU-9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274)
Reactome:R-RNO-9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274)
Reactome:R-SSC-9909648 Regulation of PD-L1(CD274) expression
Reactome:R-HSA-9920951 Dengue virus modulates apoptosis
Reactome:R-RNO-9953170 GBP-mediated host defense
Reactome:R-BTA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes
Reactome:R-BTA-9855142 Cellular responses to mechanical stimuli
Reactome:R-BTA-9860276 SLC15A4:TASL-dependent IRF5 activation
Reactome:R-DDI-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Reactome:R-DME-9841251 Mitochondrial unfolded protein response (UPRmt)
Reactome:R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes
Reactome:R-HSA-9860931 Response of endothelial cells to shear stress
Reactome:R-MMU-9855142 Cellular responses to mechanical stimuli
Reactome:R-RNO-9841251 Mitochondrial unfolded protein response (UPRmt)
Reactome:R-RNO-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Reactome:R-RNO-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Reactome:R-SCE-9860931 Response of endothelial cells to shear stress
Reactome:R-SPO-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Reactome:R-BTA-9909505 Modulation of host responses by IFN-stimulated genes
Reactome:R-RNO-9927354 ICOS co-stimulation
Reactome:R-HSA-9931529 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK
Reactome:R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins
Reactome:R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription
Reactome:R-HSA-9909648 Regulation of PD-L1(CD274) expression
Reactome:R-HSA-9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274)
Reactome:R-MMU-9909615 Regulation of PD-L1(CD274) Post-translational modification
Reactome:R-RNO-9909615 Regulation of PD-L1(CD274) Post-translational modification
Reactome:R-BTA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Reactome:R-CEL-9860931 Response of endothelial cells to shear stress
Reactome:R-DDI-9855142 Cellular responses to mechanical stimuli
Reactome:R-DME-9860931 Response of endothelial cells to shear stress
Reactome:R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes
Reactome:R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt)
Reactome:R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Reactome:R-MMU-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Reactome:R-RNO-9860931 Response of endothelial cells to shear stress
Reactome:R-RNO-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes
Reactome:R-SPO-9855142 Cellular responses to mechanical stimuli
Reactome:R-HSA-9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Reactome:R-RNO-9909505 Modulation of host responses by IFN-stimulated genes
Reactome:R-HSA-9909396 Circadian clock
Reactome:R-HSA-9764560 Regulation of CDH1 Gene Transcription
Reactome:R-MMU-9909648 Regulation of PD-L1(CD274) expression
Reactome:R-MMU-9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274)
Reactome:R-RNO-9909648 Regulation of PD-L1(CD274) expression
Reactome:R-RNO-9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274)
Reactome:R-SSC-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Reactome:R-BTA-9953170 GBP-mediated host defense
Reactome:R-HSA-9839923 Dengue Virus Infection
Reactome:R-HSA-9953170 GBP-mediated host defense
Reactome:R-RNO-9968551 Regulation of GBP-mediated host defense
Reactome:R-BTA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes
Reactome:R-BTA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Reactome:R-CEL-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Reactome:R-DDI-9860931 Response of endothelial cells to shear stress
Reactome:R-DME-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Reactome:R-HSA-9912481 Branched-chain ketoacid dehydrogenase kinase deficiency
Reactome:R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Reactome:R-HSA-9855142 Cellular responses to mechanical stimuli
Reactome:R-MMU-9860276 SLC15A4:TASL-dependent IRF5 activation
Reactome:R-MMU-9841251 Mitochondrial unfolded protein response (UPRmt)
Reactome:R-MMU-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Reactome:R-RNO-9860276 SLC15A4:TASL-dependent IRF5 activation
Reactome:R-RNO-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Reactome:R-RNO-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes
Reactome:R-SCE-9855142 Cellular responses to mechanical stimuli
Reactome:R-SPO-9860931 Response of endothelial cells to shear stress
Reactome:R-BTA-9927354 ICOS co-stimulation
Reactome:R-HSA-9927354 ICOS co-stimulation
Reactome:R-MMU-9909505 Modulation of host responses by IFN-stimulated genes
Reactome:R-HSA-9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Reactome:R-BTA-9909648 Regulation of PD-L1(CD274) expression
Reactome:R-BTA-9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274)
Reactome:R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification
Reactome:R-SSC-9909615 Regulation of PD-L1(CD274) Post-translational modification
Reactome:R-BTA-9968551 Regulation of GBP-mediated host defense
Reactome:R-HSA-9918481 Dengue Virus-Host Interactions
Reactome:R-HSA-9968551 Regulation of GBP-mediated host defense
Reactome:R-RNO-9634635 Estrogen-stimulated signaling through PRKCZ
Reactome:R-SPO-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Reactome:R-SPO-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Reactome:R-SPO-881907 Gastrin-CREB signalling pathway via PKC and MAPK
Reactome:R-SPO-9634635 Estrogen-stimulated signaling through PRKCZ
Reactome:R-BTA-8964616 G beta:gamma signalling through CDC42
Reactome:R-DME-169893 Prolonged ERK activation events
Reactome:R-DME-9634635 Estrogen-stimulated signaling through PRKCZ
Reactome:R-DME-69563 p53-Dependent G1 DNA Damage Response
Reactome:R-DDI-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Reactome:R-DDI-69202 Cyclin E associated events during G1/S transition
Reactome:R-DDI-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
Reactome:R-DDI-6804757 Regulation of TP53 Degradation
Reactome:R-SCE-9634635 Estrogen-stimulated signaling through PRKCZ
Reactome:R-MMU-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Reactome:R-MMU-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Reactome:R-HSA-9614085 FOXO-mediated transcription
Reactome:R-HSA-8964616 G beta:gamma signalling through CDC42
Reactome:R-CEL-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome:R-CEL-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
Reactome:R-RNO-9009391 Extra-nuclear estrogen signaling
Reactome:R-SPO-69618 Mitotic Spindle Checkpoint
Reactome:R-SPO-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Reactome:R-SPO-179409 APC-Cdc20 mediated degradation of Nek2A
Reactome:R-SPO-2559582 Senescence-Associated Secretory Phenotype (SASP)
Reactome:R-SPO-9009391 Extra-nuclear estrogen signaling
Reactome:R-DME-9009391 Extra-nuclear estrogen signaling
Reactome:R-DME-69580 p53-Dependent G1/S DNA damage checkpoint
Reactome:R-DME-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex
Reactome:R-DDI-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Reactome:R-DDI-9634635 Estrogen-stimulated signaling through PRKCZ
Reactome:R-DDI-69656 Cyclin A:Cdk2-associated events at S phase entry
Reactome:R-DDI-5693607 Processing of DNA double-strand break ends
Reactome:R-DDI-6806003 Regulation of TP53 Expression and Degradation
Reactome:R-SCE-9009391 Extra-nuclear estrogen signaling
Reactome:R-MMU-9634635 Estrogen-stimulated signaling through PRKCZ
Reactome:R-HSA-9614657 FOXO-mediated transcription of cell death genes
Reactome:R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Reactome:R-CEL-169893 Prolonged ERK activation events
Reactome:R-CEL-5685942 HDR through Homologous Recombination (HRR)
Reactome:R-CEL-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Reactome:R-RNO-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Reactome:R-SPO-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
Reactome:R-SPO-2465910 MASTL Facilitates Mitotic Progression
Reactome:R-SPO-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
Reactome:R-SPO-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Reactome:R-BTA-9009391 Extra-nuclear estrogen signaling
Reactome:R-DME-9614085 FOXO-mediated transcription
Reactome:R-DME-170968 Frs2-mediated activation
Reactome:R-DME-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Reactome:R-DME-69541 Stabilization of p53
Reactome:R-DDI-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex
Reactome:R-DDI-446652 Interleukin-1 family signaling
Reactome:R-DDI-6804760 Regulation of TP53 Activity through Methylation
Reactome:R-SCE-2465910 MASTL Facilitates Mitotic Progression
Reactome:R-MMU-8964616 G beta:gamma signalling through CDC42
Reactome:R-HSA-9009391 Extra-nuclear estrogen signaling
Reactome:R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors
Reactome:R-CEL-170968 Frs2-mediated activation
Reactome:R-CEL-196299 Beta-catenin phosphorylation cascade
Reactome:R-CEL-5693538 Homology Directed Repair
Reactome:R-CEL-5693579 Homologous DNA Pairing and Strand Exchange
Reactome:R-CEL-8934903 Receptor Mediated Mitophagy
Reactome:R-CEL-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Reactome:R-RNO-8964616 G beta:gamma signalling through CDC42
Reactome:R-SPO-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Reactome:R-SPO-5218921 VEGFR2 mediated cell proliferation
Reactome:R-SPO-198693 AKT phosphorylates targets in the nucleus
Reactome:R-SPO-165181 Inhibition of TSC complex formation by PKB
Reactome:R-SPO-444257 RSK activation
Reactome:R-DME-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Reactome:R-DME-9614399 Regulation of localization of FOXO transcription factors
Reactome:R-DME-399954 Sema3A PAK dependent Axon repulsion
Reactome:R-DME-111932 CaMK IV-mediated phosphorylation of CREB
Reactome:R-DDI-937042 IRAK2 mediated activation of TAK1 complex
Reactome:R-DDI-9020702 Interleukin-1 signaling
Reactome:R-DDI-9009391 Extra-nuclear estrogen signaling
Reactome:R-DDI-8953750 Transcriptional Regulation by E2F6
Reactome:R-MMU-9009391 Extra-nuclear estrogen signaling
Reactome:R-HSA-9634635 Estrogen-stimulated signaling through PRKCZ
Reactome:R-BTA-597592 Post-translational protein modification
Reactome:R-BTA-204005 COPII-mediated vesicle transport
Reactome:R-BTA-5689896 Ovarian tumor domain proteases
Reactome:R-BTA-74160 Gene expression (Transcription)
Reactome:R-BTA-73857 RNA Polymerase II Transcription
Reactome:R-BTA-3700989 Transcriptional Regulation by TP53
Reactome:R-BTA-5633007 Regulation of TP53 Activity
Reactome:R-BTA-6804756 Regulation of TP53 Activity through Phosphorylation
Reactome:R-BTA-212165 Epigenetic regulation of gene expression
Reactome:R-BTA-1640170 Cell Cycle
Reactome:R-BTA-380259 Loss of Nlp from mitotic centrosomes
Reactome:R-BTA-8854521 Interaction between PHLDA1 and AURKA
Reactome:R-BTA-109582 Hemostasis
Reactome:R-BTA-422475 Axon guidance
Reactome:R-BTA-168256 Immune System
Reactome:R-BTA-389356 CD28 co-stimulation
Reactome:R-BTA-389948 PD-1 signaling
Reactome:R-BTA-1169091 Activation of NF-kappaB in B cells
Reactome:R-BTA-168898 Toll-like Receptor Cascades
Reactome:R-BTA-937039 IRAK1 recruits IKK complex
Reactome:R-BTA-168164 Toll Like Receptor 3 (TLR3) Cascade
Reactome:R-BTA-975155 MyD88 dependent cascade initiated on endosome
Reactome:R-BTA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Reactome:R-BTA-937041 IKK complex recruitment mediated by RIP1
Reactome:R-BTA-168179 Toll Like Receptor TLR1:TLR2 Cascade
Reactome:R-BTA-1834949 Cytosolic sensors of pathogen-associated DNA
Reactome:R-BTA-2029482 Regulation of actin dynamics for phagocytic cup formation
Reactome:R-BTA-2454202 Fc epsilon receptor (FCERI) signaling
Reactome:R-BTA-913531 Interferon Signaling
Reactome:R-BTA-449147 Signaling by Interleukins
Reactome:R-BTA-912631 Regulation of signaling by CBL
Reactome:R-BTA-448424 Interleukin-17 signaling
Reactome:R-BTA-8868773 rRNA processing in the nucleus and cytosol
Reactome:R-BTA-1430728 Metabolism
Reactome:R-BTA-556833 Metabolism of lipids
Reactome:R-BTA-71291 Amino acid and derivative metabolism
Reactome:R-BTA-8953897 Cellular responses to stimuli
Reactome:R-BTA-2262752 Cellular responses to stress
Reactome:R-BTA-2559583 Cellular Senescence
Reactome:R-BTA-199991 Membrane Trafficking
Reactome:R-BTA-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-BTA-180292 GAB1 signalosome
Reactome:R-BTA-5654738 Signaling by FGFR2
Reactome:R-BTA-5654716 Downstream signaling of activated FGFR4
Reactome:R-BTA-5654720 PI-3K cascade:FGFR4
Reactome:R-BTA-1963642 PI3K events in ERBB2 signaling
Reactome:R-BTA-1250342 PI3K events in ERBB4 signaling
Reactome:R-BTA-418594 G alpha (i) signalling events
Reactome:R-BTA-196299 Beta-catenin phosphorylation cascade
Reactome:R-BTA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
Reactome:R-BTA-5632684 Hedgehog 'on' state
Reactome:R-BTA-8939211 ESR-mediated signaling
Reactome:R-BTA-5357956 TNFR1-induced NF-kappa-B signaling pathway
Reactome:R-BTA-209543 p75NTR recruits signalling complexes
Reactome:R-CEL-69613 p53-Independent G1/S DNA Damage Checkpoint
Reactome:R-CEL-69273 Cyclin A/B1/B2 associated events during G2/M transition
Reactome:R-CEL-68882 Mitotic Anaphase
Reactome:R-CEL-8854214 TBC/RABGAPs
Reactome:R-CEL-1280218 Adaptive Immune System
Reactome:R-CEL-388841 Costimulation by the CD28 family
Reactome:R-CEL-168142 Toll Like Receptor 10 (TLR10) Cascade
Reactome:R-CEL-199920 CREB phosphorylation
Reactome:R-CEL-975155 MyD88 dependent cascade initiated on endosome
Reactome:R-CEL-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Reactome:R-CEL-168179 Toll Like Receptor TLR1:TLR2 Cascade
Reactome:R-CEL-9020702 Interleukin-1 signaling
Reactome:R-CEL-2990846 SUMOylation
Reactome:R-CEL-73894 DNA Repair
Reactome:R-CEL-8953897 Cellular responses to stimuli
Reactome:R-CEL-3371556 Cellular response to heat stress
Reactome:R-CEL-187687 Signalling to ERKs
Reactome:R-CEL-112399 IRS-mediated signalling
Reactome:R-CEL-4420097 VEGFA-VEGFR2 Pathway
Reactome:R-CEL-2428928 IRS-related events triggered by IGF1R
Reactome:R-CEL-5683057 MAPK family signaling cascades
Reactome:R-CEL-5674135 MAP2K and MAPK activation
Reactome:R-CEL-9006925 Intracellular signaling by second messengers
Reactome:R-CEL-166208 mTORC1-mediated signalling
Reactome:R-CEL-428157 Sphingolipid metabolism
Reactome:R-CEL-422475 Axon guidance
Reactome:R-CEL-3700989 Transcriptional Regulation by TP53
Reactome:R-CEL-5633007 Regulation of TP53 Activity
Reactome:R-CEL-8953750 Transcriptional Regulation by E2F6
Reactome:R-CFA-69275 G2/M Transition
Reactome:R-CFA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Reactome:R-CFA-1430728 Metabolism
Reactome:R-DRE-72312 rRNA processing
Reactome:R-DRE-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-DRE-1257604 PI3K/AKT Signaling
Reactome:R-DRE-69618 Mitotic Spindle Checkpoint
Reactome:R-DRE-68886 M Phase
Reactome:R-DRE-2465910 MASTL Facilitates Mitotic Progression
Reactome:R-DRE-68877 Mitotic Prometaphase
Reactome:R-DDI-73894 DNA Repair
Reactome:R-DDI-5693606 DNA Double Strand Break Response
Reactome:R-DDI-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome:R-DDI-76002 Platelet activation, signaling and aggregation
Reactome:R-DDI-163685 Integration of energy metabolism
Reactome:R-DDI-69580 p53-Dependent G1/S DNA damage checkpoint
Reactome:R-DDI-69613 p53-Independent G1/S DNA Damage Checkpoint
Reactome:R-DDI-69473 G2/M DNA damage checkpoint
Reactome:R-DDI-453274 Mitotic G2-G2/M phases
Reactome:R-DDI-156711 Polo-like kinase mediated events
Reactome:R-DDI-162658 Golgi Cisternae Pericentriolar Stack Reorganization
Reactome:R-DDI-453276 Regulation of mitotic cell cycle
Reactome:R-DDI-176412 Phosphorylation of the APC/C
Reactome:R-DDI-179409 APC-Cdc20 mediated degradation of Nek2A
Reactome:R-DDI-5205647 Mitophagy
Reactome:R-DDI-166520 Signaling by NTRKs
Reactome:R-DDI-109704 PI3K Cascade
Reactome:R-DDI-5218921 VEGFR2 mediated cell proliferation
Reactome:R-DDI-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Reactome:R-DDI-397795 G-protein beta:gamma signalling
Reactome:R-DDI-1257604 PI3K/AKT Signaling
Reactome:R-DDI-195258 RHO GTPase Effectors
Reactome:R-DDI-166208 mTORC1-mediated signalling
Reactome:R-DDI-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Reactome:R-DDI-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
Reactome:R-DDI-422475 Axon guidance
Reactome:R-DDI-168256 Immune System
Reactome:R-DDI-388841 Costimulation by the CD28 family
Reactome:R-DDI-168898 Toll-like Receptor Cascades
Reactome:R-DDI-450302 activated TAK1 mediates p38 MAPK activation
Reactome:R-DDI-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
Reactome:R-DDI-166016 Toll Like Receptor 4 (TLR4) Cascade
Reactome:R-DDI-181438 Toll Like Receptor 2 (TLR2) Cascade
Reactome:R-DDI-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
Reactome:R-DDI-448424 Interleukin-17 signaling
Reactome:R-DME-8953854 Metabolism of RNA
Reactome:R-DME-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Reactome:R-DME-168256 Immune System
Reactome:R-DME-202424 Downstream TCR signaling
Reactome:R-DME-389359 CD28 dependent Vav1 pathway
Reactome:R-DME-168898 Toll-like Receptor Cascades
Reactome:R-DME-937039 IRAK1 recruits IKK complex
Reactome:R-DME-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Reactome:R-DME-168176 Toll Like Receptor 5 (TLR5) Cascade
Reactome:R-DME-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Reactome:R-DME-166016 Toll Like Receptor 4 (TLR4) Cascade
Reactome:R-DME-181438 Toll Like Receptor 2 (TLR2) Cascade
Reactome:R-DME-2029482 Regulation of actin dynamics for phagocytic cup formation
Reactome:R-DME-2454202 Fc epsilon receptor (FCERI) signaling
Reactome:R-DME-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
Reactome:R-DME-9020702 Interleukin-1 signaling
Reactome:R-DME-597592 Post-translational protein modification
Reactome:R-DME-8957275 Post-translational protein phosphorylation
Reactome:R-DME-381119 Unfolded Protein Response (UPR)
Reactome:R-DME-381042 PERK regulates gene expression
Reactome:R-DME-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-DME-5654743 Signaling by FGFR4
Reactome:R-DME-166520 Signaling by NTRKs
Reactome:R-DME-171007 p38MAPK events
Reactome:R-DME-74751 Insulin receptor signalling cascade
Reactome:R-DME-4420097 VEGFA-VEGFR2 Pathway
Reactome:R-DME-2428924 IGF1R signaling cascade
Reactome:R-DME-112040 G-protein mediated events
Reactome:R-DME-111933 Calmodulin induced events
Reactome:R-DME-195721 Signaling by WNT
Reactome:R-DME-5632684 Hedgehog 'on' state
Reactome:R-DME-9006931 Signaling by Nuclear Receptors
Reactome:R-DME-5673000 RAF activation
Reactome:R-DME-5687128 MAPK6/MAPK4 signaling
Reactome:R-DME-198693 AKT phosphorylates targets in the nucleus
Reactome:R-DME-194315 Signaling by Rho GTPases
Reactome:R-DME-5627123 RHO GTPases activate PAKs
Reactome:R-DME-165159 MTOR signalling
Reactome:R-DME-438064 Post NMDA receptor activation events
Reactome:R-DME-442729 CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Reactome:R-DME-5653656 Vesicle-mediated transport
Reactome:R-DME-9007101 Rab regulation of trafficking
Reactome:R-DME-1632852 Macroautophagy
Reactome:R-DME-2559583 Cellular Senescence
Reactome:R-DME-69615 G1/S DNA Damage Checkpoints
Reactome:R-DME-69481 G2/M Checkpoints
Reactome:R-DME-176187 Activation of ATR in response to replication stress
Reactome:R-DME-69278 Cell Cycle, Mitotic
