EC: 3.6.4.10

non-chaperonin molecular chaperone ATPase (ATP phosphohydrolase (polypeptide-polymerizing))

enzyme lambda metabolic reaction experiment
uniprot:P31539 [non-chaperonin molecular chaperone ATPase(Enzyme) mutant E687Q]

H2O + ATP -> Phosphate + ADP		 (( (( (kcat * E) ) * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 50 mM Hepes/KOH, 150 mM KCl, 15 mM MgCl2
PH: 7.5
Temperature: 30
uniprot:P31539 [non-chaperonin molecular chaperone ATPase(Enzyme) mutant E285Q]

H2O + ATP -> Phosphate + ADP		 (( (( (kcat * E) ) * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 50 mM Hepes/KOH, 150 mM KCl, 15 mM MgCl2
PH: 7.5
Temperature: 30
uniprot:P31539 [non-chaperonin molecular chaperone ATPase(Enzyme) wildtype His6-tagged]

ATP + H2O -> ADP + Phosphate		 (( (( (kcat * E) ) * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 50 mM Hepes/KOH, 150 mM KCl, 15 mM MgCl2
PH: 7.5
Temperature: 30
uniprot:P31539 [Dextran]

ATP + H2O -> ADP + Phosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Tris-HCl, 5 mM MgCl2, 150 mM NaCl, 0.02% (v/v) TX-100, 25% (w/v) Dextran
PH: 7.5
Temperature: 22
uniprot:P31539 [Dextran]

ATP + H2O -> ADP + Phosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Tris-HCl, 5 mM MgCl2, 150 mM NaCl, 0.02% (v/v) TX-100, 25% (w/v) Dextran
PH: 7.5
Temperature: 22
uniprot:P31539 [Dextran]

ATP + H2O -> Phosphate + ADP		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Tris-HCl, 5 mM MgCl2, 150 mM NaCl, 0.02% (v/v) TX-100, 25% (w/v) Dextran
PH: 7.5
Temperature: 22
uniprot:P31539 [Poly-L-lysine]

H2O + ATP -> ADP + Phosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Tris-HCl, 5 mM MgCl2, 150 mM NaCl, 0.02% (v/v) TX-100
PH: 7.5
Temperature: 22
uniprot:P31539 [Poly-L-lysine]

ATP + H2O -> Phosphate + ADP		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Tris-HCl, 5 mM MgCl2, 150 mM NaCl, 0.02% (v/v) TX-100
PH: 7.5
Temperature: 22
uniprot:P31539 [Poly-L-lysine]

ATP + H2O -> Phosphate + ADP		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Tris-HCl, 5 mM MgCl2, 150 mM NaCl, 0.02% (v/v) TX-100
PH: 7.5
Temperature: 22
uniprot:P31539 [Poly-L-lysine]

ATP + H2O -> Phosphate + ADP		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Tris-HCl, 5 mM MgCl2, 150 mM NaCl, 0.02% (v/v) TX-100
PH: 7.5
Temperature: 22
uniprot:P31539 [non-chaperonin molecular chaperone ATPase(Enzyme) mutant Hsp104delta22 (C-terminal)]

H2O + ATP -> ADP + Phosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Tris-HCl, 5 mM MgCl2, 150 mM NaCl, 0.02% (v/v) TX-100
PH: 7.5
Temperature: 22
uniprot:P31539 [non-chaperonin molecular chaperone ATPase(Enzyme) mutant Hsp104delta4 (C-terminal)]

H2O + ATP -> ADP + Phosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Tris-HCl, 5 mM MgCl2, 150 mM NaCl, 0.02% (v/v) TX-100
PH: 7.5
Temperature: 22
uniprot:P31539 [non-chaperonin molecular chaperone ATPase(Enzyme) mutant Hsp104delta38 (C-terminal)]

H2O + ATP -> Phosphate + ADP		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Tris-HCl, 5 mM MgCl2, 150 mM NaCl, 0.02% (v/v) TX-100
PH: 7.5
Temperature: 22
uniprot:P31539 [non-chaperonin molecular chaperone ATPase(Enzyme) mutant Hsp104delta4 (C-terminal)]

ATP + H2O -> ADP + Phosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Tris-HCl, 5 mM MgCl2, 36 mM NaCl, 0.02% (v/v) TX-100
PH: 7.5
Temperature: 22
uniprot:P31539 [non-chaperonin molecular chaperone ATPase(Enzyme) wildtype Hsp104]

ATP + H2O -> ADP + Phosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Tris-HCl, 5 mM MgCl2, 36 mM NaCl, 0.02% (v/v) TX-100
PH: 7.5
Temperature: 22
uniprot:P31539 [non-chaperonin molecular chaperone ATPase(Enzyme) wildtype Hsp104]

