PERK regulates gene expression
Scheuner D, Kaufman RJ. The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Endocr Rev. 2008 May;29(3):317–33. PMID: 18436705; PMCID: PMC2528859.; Eizirik DL, Cardozo AK, Cnop M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev. 2008 Feb;29(1):42–61. doi: 10.1210/er.2007-0015. PMID: 18048764.; Schröder M. Endoplasmic reticulum stress responses. Cellular and Molecular Life Sciences. 2007 Nov 26;65(6):862–94. doi: 10.1007/s00018-007-7383-5.; Herbert TP. PERK in the life and death of the pancreatic beta-cell. Biochem Soc Trans. 2007 Nov;35(Pt 5):1205–7. doi: 10.1042/bst0351205. PMID: 17956313.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 2.7.10.2 | non-specific protein-tyrosine kinase | ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific) | |
| 2.7.11.1 | non-specific serine/threonine protein kinase | ATP:protein phosphotransferase (non-specific) | |
| 3.6.5.3 | protein-synthesizing GTPase | GTP phosphohydrolase (mRNA-translation-assisting) |
Proteins
| Protein ID | name | full name |
|---|