Reactome:R-DME-69656 Cyclin A:Cdk2-associated events at S phase entry
Reactome:R-DME-453274 Mitotic G2-G2/M phases
Reactome:R-DME-1266738 Developmental Biology
Reactome:R-DME-186712 Regulation of beta-cell development
Reactome:R-DME-5693606 DNA Double Strand Break Response
Reactome:R-DME-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome:R-DME-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
Reactome:R-DME-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Reactome:R-DME-6804759 Regulation of TP53 Activity through Association with Co-factors
Reactome:R-DME-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
Reactome:R-DME-430116 GP1b-IX-V activation signalling
Reactome:R-DME-114604 GPVI-mediated activation cascade
Reactome:R-DME-432553 Phosphorylation of PER and TIM
Reactome:R-DME-432395 Degradation of TIM
Reactome:R-DME-538898 Dephosphorylation of TIM
Reactome:R-DME-209360 Ubiquitination and proteolysis of phosphorylated CI
Reactome:R-DME-209214 Phosphorylation of SMO
Reactome:R-DME-390150 DS ligand bound to FT receptor
Reactome:R-DME-451806 Phosphorylation-independent inhibition of YKI
Reactome:R-DME-390178 DS ligand not bound to FT receptor
Reactome:R-DME-110478 Insulin signaling pathway
Reactome:R-DME-209449 Toll pathway
Reactome:R-DME-209406 Degradation of NF-kappa-B inhibitor, CACT
Reactome:R-DME-214869 Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'
Reactome:R-DME-209413 Assembly of the 'destruction complex'
Reactome:R-DME-209469 WG ligand bound to FZ receptors
Reactome:R-GGA-217106 Chk1-controlled and DNA-damage induced centrosome duplication
Reactome:R-GGA-351470 Homologous recombination repair of replication-independent double-strand breaks
Reactome:R-GGA-5633007 Regulation of TP53 Activity
Reactome:R-GGA-69620 Cell Cycle Checkpoints
Reactome:R-GGA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Reactome:R-GGA-198725 Nuclear Events (kinase and transcription factor activation)
Reactome:R-GGA-195721 Signaling by WNT
Reactome:R-GGA-5610787 Hedgehog 'off' state
Reactome:R-GGA-5683057 MAPK family signaling cascades
Reactome:R-GGA-9006925 Intracellular signaling by second messengers
Reactome:R-GGA-5693532 DNA Double-Strand Break Repair
Reactome:R-GGA-5693538 Homology Directed Repair
Reactome:R-GGA-5693579 Homologous DNA Pairing and Strand Exchange
Reactome:R-GGA-373755 Semaphorin interactions
Reactome:R-GGA-375165 NCAM signaling for neurite out-growth
Reactome:R-GGA-430116 GP1b-IX-V activation signalling
Reactome:R-GGA-168898 Toll-like Receptor Cascades
Reactome:R-GGA-168164 Toll Like Receptor 3 (TLR3) Cascade
Reactome:R-GGA-975155 MyD88 dependent cascade initiated on endosome
Reactome:R-GGA-168138 Toll Like Receptor 9 (TLR9) Cascade
Reactome:R-GGA-166166 MyD88-independent TLR4 cascade
Reactome:R-GGA-168188 Toll Like Receptor TLR6:TLR2 Cascade
Reactome:R-GGA-5621481 C-type lectin receptors (CLRs)
Reactome:R-GGA-1280215 Cytokine Signaling in Immune system
Reactome:R-GGA-877300 Interferon gamma signaling
Reactome:R-GGA-449147 Signaling by Interleukins
Reactome:R-HSA-983712 Ion channel transport
Reactome:R-HSA-5205685 PINK1-PRKN Mediated Mitophagy
Reactome:R-HSA-199977 ER to Golgi Anterograde Transport
Reactome:R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
Reactome:R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Reactome:R-HSA-5620912 Anchoring of the basal body to the plasma membrane
Reactome:R-HSA-422475 Axon guidance
Reactome:R-HSA-445144 Signal transduction by L1
Reactome:R-HSA-2682334 EPH-Ephrin signaling
Reactome:R-HSA-418990 Adherens junctions interactions
Reactome:R-HSA-430116 GP1b-IX-V activation signalling
Reactome:R-HSA-1474165 Reproduction
Reactome:R-HSA-912446 Meiotic recombination
Reactome:R-HSA-8982491 Glycogen metabolism
Reactome:R-HSA-70263 Gluconeogenesis
Reactome:R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
Reactome:R-HSA-1660661 Sphingolipid de novo biosynthesis
Reactome:R-HSA-202131 Metabolism of nitric oxide: NOS3 activation and regulation
Reactome:R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Reactome:R-HSA-70895 Branched-chain amino acid catabolism
Reactome:R-HSA-140534 Ligand-dependent caspase activation
Reactome:R-HSA-111465 Apoptotic cleavage of cellular proteins
Reactome:R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation
Reactome:R-HSA-5675482 Regulation of necroptotic cell death
Reactome:R-HSA-5693532 DNA Double-Strand Break Repair
Reactome:R-HSA-5693538 Homology Directed Repair
Reactome:R-HSA-5693579 Homologous DNA Pairing and Strand Exchange
Reactome:R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Reactome:R-HSA-177929 Signaling by EGFR
Reactome:R-HSA-180292 GAB1 signalosome
Reactome:R-HSA-5654738 Signaling by FGFR2
Reactome:R-HSA-5654732 Negative regulation of FGFR3 signaling
Reactome:R-HSA-5654716 Downstream signaling of activated FGFR4
Reactome:R-HSA-5654720 PI-3K cascade:FGFR4
Reactome:R-HSA-187706 Signalling to p38 via RIT and RIN
Reactome:R-HSA-199920 CREB phosphorylation
Reactome:R-HSA-9034015 Signaling by NTRK3 (TRKC)
Reactome:R-HSA-9603381 Activated NTRK3 signals through PI3K
Reactome:R-HSA-109703 PKB-mediated events
Reactome:R-HSA-5218921 VEGFR2 mediated cell proliferation
Reactome:R-HSA-1227986 Signaling by ERBB2
Reactome:R-HSA-1250342 PI3K events in ERBB4 signaling
Reactome:R-HSA-2428924 IGF1R signaling cascade
Reactome:R-HSA-180024 DARPP-32 events
Reactome:R-HSA-157118 Signaling by NOTCH
Reactome:R-HSA-201681 TCF dependent signaling in response to WNT
Reactome:R-HSA-5683057 MAPK family signaling cascades
Reactome:R-HSA-5674135 MAP2K and MAPK activation
Reactome:R-HSA-9006925 Intracellular signaling by second messengers
Reactome:R-HSA-199418 Negative regulation of the PI3K/AKT network
Reactome:R-HSA-5627117 RHO GTPases Activate ROCKs
Reactome:R-HSA-5625900 RHO GTPases activate CIT
Reactome:R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases
Reactome:R-HSA-8857538 PTK6 promotes HIF1A stabilization
Reactome:R-HSA-166208 mTORC1-mediated signalling
Reactome:R-HSA-75893 TNF signaling
Reactome:R-HSA-5357905 Regulation of TNFR1 signaling
Reactome:R-HSA-3371571 HSF1-dependent transactivation
Reactome:R-HSA-112315 Transmission across Chemical Synapses
Reactome:R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
Reactome:R-HSA-442755 Activation of NMDA receptors and postsynaptic events
Reactome:R-HSA-6794361 Neurexins and neuroligins
Reactome:R-HSA-69620 Cell Cycle Checkpoints
Reactome:R-HSA-69541 Stabilization of p53
Reactome:R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint
Reactome:R-HSA-69473 G2/M DNA damage checkpoint
Reactome:R-HSA-69618 Mitotic Spindle Checkpoint
Reactome:R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
Reactome:R-HSA-69206 G1/S Transition
Reactome:R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D
Reactome:R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
Reactome:R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
Reactome:R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Reactome:R-HSA-68877 Mitotic Prometaphase
Reactome:R-HSA-2555396 Mitotic Metaphase and Anaphase
Reactome:R-HSA-453276 Regulation of mitotic cell cycle
Reactome:R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Reactome:R-HSA-392499 Metabolism of proteins
Reactome:R-HSA-597592 Post-translational protein modification
Reactome:R-HSA-2990846 SUMOylation
Reactome:R-HSA-4755510 SUMOylation of immune response proteins
Reactome:R-HSA-5689896 Ovarian tumor domain proteases
Reactome:R-HSA-381426 Regulation of IGF Activity by IGFBP
Reactome:R-HSA-381070 IRE1alpha activates chaperones
Reactome:R-HSA-1643685 Disease
Reactome:R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Reactome:R-HSA-5655253 Signaling by FGFR2 in disease
Reactome:R-HSA-5655291 Signaling by FGFR4 in disease
Reactome:R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
Reactome:R-HSA-5467337 APC truncation mutants have impaired AXIN binding
Reactome:R-HSA-4839748 Signaling by AMER1 mutants
Reactome:R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated
Reactome:R-HSA-5339716 Signaling by GSK3beta mutants
Reactome:R-HSA-6802957 Oncogenic MAPK signaling
Reactome:R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
Reactome:R-HSA-162909 Host Interactions of HIV factors
Reactome:R-HSA-168276 NS1 Mediated Effects on Host Pathways
Reactome:R-HSA-169131 Inhibition of PKR
Reactome:R-HSA-5260271 Diseases of Immune System
Reactome:R-HSA-5603029 IkBA variant leads to EDA-ID
Reactome:R-HSA-69002 DNA Replication Pre-Initiation
Reactome:R-HSA-74160 Gene expression (Transcription)
Reactome:R-HSA-73857 RNA Polymerase II Transcription
Reactome:R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes
Reactome:R-HSA-6804757 Regulation of TP53 Degradation
Reactome:R-HSA-9022692 Regulation of MECP2 expression and activity
Reactome:R-HSA-388841 Costimulation by the CD28 family
Reactome:R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR)
Reactome:R-HSA-1236975 Antigen processing-Cross presentation
Reactome:R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
Reactome:R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation
Reactome:R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
Reactome:R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7
Reactome:R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
Reactome:R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Reactome:R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
Reactome:R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling
Reactome:R-HSA-168638 NOD1/2 Signaling Pathway
Reactome:R-HSA-918233 TRAF3-dependent IRF activation pathway
Reactome:R-HSA-1810476 RIP-mediated NFkB activation via ZBP1
Reactome:R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
Reactome:R-HSA-5607764 CLEC7A (Dectin-1) signaling
Reactome:R-HSA-909733 Interferon alpha/beta signaling
Reactome:R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes
Reactome:R-HSA-446652 Interleukin-1 family signaling
Reactome:R-HSA-451927 Interleukin-2 family signaling
Reactome:R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Reactome:R-HSA-448424 Interleukin-17 signaling
Reactome:R-HSA-72172 mRNA Splicing
Reactome:R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements
Reactome:R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA
Reactome:R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Reactome:R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
Reactome:R-HSA-72306 tRNA processing
Reactome:R-MMU-1640170 Cell Cycle
Reactome:R-MMU-69563 p53-Dependent G1 DNA Damage Response
Reactome:R-MMU-69481 G2/M Checkpoints
Reactome:R-MMU-176187 Activation of ATR in response to replication stress
Reactome:R-MMU-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Reactome:R-MMU-156711 Polo-like kinase mediated events
Reactome:R-MMU-380259 Loss of Nlp from mitotic centrosomes
Reactome:R-MMU-8854521 Interaction between PHLDA1 and AURKA
Reactome:R-MMU-68882 Mitotic Anaphase
Reactome:R-MMU-176408 Regulation of APC/C activators between G1/S and early anaphase
Reactome:R-MMU-179409 APC-Cdc20 mediated degradation of Nek2A
Reactome:R-MMU-168256 Immune System
Reactome:R-MMU-389356 CD28 co-stimulation
Reactome:R-MMU-389948 PD-1 signaling
Reactome:R-MMU-1169091 Activation of NF-kappaB in B cells
Reactome:R-MMU-168249 Innate Immune System
Reactome:R-MMU-975871 MyD88 cascade initiated on plasma membrane
Reactome:R-MMU-450294 MAP kinase activation
Reactome:R-MMU-450282 MAPK targets/ Nuclear events mediated by MAP kinases
Reactome:R-MMU-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
Reactome:R-MMU-936964 Activation of IRF3, IRF7 mediated by TBK1, IKK (IKBKE)
Reactome:R-MMU-181438 Toll Like Receptor 2 (TLR2) Cascade
Reactome:R-MMU-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome:R-MMU-1810476 RIP-mediated NFkB activation via ZBP1
Reactome:R-MMU-2871837 FCERI mediated NF-kB activation
Reactome:R-MMU-913531 Interferon Signaling
Reactome:R-MMU-449147 Signaling by Interleukins
Reactome:R-MMU-912631 Regulation of signaling by CBL
Reactome:R-MMU-448424 Interleukin-17 signaling
Reactome:R-MMU-5693548 Sensing of DNA Double Strand Breaks
Reactome:R-MMU-5693607 Processing of DNA double-strand break ends
Reactome:R-MMU-5693537 Resolution of D-Loop Structures
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-70221 Glycogen breakdown (glycogenolysis)
Reactome:R-MMU-556833 Metabolism of lipids
Reactome:R-MMU-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
Reactome:R-MMU-1483255 PI Metabolism
Reactome:R-MMU-1660516 Synthesis of PIPs at the early endosome membrane
Reactome:R-MMU-202131 Metabolism of nitric oxide: NOS3 activation and regulation
Reactome:R-MMU-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Reactome:R-MMU-70895 Branched-chain amino acid catabolism
Reactome:R-MMU-8953854 Metabolism of RNA
Reactome:R-MMU-72163 pre-mRNA splicing
Reactome:R-MMU-927802 Nonsense-Mediated Decay (NMD)
Reactome:R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
Reactome:R-MMU-983712 Ion channel transport
Reactome:R-MMU-76002 Platelet activation, signaling and aggregation
Reactome:R-MMU-399954 Sema3A PAK dependent Axon repulsion
Reactome:R-MMU-8853659 RET signaling
Reactome:R-MMU-5357801 Programmed Cell Death
Reactome:R-MMU-5675482 Regulation of necroptotic cell death
Reactome:R-MMU-2559580 Oxidative Stress Induced Senescence
Reactome:R-MMU-74160 Gene expression (Transcription)
Reactome:R-MMU-73857 RNA Polymerase II Transcription
Reactome:R-MMU-3700989 Transcriptional Regulation by TP53
Reactome:R-MMU-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Reactome:R-MMU-5633007 Regulation of TP53 Activity
Reactome:R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
Reactome:R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Reactome:R-MMU-8986944 Transcriptional Regulation by MECP2
Reactome:R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
Reactome:R-MMU-212165 Epigenetic regulation of gene expression
Reactome:R-MMU-5250924 B-WICH complex positively regulates rRNA expression
Reactome:R-MMU-162582 Signaling Pathways
Reactome:R-MMU-190236 Signaling by FGFR
Reactome:R-MMU-5654726 Negative regulation of FGFR1 signaling
Reactome:R-MMU-5654727 Negative regulation of FGFR2 signaling
Reactome:R-MMU-166520 Signaling by NTRKs
Reactome:R-MMU-112399 IRS-mediated signalling
Reactome:R-MMU-1236394 Signaling by ERBB4
Reactome:R-MMU-2428928 IRS-related events triggered by IGF1R
Reactome:R-MMU-8851907 MET activates PI3K/AKT signaling
Reactome:R-MMU-388396 GPCR downstream signalling
Reactome:R-MMU-111885 Opioid Signalling
Reactome:R-MMU-9604323 Negative regulation of NOTCH4 signaling
Reactome:R-MMU-196299 Beta-catenin phosphorylation cascade
Reactome:R-MMU-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
Reactome:R-MMU-5632684 Hedgehog 'on' state
Reactome:R-MMU-8939211 ESR-mediated signaling
Reactome:R-MMU-5673001 RAF/MAP kinase cascade
Reactome:R-MMU-5674499 Negative feedback regulation of MAPK pathway
Reactome:R-MMU-9006927 Signaling by Non-Receptor Tyrosine Kinases
Reactome:R-MMU-380972 Energy dependent regulation of mTOR by LKB1-AMPK
Reactome:R-MMU-5357956 TNFR1-induced NF-kappa-B signaling pathway
Reactome:R-MMU-209543 p75NTR recruits signalling complexes
Reactome:R-MMU-3899300 SUMOylation of transcription cofactors
Reactome:R-MMU-4615885 SUMOylation of DNA replication proteins
Reactome:R-MMU-8852135 Protein ubiquitination
Reactome:R-MMU-381070 IRE1alpha activates chaperones
Reactome:R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
Reactome:R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs
Reactome:R-MMU-5205685 PINK1-PRKN Mediated Mitophagy
Reactome:R-MMU-6794362 Protein-protein interactions at synapses
Reactome:R-RNO-5620912 Anchoring of the basal body to the plasma membrane
Reactome:R-RNO-450604 KSRP (KHSRP) binds and destabilizes mRNA
Reactome:R-RNO-72312 rRNA processing
Reactome:R-RNO-70171 Glycolysis
Reactome:R-RNO-1660499 Synthesis of PIPs at the plasma membrane
Reactome:R-RNO-202131 Metabolism of nitric oxide: NOS3 activation and regulation
Reactome:R-RNO-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Reactome:R-RNO-70895 Branched-chain amino acid catabolism
Reactome:R-RNO-69620 Cell Cycle Checkpoints
Reactome:R-RNO-69613 p53-Independent G1/S DNA Damage Checkpoint
Reactome:R-RNO-69473 G2/M DNA damage checkpoint
Reactome:R-RNO-69618 Mitotic Spindle Checkpoint
Reactome:R-RNO-69275 G2/M Transition
Reactome:R-RNO-380287 Centrosome maturation
Reactome:R-RNO-68886 M Phase
Reactome:R-RNO-380320 Recruitment of NuMA to mitotic centrosomes
Reactome:R-RNO-2467813 Separation of Sister Chromatids
Reactome:R-RNO-112316 Neuronal System
Reactome:R-RNO-6794361 Neurexins and neuroligins
Reactome:R-RNO-597592 Post-translational protein modification
Reactome:R-RNO-204005 COPII-mediated vesicle transport
Reactome:R-RNO-2990846 SUMOylation
Reactome:R-RNO-5205647 Mitophagy
Reactome:R-RNO-6791312 TP53 Regulates Transcription of Cell Cycle Genes
Reactome:R-RNO-6804757 Regulation of TP53 Degradation
Reactome:R-RNO-8953750 Transcriptional Regulation by E2F6
Reactome:R-RNO-3371571 HSF1-dependent transactivation
Reactome:R-RNO-162582 Signaling Pathways
Reactome:R-RNO-190236 Signaling by FGFR
Reactome:R-RNO-5654726 Negative regulation of FGFR1 signaling
Reactome:R-RNO-5654727 Negative regulation of FGFR2 signaling
Reactome:R-RNO-166520 Signaling by NTRKs
Reactome:R-RNO-74752 Signaling by Insulin receptor
Reactome:R-RNO-109704 PI3K Cascade
Reactome:R-RNO-4420097 VEGFA-VEGFR2 Pathway
Reactome:R-RNO-1433557 Signaling by SCF-KIT
Reactome:R-RNO-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Reactome:R-RNO-6806834 Signaling by MET
Reactome:R-RNO-372790 Signaling by GPCR
Reactome:R-RNO-180024 DARPP-32 events
Reactome:R-RNO-416476 G alpha (q) signalling events
Reactome:R-RNO-9604323 Negative regulation of NOTCH4 signaling
Reactome:R-RNO-196299 Beta-catenin phosphorylation cascade
Reactome:R-RNO-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
Reactome:R-RNO-5632684 Hedgehog 'on' state
Reactome:R-RNO-9006931 Signaling by Nuclear Receptors
Reactome:R-RNO-5673000 RAF activation
Reactome:R-RNO-5687128 MAPK6/MAPK4 signaling
Reactome:R-RNO-194315 Signaling by Rho GTPases
Reactome:R-RNO-5627123 RHO GTPases activate PAKs
Reactome:R-RNO-5663220 RHO GTPases Activate Formins
Reactome:R-RNO-8848021 Signaling by PTK6
Reactome:R-RNO-165159 MTOR signalling
Reactome:R-RNO-73887 Death Receptor Signaling
Reactome:R-RNO-193704 p75 NTR receptor-mediated signalling
Reactome:R-RNO-209560 NF-kB is activated and signals survival
Reactome:R-RNO-382551 Transport of small molecules
Reactome:R-RNO-2672351 Stimuli-sensing channels
Reactome:R-RNO-73894 DNA Repair
Reactome:R-RNO-5685942 HDR through Homologous Recombination (HRR)
Reactome:R-RNO-199991 Membrane Trafficking
Reactome:R-RNO-109582 Hemostasis
Reactome:R-RNO-111465 Apoptotic cleavage of cellular proteins
Reactome:R-RNO-5213460 RIPK1-mediated regulated necrosis
Reactome:R-RNO-1280218 Adaptive Immune System
Reactome:R-RNO-389357 CD28 dependent PI3K/Akt signaling
Reactome:R-RNO-983705 B Cell Activation
Reactome:R-RNO-168898 Toll-like Receptor Cascades
Reactome:R-RNO-937039 IRAK1 recruits IKK complex
Reactome:R-RNO-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
Reactome:R-RNO-168188 Toll Like Receptor TLR6:TLR2 Cascade
Reactome:R-RNO-1606322 ZBP1(DAI) mediated induction of type I IFNs