ATP + H2O -> Phosphate + ADP		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Tris-HCl, 5 mM MgCl2, 150 mM NaCl, 0.02% (v/v) TX-100
PH: 7.5
Temperature: 22
uniprot:P31539 [non-chaperonin molecular chaperone ATPase(Enzyme) mutant Hsp104delta22 (C-terminal)]

H2O + ATP -> ADP + Phosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Tris-HCl, 5 mM MgCl2, 36 mM NaCl, 0.02% (v/v) TX-100
PH: 7.5
Temperature: 22
uniprot:P31539 [non-chaperonin molecular chaperone ATPase(Enzyme) mutant Hsp104delta38 (C-terminal)]

H2O + ATP -> ADP + Phosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Tris-HCl, 5 mM MgCl2, 36 mM NaCl, 0.02% (v/v) TX-100
PH: 7.5
Temperature: 22
uniprot:P31539 [Guanidium chloride]

ATP + H2O -> ADP + Phosphate		 (( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 50 mM Hepes/KOH, 150 mM KCl, 25 mM MgCl2, 2 mM phosphoenolpyruvate, 0.2 mM NADH, 2 units/ml pyruvate kinase, 10 units/ml L-lactate dehydrogenase
PH: 7.5
Temperature: 30
uniprot:P31539 [non-chaperonin molecular chaperone ATPase(Enzyme) wildtype]

H2O + ATP -> ADP + Phosphate		 (( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 50 mM Hepes/KOH, 150 mM KCl, 25 mM MgCl2, 2 mM phosphoenolpyruvate, 0.2 mM NADH, 2 units/ml pyruvate kinase, 10 units/ml L-lactate dehydrogenase
PH: 7.5
Temperature: 30
uniprot:P31539 [non-chaperonin molecular chaperone ATPase(Enzyme) wildtype]

ATP + H2O -> ADP + Phosphate		 (( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 50 mM Hepes/KOH, 150 mM KCl, 10 mM MgCl2, 2 mM phosphoenolpyruvate, 0.2 mM NADH, 2 units/ml pyruvate kinase, 10 units/ml L-lactate dehydrogenase
PH: 7.5
Temperature: 30
uniprot:P31539 [non-chaperonin molecular chaperone ATPase(Enzyme) wildtype]

ATP + H2O -> ADP + Phosphate		 (( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 50 mM Hepes/KOH, 150 mM KCl, 10 mM MgCl2, 2 mM phosphoenolpyruvate, 0.2 mM NADH, 2 units/ml pyruvate kinase, 10 units/ml L-lactate dehydrogenase
PH: 7.5
Temperature: 30
uniprot:P63284 [Casein]

ATP + H2O -> ADP + Phosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 100 mM Tris-HCl, 1 mM Dithiothreitol, 1 mM EDTA
PH: 8
Temperature: 37
uniprot:Q51416 [Mg2+]

H2O + ATP -> ADP + Phosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 100 mM Tris-HCl, 15% (v/v) Glycerol, 10% (v/v) Dimethyl sulfoxide
PH: 8
Temperature: 37
uniprot:P0ABH9 [Casein]

ATP + H2O -> Phosphate + ADP		 (( (Vmax * A) ) / (Km + A)) buffer: 100 mM Tris-HCl, 10 mM MgCl2, 1 mM Dithiothreitol, 1 mM EDTA
PH: 8
Temperature: 37
uniprot:P0ABH9 [Casein]

H2O + ATP -> Phosphate + ADP		 (( (Vmax * A) ) / (Km + A)) buffer: 100 mM Tris-HCl, 10 mM MgCl2, 1 mM Dithiothreitol, 1 mM EDTA
PH: 8
Temperature: 37
uniprot:P31539 [non-chaperonin molecular chaperone ATPase(Enzyme) wildtype Hsp104]

H2O + ATP -> ADP + Phosphate		 (( (( (( (kcat_1 * E) ) * (A ^ n_1)) ) / (( (Km_1 ^ n_1) ) + (A ^ n_1))) ) + (( (( (kcat_2 * E) ) * (A ^ n_2)) ) / (( (Km_2 ^ n_2) ) + (A ^ n_2)))) buffer: 20 mM HEPES, 20 mM NaCl, 10 mM MgCl2
PH: 7.5
Temperature: 30
uniprot:P31539 [non-chaperonin molecular chaperone ATPase(Enzyme) mutant Hsp104 Y819W]

H2O + ATP -> Phosphate + ADP		 (( (( (( (kcat_1 * E) ) * (A ^ n_1)) ) / (( (Km_1 ^ n_1) ) + (A ^ n_1))) ) + (( (( (kcat_2 * E) ) * (A ^ n_2)) ) / (( (Km_2 ^ n_2) ) + (A ^ n_2)))) buffer: 20 mM HEPES, 20 mM NaCl, 10 mM MgCl2
PH: 7.5
Temperature: 30
uniprot:P31539 [non-chaperonin molecular chaperone ATPase(Enzyme) mutant Hsp104 R826M]

