Organelle biogenesis and maintenance

Zheng J, Shan Y, Lambrecht RW, Donohue SE, Bonkovsky HL. Differential regulation of human ALAS1 mRNA and protein levels by heme and cobalt protoporphyrin. Molecular and Cellular Biochemistry. 2008 Aug 22;319(1-2):153–61. doi: 10.1007/s11010-008-9888-0.; Dhaunsi GS. Molecular mechanisms of organelle biogenesis and related metabolic diseases. Med Princ Pract. 2005;14 Suppl 1():49–57. doi: 10.1159/000086184. PMID: 16103713.; Roberts AG, Elder GH. Alternative splicing and tissue-specific transcription of human and rodent ubiquitous 5-aminolevulinate synthase (ALAS1) genes. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 2001 Mar;1518(1-2):95–105. doi: 10.1016/s0167-4781(01)00187-7.; Nunnari J, Walter P. Regulation of organelle biogenesis. Cell. 1996 Feb 09;84(3):389–94. doi: 10.1016/s0092-8674(00)81283-0. PMID: 8608592.

Metabolites

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Nicotinamide

Formula: C6H6N2O (122.0480106)

CAS ID: 98-92-0

O-Acetyl-ADP-ribose

Formula: C17H25N5O15P2 (601.0822360000001)

CAS ID:

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

2''-O-acetyl-ADP-D-ribose(2-)

Formula: C17H23N5O15P2 (599.0665868000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.1.1.-
2.3.1.108 alpha-tubulin N-acetyltransferase acetyl-CoA:[alpha-tubulin]-L-lysine N6-acetyltransferase
2.3.1.286 protein acetyllysine N-acetyltransferase [protein]-N6-acetyl-L-lysine:NAD+ N-acetyltransferase (NAD+-hydrolysing; 2''-O-acetyl-ADP-D-ribose-forming)
2.3.1.37 5-aminolevulinate synthase succinyl-CoA:glycine C-succinyltransferase (decarboxylating)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.11 cAMP-dependent protein kinase ATP:protein Ser/Thr-phosphotransferase (3',5'-cAMP-dependent)
2.7.11.17 Ca2+/calmodulin-dependent protein kinase ATP:protein phosphotransferase (Ca2+/calmodulin-dependent)
2.7.11.21 polo kinase ATP:protein phosphotransferase (spindle-pole-dependent)
2.7.11.22 cyclin-dependent kinase ATP:cyclin phosphotransferase
2.7.11.23 [RNA-polymerase]-subunit kinase ATP:[DNA-directed RNA polymerase] phosphotransferase
2.7.11.26 tau-protein kinase ATP:[tau-protein] O-phosphotransferase
2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase ATP:[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphotransferase
2.7.7.6 DNA-directed RNA polymerase nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)
3.1.3.36 phosphoinositide 5-phosphatase phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase
3.1.3.86 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase
3.5.1.98 histone deacetylase histone amidohydrolase
3.6.4.10 non-chaperonin molecular chaperone ATPase ATP phosphohydrolase (polypeptide-polymerizing)
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)
5.6.2.3 DNA 5'-3' helicase DNA 5'-3' helicase (ATP-hydrolysing)
7.1.2.2 H+-transporting two-sector ATPase ATP phosphohydrolase (H+-transporting)


Proteins

Protein ID name full name