Reactome:R-RNO-2871796 FCERI mediated MAPK activation
Reactome:R-RNO-5621481 C-type lectin receptors (CLRs)
Reactome:R-RNO-1169410 Antiviral mechanism by IFN-stimulated genes
Reactome:R-RNO-446652 Interleukin-1 family signaling
Reactome:R-RNO-451927 Interleukin-2 family signaling
Reactome:R-RNO-1266738 Developmental Biology
Reactome:R-RNO-399956 CRMPs in Sema3A signaling
Reactome:R-RNO-373752 Netrin-1 signaling
Reactome:R-RNO-445144 Signal transduction by L1
Reactome:R-RNO-3928662 EPHB-mediated forward signaling
Reactome:R-SCE-1266738 Developmental Biology
Reactome:R-SCE-76002 Platelet activation, signaling and aggregation
Reactome:R-SCE-72312 rRNA processing
Reactome:R-SCE-109581 Apoptosis
Reactome:R-SCE-3700989 Transcriptional Regulation by TP53
Reactome:R-SCE-8953897 Cellular responses to stimuli
Reactome:R-SCE-3371556 Cellular response to heat stress
Reactome:R-SCE-2559582 Senescence-Associated Secretory Phenotype (SASP)
Reactome:R-SCE-202403 TCR signaling
Reactome:R-SCE-389356 CD28 co-stimulation
Reactome:R-SCE-975871 MyD88 cascade initiated on plasma membrane
Reactome:R-SCE-450282 MAPK targets/ Nuclear events mediated by MAP kinases
Reactome:R-SCE-168176 Toll Like Receptor 5 (TLR5) Cascade
Reactome:R-SCE-168138 Toll Like Receptor 9 (TLR9) Cascade
Reactome:R-SCE-937061 TRIF (TICAM1)-mediated TLR4 signaling
Reactome:R-SCE-448424 Interleukin-17 signaling
Reactome:R-SCE-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-SCE-198725 Nuclear Events (kinase and transcription factor activation)
Reactome:R-SCE-109704 PI3K Cascade
Reactome:R-SCE-4420097 VEGFA-VEGFR2 Pathway
Reactome:R-SCE-2428924 IGF1R signaling cascade
Reactome:R-SCE-9006931 Signaling by Nuclear Receptors
Reactome:R-SCE-9006925 Intracellular signaling by second messengers
Reactome:R-SCE-194315 Signaling by Rho GTPases
Reactome:R-SCE-5627123 RHO GTPases activate PAKs
Reactome:R-SCE-165159 MTOR signalling
Reactome:R-SCE-163680 AMPK inhibits chREBP transcriptional activation activity
Reactome:R-SCE-112315 Transmission across Chemical Synapses
Reactome:R-SCE-442755 Activation of NMDA receptors and postsynaptic events
Reactome:R-SCE-1640170 Cell Cycle
Reactome:R-SCE-69206 G1/S Transition
Reactome:R-SCE-69275 G2/M Transition
Reactome:R-SCE-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Reactome:R-SPO-8934903 Receptor Mediated Mitophagy
Reactome:R-SPO-202424 Downstream TCR signaling
Reactome:R-SPO-389359 CD28 dependent Vav1 pathway
Reactome:R-SPO-168142 Toll Like Receptor 10 (TLR10) Cascade
Reactome:R-SPO-975155 MyD88 dependent cascade initiated on endosome
Reactome:R-SPO-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Reactome:R-SPO-168179 Toll Like Receptor TLR1:TLR2 Cascade
Reactome:R-SPO-69002 DNA Replication Pre-Initiation
Reactome:R-SPO-68962 Activation of the pre-replicative complex
Reactome:R-SPO-69620 Cell Cycle Checkpoints
Reactome:R-SPO-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Reactome:R-SPO-69206 G1/S Transition
Reactome:R-SPO-453274 Mitotic G2-G2/M phases
Reactome:R-SPO-176408 Regulation of APC/C activators between G1/S and early anaphase
Reactome:R-SPO-112316 Neuronal System
Reactome:R-SPO-442755 Activation of NMDA receptors and postsynaptic events
Reactome:R-SPO-3700989 Transcriptional Regulation by TP53
Reactome:R-SPO-6804757 Regulation of TP53 Degradation
Reactome:R-SPO-5693532 DNA Double-Strand Break Repair
Reactome:R-SPO-1430728 Metabolism
Reactome:R-SPO-1660517 Synthesis of PIPs at the late endosome membrane
Reactome:R-SPO-187037 Signaling by NTRK1 (TRKA)
Reactome:R-SPO-74751 Insulin receptor signalling cascade
Reactome:R-SPO-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Reactome:R-SPO-388396 GPCR downstream signalling
Reactome:R-SPO-416476 G alpha (q) signalling events
Reactome:R-SPO-8939211 ESR-mediated signaling
Reactome:R-SPO-9006925 Intracellular signaling by second messengers
Reactome:R-SPO-194315 Signaling by Rho GTPases
Reactome:R-SPO-5625740 RHO GTPases activate PKNs
Reactome:R-SPO-5668599 RHO GTPases Activate NADPH Oxidases
Reactome:R-SSC-8953897 Cellular responses to stimuli
Reactome:R-SSC-2262752 Cellular responses to stress
Reactome:R-SSC-200425 Carnitine shuttle
Reactome:R-SSC-163685 Integration of energy metabolism
Reactome:R-SSC-69278 Cell Cycle, Mitotic
Reactome:R-SSC-8854518 AURKA Activation by TPX2
Reactome:R-SSC-168256 Immune System
Reactome:R-SSC-389948 PD-1 signaling
Reactome:R-XTR-5633007 Regulation of TP53 Activity
Reactome:R-XTR-6804756 Regulation of TP53 Activity through Phosphorylation
Reactome:R-XTR-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome:R-XTR-5654738 Signaling by FGFR2
Reactome:R-XTR-5654732 Negative regulation of FGFR3 signaling
Reactome:R-XTR-194315 Signaling by Rho GTPases
Reactome:R-XTR-5663220 RHO GTPases Activate Formins
Reactome:R-XTR-3108232 SUMO E3 ligases SUMOylate target proteins
Reactome:R-HSA-70171 Glycolysis
Reactome:R-BTA-6791312 TP53 Regulates Transcription of Cell Cycle Genes
Reactome:R-BTA-453274 Mitotic G2-G2/M phases
Reactome:R-BTA-2565942 Regulation of PLK1 Activity at G2/M Transition
Reactome:R-BTA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
Reactome:R-BTA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Reactome:R-BTA-68877 Mitotic Prometaphase
Reactome:R-BTA-1266738 Developmental Biology
Reactome:R-BTA-388841 Costimulation by the CD28 family
Reactome:R-BTA-1168372 Downstream signaling events of B Cell Receptor (BCR)
Reactome:R-BTA-168249 Innate Immune System
Reactome:R-BTA-975871 MyD88 cascade initiated on plasma membrane
Reactome:R-BTA-450294 MAP kinase activation
Reactome:R-BTA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
Reactome:R-BTA-181438 Toll Like Receptor 2 (TLR2) Cascade
Reactome:R-BTA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome:R-BTA-1810476 RIP-mediated NFkB activation via ZBP1
Reactome:R-BTA-2871837 FCERI mediated NF-kB activation
Reactome:R-BTA-1280215 Cytokine Signaling in Immune system
Reactome:R-BTA-9020702 Interleukin-1 signaling
Reactome:R-BTA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
Reactome:R-BTA-72312 rRNA processing
Reactome:R-BTA-70171 Glycolysis
Reactome:R-BTA-1483255 PI Metabolism
Reactome:R-BTA-70895 Branched-chain amino acid catabolism
Reactome:R-BTA-5653656 Vesicle-mediated transport
Reactome:R-BTA-5620912 Anchoring of the basal body to the plasma membrane
Reactome:R-BTA-162582 Signaling Pathways
Reactome:R-BTA-5654736 Signaling by FGFR1
Reactome:R-BTA-5654741 Signaling by FGFR3
Reactome:R-BTA-5654708 Downstream signaling of activated FGFR3
Reactome:R-BTA-5654710 PI-3K cascade:FGFR3
Reactome:R-BTA-1433557 Signaling by SCF-KIT
Reactome:R-BTA-6806834 Signaling by MET
Reactome:R-BTA-372790 Signaling by GPCR
Reactome:R-BTA-195253 Degradation of beta-catenin by the destruction complex
Reactome:R-BTA-1257604 PI3K/AKT Signaling
Reactome:R-BTA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Reactome:R-BTA-195258 RHO GTPase Effectors
Reactome:R-BTA-75893 TNF signaling
Reactome:R-BTA-5357905 Regulation of TNFR1 signaling
Reactome:R-BTA-193639 p75NTR signals via NF-kB
Reactome:R-BTA-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Reactome:R-CEL-69615 G1/S DNA Damage Checkpoints
Reactome:R-CEL-69481 G2/M Checkpoints
Reactome:R-CEL-176187 Activation of ATR in response to replication stress
Reactome:R-CEL-69278 Cell Cycle, Mitotic
Reactome:R-CEL-69275 G2/M Transition
Reactome:R-CEL-68886 M Phase
Reactome:R-CEL-2555396 Mitotic Metaphase and Anaphase
Reactome:R-CEL-2995383 Initiation of Nuclear Envelope (NE) Reformation
Reactome:R-CEL-199991 Membrane Trafficking
Reactome:R-CEL-168256 Immune System
Reactome:R-CEL-389359 CD28 dependent Vav1 pathway
Reactome:R-CEL-168898 Toll-like Receptor Cascades
Reactome:R-CEL-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
Reactome:R-CEL-166016 Toll Like Receptor 4 (TLR4) Cascade
Reactome:R-CEL-181438 Toll Like Receptor 2 (TLR2) Cascade
Reactome:R-CEL-446652 Interleukin-1 family signaling
Reactome:R-CEL-448424 Interleukin-17 signaling
Reactome:R-CEL-392499 Metabolism of proteins
Reactome:R-CEL-597592 Post-translational protein modification
Reactome:R-CEL-3899300 SUMOylation of transcription cofactors
Reactome:R-CEL-381070 IRE1alpha activates chaperones
Reactome:R-CEL-187037 Signaling by NTRK1 (TRKA)
Reactome:R-CEL-74751 Insulin receptor signalling cascade
Reactome:R-CEL-194138 Signaling by VEGF
Reactome:R-CEL-195253 Degradation of beta-catenin by the destruction complex
Reactome:R-CEL-2028269 Signaling by Hippo
Reactome:R-CEL-5673000 RAF activation
Reactome:R-CEL-5687128 MAPK6/MAPK4 signaling
Reactome:R-CEL-194315 Signaling by Rho GTPases
Reactome:R-CEL-5627123 RHO GTPases activate PAKs
Reactome:R-CEL-165159 MTOR signalling
Reactome:R-CEL-556833 Metabolism of lipids
Reactome:R-CEL-1266738 Developmental Biology
Reactome:R-CEL-5205685 PINK1-PRKN Mediated Mitophagy
Reactome:R-CEL-382551 Transport of small molecules
Reactome:R-CEL-983712 Ion channel transport
Reactome:R-CEL-212436 Generic Transcription Pathway
Reactome:R-CFA-1640170 Cell Cycle
Reactome:R-CFA-8854521 Interaction between PHLDA1 and AURKA
Reactome:R-CFA-74160 Gene expression (Transcription)
Reactome:R-CFA-212436 Generic Transcription Pathway
Reactome:R-CFA-3700989 Transcriptional Regulation by TP53
Reactome:R-CFA-5633007 Regulation of TP53 Activity
Reactome:R-CFA-6804756 Regulation of TP53 Activity through Phosphorylation
Reactome:R-DRE-8953854 Metabolism of RNA
Reactome:R-DRE-162582 Signaling Pathways
Reactome:R-DRE-2028269 Signaling by Hippo
Reactome:R-DRE-9006925 Intracellular signaling by second messengers
Reactome:R-DRE-212436 Generic Transcription Pathway
Reactome:R-DRE-3700989 Transcriptional Regulation by TP53
Reactome:R-DRE-6806003 Regulation of TP53 Expression and Degradation
Reactome:R-DRE-69620 Cell Cycle Checkpoints
Reactome:R-DRE-380320 Recruitment of NuMA to mitotic centrosomes
Reactome:R-DDI-5693532 DNA Double-Strand Break Repair
Reactome:R-DDI-5693538 Homology Directed Repair
Reactome:R-DDI-2262752 Cellular responses to stress
Reactome:R-DDI-3371571 HSF1-dependent transactivation
Reactome:R-DDI-8978868 Fatty acid metabolism
Reactome:R-DDI-200425 Carnitine shuttle
Reactome:R-DDI-5357801 Programmed Cell Death
Reactome:R-DDI-199991 Membrane Trafficking
Reactome:R-DDI-8854214 TBC/RABGAPs
Reactome:R-DDI-69615 G1/S DNA Damage Checkpoints
Reactome:R-DDI-349425 Autodegradation of the E3 ubiquitin ligase COP1
Reactome:R-DDI-69481 G2/M Checkpoints
Reactome:R-DDI-453279 Mitotic G1 phase and G1/S transition
Reactome:R-DDI-69206 G1/S Transition
Reactome:R-DDI-2565942 Regulation of PLK1 Activity at G2/M Transition
Reactome:R-DDI-68875 Mitotic Prophase
Reactome:R-DDI-68884 cell division
Reactome:R-DDI-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Reactome:R-DDI-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-DDI-198753 ERK/MAPK targets
Reactome:R-DDI-112399 IRS-mediated signalling
Reactome:R-DDI-5218920 VEGFR2 mediated vascular permeability
Reactome:R-DDI-372790 Signaling by GPCR
Reactome:R-DDI-5683057 MAPK family signaling cascades
Reactome:R-DDI-9006925 Intracellular signaling by second messengers
Reactome:R-DDI-165181 Inhibition of TSC complex formation by PKB
Reactome:R-DDI-3700989 Transcriptional Regulation by TP53
Reactome:R-DDI-6791312 TP53 Regulates Transcription of Cell Cycle Genes
Reactome:R-DDI-6804756 Regulation of TP53 Activity through Phosphorylation
Reactome:R-DDI-8868773 rRNA processing in the nucleus and cytosol
Reactome:R-DDI-1266738 Developmental Biology
Reactome:R-DDI-375165 NCAM signaling for neurite out-growth
Reactome:R-DDI-202424 Downstream TCR signaling
Reactome:R-DDI-389359 CD28 dependent Vav1 pathway
Reactome:R-DDI-168249 Innate Immune System
Reactome:R-DDI-450294 MAP kinase activation
Reactome:R-DDI-168176 Toll Like Receptor 5 (TLR5) Cascade
Reactome:R-DDI-168138 Toll Like Receptor 9 (TLR9) Cascade
Reactome:R-DDI-937061 TRIF (TICAM1)-mediated TLR4 signaling
Reactome:R-DDI-2029482 Regulation of actin dynamics for phagocytic cup formation
Reactome:R-DME-389357 CD28 dependent PI3K/Akt signaling
Reactome:R-DME-168249 Innate Immune System
Reactome:R-DME-975871 MyD88 cascade initiated on plasma membrane
Reactome:R-DME-450294 MAP kinase activation
Reactome:R-DME-198753 ERK/MAPK targets
Reactome:R-DME-168164 Toll Like Receptor 3 (TLR3) Cascade
Reactome:R-DME-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Reactome:R-DME-168138 Toll Like Receptor 9 (TLR9) Cascade
Reactome:R-DME-937061 TRIF (TICAM1)-mediated TLR4 signaling
Reactome:R-DME-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
Reactome:R-DME-913531 Interferon Signaling
Reactome:R-DME-1169410 Antiviral mechanism by IFN-stimulated genes
Reactome:R-DME-446652 Interleukin-1 family signaling
Reactome:R-DME-448424 Interleukin-17 signaling
Reactome:R-DME-381426 Regulation of IGF Activity by IGFBP
Reactome:R-DME-162582 Signaling Pathways
Reactome:R-DME-5654736 Signaling by FGFR1
Reactome:R-DME-5654738 Signaling by FGFR2
Reactome:R-DME-5654732 Negative regulation of FGFR3 signaling
Reactome:R-DME-5654733 Negative regulation of FGFR4 signaling
Reactome:R-DME-167044 Signalling to RAS
Reactome:R-DME-74752 Signaling by Insulin receptor
Reactome:R-DME-165158 Activation of PKB
Reactome:R-DME-194138 Signaling by VEGF
Reactome:R-DME-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Reactome:R-DME-388396 GPCR downstream signalling
Reactome:R-DME-111997 CaM pathway
Reactome:R-DME-157118 Signaling by NOTCH
Reactome:R-DME-9604323 Negative regulation of NOTCH4 signaling
Reactome:R-DME-196299 Beta-catenin phosphorylation cascade
Reactome:R-DME-8939211 ESR-mediated signaling
Reactome:R-DME-5673001 RAF/MAP kinase cascade
Reactome:R-DME-5674499 Negative feedback regulation of MAPK pathway
Reactome:R-DME-198323 AKT phosphorylates targets in the cytosol
Reactome:R-DME-6807070 PTEN Regulation
Reactome:R-DME-1489509 DAG and IP3 signaling
Reactome:R-DME-112315 Transmission across Chemical Synapses
Reactome:R-DME-8953897 Cellular responses to stimuli
Reactome:R-DME-3371556 Cellular response to heat stress
Reactome:R-DME-3371453 Regulation of HSF1-mediated heat shock response
Reactome:R-DME-2559586 DNA Damage/Telomere Stress Induced Senescence
Reactome:R-DME-69620 Cell Cycle Checkpoints
Reactome:R-DME-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Reactome:R-DME-69478 G2/M DNA replication checkpoint
Reactome:R-DME-69242 S Phase
Reactome:R-DME-69273 Cyclin A/B1/B2 associated events during G2/M transition
Reactome:R-DME-375165 NCAM signaling for neurite out-growth
Reactome:R-DME-73894 DNA Repair
Reactome:R-DME-5693532 DNA Double-Strand Break Repair
Reactome:R-DME-5693538 Homology Directed Repair
Reactome:R-DME-5693579 Homologous DNA Pairing and Strand Exchange
Reactome:R-DME-5633008 TP53 Regulates Transcription of Cell Death Genes
Reactome:R-DME-6804756 Regulation of TP53 Activity through Phosphorylation
Reactome:R-DME-674695 RNA Polymerase II Pre-transcription Events
Reactome:R-DME-73776 RNA Polymerase II Promoter Escape
Reactome:R-DME-109582 Hemostasis
Reactome:R-DME-76002 Platelet activation, signaling and aggregation
Reactome:R-DME-5205685 PINK1-PRKN Mediated Mitophagy
Reactome:R-DME-432524 Degradation of PER
Reactome:R-DME-432620 Dephosphorylation of PER
Reactome:R-DME-209392 Hedgehog pathway
Reactome:R-DME-209190 Phosphorylation of CI
Reactome:R-DME-216217 Activation of SMO
Reactome:R-DME-390146 Hippo/Warts pathway
Reactome:R-DME-390098 Phosphorylation-dependent inhibition of YKI
Reactome:R-DME-214874 PLL kinase binds to TUB in the TL receptor 'signalling complex'
Reactome:R-DME-214844 DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'
Reactome:R-DME-209441 WG ligand not bound to FZ receptors
Reactome:R-DME-209461 Ubiquitination and degradation of phosphorylated ARM
Reactome:R-DME-209440 Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM
Reactome:R-DME-1430728 Metabolism
Reactome:R-DME-202131 Metabolism of nitric oxide: NOS3 activation and regulation
Reactome:R-DME-8978934 Metabolism of cofactors
Reactome:R-GGA-351451 Homologous recombination repair of replication-dependent DSB
Reactome:R-GGA-8953750 Transcriptional Regulation by E2F6
Reactome:R-GGA-983712 Ion channel transport
Reactome:R-GGA-1640170 Cell Cycle
Reactome:R-GGA-176187 Activation of ATR in response to replication stress
Reactome:R-GGA-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-GGA-199920 CREB phosphorylation
Reactome:R-GGA-196299 Beta-catenin phosphorylation cascade
Reactome:R-GGA-5632684 Hedgehog 'on' state
Reactome:R-GGA-195258 RHO GTPase Effectors
Reactome:R-GGA-5685942 HDR through Homologous Recombination (HRR)
Reactome:R-GGA-422475 Axon guidance
Reactome:R-GGA-76002 Platelet activation, signaling and aggregation
Reactome:R-GGA-1280218 Adaptive Immune System
Reactome:R-GGA-168249 Innate Immune System
Reactome:R-GGA-975871 MyD88 cascade initiated on plasma membrane
Reactome:R-GGA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
Reactome:R-GGA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Reactome:R-GGA-168179 Toll Like Receptor TLR1:TLR2 Cascade
Reactome:R-GGA-2029482 Regulation of actin dynamics for phagocytic cup formation
Reactome:R-GGA-448424 Interleukin-17 signaling
Reactome:R-HSA-5205647 Mitophagy
Reactome:R-HSA-199991 Membrane Trafficking
Reactome:R-HSA-8854214 TBC/RABGAPs
Reactome:R-HSA-1592230 Mitochondrial biogenesis
Reactome:R-HSA-5617833 Cilium Assembly
Reactome:R-HSA-1266738 Developmental Biology
Reactome:R-HSA-399956 CRMPs in Sema3A signaling
Reactome:R-HSA-421270 Cell-cell junction organization
Reactome:R-HSA-76002 Platelet activation, signaling and aggregation
Reactome:R-HSA-1500620 Meiosis
Reactome:R-HSA-71387 Carbohydrate metabolism
Reactome:R-HSA-70326 Glucose metabolism
Reactome:R-HSA-556833 Metabolism of lipids
Reactome:R-HSA-8978868 Fatty acid metabolism
Reactome:R-HSA-1660514 Synthesis of PIPs at the Golgi membrane
Reactome:R-HSA-1660516 Synthesis of PIPs at the early endosome membrane
Reactome:R-HSA-428157 Sphingolipid metabolism
Reactome:R-HSA-70268 Pyruvate metabolism
Reactome:R-HSA-196854 Metabolism of vitamins and cofactors
Reactome:R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway
Reactome:R-HSA-75153 Apoptotic execution phase
Reactome:R-HSA-169911 Regulation of Apoptosis
Reactome:R-HSA-5213460 RIPK1-mediated regulated necrosis
Reactome:R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Reactome:R-HSA-5685942 HDR through Homologous Recombination (HRR)
Reactome:R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
Reactome:R-HSA-5693571 Nonhomologous End-Joining (NHEJ)
Reactome:R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-HSA-5654736 Signaling by FGFR1
Reactome:R-HSA-1295596 Spry regulation of FGF signaling
Reactome:R-HSA-5654741 Signaling by FGFR3
Reactome:R-HSA-5654708 Downstream signaling of activated FGFR3
Reactome:R-HSA-5654710 PI-3K cascade:FGFR3
Reactome:R-HSA-170984 ARMS-mediated activation
Reactome:R-HSA-9028335 Activated NTRK2 signals through PI3K
Reactome:R-HSA-9032845 Activated NTRK2 signals through CDK5
Reactome:R-HSA-74751 Insulin receptor signalling cascade
Reactome:R-HSA-165158 Activation of PKB
Reactome:R-HSA-194138 Signaling by VEGF
Reactome:R-HSA-5218920 VEGFR2 mediated vascular permeability
Reactome:R-HSA-1963642 PI3K events in ERBB2 signaling
Reactome:R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Reactome:R-HSA-6806834 Signaling by MET