ATP + H2O -> ADP + Phosphate		 (( (( (( (kcat_1 * E) ) * (A ^ n_1)) ) / (( (Km_1 ^ n_1) ) + (A ^ n_1))) ) + (( (( (kcat_2 * E) ) * (A ^ n_2)) ) / (( (Km_2 ^ n_2) ) + (A ^ n_2)))) buffer: 20 mM HEPES, 20 mM NaCl, 10 mM MgCl2
PH: 7.5
Temperature: 30
uniprot:P31539 [non-chaperonin molecular chaperone ATPase(Enzyme) wildtype]

H2O + ATP -> Phosphate + ADP		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 20 mM Hepes, 140 mM KCl, 15 mM NaCl, 5 mM MgCl2
PH: 7.5
Temperature: 37
uniprot:P31539 [non-chaperonin molecular chaperone ATPase(Enzyme) mutant K620T]

ATP + H2O -> ADP + Phosphate		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 20 mM Hepes, 140 mM KCl, 15 mM NaCl, 5 mM MgCl2
PH: 7.5
Temperature: 37
uniprot:P31539 [non-chaperonin molecular chaperone ATPase(Enzyme) wildtype]

H2O + ATP -> Phosphate + ADP		 (( (Vmax * A) ) / (Km + A)) buffer: 20 mM Hepes, 140 mM KCl, 15 mM NaCl, 5 mM MgCl2, 2 mM DTT, 0.01% Glutaraldehyde
PH: 7.5
Temperature: 37
uniprot:P31539 [non-chaperonin molecular chaperone ATPase(Enzyme) wildtype]

H2O + ATP -> ADP + Phosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 20 mM Hepes, 140 mM KCl, 15 mM NaCl, 5 mM MgCl2, 2 mM DTT, 0.01% Glutaraldehyde
PH: 7.5
Temperature: 37
uniprot:P31539 [non-chaperonin molecular chaperone ATPase(Enzyme) mutant Hsp104 T317A]

ATP + H2O -> ADP + Phosphate		 (( (( (( (kcat_1 * E) ) * (A ^ n_1)) ) / (( (Km_1 ^ n_1) ) + (A ^ n_1))) ) + (( (( (kcat_2 * E) ) * (A ^ n_2)) ) / (( (Km_2 ^ n_2) ) + (A ^ n_2)))) buffer: 20 mM HEPES, 20 mM NaCl, 10 mM MgCl2
PH: 7.5
Temperature: 30
uniprot:P31539 [non-chaperonin molecular chaperone ATPase(Enzyme) wildtype Hsp104]

ATP + H2O -> Phosphate + ADP		 (( (( (( (kcat_1 * E) ) * (A ^ n_1)) ) / (( (Km_1 ^ n_1) ) + (A ^ n_1))) ) + (( (( (kcat_2 * E) ) * (A ^ n_2)) ) / (( (Km_2 ^ n_2) ) + (A ^ n_2)))) buffer: 20 mM HEPES, 20 mM NaCl, 10 mM MgCl2
PH: 7.5
Temperature: 30
uniprot:P31539 [non-chaperonin molecular chaperone ATPase(Enzyme) mutant Hsp104 N728A]

ATP + H2O -> ADP + Phosphate		 (( (( (kcat_1 * E) ) * (A ^ n_1)) ) / (( (Km_1 ^ n_1) ) + (A ^ n_1))) buffer: 20 mM HEPES, 20 mM NaCl, 10 mM MgCl2
PH: 7.5
Temperature: 30
uniprot:P31539 [non-chaperonin molecular chaperone ATPase(Enzyme) mutant K620T]

H2O + ATP -> Phosphate + ADP		 (( (Vmax * A) ) / (Km + A)) buffer: 20 mM Hepes, 140 mM KCl, 15 mM NaCl, 5 mM MgCl2, 2 mM DTT, 0.01% Glutaraldehyde
PH: 7.5
Temperature: 37
uniprot:P31539 [non-chaperonin molecular chaperone ATPase(Enzyme) mutant K620T]

ATP + H2O -> ADP + Phosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 20 mM Hepes, 140 mM KCl, 15 mM NaCl, 5 mM MgCl2, 2 mM DTT, 0.01% Glutaraldehyde
PH: 7.5
Temperature: 37