Reactome:R-HSA-372790 Signaling by GPCR
Reactome:R-HSA-9013694 Signaling by NOTCH4
Reactome:R-HSA-195721 Signaling by WNT
Reactome:R-HSA-5610783 Degradation of GLI2 by the proteasome
Reactome:R-HSA-5635838 Activation of SMO
Reactome:R-HSA-9006931 Signaling by Nuclear Receptors
Reactome:R-HSA-5673000 RAF activation
Reactome:R-HSA-5687128 MAPK6/MAPK4 signaling
Reactome:R-HSA-198693 AKT phosphorylates targets in the nucleus
Reactome:R-HSA-195258 RHO GTPase Effectors
Reactome:R-HSA-5668599 RHO GTPases Activate NADPH Oxidases
Reactome:R-HSA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
Reactome:R-HSA-165181 Inhibition of TSC complex formation by PKB
Reactome:R-HSA-209560 NF-kB is activated and signals survival
Reactome:R-HSA-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Reactome:R-HSA-2262752 Cellular responses to stress
Reactome:R-HSA-2559583 Cellular Senescence
Reactome:R-HSA-390522 Striated Muscle Contraction
Reactome:R-HSA-5578775 Ion homeostasis
Reactome:R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Reactome:R-HSA-6794362 Protein-protein interactions at synapses
Reactome:R-HSA-1640170 Cell Cycle
Reactome:R-HSA-69563 p53-Dependent G1 DNA Damage Response
Reactome:R-HSA-69481 G2/M Checkpoints
Reactome:R-HSA-176187 Activation of ATR in response to replication stress
Reactome:R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Reactome:R-HSA-453274 Mitotic G2-G2/M phases
Reactome:R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
Reactome:R-HSA-8854518 AURKA Activation by TPX2
Reactome:R-HSA-68875 Mitotic Prophase
Reactome:R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
Reactome:R-HSA-2467813 Separation of Sister Chromatids
Reactome:R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
Reactome:R-HSA-3899300 SUMOylation of transcription cofactors
Reactome:R-HSA-4615885 SUMOylation of DNA replication proteins
Reactome:R-HSA-8852135 Protein ubiquitination
Reactome:R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer
Reactome:R-HSA-1839124 FGFR1 mutant receptor activation
Reactome:R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
Reactome:R-HSA-5467340 AXIN missense mutants destabilize the destruction complex
Reactome:R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants
Reactome:R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated
Reactome:R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
Reactome:R-HSA-162906 HIV Infection
Reactome:R-HSA-5602636 IKBKB deficiency causes SCID
Reactome:R-HSA-69306 DNA Replication
Reactome:R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes
Reactome:R-HSA-6804760 Regulation of TP53 Activity through Methylation
Reactome:R-HSA-8939902 Regulation of RUNX2 expression and activity
Reactome:R-HSA-8986944 Transcriptional Regulation by MECP2
Reactome:R-HSA-212165 Epigenetic regulation of gene expression
Reactome:R-HSA-5250924 B-WICH complex positively regulates rRNA expression
Reactome:R-HSA-202403 TCR signaling
Reactome:R-HSA-202424 Downstream TCR signaling
Reactome:R-HSA-389359 CD28 dependent Vav1 pathway
Reactome:R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome:R-HSA-392517 Rap1 signalling
Reactome:R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
Reactome:R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Reactome:R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
Reactome:R-HSA-166166 MyD88-independent TLR4 cascade
Reactome:R-HSA-2562578 TRIF-mediated programmed cell death
Reactome:R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
Reactome:R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Reactome:R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome:R-HSA-933542 TRAF6 mediated NF-kB activation
Reactome:R-HSA-1606341 IRF3 mediated activation of type 1 IFN
Reactome:R-HSA-3249367 STAT6-mediated induction of chemokines
Reactome:R-HSA-2871796 FCERI mediated MAPK activation
Reactome:R-HSA-5621481 C-type lectin receptors (CLRs)
Reactome:R-HSA-913531 Interferon Signaling
Reactome:R-HSA-449147 Signaling by Interleukins
Reactome:R-HSA-912631 Regulation of signaling by CBL
Reactome:R-HSA-9020591 Interleukin-12 signaling
Reactome:R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
Reactome:R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Reactome:R-HSA-927802 Nonsense-Mediated Decay (NMD)
Reactome:R-HSA-8868773 rRNA processing in the nucleus and cytosol
Reactome:R-MMU-69580 p53-Dependent G1/S DNA damage checkpoint
Reactome:R-MMU-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Reactome:R-MMU-69478 G2/M DNA replication checkpoint
Reactome:R-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome:R-MMU-453279 Mitotic G1 phase and G1/S transition
Reactome:R-MMU-69206 G1/S Transition
Reactome:R-MMU-68962 Activation of the pre-replicative complex
Reactome:R-MMU-453274 Mitotic G2-G2/M phases
Reactome:R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
Reactome:R-MMU-380284 Loss of proteins required for interphase microtubule organization from the centrosome
Reactome:R-MMU-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Reactome:R-MMU-2500257 Resolution of Sister Chromatid Cohesion
Reactome:R-MMU-174143 APC/C-mediated degradation of cell cycle proteins
Reactome:R-MMU-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Reactome:R-MMU-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Reactome:R-MMU-69002 DNA Replication Pre-Initiation
Reactome:R-MMU-388841 Costimulation by the CD28 family
Reactome:R-MMU-1168372 Downstream signaling events of B Cell Receptor (BCR)
Reactome:R-MMU-168142 Toll Like Receptor 10 (TLR10) Cascade
Reactome:R-MMU-445989 TAK1-dependent IKK and NF-kappa-B activation
Reactome:R-MMU-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
Reactome:R-MMU-199920 CREB phosphorylation
Reactome:R-MMU-168176 Toll Like Receptor 5 (TLR5) Cascade
Reactome:R-MMU-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Reactome:R-MMU-166016 Toll Like Receptor 4 (TLR4) Cascade
Reactome:R-MMU-937061 TRIF (TICAM1)-mediated TLR4 signaling
Reactome:R-MMU-933542 TRAF6 mediated NF-kB activation
Reactome:R-MMU-3249367 STAT6-mediated induction of chemokines
Reactome:R-MMU-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
Reactome:R-MMU-5607764 CLEC7A (Dectin-1) signaling
Reactome:R-MMU-5621575 CD209 (DC-SIGN) signaling
Reactome:R-MMU-1280215 Cytokine Signaling in Immune system
Reactome:R-MMU-877300 Interferon gamma signaling
Reactome:R-MMU-9020702 Interleukin-1 signaling
Reactome:R-MMU-9008059 Interleukin-37 signaling
Reactome:R-MMU-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
Reactome:R-MMU-5693606 DNA Double Strand Break Response
Reactome:R-MMU-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome:R-MMU-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
Reactome:R-MMU-5685938 HDR through Single Strand Annealing (SSA)
Reactome:R-MMU-6783310 Fanconi Anemia Pathway
Reactome:R-MMU-70171 Glycolysis
Reactome:R-MMU-8978868 Fatty acid metabolism
Reactome:R-MMU-1660499 Synthesis of PIPs at the plasma membrane
Reactome:R-MMU-163685 Integration of energy metabolism
Reactome:R-MMU-70268 Pyruvate metabolism
Reactome:R-MMU-196854 Metabolism of vitamins and cofactors
Reactome:R-MMU-72172 mRNA Splicing
Reactome:R-MMU-450531 Regulation of mRNA stability by proteins that bind AU-rich elements
Reactome:R-MMU-8868773 rRNA processing in the nucleus and cytosol
Reactome:R-MMU-114604 GPVI-mediated activation cascade
Reactome:R-MMU-373755 Semaphorin interactions
Reactome:R-MMU-375165 NCAM signaling for neurite out-growth
Reactome:R-MMU-2682334 EPH-Ephrin signaling
Reactome:R-MMU-140534 Ligand-dependent caspase activation
Reactome:R-MMU-111465 Apoptotic cleavage of cellular proteins
Reactome:R-MMU-5213460 RIPK1-mediated regulated necrosis
Reactome:R-MMU-3371571 HSF1-dependent transactivation
Reactome:R-MMU-5578775 Ion homeostasis
Reactome:R-MMU-6791312 TP53 Regulates Transcription of Cell Cycle Genes
Reactome:R-MMU-6804757 Regulation of TP53 Degradation
Reactome:R-MMU-674695 RNA Polymerase II Pre-transcription Events
Reactome:R-MMU-73776 RNA Polymerase II Promoter Escape
Reactome:R-MMU-5250913 Positive epigenetic regulation of rRNA expression
Reactome:R-MMU-5654687 Downstream signaling of activated FGFR1
Reactome:R-MMU-5654689 PI-3K cascade:FGFR1
Reactome:R-MMU-5654696 Downstream signaling of activated FGFR2
Reactome:R-MMU-5654695 PI-3K cascade:FGFR2
Reactome:R-MMU-5654743 Signaling by FGFR4
Reactome:R-MMU-5654733 Negative regulation of FGFR4 signaling
Reactome:R-MMU-187037 Signaling by NTRK1 (TRKA)
Reactome:R-MMU-198725 Nuclear Events (kinase and transcription factor activation)
Reactome:R-MMU-5218921 VEGFR2 mediated cell proliferation
Reactome:R-MMU-1227986 Signaling by ERBB2
Reactome:R-MMU-418594 G alpha (i) signalling events
Reactome:R-MMU-392451 G beta:gamma signalling through PI3Kgamma
Reactome:R-MMU-195253 Degradation of beta-catenin by the destruction complex
Reactome:R-MMU-201688 WNT mediated activation of DVL
Reactome:R-MMU-5684996 ERK1/ERK2 pathway
Reactome:R-MMU-5675221 Negative regulation of MAPK pathway
Reactome:R-MMU-1257604 PI3K/AKT Signaling
Reactome:R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Reactome:R-MMU-195258 RHO GTPase Effectors
Reactome:R-MMU-5668599 RHO GTPases Activate NADPH Oxidases
Reactome:R-MMU-8857538 PTK6 promotes HIF1A stabilization
Reactome:R-MMU-166208 mTORC1-mediated signalling
Reactome:R-MMU-75893 TNF signaling
Reactome:R-MMU-5357905 Regulation of TNFR1 signaling
Reactome:R-MMU-193639 p75NTR signals via NF-kB
Reactome:R-MMU-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Reactome:R-MMU-199977 ER to Golgi Anterograde Transport
Reactome:R-MMU-8957275 Post-translational protein phosphorylation
Reactome:R-MMU-8856828 Clathrin-mediated endocytosis
Reactome:R-MMU-9007101 Rab regulation of trafficking
Reactome:R-MMU-5205647 Mitophagy
Reactome:R-MMU-112310 Neurotransmitter release cycle
Reactome:R-MMU-212676 Dopamine Neurotransmitter Release Cycle
Reactome:R-RNO-1852241 Organelle biogenesis and maintenance
Reactome:R-RNO-5617833 Cilium Assembly
Reactome:R-RNO-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Reactome:R-RNO-8982491 Glycogen metabolism
Reactome:R-RNO-70263 Gluconeogenesis
Reactome:R-RNO-196854 Metabolism of vitamins and cofactors
Reactome:R-RNO-1640170 Cell Cycle
Reactome:R-RNO-69481 G2/M Checkpoints
Reactome:R-RNO-176187 Activation of ATR in response to replication stress
Reactome:R-RNO-380259 Loss of Nlp from mitotic centrosomes
Reactome:R-RNO-8854521 Interaction between PHLDA1 and AURKA
Reactome:R-RNO-68882 Mitotic Anaphase
Reactome:R-RNO-112315 Transmission across Chemical Synapses
Reactome:R-RNO-6794362 Protein-protein interactions at synapses
Reactome:R-RNO-392499 Metabolism of proteins
Reactome:R-RNO-4615885 SUMOylation of DNA replication proteins
Reactome:R-RNO-8953897 Cellular responses to stimuli
Reactome:R-RNO-2262752 Cellular responses to stress
Reactome:R-RNO-2559583 Cellular Senescence
Reactome:R-RNO-5654687 Downstream signaling of activated FGFR1
Reactome:R-RNO-5654689 PI-3K cascade:FGFR1
Reactome:R-RNO-5654696 Downstream signaling of activated FGFR2
Reactome:R-RNO-5654695 PI-3K cascade:FGFR2
Reactome:R-RNO-5654743 Signaling by FGFR4
Reactome:R-RNO-5654733 Negative regulation of FGFR4 signaling
Reactome:R-RNO-187037 Signaling by NTRK1 (TRKA)
Reactome:R-RNO-198725 Nuclear Events (kinase and transcription factor activation)
Reactome:R-RNO-112399 IRS-mediated signalling
Reactome:R-RNO-1236394 Signaling by ERBB4
Reactome:R-RNO-2428928 IRS-related events triggered by IGF1R
Reactome:R-RNO-8851907 MET activates PI3K/AKT signaling
Reactome:R-RNO-388396 GPCR downstream signalling
Reactome:R-RNO-111885 Opioid Signalling
Reactome:R-RNO-392451 G beta:gamma signalling through PI3Kgamma
Reactome:R-RNO-195253 Degradation of beta-catenin by the destruction complex
Reactome:R-RNO-8939211 ESR-mediated signaling
Reactome:R-RNO-5673001 RAF/MAP kinase cascade
Reactome:R-RNO-5674499 Negative feedback regulation of MAPK pathway
Reactome:R-RNO-5625900 RHO GTPases activate CIT
Reactome:R-RNO-9006927 Signaling by Non-Receptor Tyrosine Kinases
Reactome:R-RNO-380972 Energy dependent regulation of mTOR by LKB1-AMPK
Reactome:R-RNO-5357956 TNFR1-induced NF-kappa-B signaling pathway
Reactome:R-RNO-209543 p75NTR recruits signalling complexes
Reactome:R-RNO-5693607 Processing of DNA double-strand break ends
Reactome:R-RNO-5653656 Vesicle-mediated transport
Reactome:R-RNO-430116 GP1b-IX-V activation signalling
Reactome:R-RNO-75153 Apoptotic execution phase
Reactome:R-RNO-5218859 Regulated Necrosis
Reactome:R-RNO-168256 Immune System
Reactome:R-RNO-389356 CD28 co-stimulation
Reactome:R-RNO-389948 PD-1 signaling
Reactome:R-RNO-1169091 Activation of NF-kappaB in B cells
Reactome:R-RNO-168249 Innate Immune System
Reactome:R-RNO-975871 MyD88 cascade initiated on plasma membrane
Reactome:R-RNO-450294 MAP kinase activation
Reactome:R-RNO-168176 Toll Like Receptor 5 (TLR5) Cascade
Reactome:R-RNO-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Reactome:R-RNO-166016 Toll Like Receptor 4 (TLR4) Cascade
Reactome:R-RNO-937061 TRIF (TICAM1)-mediated TLR4 signaling
Reactome:R-RNO-168179 Toll Like Receptor TLR1:TLR2 Cascade
Reactome:R-RNO-1834949 Cytosolic sensors of pathogen-associated DNA
Reactome:R-RNO-2029482 Regulation of actin dynamics for phagocytic cup formation
Reactome:R-RNO-2454202 Fc epsilon receptor (FCERI) signaling
Reactome:R-RNO-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
Reactome:R-RNO-913531 Interferon Signaling
Reactome:R-RNO-449147 Signaling by Interleukins
Reactome:R-RNO-912631 Regulation of signaling by CBL
Reactome:R-RNO-448424 Interleukin-17 signaling
Reactome:R-RNO-399954 Sema3A PAK dependent Axon repulsion
Reactome:R-RNO-8853659 RET signaling
Reactome:R-SCE-109582 Hemostasis
Reactome:R-SCE-114604 GPVI-mediated activation cascade
Reactome:R-SCE-8953854 Metabolism of RNA
Reactome:R-SCE-8934903 Receptor Mediated Mitophagy
Reactome:R-SCE-5357801 Programmed Cell Death
Reactome:R-SCE-212436 Generic Transcription Pathway
Reactome:R-SCE-6804757 Regulation of TP53 Degradation
Reactome:R-SCE-1280218 Adaptive Immune System
Reactome:R-SCE-388841 Costimulation by the CD28 family
Reactome:R-SCE-168142 Toll Like Receptor 10 (TLR10) Cascade
Reactome:R-SCE-168164 Toll Like Receptor 3 (TLR3) Cascade
Reactome:R-SCE-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Reactome:R-SCE-166166 MyD88-independent TLR4 cascade
Reactome:R-SCE-168188 Toll Like Receptor TLR6:TLR2 Cascade
Reactome:R-SCE-5607764 CLEC7A (Dectin-1) signaling
Reactome:R-SCE-449147 Signaling by Interleukins
Reactome:R-SCE-162582 Signaling Pathways
Reactome:R-SCE-112399 IRS-mediated signalling
Reactome:R-SCE-194138 Signaling by VEGF
Reactome:R-SCE-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Reactome:R-SCE-388396 GPCR downstream signalling
Reactome:R-SCE-881907 Gastrin-CREB signalling pathway via PKC and MAPK
Reactome:R-SCE-392451 G beta:gamma signalling through PI3Kgamma
Reactome:R-SCE-8939211 ESR-mediated signaling
Reactome:R-SCE-5687128 MAPK6/MAPK4 signaling
Reactome:R-SCE-5668599 RHO GTPases Activate NADPH Oxidases
Reactome:R-SCE-1430728 Metabolism
Reactome:R-SCE-8978868 Fatty acid metabolism
Reactome:R-SCE-1660514 Synthesis of PIPs at the Golgi membrane
Reactome:R-SCE-163685 Integration of energy metabolism
Reactome:R-SCE-112316 Neuronal System
Reactome:R-SCE-112314 Neurotransmitter receptors and postsynaptic signal transmission
Reactome:R-SCE-444257 RSK activation
Reactome:R-SCE-69613 p53-Independent G1/S DNA Damage Checkpoint
Reactome:R-SCE-453279 Mitotic G1 phase and G1/S transition
Reactome:R-SCE-68962 Activation of the pre-replicative complex
Reactome:R-SCE-453274 Mitotic G2-G2/M phases
Reactome:R-SCE-156711 Polo-like kinase mediated events
Reactome:R-SCE-69002 DNA Replication Pre-Initiation
Reactome:R-SPO-5205647 Mitophagy
Reactome:R-SPO-202403 TCR signaling
Reactome:R-SPO-389357 CD28 dependent PI3K/Akt signaling
Reactome:R-SPO-168898 Toll-like Receptor Cascades
Reactome:R-SPO-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
Reactome:R-SPO-166016 Toll Like Receptor 4 (TLR4) Cascade
Reactome:R-SPO-181438 Toll Like Receptor 2 (TLR2) Cascade
Reactome:R-SPO-2454202 Fc epsilon receptor (FCERI) signaling
Reactome:R-SPO-449147 Signaling by Interleukins
Reactome:R-SPO-8953854 Metabolism of RNA
Reactome:R-SPO-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
Reactome:R-SPO-69306 DNA Replication
Reactome:R-SPO-1640170 Cell Cycle
Reactome:R-SPO-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Reactome:R-SPO-453279 Mitotic G1 phase and G1/S transition
Reactome:R-SPO-174143 APC/C-mediated degradation of cell cycle proteins
Reactome:R-SPO-112314 Neurotransmitter receptors and postsynaptic signal transmission
Reactome:R-SPO-212436 Generic Transcription Pathway
Reactome:R-SPO-6806003 Regulation of TP53 Expression and Degradation
Reactome:R-SPO-3899300 SUMOylation of transcription cofactors
Reactome:R-SPO-381070 IRE1alpha activates chaperones
Reactome:R-SPO-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Reactome:R-SPO-8978868 Fatty acid metabolism
Reactome:R-SPO-1483257 Phospholipid metabolism
Reactome:R-SPO-1483255 PI Metabolism
Reactome:R-SPO-1660516 Synthesis of PIPs at the early endosome membrane
Reactome:R-SPO-163685 Integration of energy metabolism
Reactome:R-SPO-199991 Membrane Trafficking
Reactome:R-SPO-8876198 RAB GEFs exchange GTP for GDP on RABs
Reactome:R-SPO-2262752 Cellular responses to stress
Reactome:R-SPO-3371571 HSF1-dependent transactivation
Reactome:R-SPO-166520 Signaling by NTRKs
Reactome:R-SPO-74752 Signaling by Insulin receptor
Reactome:R-SPO-165158 Activation of PKB
Reactome:R-SPO-5218920 VEGFR2 mediated vascular permeability
Reactome:R-SPO-372790 Signaling by GPCR
Reactome:R-SPO-392451 G beta:gamma signalling through PI3Kgamma
Reactome:R-SPO-5687128 MAPK6/MAPK4 signaling
Reactome:R-SPO-5627123 RHO GTPases activate PAKs
Reactome:R-SSC-1632852 Macroautophagy
Reactome:R-SSC-1430728 Metabolism
Reactome:R-SSC-556833 Metabolism of lipids
Reactome:R-SSC-163680 AMPK inhibits chREBP transcriptional activation activity
Reactome:R-SSC-212436 Generic Transcription Pathway
Reactome:R-SSC-5628897 TP53 Regulates Metabolic Genes
Reactome:R-SSC-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Reactome:R-SSC-69275 G2/M Transition
Reactome:R-SSC-388841 Costimulation by the CD28 family
Reactome:R-XTR-141424 Amplification of signal from the kinetochores
Reactome:R-XTR-69278 Cell Cycle, Mitotic
Reactome:R-XTR-68877 Mitotic Prometaphase
Reactome:R-XTR-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-XTR-5654736 Signaling by FGFR1
Reactome:R-XTR-1295596 Spry regulation of FGF signaling
Reactome:R-XTR-5654741 Signaling by FGFR3
Reactome:R-XTR-597592 Post-translational protein modification
Reactome:R-XTR-2990846 SUMOylation
Reactome:R-BTA-392499 Metabolism of proteins
Reactome:R-BTA-446203 Asparagine N-linked glycosylation
Reactome:R-BTA-948021 Transport to the Golgi and subsequent modification
Reactome:R-BTA-5688426 Deubiquitination
Reactome:R-BTA-381119 Unfolded Protein Response (UPR)
Reactome:R-BTA-381042 PERK regulates gene expression
Reactome:R-BTA-212436 Generic Transcription Pathway
Reactome:R-BTA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Reactome:R-BTA-69275 G2/M Transition
Reactome:R-BTA-380287 Centrosome maturation
Reactome:R-BTA-68886 M Phase
Reactome:R-BTA-114604 GPVI-mediated activation cascade
Reactome:R-BTA-373755 Semaphorin interactions
Reactome:R-BTA-399954 Sema3A PAK dependent Axon repulsion
Reactome:R-BTA-8853659 RET signaling
Reactome:R-BTA-1280218 Adaptive Immune System
Reactome:R-BTA-389357 CD28 dependent PI3K/Akt signaling
Reactome:R-BTA-983705 B Cell Activation
Reactome:R-BTA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Reactome:R-BTA-168138 Toll Like Receptor 9 (TLR9) Cascade
Reactome:R-BTA-166166 MyD88-independent TLR4 cascade
Reactome:R-BTA-168188 Toll Like Receptor TLR6:TLR2 Cascade
Reactome:R-BTA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Reactome:R-BTA-1606322 ZBP1(DAI) mediated induction of type I IFNs
Reactome:R-BTA-2871796 FCERI mediated MAPK activation
Reactome:R-BTA-5621481 C-type lectin receptors (CLRs)
Reactome:R-BTA-1169410 Antiviral mechanism by IFN-stimulated genes
Reactome:R-BTA-446652 Interleukin-1 family signaling
Reactome:R-BTA-451927 Interleukin-2 family signaling
Reactome:R-BTA-8953854 Metabolism of RNA
Reactome:R-BTA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
Reactome:R-BTA-71387 Carbohydrate metabolism
Reactome:R-BTA-70326 Glucose metabolism
Reactome:R-BTA-1483257 Phospholipid metabolism
Reactome:R-BTA-15869 Nucleotide metabolism
Reactome:R-BTA-499943 Interconversion of nucleotide di- and triphosphates
Reactome:R-BTA-177929 Signaling by EGFR
Reactome:R-BTA-5654687 Downstream signaling of activated FGFR1
Reactome:R-BTA-5654689 PI-3K cascade:FGFR1
Reactome:R-BTA-5654696 Downstream signaling of activated FGFR2
Reactome:R-BTA-5654695 PI-3K cascade:FGFR2
Reactome:R-BTA-5654743 Signaling by FGFR4
Reactome:R-BTA-1227986 Signaling by ERBB2
Reactome:R-BTA-388396 GPCR downstream signalling
Reactome:R-BTA-111885 Opioid Signalling
Reactome:R-BTA-195721 Signaling by WNT
Reactome:R-BTA-2028269 Signaling by Hippo
Reactome:R-BTA-5610787 Hedgehog 'off' state
Reactome:R-BTA-9006931 Signaling by Nuclear Receptors
Reactome:R-BTA-5687128 MAPK6/MAPK4 signaling
Reactome:R-BTA-194315 Signaling by Rho GTPases
Reactome:R-BTA-5627123 RHO GTPases activate PAKs
Reactome:R-BTA-73887 Death Receptor Signaling
Reactome:R-BTA-193704 p75 NTR receptor-mediated signalling
Reactome:R-BTA-209560 NF-kB is activated and signals survival
Reactome:R-CEL-1640170 Cell Cycle
Reactome:R-CEL-109582 Hemostasis
Reactome:R-CEL-76002 Platelet activation, signaling and aggregation
Reactome:R-CEL-389356 CD28 co-stimulation
Reactome:R-CEL-392517 Rap1 signalling
Reactome:R-CEL-975871 MyD88 cascade initiated on plasma membrane
Reactome:R-CEL-450282 MAPK targets/ Nuclear events mediated by MAP kinases
Reactome:R-CEL-168164 Toll Like Receptor 3 (TLR3) Cascade
Reactome:R-CEL-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Reactome:R-CEL-166166 MyD88-independent TLR4 cascade
Reactome:R-CEL-168188 Toll Like Receptor TLR6:TLR2 Cascade
Reactome:R-CEL-5621481 C-type lectin receptors (CLRs)
Reactome:R-CEL-5621575 CD209 (DC-SIGN) signaling
Reactome:R-CEL-3108232 SUMO E3 ligases SUMOylate target proteins
Reactome:R-CEL-381426 Regulation of IGF Activity by IGFBP
Reactome:R-CEL-5693532 DNA Double-Strand Break Repair
Reactome:R-CEL-1632852 Macroautophagy
Reactome:R-CEL-162582 Signaling Pathways
Reactome:R-CEL-198725 Nuclear Events (kinase and transcription factor activation)
Reactome:R-CEL-109704 PI3K Cascade
Reactome:R-CEL-5218920 VEGFR2 mediated vascular permeability
Reactome:R-CEL-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Reactome:R-CEL-195721 Signaling by WNT
Reactome:R-CEL-201681 TCF dependent signaling in response to WNT
Reactome:R-CEL-5684996 ERK1/ERK2 pathway
Reactome:R-CEL-5675221 Negative regulation of MAPK pathway
Reactome:R-CEL-1257604 PI3K/AKT Signaling
Reactome:R-CEL-195258 RHO GTPase Effectors
Reactome:R-CEL-1660661 Sphingolipid de novo biosynthesis
Reactome:R-CEL-375165 NCAM signaling for neurite out-growth
Reactome:R-CEL-5357801 Programmed Cell Death
Reactome:R-CEL-75153 Apoptotic execution phase
Reactome:R-CEL-2672351 Stimuli-sensing channels
Reactome:R-CEL-74160 Gene expression (Transcription)
Reactome:R-CEL-6806003 Regulation of TP53 Expression and Degradation
Reactome:R-CFA-69278 Cell Cycle, Mitotic
Reactome:R-CFA-8854518 AURKA Activation by TPX2
Reactome:R-CFA-15869 Nucleotide metabolism
Reactome:R-CFA-499943 Interconversion of nucleotide di- and triphosphates
Reactome:R-DRE-927802 Nonsense-Mediated Decay (NMD)
Reactome:R-DRE-8868773 rRNA processing in the nucleus and cytosol
Reactome:R-DRE-187037 Signaling by NTRK1 (TRKA)
Reactome:R-DRE-198725 Nuclear Events (kinase and transcription factor activation)
Reactome:R-DRE-6804757 Regulation of TP53 Degradation
Reactome:R-DRE-141424 Amplification of signal from the kinetochores
Reactome:R-DRE-69278 Cell Cycle, Mitotic
Reactome:R-DRE-68875 Mitotic Prophase
Reactome:R-DDI-5693548 Sensing of DNA Double Strand Breaks
Reactome:R-DDI-5685942 HDR through Homologous Recombination (HRR)
Reactome:R-DDI-109582 Hemostasis
Reactome:R-DDI-114604 GPVI-mediated activation cascade
Reactome:R-DDI-8953897 Cellular responses to stimuli
Reactome:R-DDI-3371556 Cellular response to heat stress
Reactome:R-DDI-163680 AMPK inhibits chREBP transcriptional activation activity
Reactome:R-DDI-9007101 Rab regulation of trafficking
Reactome:R-DDI-1640170 Cell Cycle
Reactome:R-DDI-69563 p53-Dependent G1 DNA Damage Response
Reactome:R-DDI-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Reactome:R-DDI-69275 G2/M Transition
Reactome:R-DDI-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Reactome:R-DDI-2299718 Condensation of Prophase Chromosomes
Reactome:R-DDI-68877 Mitotic Prometaphase
Reactome:R-DDI-174143 APC/C-mediated degradation of cell cycle proteins
Reactome:R-DDI-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
Reactome:R-DDI-8934903 Receptor Mediated Mitophagy
Reactome:R-DDI-187037 Signaling by NTRK1 (TRKA)
Reactome:R-DDI-74752 Signaling by Insulin receptor
Reactome:R-DDI-165158 Activation of PKB
Reactome:R-DDI-194138 Signaling by VEGF
Reactome:R-DDI-2428924 IGF1R signaling cascade
Reactome:R-DDI-392451 G beta:gamma signalling through PI3Kgamma
Reactome:R-DDI-8939211 ESR-mediated signaling
Reactome:R-DDI-5627123 RHO GTPases activate PAKs
Reactome:R-DDI-74160 Gene expression (Transcription)
Reactome:R-DDI-73857 RNA Polymerase II Transcription
Reactome:R-DDI-5633008 TP53 Regulates Transcription of Cell Death Genes
Reactome:R-DDI-8953854 Metabolism of RNA
Reactome:R-DDI-373755 Semaphorin interactions
Reactome:R-DDI-1280218 Adaptive Immune System
Reactome:R-DDI-389356 CD28 co-stimulation
Reactome:R-DDI-168142 Toll Like Receptor 10 (TLR10) Cascade
Reactome:R-DDI-450282 MAPK targets/ Nuclear events mediated by MAP kinases
Reactome:R-DDI-975155 MyD88 dependent cascade initiated on endosome
Reactome:R-DDI-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Reactome:R-DDI-168179 Toll Like Receptor TLR1:TLR2 Cascade
Reactome:R-DDI-2454202 Fc epsilon receptor (FCERI) signaling
Reactome:R-DDI-1280215 Cytokine Signaling in Immune system
Reactome:R-DDI-449147 Signaling by Interleukins
Reactome:R-DME-450604 KSRP (KHSRP) binds and destabilizes mRNA
Reactome:R-DME-1280218 Adaptive Immune System
Reactome:R-DME-388841 Costimulation by the CD28 family
Reactome:R-DME-389513 Co-inhibition by CTLA4
Reactome:R-DME-937042 IRAK2 mediated activation of TAK1 complex
Reactome:R-DME-450302 activated TAK1 mediates p38 MAPK activation
Reactome:R-DME-199920 CREB phosphorylation
Reactome:R-DME-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
Reactome:R-DME-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Reactome:R-DME-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Reactome:R-DME-168179 Toll Like Receptor TLR1:TLR2 Cascade
Reactome:R-DME-5621481 C-type lectin receptors (CLRs)
Reactome:R-DME-5621575 CD209 (DC-SIGN) signaling
Reactome:R-DME-392499 Metabolism of proteins
Reactome:R-DME-5654726 Negative regulation of FGFR1 signaling
Reactome:R-DME-5654727 Negative regulation of FGFR2 signaling
Reactome:R-DME-187037 Signaling by NTRK1 (TRKA)
Reactome:R-DME-112399 IRS-mediated signalling
Reactome:R-DME-5218920 VEGFR2 mediated vascular permeability
Reactome:R-DME-1227986 Signaling by ERBB2
Reactome:R-DME-8863795 Downregulation of ERBB2 signaling
Reactome:R-DME-372790 Signaling by GPCR
Reactome:R-DME-418594 G alpha (i) signalling events
Reactome:R-DME-112043 PLC beta mediated events
Reactome:R-DME-397795 G-protein beta:gamma signalling
Reactome:R-DME-9013694 Signaling by NOTCH4
Reactome:R-DME-201681 TCF dependent signaling in response to WNT
Reactome:R-DME-3769402 Deactivation of the beta-catenin transactivating complex
Reactome:R-DME-2028269 Signaling by Hippo
Reactome:R-DME-5610787 Hedgehog 'off' state
Reactome:R-DME-5683057 MAPK family signaling cascades
Reactome:R-DME-5674135 MAP2K and MAPK activation
Reactome:R-DME-9006925 Intracellular signaling by second messengers
Reactome:R-DME-199418 Negative regulation of the PI3K/AKT network
Reactome:R-DME-5625740 RHO GTPases activate PKNs
Reactome:R-DME-165181 Inhibition of TSC complex formation by PKB
Reactome:R-DME-199991 Membrane Trafficking
Reactome:R-DME-8876198 RAB GEFs exchange GTP for GDP on RABs
Reactome:R-DME-2262752 Cellular responses to stress
Reactome:R-DME-3371571 HSF1-dependent transactivation
Reactome:R-DME-69613 p53-Independent G1/S DNA Damage Checkpoint
Reactome:R-DME-69473 G2/M DNA damage checkpoint
Reactome:R-DME-453279 Mitotic G1 phase and G1/S transition
Reactome:R-DME-69206 G1/S Transition
Reactome:R-DME-156711 Polo-like kinase mediated events
Reactome:R-DME-422475 Axon guidance
Reactome:R-DME-210745 Regulation of gene expression in beta cells
Reactome:R-DME-5693548 Sensing of DNA Double Strand Breaks
Reactome:R-DME-5693607 Processing of DNA double-strand break ends
Reactome:R-DME-74160 Gene expression (Transcription)
Reactome:R-DME-73857 RNA Polymerase II Transcription
Reactome:R-DME-3700989 Transcriptional Regulation by TP53
Reactome:R-DME-6804758 Regulation of TP53 Activity through Acetylation
Reactome:R-DME-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
Reactome:R-DME-5252538 Drosophila signaling pathways
Reactome:R-DME-432490 Nuclear import of PER and TIM
Reactome:R-DME-209446 N-HH ligand not bound to PTC receptor complex
Reactome:R-DME-209452 N-HH ligand bound to PTC receptor complex
Reactome:R-DME-216119 Activation of CI
Reactome:R-DME-390023 Subcellular localisation of D
Reactome:R-DME-110523 TOR signaling pathway
Reactome:R-DME-209442 Formation of the trans-membrane 'signalling complex'
Reactome:R-DME-214862 Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'
Reactome:R-DME-209155 Phosphorylation of AXN and APC
Reactome:R-DME-209472 Assembly of receptor complex
Reactome:R-DME-203615 eNOS activation
Reactome:R-GGA-1670466 DNA replication and repair
Reactome:R-GGA-353371 Double strand break repair
Reactome:R-GGA-351442 ATM mediated response to DNA double-strand break
Reactome:R-GGA-74160 Gene expression (Transcription)
Reactome:R-GGA-73857 RNA Polymerase II Transcription
Reactome:R-GGA-3700989 Transcriptional Regulation by TP53
Reactome:R-GGA-6806003 Regulation of TP53 Expression and Degradation
Reactome:R-GGA-382551 Transport of small molecules
Reactome:R-GGA-2672351 Stimuli-sensing channels
Reactome:R-GGA-69615 G1/S DNA Damage Checkpoints
Reactome:R-GGA-69481 G2/M Checkpoints
Reactome:R-GGA-187037 Signaling by NTRK1 (TRKA)
Reactome:R-GGA-198753 ERK/MAPK targets
Reactome:R-GGA-5358351 Signaling by Hedgehog
Reactome:R-GGA-5610785 GLI3 is processed to GLI3R by the proteasome
Reactome:R-GGA-5635838 Activation of SMO
Reactome:R-GGA-5684996 ERK1/ERK2 pathway
Reactome:R-GGA-5675221 Negative regulation of MAPK pathway
Reactome:R-GGA-1257604 PI3K/AKT Signaling
Reactome:R-GGA-194315 Signaling by Rho GTPases
Reactome:R-GGA-5627123 RHO GTPases activate PAKs
Reactome:R-GGA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome:R-GGA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
Reactome:R-GGA-399954 Sema3A PAK dependent Axon repulsion
Reactome:R-GGA-109582 Hemostasis
Reactome:R-GGA-392517 Rap1 signalling
Reactome:R-GGA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Reactome:R-GGA-166016 Toll Like Receptor 4 (TLR4) Cascade
Reactome:R-GGA-937061 TRIF (TICAM1)-mediated TLR4 signaling
Reactome:R-GGA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
Reactome:R-GGA-913531 Interferon Signaling
Reactome:R-HSA-8934903 Receptor Mediated Mitophagy
Reactome:R-HSA-8856828 Clathrin-mediated endocytosis
Reactome:R-HSA-9007101 Rab regulation of trafficking
Reactome:R-HSA-373755 Semaphorin interactions
Reactome:R-HSA-375165 NCAM signaling for neurite out-growth
Reactome:R-HSA-373760 L1CAM interactions
Reactome:R-HSA-8853659 RET signaling
Reactome:R-HSA-1500931 Cell-Cell communication
Reactome:R-HSA-373753 Nephrin family interactions
Reactome:R-HSA-3000171 Non-integrin membrane-ECM interactions
Reactome:R-HSA-109582 Hemostasis
Reactome:R-HSA-1221632 Meiotic synapsis
Reactome:R-HSA-1483257 Phospholipid metabolism
Reactome:R-HSA-1483255 PI Metabolism
Reactome:R-HSA-1660499 Synthesis of PIPs at the plasma membrane
Reactome:R-HSA-163680 AMPK inhibits chREBP transcriptional activation activity
Reactome:R-HSA-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-HSA-8978934 Metabolism of cofactors
Reactome:R-HSA-71291 Amino acid and derivative metabolism
Reactome:R-HSA-5357801 Programmed Cell Death
Reactome:R-HSA-211728 Regulation of PAK-2p34 activity by PS-GAP/RHG10
Reactome:R-HSA-5693606 DNA Double Strand Break Response
Reactome:R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome:R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
Reactome:R-HSA-5685938 HDR through Single Strand Annealing (SSA)
Reactome:R-HSA-6783310 Fanconi Anemia Pathway
Reactome:R-HSA-5654687 Downstream signaling of activated FGFR1
Reactome:R-HSA-5654689 PI-3K cascade:FGFR1
Reactome:R-HSA-5654696 Downstream signaling of activated FGFR2
Reactome:R-HSA-5654695 PI-3K cascade:FGFR2
Reactome:R-HSA-5654743 Signaling by FGFR4
Reactome:R-HSA-5654733 Negative regulation of FGFR4 signaling
Reactome:R-HSA-187037 Signaling by NTRK1 (TRKA)
Reactome:R-HSA-187687 Signalling to ERKs
Reactome:R-HSA-169893 Prolonged ERK activation events
Reactome:R-HSA-198725 Nuclear Events (kinase and transcription factor activation)
Reactome:R-HSA-9006115 Signaling by NTRK2 (TRKB)
Reactome:R-HSA-112399 IRS-mediated signalling
Reactome:R-HSA-165160 PDE3B signalling
Reactome:R-HSA-418594 G alpha (i) signalling events
Reactome:R-HSA-416476 G alpha (q) signalling events
Reactome:R-HSA-397795 G-protein beta:gamma signalling
Reactome:R-HSA-195253 Degradation of beta-catenin by the destruction complex
Reactome:R-HSA-201688 WNT mediated activation of DVL
Reactome:R-HSA-2028269 Signaling by Hippo
Reactome:R-HSA-5610787 Hedgehog 'off' state
Reactome:R-HSA-5632684 Hedgehog 'on' state
Reactome:R-HSA-5684996 ERK1/ERK2 pathway
Reactome:R-HSA-5675221 Negative regulation of MAPK pathway
Reactome:R-HSA-1257604 PI3K/AKT Signaling
Reactome:R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Reactome:R-HSA-194315 Signaling by Rho GTPases
Reactome:R-HSA-5627123 RHO GTPases activate PAKs
Reactome:R-HSA-5663220 RHO GTPases Activate Formins
Reactome:R-HSA-8848021 Signaling by PTK6
Reactome:R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK
Reactome:R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway
Reactome:R-HSA-193639 p75NTR signals via NF-kB
Reactome:R-HSA-9006335 Signaling by Erythropoietin
Reactome:R-HSA-2559580 Oxidative Stress Induced Senescence
Reactome:R-HSA-5576891 Cardiac conduction
Reactome:R-HSA-112316 Neuronal System
Reactome:R-HSA-444257 RSK activation
Reactome:R-HSA-69615 G1/S DNA Damage Checkpoints
Reactome:R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1
Reactome:R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Reactome:R-HSA-141424 Amplification of signal from the kinetochores
Reactome:R-HSA-69278 Cell Cycle, Mitotic
Reactome:R-HSA-69275 G2/M Transition
Reactome:R-HSA-156711 Polo-like kinase mediated events
Reactome:R-HSA-380259 Loss of Nlp from mitotic centrosomes
Reactome:R-HSA-8854521 Interaction between PHLDA1 and AURKA
Reactome:R-HSA-2500257 Resolution of Sister Chromatid Cohesion
Reactome:R-HSA-174143 APC/C-mediated degradation of cell cycle proteins
Reactome:R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Reactome:R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Reactome:R-HSA-446203 Asparagine N-linked glycosylation
Reactome:R-HSA-948021 Transport to the Golgi and subsequent modification
Reactome:R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
Reactome:R-HSA-5688426 Deubiquitination
Reactome:R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins
Reactome:R-HSA-381119 Unfolded Protein Response (UPR)
Reactome:R-HSA-381038 XBP1(S) activates chaperone genes
Reactome:R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
Reactome:R-HSA-5637812 Signaling by EGFRvIII in Cancer
Reactome:R-HSA-1226099 Signaling by FGFR in disease
Reactome:R-HSA-4791275 Signaling by WNT in cancer
Reactome:R-HSA-4839735 Signaling by AXIN mutants
Reactome:R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated
Reactome:R-HSA-6802949 Signaling by RAS mutants
Reactome:R-HSA-6802952 Signaling by BRAF and RAF1 fusions
Reactome:R-HSA-5668914 Diseases of metabolism
Reactome:R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis
Reactome:R-HSA-5602358 Defects in Toll-like Receptor Cascades
Reactome:R-HSA-8863678 Neurodegenerative Diseases
Reactome:R-HSA-212436 Generic Transcription Pathway
Reactome:R-HSA-3700989 Transcriptional Regulation by TP53
Reactome:R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Reactome:R-HSA-5633007 Regulation of TP53 Activity
Reactome:R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
Reactome:R-HSA-8878171 Transcriptional regulation by RUNX1
Reactome:R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Reactome:R-HSA-8953750 Transcriptional Regulation by E2F6
Reactome:R-HSA-168256 Immune System
Reactome:R-HSA-389356 CD28 co-stimulation
Reactome:R-HSA-389948 PD-1 signaling
Reactome:R-HSA-1169091 Activation of NF-kappaB in B cells
Reactome:R-HSA-983169 Class I MHC mediated antigen processing & presentation
Reactome:R-HSA-168249 Innate Immune System
Reactome:R-HSA-975871 MyD88 cascade initiated on plasma membrane
Reactome:R-HSA-450294 MAP kinase activation
Reactome:R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases
Reactome:R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment
Reactome:R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
Reactome:R-HSA-936964 Activation of IRF3, IRF7 mediated by TBK1, IKK (IKBKE)
Reactome:R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
Reactome:R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Reactome:R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA
Reactome:R-HSA-1834941 STING mediated induction of host immune responses
Reactome:R-HSA-2871837 FCERI mediated NF-kB activation
Reactome:R-HSA-5621575 CD209 (DC-SIGN) signaling
Reactome:R-HSA-912526 Interleukin receptor SHC signaling
Reactome:R-HSA-8953854 Metabolism of RNA
Reactome:R-HSA-72163 pre-mRNA splicing
Reactome:R-MMU-69620 Cell Cycle Checkpoints
Reactome:R-MMU-69541 Stabilization of p53
Reactome:R-MMU-69613 p53-Independent G1/S DNA Damage Checkpoint
Reactome:R-MMU-69473 G2/M DNA damage checkpoint
Reactome:R-MMU-69618 Mitotic Spindle Checkpoint
Reactome:R-MMU-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
Reactome:R-MMU-69275 G2/M Transition
Reactome:R-MMU-380287 Centrosome maturation
Reactome:R-MMU-68886 M Phase
Reactome:R-MMU-2465910 MASTL Facilitates Mitotic Progression
Reactome:R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
Reactome:R-MMU-2467813 Separation of Sister Chromatids
Reactome:R-MMU-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
Reactome:R-MMU-1280218 Adaptive Immune System
Reactome:R-MMU-389357 CD28 dependent PI3K/Akt signaling
Reactome:R-MMU-983705 B Cell Activation
Reactome:R-MMU-168898 Toll-like Receptor Cascades
Reactome:R-MMU-937039 IRAK1 recruits IKK complex
Reactome:R-MMU-198753 ERK/MAPK targets
Reactome:R-MMU-168164 Toll Like Receptor 3 (TLR3) Cascade
Reactome:R-MMU-975155 MyD88 dependent cascade initiated on endosome
Reactome:R-MMU-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Reactome:R-MMU-937041 IKK complex recruitment mediated by RIP1
Reactome:R-MMU-168179 Toll Like Receptor TLR1:TLR2 Cascade
Reactome:R-MMU-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Reactome:R-MMU-1834949 Cytosolic sensors of pathogen-associated DNA
Reactome:R-MMU-1834941 STING mediated induction of host immune responses
Reactome:R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
Reactome:R-MMU-2454202 Fc epsilon receptor (FCERI) signaling
Reactome:R-MMU-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
Reactome:R-MMU-1169410 Antiviral mechanism by IFN-stimulated genes
Reactome:R-MMU-446652 Interleukin-1 family signaling
Reactome:R-MMU-451927 Interleukin-2 family signaling
Reactome:R-MMU-73894 DNA Repair
Reactome:R-MMU-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Reactome:R-MMU-5685942 HDR through Homologous Recombination (HRR)
Reactome:R-MMU-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
Reactome:R-MMU-5693571 Nonhomologous End-Joining (NHEJ)
Reactome:R-MMU-71387 Carbohydrate metabolism
Reactome:R-MMU-70326 Glucose metabolism
Reactome:R-MMU-1483257 Phospholipid metabolism
Reactome:R-MMU-1660517 Synthesis of PIPs at the late endosome membrane
Reactome:R-MMU-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-MMU-8978934 Metabolism of cofactors
Reactome:R-MMU-71291 Amino acid and derivative metabolism
Reactome:R-MMU-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Reactome:R-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Reactome:R-MMU-430116 GP1b-IX-V activation signalling
Reactome:R-MMU-1266738 Developmental Biology
Reactome:R-MMU-399956 CRMPs in Sema3A signaling
Reactome:R-MMU-445144 Signal transduction by L1
Reactome:R-MMU-3928662 EPHB-mediated forward signaling
Reactome:R-MMU-109581 Apoptosis
Reactome:R-MMU-3371378 Regulation by c-FLIP
Reactome:R-MMU-1632852 Macroautophagy
Reactome:R-MMU-3371556 Cellular response to heat stress
Reactome:R-MMU-3371453 Regulation of HSF1-mediated heat shock response
Reactome:R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence
Reactome:R-MMU-5576891 Cardiac conduction
Reactome:R-MMU-1852241 Organelle biogenesis and maintenance
Reactome:R-MMU-5617833 Cilium Assembly
Reactome:R-MMU-212436 Generic Transcription Pathway
Reactome:R-MMU-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases
Reactome:R-MMU-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Reactome:R-MMU-6806003 Regulation of TP53 Expression and Degradation
Reactome:R-MMU-9022692 Regulation of MECP2 expression and activity
Reactome:R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
Reactome:R-MMU-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-MMU-5654736 Signaling by FGFR1
Reactome:R-MMU-1295596 Spry regulation of FGF signaling
Reactome:R-MMU-5654741 Signaling by FGFR3
Reactome:R-MMU-5654708 Downstream signaling of activated FGFR3
Reactome:R-MMU-5654710 PI-3K cascade:FGFR3
Reactome:R-MMU-169893 Prolonged ERK activation events
Reactome:R-MMU-74752 Signaling by Insulin receptor
Reactome:R-MMU-109704 PI3K Cascade
Reactome:R-MMU-4420097 VEGFA-VEGFR2 Pathway
Reactome:R-MMU-1433557 Signaling by SCF-KIT
Reactome:R-MMU-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Reactome:R-MMU-6806834 Signaling by MET
Reactome:R-MMU-372790 Signaling by GPCR
Reactome:R-MMU-157118 Signaling by NOTCH
Reactome:R-MMU-195721 Signaling by WNT
Reactome:R-MMU-2028269 Signaling by Hippo
Reactome:R-MMU-5610787 Hedgehog 'off' state
Reactome:R-MMU-9006931 Signaling by Nuclear Receptors
Reactome:R-MMU-5673000 RAF activation
Reactome:R-MMU-5687128 MAPK6/MAPK4 signaling
Reactome:R-MMU-198693 AKT phosphorylates targets in the nucleus
Reactome:R-MMU-194315 Signaling by Rho GTPases
Reactome:R-MMU-5627123 RHO GTPases activate PAKs
Reactome:R-MMU-5663220 RHO GTPases Activate Formins
Reactome:R-MMU-8848021 Signaling by PTK6
Reactome:R-MMU-165159 MTOR signalling
Reactome:R-MMU-73887 Death Receptor Signaling
Reactome:R-MMU-5357786 TNFR1-induced proapoptotic signaling
Reactome:R-MMU-193704 p75 NTR receptor-mediated signalling
Reactome:R-MMU-209560 NF-kB is activated and signals survival
Reactome:R-MMU-392499 Metabolism of proteins
Reactome:R-MMU-597592 Post-translational protein modification
Reactome:R-MMU-204005 COPII-mediated vesicle transport
Reactome:R-MMU-2990846 SUMOylation
Reactome:R-MMU-5689896 Ovarian tumor domain proteases
Reactome:R-MMU-381426 Regulation of IGF Activity by IGFBP
Reactome:R-MMU-5653656 Vesicle-mediated transport
Reactome:R-MMU-8854214 TBC/RABGAPs
Reactome:R-MMU-8934903 Receptor Mediated Mitophagy
Reactome:R-MMU-112315 Transmission across Chemical Synapses
Reactome:R-MMU-6794361 Neurexins and neuroligins
Reactome:R-RNO-450531 Regulation of mRNA stability by proteins that bind AU-rich elements
Reactome:R-RNO-8868773 rRNA processing in the nucleus and cytosol
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-70221 Glycogen breakdown (glycogenolysis)
Reactome:R-RNO-556833 Metabolism of lipids
Reactome:R-RNO-1483255 PI Metabolism
Reactome:R-RNO-8978934 Metabolism of cofactors
Reactome:R-RNO-71291 Amino acid and derivative metabolism
Reactome:R-RNO-69615 G1/S DNA Damage Checkpoints
Reactome:R-RNO-141424 Amplification of signal from the kinetochores
Reactome:R-RNO-69278 Cell Cycle, Mitotic
Reactome:R-RNO-380270 Recruitment of mitotic centrosome proteins and complexes
Reactome:R-RNO-8854518 AURKA Activation by TPX2
Reactome:R-RNO-68877 Mitotic Prometaphase
Reactome:R-RNO-2555396 Mitotic Metaphase and Anaphase
Reactome:R-RNO-112310 Neurotransmitter release cycle
Reactome:R-RNO-212676 Dopamine Neurotransmitter Release Cycle
Reactome:R-RNO-446203 Asparagine N-linked glycosylation
Reactome:R-RNO-948021 Transport to the Golgi and subsequent modification
Reactome:R-RNO-3108232 SUMO E3 ligases SUMOylate target proteins
Reactome:R-RNO-381119 Unfolded Protein Response (UPR)
Reactome:R-RNO-381042 PERK regulates gene expression
Reactome:R-RNO-5205685 PINK1-PRKN Mediated Mitophagy
Reactome:R-RNO-74160 Gene expression (Transcription)
Reactome:R-RNO-73857 RNA Polymerase II Transcription
Reactome:R-RNO-3700989 Transcriptional Regulation by TP53
Reactome:R-RNO-5633007 Regulation of TP53 Activity
Reactome:R-RNO-6804756 Regulation of TP53 Activity through Phosphorylation
Reactome:R-RNO-5250913 Positive epigenetic regulation of rRNA expression
Reactome:R-RNO-2559580 Oxidative Stress Induced Senescence
Reactome:R-RNO-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-RNO-5654736 Signaling by FGFR1
Reactome:R-RNO-1295596 Spry regulation of FGF signaling
Reactome:R-RNO-5654741 Signaling by FGFR3
Reactome:R-RNO-5654708 Downstream signaling of activated FGFR3
Reactome:R-RNO-5654710 PI-3K cascade:FGFR3
Reactome:R-RNO-74751 Insulin receptor signalling cascade
Reactome:R-RNO-165158 Activation of PKB
Reactome:R-RNO-194138 Signaling by VEGF
Reactome:R-RNO-5218920 VEGFR2 mediated vascular permeability
Reactome:R-RNO-1963642 PI3K events in ERBB2 signaling
Reactome:R-RNO-1250342 PI3K events in ERBB4 signaling
Reactome:R-RNO-2428924 IGF1R signaling cascade
Reactome:R-RNO-157118 Signaling by NOTCH
Reactome:R-RNO-195721 Signaling by WNT
Reactome:R-RNO-2028269 Signaling by Hippo
Reactome:R-RNO-5610787 Hedgehog 'off' state
Reactome:R-RNO-5683057 MAPK family signaling cascades
Reactome:R-RNO-5674135 MAP2K and MAPK activation
Reactome:R-RNO-9006925 Intracellular signaling by second messengers
Reactome:R-RNO-199418 Negative regulation of the PI3K/AKT network
Reactome:R-RNO-5625740 RHO GTPases activate PKNs
Reactome:R-RNO-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
Reactome:R-RNO-165181 Inhibition of TSC complex formation by PKB
Reactome:R-RNO-9006335 Signaling by Erythropoietin
Reactome:R-RNO-5693532 DNA Double-Strand Break Repair
Reactome:R-RNO-5693538 Homology Directed Repair
Reactome:R-RNO-5693579 Homologous DNA Pairing and Strand Exchange
Reactome:R-RNO-8856828 Clathrin-mediated endocytosis
Reactome:R-RNO-114604 GPVI-mediated activation cascade
Reactome:R-RNO-5357801 Programmed Cell Death
Reactome:R-RNO-5675482 Regulation of necroptotic cell death
Reactome:R-RNO-202403 TCR signaling
Reactome:R-RNO-202424 Downstream TCR signaling
Reactome:R-RNO-389359 CD28 dependent Vav1 pathway
Reactome:R-RNO-392517 Rap1 signalling
Reactome:R-RNO-168164 Toll Like Receptor 3 (TLR3) Cascade
Reactome:R-RNO-975155 MyD88 dependent cascade initiated on endosome
Reactome:R-RNO-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Reactome:R-RNO-933542 TRAF6 mediated NF-kB activation
Reactome:R-RNO-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
Reactome:R-RNO-5607764 CLEC7A (Dectin-1) signaling
Reactome:R-RNO-5621575 CD209 (DC-SIGN) signaling
Reactome:R-RNO-912526 Interleukin receptor SHC signaling
Reactome:R-RNO-422475 Axon guidance
Reactome:R-RNO-418885 DCC mediated attractive signaling
Reactome:R-RNO-373760 L1CAM interactions
Reactome:R-SCE-8868773 rRNA processing in the nucleus and cytosol
Reactome:R-SCE-5633007 Regulation of TP53 Activity
Reactome:R-SCE-1632852 Macroautophagy
Reactome:R-SCE-2559583 Cellular Senescence
Reactome:R-SCE-389357 CD28 dependent PI3K/Akt signaling
Reactome:R-SCE-168249 Innate Immune System
Reactome:R-SCE-450294 MAP kinase activation
Reactome:R-SCE-198753 ERK/MAPK targets
Reactome:R-SCE-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
Reactome:R-SCE-166016 Toll Like Receptor 4 (TLR4) Cascade
Reactome:R-SCE-181438 Toll Like Receptor 2 (TLR2) Cascade
Reactome:R-SCE-2454202 Fc epsilon receptor (FCERI) signaling
Reactome:R-SCE-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
Reactome:R-SCE-5607761 Dectin-1 mediated noncanonical NF-kB signaling
Reactome:R-SCE-5668541 TNFR2 non-canonical NF-kB pathway
Reactome:R-SCE-166520 Signaling by NTRKs
Reactome:R-SCE-74752 Signaling by Insulin receptor
Reactome:R-SCE-165158 Activation of PKB
Reactome:R-SCE-5218920 VEGFR2 mediated vascular permeability
Reactome:R-SCE-2428928 IRS-related events triggered by IGF1R
Reactome:R-SCE-5683057 MAPK family signaling cascades
Reactome:R-SCE-1257604 PI3K/AKT Signaling
Reactome:R-SCE-5625740 RHO GTPases activate PKNs
Reactome:R-SCE-166208 mTORC1-mediated signalling
Reactome:R-SCE-556833 Metabolism of lipids
Reactome:R-SCE-1483255 PI Metabolism
Reactome:R-SCE-1660516 Synthesis of PIPs at the early endosome membrane
Reactome:R-SCE-438064 Post NMDA receptor activation events
Reactome:R-SCE-69620 Cell Cycle Checkpoints
Reactome:R-SCE-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Reactome:R-SCE-68886 M Phase
Reactome:R-SCE-381119 Unfolded Protein Response (UPR)
Reactome:R-SPO-109582 Hemostasis
Reactome:R-SPO-76002 Platelet activation, signaling and aggregation
Reactome:R-SPO-168256 Immune System
Reactome:R-SPO-388841 Costimulation by the CD28 family
Reactome:R-SPO-975871 MyD88 cascade initiated on plasma membrane
Reactome:R-SPO-450282 MAPK targets/ Nuclear events mediated by MAP kinases
Reactome:R-SPO-168164 Toll Like Receptor 3 (TLR3) Cascade
Reactome:R-SPO-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Reactome:R-SPO-166166 MyD88-independent TLR4 cascade
Reactome:R-SPO-168188 Toll Like Receptor TLR6:TLR2 Cascade
Reactome:R-SPO-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
Reactome:R-SPO-72312 rRNA processing
Reactome:R-SPO-69615 G1/S DNA Damage Checkpoints
Reactome:R-SPO-69481 G2/M Checkpoints
Reactome:R-SPO-69275 G2/M Transition
Reactome:R-SPO-68886 M Phase
Reactome:R-SPO-112315 Transmission across Chemical Synapses
Reactome:R-SPO-438064 Post NMDA receptor activation events
Reactome:R-SPO-74160 Gene expression (Transcription)
Reactome:R-SPO-392499 Metabolism of proteins
Reactome:R-SPO-2990846 SUMOylation
Reactome:R-SPO-5693606 DNA Double Strand Break Response
Reactome:R-SPO-1660514 Synthesis of PIPs at the Golgi membrane
Reactome:R-SPO-8953897 Cellular responses to stimuli
Reactome:R-SPO-3371556 Cellular response to heat stress
Reactome:R-SPO-2559583 Cellular Senescence
Reactome:R-SPO-162582 Signaling Pathways
Reactome:R-SPO-112399 IRS-mediated signalling
Reactome:R-SPO-194138 Signaling by VEGF
Reactome:R-SPO-2428924 IGF1R signaling cascade
Reactome:R-SPO-9006931 Signaling by Nuclear Receptors
Reactome:R-SPO-1257604 PI3K/AKT Signaling
Reactome:R-SPO-165159 MTOR signalling
Reactome:R-SSC-6791312 TP53 Regulates Transcription of Cell Cycle Genes
Reactome:R-SSC-453274 Mitotic G2-G2/M phases
Reactome:R-SSC-2565942 Regulation of PLK1 Activity at G2/M Transition
Reactome:R-SSC-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Reactome:R-SSC-380972 Energy dependent regulation of mTOR by LKB1-AMPK
Reactome:R-SSC-1280218 Adaptive Immune System
Reactome:R-XTR-74160 Gene expression (Transcription)
Reactome:R-XTR-73857 RNA Polymerase II Transcription
Reactome:R-XTR-3700989 Transcriptional Regulation by TP53
Reactome:R-XTR-1640170 Cell Cycle
Reactome:R-XTR-68886 M Phase
Reactome:R-XTR-5654743 Signaling by FGFR4
Reactome:R-XTR-5654733 Negative regulation of FGFR4 signaling
Reactome:R-XTR-392499 Metabolism of proteins
Reactome:R-BTA-199977 ER to Golgi Anterograde Transport
Reactome:R-BTA-69278 Cell Cycle, Mitotic
Reactome:R-BTA-380270 Recruitment of mitotic centrosome proteins and complexes
Reactome:R-BTA-8854518 AURKA Activation by TPX2
Reactome:R-BTA-380320 Recruitment of NuMA to mitotic centrosomes
Reactome:R-BTA-76002 Platelet activation, signaling and aggregation
Reactome:R-BTA-202403 TCR signaling
Reactome:R-BTA-202424 Downstream TCR signaling
Reactome:R-BTA-389359 CD28 dependent Vav1 pathway
Reactome:R-BTA-168142 Toll Like Receptor 10 (TLR10) Cascade
Reactome:R-BTA-445989 TAK1-dependent IKK and NF-kappa-B activation
Reactome:R-BTA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
Reactome:R-BTA-168176 Toll Like Receptor 5 (TLR5) Cascade
Reactome:R-BTA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Reactome:R-BTA-166016 Toll Like Receptor 4 (TLR4) Cascade
Reactome:R-BTA-937061 TRIF (TICAM1)-mediated TLR4 signaling
Reactome:R-BTA-168638 NOD1/2 Signaling Pathway
Reactome:R-BTA-933542 TRAF6 mediated NF-kB activation
Reactome:R-BTA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
Reactome:R-BTA-5607764 CLEC7A (Dectin-1) signaling
Reactome:R-BTA-912526 Interleukin receptor SHC signaling
Reactome:R-BTA-70263 Gluconeogenesis
Reactome:R-BTA-1660499 Synthesis of PIPs at the plasma membrane
Reactome:R-BTA-2559580 Oxidative Stress Induced Senescence
Reactome:R-BTA-1852241 Organelle biogenesis and maintenance
Reactome:R-BTA-5617833 Cilium Assembly
Reactome:R-BTA-190236 Signaling by FGFR
Reactome:R-BTA-1236394 Signaling by ERBB4
Reactome:R-BTA-8851907 MET activates PI3K/AKT signaling
Reactome:R-BTA-180024 DARPP-32 events
Reactome:R-BTA-416476 G alpha (q) signalling events
Reactome:R-BTA-397795 G-protein beta:gamma signalling
Reactome:R-BTA-201681 TCF dependent signaling in response to WNT
Reactome:R-BTA-5358351 Signaling by Hedgehog
Reactome:R-BTA-5610785 GLI3 is processed to GLI3R by the proteasome
Reactome:R-BTA-5635838 Activation of SMO
Reactome:R-BTA-5683057 MAPK family signaling cascades
Reactome:R-BTA-9006925 Intracellular signaling by second messengers
Reactome:R-BTA-199418 Negative regulation of the PI3K/AKT network
Reactome:R-BTA-9006335 Signaling by Erythropoietin
Reactome:R-CEL-69620 Cell Cycle Checkpoints
Reactome:R-CEL-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Reactome:R-CEL-69478 G2/M DNA replication checkpoint
Reactome:R-CEL-453274 Mitotic G2-G2/M phases
Reactome:R-CEL-156711 Polo-like kinase mediated events
Reactome:R-CEL-2995410 Nuclear Envelope (NE) Reassembly
Reactome:R-CEL-5653656 Vesicle-mediated transport
Reactome:R-CEL-9007101 Rab regulation of trafficking
Reactome:R-CEL-430116 GP1b-IX-V activation signalling
Reactome:R-CEL-389357 CD28 dependent PI3K/Akt signaling
Reactome:R-CEL-168249 Innate Immune System
Reactome:R-CEL-450294 MAP kinase activation
Reactome:R-CEL-198753 ERK/MAPK targets
Reactome:R-CEL-168176 Toll Like Receptor 5 (TLR5) Cascade
Reactome:R-CEL-168138 Toll Like Receptor 9 (TLR9) Cascade
Reactome:R-CEL-937061 TRIF (TICAM1)-mediated TLR4 signaling
Reactome:R-CEL-1280215 Cytokine Signaling in Immune system
Reactome:R-CEL-449147 Signaling by Interleukins
Reactome:R-CEL-8957275 Post-translational protein phosphorylation
Reactome:R-CEL-381119 Unfolded Protein Response (UPR)
Reactome:R-CEL-2262752 Cellular responses to stress
Reactome:R-CEL-3371571 HSF1-dependent transactivation
Reactome:R-CEL-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-CEL-166520 Signaling by NTRKs
Reactome:R-CEL-74752 Signaling by Insulin receptor
Reactome:R-CEL-165158 Activation of PKB
Reactome:R-CEL-2428924 IGF1R signaling cascade
Reactome:R-CEL-201688 WNT mediated activation of DVL
Reactome:R-CEL-5673001 RAF/MAP kinase cascade
Reactome:R-CEL-5674499 Negative feedback regulation of MAPK pathway
Reactome:R-CEL-1430728 Metabolism
Reactome:R-CEL-109581 Apoptosis
Reactome:R-CEL-5205647 Mitophagy
Reactome:R-CEL-73857 RNA Polymerase II Transcription
Reactome:R-CEL-6804757 Regulation of TP53 Degradation
Reactome:R-CEL-8878171 Transcriptional regulation by RUNX1
Reactome:R-CFA-453274 Mitotic G2-G2/M phases
Reactome:R-CFA-2565942 Regulation of PLK1 Activity at G2/M Transition
Reactome:R-CFA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Reactome:R-CFA-73857 RNA Polymerase II Transcription
Reactome:R-CFA-6791312 TP53 Regulates Transcription of Cell Cycle Genes
Reactome:R-DRE-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Reactome:R-DRE-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
Reactome:R-DRE-166520 Signaling by NTRKs
Reactome:R-DRE-74160 Gene expression (Transcription)
Reactome:R-DRE-73857 RNA Polymerase II Transcription
Reactome:R-DRE-5633007 Regulation of TP53 Activity
Reactome:R-DRE-6804756 Regulation of TP53 Activity through Phosphorylation
Reactome:R-DRE-1640170 Cell Cycle
Reactome:R-DRE-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome:R-DDI-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Reactome:R-DDI-5693579 Homologous DNA Pairing and Strand Exchange
Reactome:R-DDI-5693571 Nonhomologous End-Joining (NHEJ)
Reactome:R-DDI-1632852 Macroautophagy
Reactome:R-DDI-2559583 Cellular Senescence
Reactome:R-DDI-1430728 Metabolism
Reactome:R-DDI-556833 Metabolism of lipids
Reactome:R-DDI-5653656 Vesicle-mediated transport
Reactome:R-DDI-8876198 RAB GEFs exchange GTP for GDP on RABs
Reactome:R-DDI-69620 Cell Cycle Checkpoints
Reactome:R-DDI-69541 Stabilization of p53
Reactome:R-DDI-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Reactome:R-DDI-176187 Activation of ATR in response to replication stress
Reactome:R-DDI-69278 Cell Cycle, Mitotic
Reactome:R-DDI-69242 S Phase
Reactome:R-DDI-68886 M Phase
Reactome:R-DDI-2500257 Resolution of Sister Chromatid Cohesion
Reactome:R-DDI-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Reactome:R-DDI-162582 Signaling Pathways
Reactome:R-DDI-198725 Nuclear Events (kinase and transcription factor activation)
Reactome:R-DDI-74751 Insulin receptor signalling cascade
Reactome:R-DDI-4420097 VEGFA-VEGFR2 Pathway
Reactome:R-DDI-2428928 IRS-related events triggered by IGF1R
Reactome:R-DDI-388396 GPCR downstream signalling
Reactome:R-DDI-9006931 Signaling by Nuclear Receptors
Reactome:R-DDI-5687128 MAPK6/MAPK4 signaling
Reactome:R-DDI-198693 AKT phosphorylates targets in the nucleus
Reactome:R-DDI-194315 Signaling by Rho GTPases
Reactome:R-DDI-5668599 RHO GTPases Activate NADPH Oxidases
Reactome:R-DDI-165159 MTOR signalling
Reactome:R-DDI-212436 Generic Transcription Pathway
Reactome:R-DDI-5633007 Regulation of TP53 Activity
Reactome:R-DDI-72312 rRNA processing
Reactome:R-DDI-399954 Sema3A PAK dependent Axon repulsion
Reactome:R-DDI-202403 TCR signaling
Reactome:R-DDI-389357 CD28 dependent PI3K/Akt signaling
Reactome:R-DDI-975871 MyD88 cascade initiated on plasma membrane
Reactome:R-DDI-168164 Toll Like Receptor 3 (TLR3) Cascade
Reactome:R-DDI-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Reactome:R-DDI-166166 MyD88-independent TLR4 cascade
Reactome:R-DDI-168188 Toll Like Receptor TLR6:TLR2 Cascade
Reactome:R-DDI-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
Reactome:R-DME-450531 Regulation of mRNA stability by proteins that bind AU-rich elements
Reactome:R-DME-202403 TCR signaling
Reactome:R-DME-389356 CD28 co-stimulation
Reactome:R-DME-392517 Rap1 signalling
Reactome:R-DME-168142 Toll Like Receptor 10 (TLR10) Cascade
Reactome:R-DME-445989 TAK1-dependent IKK and NF-kappa-B activation
Reactome:R-DME-450282 MAPK targets/ Nuclear events mediated by MAP kinases
Reactome:R-DME-975155 MyD88 dependent cascade initiated on endosome
Reactome:R-DME-166166 MyD88-independent TLR4 cascade
Reactome:R-DME-168188 Toll Like Receptor TLR6:TLR2 Cascade
Reactome:R-DME-1280215 Cytokine Signaling in Immune system
Reactome:R-DME-449147 Signaling by Interleukins
Reactome:R-DME-190236 Signaling by FGFR
Reactome:R-DME-1295596 Spry regulation of FGF signaling
Reactome:R-DME-5654741 Signaling by FGFR3
Reactome:R-DME-187687 Signalling to ERKs
Reactome:R-DME-198725 Nuclear Events (kinase and transcription factor activation)
Reactome:R-DME-109704 PI3K Cascade
Reactome:R-DME-5218921 VEGFR2 mediated cell proliferation
Reactome:R-DME-1358803 Downregulation of ERBB2:ERBB3 signaling
Reactome:R-DME-2428928 IRS-related events triggered by IGF1R
Reactome:R-DME-111885 Opioid Signalling
Reactome:R-DME-111996 Ca-dependent events
Reactome:R-DME-392451 G beta:gamma signalling through PI3Kgamma
Reactome:R-DME-195253 Degradation of beta-catenin by the destruction complex
Reactome:R-DME-201688 WNT mediated activation of DVL
Reactome:R-DME-5358351 Signaling by Hedgehog
Reactome:R-DME-5610785 GLI3 is processed to GLI3R by the proteasome
Reactome:R-DME-5635838 Activation of SMO
Reactome:R-DME-5684996 ERK1/ERK2 pathway
Reactome:R-DME-5675221 Negative regulation of MAPK pathway
Reactome:R-DME-1257604 PI3K/AKT Signaling
Reactome:R-DME-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Reactome:R-DME-8948751 Regulation of PTEN stability and activity
Reactome:R-DME-195258 RHO GTPase Effectors
Reactome:R-DME-112316 Neuronal System
Reactome:R-DME-112314 Neurotransmitter receptors and postsynaptic signal transmission
Reactome:R-DME-442755 Activation of NMDA receptors and postsynaptic events
Reactome:R-DME-2559580 Oxidative Stress Induced Senescence
Reactome:R-DME-1640170 Cell Cycle
Reactome:R-DME-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Reactome:R-DME-69202 Cyclin E associated events during G1/S transition
Reactome:R-DME-69275 G2/M Transition
Reactome:R-DME-373755 Semaphorin interactions
Reactome:R-DME-211163 AKT-mediated inactivation of FOXO1A
Reactome:R-DME-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Reactome:R-DME-5685942 HDR through Homologous Recombination (HRR)
Reactome:R-DME-212436 Generic Transcription Pathway
Reactome:R-DME-5628897 TP53 Regulates Metabolic Genes
Reactome:R-DME-5633007 Regulation of TP53 Activity
Reactome:R-DME-8953750 Transcriptional Regulation by E2F6
Reactome:R-DME-75953 RNA Polymerase II Transcription Initiation
Reactome:R-DME-5205647 Mitophagy
Reactome:R-DME-432626 Circadian Clock pathway
Reactome:R-DME-432501 Transcription repression by PER and activation by PDP1
Reactome:R-DME-209159 Assembly of the CI containing complexes
Reactome:R-DME-209338 Assembly of the 'signalling complexes'
Reactome:R-DME-390089 Formation of the Hippo kinase cassette
Reactome:R-DME-110526 Insulin receptor mediated signaling
Reactome:R-DME-214842 DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'
Reactome:R-DME-209412 Wingless pathway
Reactome:R-DME-209396 Phosphorylation of ARM
Reactome:R-DME-209387 Phosphorylation of ARR
Reactome:R-DME-196854 Metabolism of vitamins and cofactors
Reactome:R-DME-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Reactome:R-GGA-353377 DNA repair
Reactome:R-GGA-353295 Homologous recombination repair
Reactome:R-GGA-351433 ATM mediated phosphorylation of repair proteins
Reactome:R-GGA-353423 Non-homologous end joining (NHEJ)
Reactome:R-GGA-212436 Generic Transcription Pathway
Reactome:R-GGA-6804757 Regulation of TP53 Degradation
Reactome:R-GGA-69613 p53-Independent G1/S DNA Damage Checkpoint
Reactome:R-GGA-69473 G2/M DNA damage checkpoint
Reactome:R-GGA-162582 Signaling Pathways
Reactome:R-GGA-166520 Signaling by NTRKs
Reactome:R-GGA-195253 Degradation of beta-catenin by the destruction complex
Reactome:R-GGA-5673001 RAF/MAP kinase cascade
Reactome:R-GGA-5674499 Negative feedback regulation of MAPK pathway
Reactome:R-GGA-73894 DNA Repair
Reactome:R-GGA-5693607 Processing of DNA double-strand break ends
Reactome:R-GGA-1266738 Developmental Biology
Reactome:R-GGA-168256 Immune System
Reactome:R-GGA-168142 Toll Like Receptor 10 (TLR10) Cascade
Reactome:R-GGA-450294 MAP kinase activation
Reactome:R-GGA-450282 MAPK targets/ Nuclear events mediated by MAP kinases
Reactome:R-GGA-168176 Toll Like Receptor 5 (TLR5) Cascade
Reactome:R-GGA-181438 Toll Like Receptor 2 (TLR2) Cascade
Reactome:R-GGA-5621575 CD209 (DC-SIGN) signaling
Reactome:R-HSA-382551 Transport of small molecules
Reactome:R-HSA-2672351 Stimuli-sensing channels
Reactome:R-HSA-5653656 Vesicle-mediated transport
Reactome:R-HSA-204005 COPII-mediated vesicle transport
Reactome:R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
Reactome:R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs
Reactome:R-HSA-1852241 Organelle biogenesis and maintenance
Reactome:R-HSA-399954 Sema3A PAK dependent Axon repulsion
Reactome:R-HSA-3928662 EPHB-mediated forward signaling
Reactome:R-HSA-446728 Cell junction organization
Reactome:R-HSA-1474244 Extracellular matrix organization
Reactome:R-HSA-3000170 Syndecan interactions
Reactome:R-HSA-114604 GPVI-mediated activation cascade
Reactome:R-HSA-983231 Factors involved in megakaryocyte development and platelet production
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-70221 Glycogen breakdown (glycogenolysis)
Reactome:R-HSA-2142753 Arachidonate metabolism
Reactome:R-HSA-200425 Carnitine shuttle
Reactome:R-HSA-1660517 Synthesis of PIPs at the late endosome membrane
Reactome:R-HSA-163685 Integration of energy metabolism
Reactome:R-HSA-203615 eNOS activation
Reactome:R-HSA-15869 Nucleotide metabolism
Reactome:R-HSA-499943 Interconversion of nucleotide di- and triphosphates
Reactome:R-HSA-109581 Apoptosis
Reactome:R-HSA-3371378 Regulation by c-FLIP
Reactome:R-HSA-211736 Stimulation of the cell death response by PAK-2p34
Reactome:R-HSA-5218859 Regulated Necrosis
Reactome:R-HSA-73894 DNA Repair
Reactome:R-HSA-5693548 Sensing of DNA Double Strand Breaks
Reactome:R-HSA-5693607 Processing of DNA double-strand break ends
Reactome:R-HSA-5693537 Resolution of D-Loop Structures
Reactome:R-HSA-162582 Signaling Pathways
Reactome:R-HSA-190236 Signaling by FGFR
Reactome:R-HSA-5654726 Negative regulation of FGFR1 signaling
Reactome:R-HSA-5654727 Negative regulation of FGFR2 signaling
Reactome:R-HSA-166520 Signaling by NTRKs
Reactome:R-HSA-170968 Frs2-mediated activation
Reactome:R-HSA-198753 ERK/MAPK targets
Reactome:R-HSA-74752 Signaling by Insulin receptor
Reactome:R-HSA-109704 PI3K Cascade
Reactome:R-HSA-4420097 VEGFA-VEGFR2 Pathway
Reactome:R-HSA-1433557 Signaling by SCF-KIT
Reactome:R-HSA-1236394 Signaling by ERBB4
Reactome:R-HSA-2428928 IRS-related events triggered by IGF1R
Reactome:R-HSA-8851907 MET activates PI3K/AKT signaling
Reactome:R-HSA-388396 GPCR downstream signalling
Reactome:R-HSA-111885 Opioid Signalling
Reactome:R-HSA-392451 G beta:gamma signalling through PI3Kgamma
Reactome:R-HSA-9604323 Negative regulation of NOTCH4 signaling
Reactome:R-HSA-196299 Beta-catenin phosphorylation cascade
Reactome:R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
Reactome:R-HSA-5358351 Signaling by Hedgehog
Reactome:R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome
Reactome:R-HSA-8939211 ESR-mediated signaling
Reactome:R-HSA-5673001 RAF/MAP kinase cascade
Reactome:R-HSA-5674499 Negative feedback regulation of MAPK pathway
Reactome:R-HSA-5625740 RHO GTPases activate PKNs
Reactome:R-HSA-165159 MTOR signalling
Reactome:R-HSA-73887 Death Receptor Signaling
Reactome:R-HSA-5357786 TNFR1-induced proapoptotic signaling
Reactome:R-HSA-193704 p75 NTR receptor-mediated signalling
Reactome:R-HSA-209543 p75NTR recruits signalling complexes
Reactome:R-HSA-8953897 Cellular responses to stimuli
Reactome:R-HSA-1632852 Macroautophagy
Reactome:R-HSA-3371556 Cellular response to heat stress
Reactome:R-HSA-3371453 Regulation of HSF1-mediated heat shock response
Reactome:R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence
Reactome:R-HSA-397014 Muscle contraction
Reactome:R-HSA-112310 Neurotransmitter release cycle
Reactome:R-HSA-212676 Dopamine Neurotransmitter Release Cycle
Reactome:R-HSA-438064 Post NMDA receptor activation events
Reactome:R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint
Reactome:R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Reactome:R-HSA-69478 G2/M DNA replication checkpoint
Reactome:R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome:R-HSA-453279 Mitotic G1 phase and G1/S transition
Reactome:R-HSA-68962 Activation of the pre-replicative complex
Reactome:R-HSA-69242 S Phase
Reactome:R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition
Reactome:R-HSA-380287 Centrosome maturation
Reactome:R-HSA-68886 M Phase
Reactome:R-HSA-2465910 MASTL Facilitates Mitotic Progression
Reactome:R-HSA-68882 Mitotic Anaphase
Reactome:R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase
Reactome:R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A
Reactome:R-HSA-8957275 Post-translational protein phosphorylation
Reactome:R-HSA-381042 PERK regulates gene expression
Reactome:R-HSA-1643713 Signaling by EGFR in Cancer
Reactome:R-HSA-5637810 Constitutive Signaling by EGFRvIII
Reactome:R-HSA-5655302 Signaling by FGFR1 in disease
Reactome:R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants
Reactome:R-HSA-5655332 Signaling by FGFR3 in disease
Reactome:R-HSA-2219528 PI3K/AKT Signaling in Cancer
Reactome:R-HSA-4839744 Signaling by APC mutants
Reactome:R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex
Reactome:R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated
Reactome:R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
Reactome:R-HSA-5663205 Infectious disease
Reactome:R-HSA-164944 Nef and signal transduction
Reactome:R-HSA-168255 Influenza Infection
Reactome:R-HSA-5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
Reactome:R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Reactome:R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases
Reactome:R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Reactome:R-HSA-6806003 Regulation of TP53 Expression and Degradation
Reactome:R-HSA-8878166 Transcriptional regulation by RUNX2
Reactome:R-HSA-5250913 Positive epigenetic regulation of rRNA expression
Reactome:R-HSA-1280218 Adaptive Immune System
Reactome:R-HSA-389357 CD28 dependent PI3K/Akt signaling
Reactome:R-HSA-983705 B Cell Activation
Reactome:R-HSA-1236974 ER-Phagosome pathway
Reactome:R-HSA-168898 Toll-like Receptor Cascades
Reactome:R-HSA-937039 IRAK1 recruits IKK complex
Reactome:R-HSA-9013957 TLR3-mediated TICAM1-dependent programmed cell death
Reactome:R-HSA-975155 MyD88 dependent cascade initiated on endosome
Reactome:R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
Reactome:R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Reactome:R-HSA-937041 IKK complex recruitment mediated by RIP1
Reactome:R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
Reactome:R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs
Reactome:R-HSA-3270619 IRF3-mediated induction of type I IFN
Reactome:R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA
Reactome:R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
Reactome:R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
Reactome:R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
Reactome:R-HSA-1280215 Cytokine Signaling in Immune system
Reactome:R-HSA-877300 Interferon gamma signaling
Reactome:R-HSA-9020702 Interleukin-1 signaling
Reactome:R-HSA-9008059 Interleukin-37 signaling
Reactome:R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
Reactome:R-HSA-447115 Interleukin-12 family signaling
Reactome:R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Reactome:R-HSA-72312 rRNA processing
Reactome:R-HSA-6782315 tRNA modification in the nucleus and cytosol
Reactome:R-MMU-69615 G1/S DNA Damage Checkpoints
Reactome:R-MMU-349425 Autodegradation of the E3 ubiquitin ligase COP1
Reactome:R-MMU-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Reactome:R-MMU-141424 Amplification of signal from the kinetochores
Reactome:R-MMU-69278 Cell Cycle, Mitotic
Reactome:R-MMU-69273 Cyclin A/B1/B2 associated events during G2/M transition
Reactome:R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
Reactome:R-MMU-8854518 AURKA Activation by TPX2
Reactome:R-MMU-68875 Mitotic Prophase
Reactome:R-MMU-68877 Mitotic Prometaphase
Reactome:R-MMU-2555396 Mitotic Metaphase and Anaphase
Reactome:R-MMU-453276 Regulation of mitotic cell cycle
Reactome:R-MMU-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Reactome:R-MMU-69306 DNA Replication
Reactome:R-MMU-202403 TCR signaling
Reactome:R-MMU-202424 Downstream TCR signaling
Reactome:R-MMU-389359 CD28 dependent Vav1 pathway
Reactome:R-MMU-392517 Rap1 signalling
Reactome:R-MMU-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Reactome:R-MMU-168138 Toll Like Receptor 9 (TLR9) Cascade
Reactome:R-MMU-166166 MyD88-independent TLR4 cascade
Reactome:R-MMU-2562578 TRIF-mediated programmed cell death
Reactome:R-MMU-168188 Toll Like Receptor TLR6:TLR2 Cascade
Reactome:R-MMU-168638 NOD1/2 Signaling Pathway
Reactome:R-MMU-1606322 ZBP1(DAI) mediated induction of type I IFNs
Reactome:R-MMU-3270619 IRF3-mediated induction of type I IFN
Reactome:R-MMU-3134975 Regulation of innate immune responses to cytosolic DNA
Reactome:R-MMU-2871796 FCERI mediated MAPK activation
Reactome:R-MMU-5621481 C-type lectin receptors (CLRs)
Reactome:R-MMU-912526 Interleukin receptor SHC signaling
Reactome:R-MMU-5693532 DNA Double-Strand Break Repair
Reactome:R-MMU-5693538 Homology Directed Repair
Reactome:R-MMU-5693579 Homologous DNA Pairing and Strand Exchange
Reactome:R-MMU-8982491 Glycogen metabolism
Reactome:R-MMU-70263 Gluconeogenesis
Reactome:R-MMU-2142753 Arachidonate metabolism
Reactome:R-MMU-200425 Carnitine shuttle
Reactome:R-MMU-1660514 Synthesis of PIPs at the Golgi membrane
Reactome:R-MMU-163680 AMPK inhibits chREBP transcriptional activation activity
Reactome:R-MMU-203615 eNOS activation
Reactome:R-MMU-15869 Nucleotide metabolism
Reactome:R-MMU-499943 Interconversion of nucleotide di- and triphosphates
Reactome:R-MMU-72203 Processing of Capped Intron-Containing Pre-mRNA
Reactome:R-MMU-450604 KSRP (KHSRP) binds and destabilizes mRNA
Reactome:R-MMU-72312 rRNA processing
Reactome:R-MMU-382551 Transport of small molecules
Reactome:R-MMU-2672351 Stimuli-sensing channels
Reactome:R-MMU-109582 Hemostasis
Reactome:R-MMU-422475 Axon guidance
Reactome:R-MMU-373760 L1CAM interactions
Reactome:R-MMU-5357769 Caspase activation via extrinsic apoptotic signalling pathway
Reactome:R-MMU-75153 Apoptotic execution phase
Reactome:R-MMU-5218859 Regulated Necrosis
Reactome:R-MMU-8953897 Cellular responses to stimuli
Reactome:R-MMU-2262752 Cellular responses to stress
Reactome:R-MMU-2559583 Cellular Senescence
Reactome:R-MMU-397014 Muscle contraction
Reactome:R-MMU-5620912 Anchoring of the basal body to the plasma membrane
Reactome:R-MMU-5633008 TP53 Regulates Transcription of Cell Death Genes
Reactome:R-MMU-6804760 Regulation of TP53 Activity through Methylation
Reactome:R-MMU-8878171 Transcriptional regulation by RUNX1
Reactome:R-MMU-8953750 Transcriptional Regulation by E2F6
Reactome:R-MMU-75953 RNA Polymerase II Transcription Initiation
Reactome:R-MMU-177929 Signaling by EGFR
Reactome:R-MMU-180292 GAB1 signalosome
Reactome:R-MMU-5654738 Signaling by FGFR2
Reactome:R-MMU-5654732 Negative regulation of FGFR3 signaling
Reactome:R-MMU-5654716 Downstream signaling of activated FGFR4
Reactome:R-MMU-5654720 PI-3K cascade:FGFR4
Reactome:R-MMU-187687 Signalling to ERKs
Reactome:R-MMU-170968 Frs2-mediated activation
Reactome:R-MMU-74751 Insulin receptor signalling cascade
Reactome:R-MMU-165158 Activation of PKB
Reactome:R-MMU-194138 Signaling by VEGF
Reactome:R-MMU-5218920 VEGFR2 mediated vascular permeability
Reactome:R-MMU-1963642 PI3K events in ERBB2 signaling
Reactome:R-MMU-1250342 PI3K events in ERBB4 signaling
Reactome:R-MMU-2428924 IGF1R signaling cascade
Reactome:R-MMU-180024 DARPP-32 events
Reactome:R-MMU-416476 G alpha (q) signalling events
Reactome:R-MMU-397795 G-protein beta:gamma signalling
Reactome:R-MMU-9013694 Signaling by NOTCH4
Reactome:R-MMU-201681 TCF dependent signaling in response to WNT
Reactome:R-MMU-5358351 Signaling by Hedgehog
Reactome:R-MMU-5610785 GLI3 is processed to GLI3R by the proteasome
Reactome:R-MMU-5635838 Activation of SMO
Reactome:R-MMU-5683057 MAPK family signaling cascades
Reactome:R-MMU-5674135 MAP2K and MAPK activation
Reactome:R-MMU-9006925 Intracellular signaling by second messengers
Reactome:R-MMU-199418 Negative regulation of the PI3K/AKT network
Reactome:R-MMU-5625740 RHO GTPases activate PKNs
Reactome:R-MMU-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
Reactome:R-MMU-165181 Inhibition of TSC complex formation by PKB
Reactome:R-MMU-9006335 Signaling by Erythropoietin
Reactome:R-MMU-446203 Asparagine N-linked glycosylation
Reactome:R-MMU-948021 Transport to the Golgi and subsequent modification
Reactome:R-MMU-3108232 SUMO E3 ligases SUMOylate target proteins
Reactome:R-MMU-5688426 Deubiquitination
Reactome:R-MMU-8866654 E3 ubiquitin ligases ubiquitinate target proteins
Reactome:R-MMU-381119 Unfolded Protein Response (UPR)
Reactome:R-MMU-381042 PERK regulates gene expression
Reactome:R-MMU-199991 Membrane Trafficking
Reactome:R-MMU-112316 Neuronal System
Reactome:R-RNO-8953854 Metabolism of RNA
Reactome:R-RNO-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
Reactome:R-RNO-71387 Carbohydrate metabolism
Reactome:R-RNO-70326 Glucose metabolism
Reactome:R-RNO-1483257 Phospholipid metabolism
Reactome:R-RNO-203615 eNOS activation
Reactome:R-RNO-15869 Nucleotide metabolism
Reactome:R-RNO-499943 Interconversion of nucleotide di- and triphosphates
Reactome:R-RNO-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Reactome:R-RNO-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome:R-RNO-453274 Mitotic G2-G2/M phases
Reactome:R-RNO-2565942 Regulation of PLK1 Activity at G2/M Transition
Reactome:R-RNO-380284 Loss of proteins required for interphase microtubule organization from the centrosome
Reactome:R-RNO-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Reactome:R-RNO-2500257 Resolution of Sister Chromatid Cohesion
Reactome:R-RNO-199977 ER to Golgi Anterograde Transport
Reactome:R-RNO-212436 Generic Transcription Pathway
Reactome:R-RNO-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Reactome:R-RNO-6806003 Regulation of TP53 Expression and Degradation
Reactome:R-RNO-212165 Epigenetic regulation of gene expression
Reactome:R-RNO-5250924 B-WICH complex positively regulates rRNA expression
Reactome:R-RNO-1632852 Macroautophagy
Reactome:R-RNO-3371556 Cellular response to heat stress
Reactome:R-RNO-3371453 Regulation of HSF1-mediated heat shock response
Reactome:R-RNO-177929 Signaling by EGFR
Reactome:R-RNO-180292 GAB1 signalosome
Reactome:R-RNO-5654738 Signaling by FGFR2
Reactome:R-RNO-5654732 Negative regulation of FGFR3 signaling
Reactome:R-RNO-5654716 Downstream signaling of activated FGFR4
Reactome:R-RNO-5654720 PI-3K cascade:FGFR4
Reactome:R-RNO-5218921 VEGFR2 mediated cell proliferation
Reactome:R-RNO-1227986 Signaling by ERBB2
Reactome:R-RNO-418594 G alpha (i) signalling events
Reactome:R-RNO-397795 G-protein beta:gamma signalling
Reactome:R-RNO-9013694 Signaling by NOTCH4
Reactome:R-RNO-201681 TCF dependent signaling in response to WNT
Reactome:R-RNO-5358351 Signaling by Hedgehog
Reactome:R-RNO-5610785 GLI3 is processed to GLI3R by the proteasome
Reactome:R-RNO-5635838 Activation of SMO
Reactome:R-RNO-5684996 ERK1/ERK2 pathway
Reactome:R-RNO-5675221 Negative regulation of MAPK pathway
Reactome:R-RNO-1257604 PI3K/AKT Signaling
Reactome:R-RNO-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Reactome:R-RNO-195258 RHO GTPase Effectors
Reactome:R-RNO-5668599 RHO GTPases Activate NADPH Oxidases
Reactome:R-RNO-166208 mTORC1-mediated signalling
Reactome:R-RNO-75893 TNF signaling
Reactome:R-RNO-5357905 Regulation of TNFR1 signaling
Reactome:R-RNO-193639 p75NTR signals via NF-kB
Reactome:R-RNO-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Reactome:R-RNO-983712 Ion channel transport
Reactome:R-RNO-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome:R-RNO-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
Reactome:R-RNO-8856825 Cargo recognition for clathrin-mediated endocytosis
Reactome:R-RNO-76002 Platelet activation, signaling and aggregation
Reactome:R-RNO-109581 Apoptosis
Reactome:R-RNO-388841 Costimulation by the CD28 family
Reactome:R-RNO-1168372 Downstream signaling events of B Cell Receptor (BCR)
Reactome:R-RNO-168142 Toll Like Receptor 10 (TLR10) Cascade
Reactome:R-RNO-445989 TAK1-dependent IKK and NF-kappa-B activation
Reactome:R-RNO-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
Reactome:R-RNO-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Reactome:R-RNO-168138 Toll Like Receptor 9 (TLR9) Cascade
Reactome:R-RNO-166166 MyD88-independent TLR4 cascade
Reactome:R-RNO-181438 Toll Like Receptor 2 (TLR2) Cascade
Reactome:R-RNO-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome:R-RNO-1810476 RIP-mediated NFkB activation via ZBP1
Reactome:R-RNO-2871837 FCERI mediated NF-kB activation
Reactome:R-RNO-1280215 Cytokine Signaling in Immune system
Reactome:R-RNO-877300 Interferon gamma signaling
Reactome:R-RNO-9020702 Interleukin-1 signaling
Reactome:R-RNO-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
Reactome:R-RNO-373755 Semaphorin interactions
Reactome:R-RNO-2682334 EPH-Ephrin signaling
Reactome:R-SCE-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
Reactome:R-SCE-5205647 Mitophagy
Reactome:R-SCE-75153 Apoptotic execution phase
Reactome:R-SCE-74160 Gene expression (Transcription)
Reactome:R-SCE-73857 RNA Polymerase II Transcription
Reactome:R-SCE-6806003 Regulation of TP53 Expression and Degradation
Reactome:R-SCE-2262752 Cellular responses to stress
Reactome:R-SCE-3371571 HSF1-dependent transactivation
Reactome:R-SCE-168256 Immune System
Reactome:R-SCE-202424 Downstream TCR signaling
Reactome:R-SCE-389359 CD28 dependent Vav1 pathway
Reactome:R-SCE-168898 Toll-like Receptor Cascades
Reactome:R-SCE-975155 MyD88 dependent cascade initiated on endosome
Reactome:R-SCE-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Reactome:R-SCE-168179 Toll Like Receptor TLR1:TLR2 Cascade
Reactome:R-SCE-2871796 FCERI mediated MAPK activation
Reactome:R-SCE-5621481 C-type lectin receptors (CLRs)
Reactome:R-SCE-1280215 Cytokine Signaling in Immune system
Reactome:R-SCE-5676590 NIK-->noncanonical NF-kB signaling
Reactome:R-SCE-187037 Signaling by NTRK1 (TRKA)
Reactome:R-SCE-74751 Insulin receptor signalling cascade
Reactome:R-SCE-5218921 VEGFR2 mediated cell proliferation
Reactome:R-SCE-372790 Signaling by GPCR
Reactome:R-SCE-416476 G alpha (q) signalling events
Reactome:R-SCE-397795 G-protein beta:gamma signalling
Reactome:R-SCE-198693 AKT phosphorylates targets in the nucleus
Reactome:R-SCE-195258 RHO GTPase Effectors
Reactome:R-SCE-200425 Carnitine shuttle
Reactome:R-SCE-1483257 Phospholipid metabolism
Reactome:R-SCE-1660517 Synthesis of PIPs at the late endosome membrane
Reactome:R-SCE-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Reactome:R-SCE-69615 G1/S DNA Damage Checkpoints
Reactome:R-SCE-69278 Cell Cycle, Mitotic
Reactome:R-SCE-68875 Mitotic Prophase
Reactome:R-SCE-381070 IRE1alpha activates chaperones
Reactome:R-SCE-69306 DNA Replication
Reactome:R-SPO-114604 GPVI-mediated activation cascade
Reactome:R-SPO-1280218 Adaptive Immune System
Reactome:R-SPO-389356 CD28 co-stimulation
Reactome:R-SPO-168249 Innate Immune System
Reactome:R-SPO-450294 MAP kinase activation
Reactome:R-SPO-198753 ERK/MAPK targets
Reactome:R-SPO-168176 Toll Like Receptor 5 (TLR5) Cascade
Reactome:R-SPO-168138 Toll Like Receptor 9 (TLR9) Cascade
Reactome:R-SPO-937061 TRIF (TICAM1)-mediated TLR4 signaling
Reactome:R-SPO-1280215 Cytokine Signaling in Immune system
Reactome:R-SPO-448424 Interleukin-17 signaling
Reactome:R-SPO-8868773 rRNA processing in the nucleus and cytosol
Reactome:R-SPO-69613 p53-Independent G1/S DNA Damage Checkpoint
Reactome:R-SPO-69473 G2/M DNA damage checkpoint
Reactome:R-SPO-69278 Cell Cycle, Mitotic
Reactome:R-SPO-68875 Mitotic Prophase
Reactome:R-SPO-453276 Regulation of mitotic cell cycle
Reactome:R-SPO-73857 RNA Polymerase II Transcription
Reactome:R-SPO-5633007 Regulation of TP53 Activity
Reactome:R-SPO-597592 Post-translational protein modification
Reactome:R-SPO-3108232 SUMO E3 ligases SUMOylate target proteins
Reactome:R-SPO-381119 Unfolded Protein Response (UPR)
Reactome:R-SPO-73894 DNA Repair
Reactome:R-SPO-556833 Metabolism of lipids
Reactome:R-SPO-200425 Carnitine shuttle
Reactome:R-SPO-163680 AMPK inhibits chREBP transcriptional activation activity
Reactome:R-SPO-5653656 Vesicle-mediated transport
Reactome:R-SPO-9007101 Rab regulation of trafficking
Reactome:R-SPO-1632852 Macroautophagy
Reactome:R-SPO-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-SPO-198725 Nuclear Events (kinase and transcription factor activation)
Reactome:R-SPO-109704 PI3K Cascade
Reactome:R-SPO-4420097 VEGFA-VEGFR2 Pathway
Reactome:R-SPO-2428928 IRS-related events triggered by IGF1R
Reactome:R-SPO-397795 G-protein beta:gamma signalling
Reactome:R-SPO-5683057 MAPK family signaling cascades
Reactome:R-SPO-195258 RHO GTPase Effectors
Reactome:R-SPO-166208 mTORC1-mediated signalling
Reactome:R-SSC-8978868 Fatty acid metabolism
Reactome:R-SSC-74160 Gene expression (Transcription)
Reactome:R-SSC-73857 RNA Polymerase II Transcription
Reactome:R-SSC-3700989 Transcriptional Regulation by TP53
Reactome:R-SSC-5633007 Regulation of TP53 Activity
Reactome:R-SSC-6804756 Regulation of TP53 Activity through Phosphorylation
Reactome:R-SSC-1640170 Cell Cycle
Reactome:R-SSC-8854521 Interaction between PHLDA1 and AURKA
Reactome:R-SSC-162582 Signaling Pathways
Reactome:R-SSC-165159 MTOR signalling
Reactome:R-XTR-212436 Generic Transcription Pathway
Reactome:R-XTR-69620 Cell Cycle Checkpoints
Reactome:R-XTR-69618 Mitotic Spindle Checkpoint
Reactome:R-XTR-162582 Signaling Pathways
Reactome:R-XTR-190236 Signaling by FGFR
Reactome:R-XTR-5654726 Negative regulation of FGFR1 signaling
Reactome:R-XTR-5654727 Negative regulation of FGFR2 signaling
Reactome:R-XTR-195258 RHO GTPase Effectors
Reactome:R-XTR-4615885 SUMOylation of DNA replication proteins
WikiPathways:WP4763 Regulation of Pgc1a expression by a Gsk3b-Tfeb signaling axis in skeletal muscle
WikiPathways:WP4861 Endoplasmic reticulum stress response in coronavirus infection
WikiPathways:WP4971 Phosphoinositides metabolism
WikiPathways:WP5049 Glycolysis in senescence
WikiPathways:WP5117 Cohesin complex - Cornelia de Lange syndrome
WikiPathways:WP5144 NRP1-triggered signaling pathways in pancreatic cancer
WikiPathways:WP5298 Dravet syndrome: Scn1a-A1783V point mutation model
WikiPathways:WP339 ESC pluripotency pathways
WikiPathways:WP5381 Smith-Magenis and Potocki-Lupski syndrome copy number variation
WikiPathways:WP2643 Nanoparticle-mediated activation of receptor signaling
WikiPathways:WP5021 SARS-CoV-2 Infection
WikiPathways:WP5055 Burn wound healing
WikiPathways:WP5115 Network map of SARS-CoV-2 signaling pathway
WikiPathways:WP5200 Dravet syndrome
WikiPathways:WP1971 Integrated cancer pathway
WikiPathways:WP2516 ATM signaling pathway
WikiPathways:WP3959 DNA IR-double strand breaks and cellular response via ATM
WikiPathways:WP4016 DNA IR-damage and cellular response via ATR
WikiPathways:WP4936 Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins
WikiPathways:WP5044 Kynurenine pathway and links to cell senescence
WikiPathways:WP5098 T-cell activation SARS-CoV-2
WikiPathways:WP5156 SARS-CoV-2 replication organelle formation
WikiPathways:WP5181 Roles of ceramides in development of insulin resistance
WikiPathways:WP5220 Metabolic reprogramming in pancreatic cancer
WikiPathways:WP2263 Androgen receptor network in prostate cancer
WikiPathways:WP5322 CKAP4 signaling pathway map
WikiPathways:WP5158 Urotensin-II-mediated signaling pathway
WikiPathways:WP5372 Involvement of -secretase in neurodegenerative diseases
WikiPathways:WP2526 PDGF pathway
WikiPathways:WP3634 Insulin signaling in adipocytes (normal condition)
WikiPathways:WP4183 Distal convoluted tubule 1 (DCT1) cell
WikiPathways:WP4863 Host-pathogen interaction of human coronaviruses - autophagy
WikiPathways:WP5020 SARS-CoV-1 Infection
WikiPathways:WP5182 Pro-survival signaling of neuroprotectin D1
WikiPathways:WP5191 Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution
WikiPathways:WP5242 Comprehensive IL-17A signaling
WikiPathways:WP3830 Toll, IMD, JAK/STAT pathways for immune response to pathogens
WikiPathways:WP5376 17p13.3 (YWHAE) copy number variation
WikiPathways:WP1984 Integrated breast cancer pathway
WikiPathways:WP2366 Butyrate-induced histone acetylation
WikiPathways:WP2533 Glycerophospholipid biosynthetic pathway
WikiPathways:WP3635 Insulin signaling in adipocytes (diabetic condition)
PathBank:SMP0031696 Dasatinib Inhibition of BCR-ABL
PathBank:SMP0031700 Ponatinib Inhibition of BCR-ABL
PathBank:SMP0108149 Lysophosphatidic Acid LPA4 Signalling
PathBank:SMP0108189 Insulin Signalling
PathBank:SMP0108209 Phospholipase C Signaling Pathway
PathBank:SMP0108225 Insulin Signalling
PathBank:SMP0108229 Lysophosphatidic Acid LPA4 Signalling
PathBank:SMP0119382 Circadian Rhythms
PathBank:SMP0120885 Rac 1 Cell Motility Signaling Pathway
PathBank:SMP0120899 Growth Hormone Signaling Pathway
PathBank:SMP0120911 T Cell Receptor Signaling Pathway
PathBank:SMP0120915 FAS signaling pathway ( CD95 )
PathBank:SMP0120923 Growth Hormone Signaling Pathway
PathBank:SMP0120931 Toll-Like Receptor Pathway 1
PathBank:SMP0120935 T Cell Receptor Signaling Pathway
PathBank:SMP0120939 FAS signaling pathway ( CD95 )
PathBank:SMP0120947 Growth Hormone Signaling Pathway
PathBank:SMP0120955 Toll-Like Receptor Pathway 1
PathBank:SMP0120959 T Cell Receptor Signaling Pathway
PathBank:SMP0120963 FAS signaling pathway ( CD95 )
PathBank:SMP0000572 Fanconi-Bickel Syndrome
PathBank:SMP0000629 Adefovir Dipivoxil Metabolism Pathway
PathBank:SMP0000649 Lamivudine Metabolism Pathway
PathBank:SMP0002397 Inositol Metabolism
PathBank:SMP0087242 Inositol Metabolism
PathBank:SMP0087258 Phosphatidylinositol Phosphate Metabolism
PathBank:SMP0087270 Warburg Effect
PathBank:SMP0087410 Phosphatidylinositol Phosphate Metabolism
PathBank:SMP0089759 CD40L Signalling Pathway
PathBank:SMP0063753 Lysophosphatidic Acid LPA2 Signalling
PathBank:SMP0063759 Lysophosphatidic Acid LPA6 Signalling
PathBank:SMP0063783 Phospholipase C Signaling Pathway
PathBank:SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages
PathBank:SMP0063810 EGF Signalling Pathway
PathBank:SMP0063899 Toll-Like Receptor Pathway 1
PathBank:SMP0100469 Rac 1 cell motility signaling pathway
PathBank:SMP0100484 Rac 1 cell motility signaling pathway
PathBank:SMP0100499 Rac 1 cell motility signaling pathway
PathBank:SMP0066977 T Cell Receptor Signaling Pathway
PathBank:SMP0067587 Stat3 Signaling Pathway
PathBank:SMP0120865 Joubert Syndrome
PathBank:SMP0031694 Imatinib Inhibition of BCR-ABL
PathBank:SMP0031699 Bafetinib Inhibition of BCR-ABL
PathBank:SMP0108010 Leucine Stimulation on Insulin Signaling
PathBank:SMP0108144 Lysophosphatidic Acid LPA1 Signalling
PathBank:SMP0108148 Lysophosphatidic Acid LPA3 Signalling
PathBank:SMP0108152 Lysophosphatidic Acid LPA6 Signalling
PathBank:SMP0108220 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
PathBank:SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells
PathBank:SMP0108228 Lysophosphatidic Acid LPA3 Signalling
PathBank:SMP0108240 Cadmium Induces DNA Synthesis and Proliferation in Macrophages
PathBank:SMP0069695 FAS signaling pathway ( CD95 )
PathBank:SMP0120888 Succinate Signalling During Inflammation
PathBank:SMP0120914 EPO Signaling Pathway
PathBank:SMP0120926 NF-kB Signaling Pathway
PathBank:SMP0120942 CD40L Signalling Pathway
PathBank:SMP0120946 LPS and Citrate Signaling and Inflammation
PathBank:SMP0120950 NF-kB Signaling Pathway
PathBank:SMP0120962 EPO Signaling Pathway
PathBank:SMP0120966 CD40L Signalling Pathway
PathBank:SMP0120970 LPS and Citrate Signaling and Inflammation
PathBank:SMP0000040 Glycolysis
PathBank:SMP0000011 Inositol Metabolism
PathBank:SMP0000463 Phosphatidylinositol Phosphate Metabolism
PathBank:SMP0000446 Gemcitabine Action Pathway
PathBank:SMP0000531 Glycogenosis, Type VII. Tarui Disease
PathBank:SMP0002411 Stress-Activated Signalling Pathways: High Osmolarity
PathBank:SMP0063629 Inositol Metabolism
PathBank:SMP0063651 Phosphatidylinositol Phosphate Metabolism
PathBank:SMP0063746 Lysophosphatidic Acid LPA1 Signalling
PathBank:SMP0063757 Lysophosphatidic Acid LPA5 Signalling
PathBank:SMP0063795 Rac 1 Cell Motility Signaling Pathway
PathBank:SMP0100468 TNF/Stress Related Signaling
PathBank:SMP0100483 TNF/Stress Related Signaling
PathBank:SMP0100498 TNF/Stress Related Signaling
PathBank:SMP0031692 BCR-ABL Action in CML Pathogenesis
PathBank:SMP0031698 Bosutinib Inhibition of BCR-ABL
PathBank:SMP0108000 Leucine Stimulation on Insulin Signaling
PathBank:SMP0108130 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
PathBank:SMP0108142 Insulin Signalling
PathBank:SMP0108146 Lysophosphatidic Acid LPA2 Signalling
PathBank:SMP0108174 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
PathBank:SMP0108178 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
PathBank:SMP0108186 Fc Epsilon Receptor I Signaling in Mast Cells
PathBank:SMP0108210 Ras Signaling Pathway
PathBank:SMP0108226 Lysophosphatidic Acid LPA1 Signalling
PathBank:SMP0108230 Lysophosphatidic Acid LPA5 Signalling
PathBank:SMP0108238 Phospholipase C Signaling Pathway
PathBank:SMP0069678 EPO Signaling Pathway
PathBank:SMP0069871 BCR Signaling Pathway
PathBank:SMP0119399 Circadian Rhythms
PathBank:SMP0120646 Joubert Syndrome
PathBank:SMP0120886 Succinate Signalling During Inflammation
PathBank:SMP0120916 BCR Signaling Pathway
PathBank:SMP0120924 EGF Signalling Pathway
PathBank:SMP0120940 BCR Signaling Pathway
PathBank:SMP0120948 EGF Signalling Pathway
PathBank:SMP0120960 Stat3 Signaling Pathway
PathBank:SMP0120964 BCR Signaling Pathway
PathBank:SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
PathBank:SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells
PathBank:SMP0000630 Tenofovir Metabolism Pathway
PathBank:SMP0000654 Warburg Effect
PathBank:SMP0000682 Leucine Stimulation on Insulin Signaling
PathBank:SMP0002409 TOR Signalling Pathway: Rapamycin-Based Repression
PathBank:SMP0087396 Inositol Metabolism
PathBank:SMP0090831 Circadian Rhythms
PathBank:SMP0063756 Lysophosphatidic Acid LPA4 Signalling
PathBank:SMP0063792 TNF/Stress Related Signaling
PathBank:SMP0063813 NF-kB Signaling Pathway
PathBank:SMP0100046 LPS and Citrate Signaling and Inflammation
PathBank:SMP0031697 Nilotinib Inhibition of BCR-ABL
PathBank:SMP0107989 Leucine Stimulation on Insulin Signaling
PathBank:SMP0108127 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
PathBank:SMP0108139 Fc Epsilon Receptor I Signaling in Mast Cells
PathBank:SMP0108151 Lysophosphatidic Acid LPA5 Signalling
PathBank:SMP0108163 Ras Signaling Pathway
PathBank:SMP0108219 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
PathBank:SMP0108227 Lysophosphatidic Acid LPA2 Signalling
PathBank:SMP0108231 Lysophosphatidic Acid LPA6 Signalling
PathBank:SMP0108239 Ras Signaling Pathway
PathBank:SMP0069593 Toll-Like Receptor Pathway 2
PathBank:SMP0120883 Rac 1 Cell Motility Signaling Pathway
PathBank:SMP0120887 Rac 1 Cell Motility Signaling Pathway
PathBank:SMP0120901 GnRH Signaling Pathway
PathBank:SMP0120909 CXCR4 Signaling Pathway
PathBank:SMP0120925 GnRH Signaling Pathway
PathBank:SMP0120933 CXCR4 Signaling Pathway
PathBank:SMP0120937 Toll-Like Receptor Pathway 2
PathBank:SMP0120949 GnRH Signaling Pathway
PathBank:SMP0120957 CXCR4 Signaling Pathway
PathBank:SMP0120961 Toll-Like Receptor Pathway 2
PathBank:SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
PathBank:SMP0000391 Insulin Signalling
PathBank:SMP0000582 Joubert Syndrome
PathBank:SMP0000603 Gemcitabine Metabolism Pathway
PathBank:SMP0002410 Stress-Activated Signalling Pathways: Low Osmolarity
PathBank:SMP0084634 Succinate Signalling During Inflammation
PathBank:SMP0087239 Purine Metabolism
PathBank:SMP0087247 Pyrimidine Metabolism
PathBank:SMP0087335 Inositol Metabolism
PathBank:SMP0087351 Phosphatidylinositol Phosphate Metabolism
PathBank:SMP0063755 Lysophosphatidic Acid LPA3 Signalling
PathBank:SMP0063784 Ras Signaling Pathway
PathBank:SMP0063807 Growth Hormone Signaling Pathway
PathBank:SMP0063811 GnRH Signaling Pathway
PathBank:SMP0064625 CXCR4 Signaling Pathway
PathBank:SMP0100480 Phospholipase C Signaling Pathway
PathBank:SMP0100495 Phospholipase C Signaling Pathway