Pathways

pathway id name
BioCyc:YEAST_PWY-7250 iron-sulfur cluster biosynthesis
BioCyc:META_PWY-7250 [2Fe-2S] iron-sulfur cluster biosynthesis
Reactome:R-HSA-9613354 Lipophagy
Reactome:R-HSA-9664565 Signaling by ERBB2 KD Mutants
Reactome:R-HSA-9665246 Resistance of ERBB2 KD mutants to neratinib
Reactome:R-HSA-9665244 Resistance of ERBB2 KD mutants to sapitinib
Reactome:R-HSA-9652282 Drug-mediated inhibition of ERBB2 signaling
Reactome:R-HSA-9646399 Aggrephagy
Reactome:R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2
Reactome:R-HSA-9665251 Resistance of ERBB2 KD mutants to lapatinib
Reactome:R-HSA-9665245 Resistance of ERBB2 KD mutants to tesevatinib
Reactome:R-HSA-9663891 Selective autophagy
Reactome:R-HSA-9615710 Late endosomal microautophagy
Reactome:R-HSA-1227990 Signaling by ERBB2 in Cancer
Reactome:R-HSA-9665233 Resistance of ERBB2 KD mutants to trastuzumab
Reactome:R-HSA-9665249 Resistance of ERBB2 KD mutants to afatinib
Reactome:R-HSA-9612973 Autophagy
Reactome:R-HSA-9613829 Chaperone Mediated Autophagy
Reactome:R-HSA-9665230 Drug resistance in ERBB2 KD mutants
Reactome:R-HSA-9665247 Resistance of ERBB2 KD mutants to osimertinib
Reactome:R-HSA-9665250 Resistance of ERBB2 KD mutants to AEE788
Reactome:R-RNO-9652282 Drug-mediated inhibition of ERBB2 signaling
Reactome:R-BTA-9652282 Drug-mediated inhibition of ERBB2 signaling
Reactome:R-HSA-9824439 Bacterial Infection Pathways
Reactome:R-HSA-9820965 Respiratory syncytial virus (RSV) genome replication, transcription and translation
Reactome:R-RNO-9837999 Mitochondrial protein degradation
Reactome:R-HSA-9675108 Nervous system development
Reactome:R-HSA-9665737 Drug resistance in ERBB2 TMD/JMD mutants
Reactome:R-MMU-9652282 Drug-mediated inhibition of ERBB2 signaling
Reactome:R-SSC-9652282 Drug-mediated inhibition of ERBB2 signaling
Reactome:R-HSA-9665348 Signaling by ERBB2 ECD mutants
Reactome:R-HSA-9824446 Viral Infection Pathways
Reactome:R-HSA-8874177 ATF6B (ATF6-beta) activates chaperones
Reactome:R-HSA-9828642 Respiratory syncytial virus genome transcription
Reactome:R-MMU-9837999 Mitochondrial protein degradation
Reactome:R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants
Reactome:R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway
Reactome:R-HSA-9837999 Mitochondrial protein degradation
Reactome:R-MMU-9865881 Complex III assembly
Reactome:R-RNO-9865881 Complex III assembly
Reactome:R-GGA-9909505 Modulation of host responses by IFN-stimulated genes
Reactome:R-HSA-9909505 Modulation of host responses by IFN-stimulated genes
Reactome:R-HSA-9918432 Maturation of DENV proteins
Reactome:R-BTA-9909505 Modulation of host responses by IFN-stimulated genes
Reactome:R-HSA-9918487 Dengue Virus Genome Translation and Replication
Reactome:R-BTA-9865881 Complex III assembly
Reactome:R-HSA-9865881 Complex III assembly
Reactome:R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt)
Reactome:R-SCE-9865881 Complex III assembly
Reactome:R-SPO-9865881 Complex III assembly
Reactome:R-HSA-9839923 Dengue Virus Infection
Reactome:R-HSA-9918485 Dengue Virus Attachment and Entry
Reactome:R-HSA-9918481 Dengue Virus-Host Interactions
Reactome:R-RNO-9009391 Extra-nuclear estrogen signaling
Reactome:R-BTA-9009391 Extra-nuclear estrogen signaling
Reactome:R-HSA-9009391 Extra-nuclear estrogen signaling
Reactome:R-MMU-9009391 Extra-nuclear estrogen signaling
Reactome:R-BTA-597592 Post-translational protein modification
Reactome:R-BTA-1640170 Cell Cycle
Reactome:R-BTA-380259 Loss of Nlp from mitotic centrosomes
Reactome:R-BTA-168256 Immune System
Reactome:R-BTA-913531 Interferon Signaling
Reactome:R-BTA-72172 mRNA Splicing
Reactome:R-BTA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements
Reactome:R-BTA-1430728 Metabolism
Reactome:R-BTA-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-BTA-6799198 Complex I biogenesis
Reactome:R-BTA-8978934 Metabolism of cofactors
Reactome:R-BTA-8953897 Cellular responses to stimuli
Reactome:R-BTA-2262752 Cellular responses to stress
Reactome:R-BTA-3371511 HSF1 activation
Reactome:R-BTA-199991 Membrane Trafficking
Reactome:R-BTA-112310 Neurotransmitter release cycle
Reactome:R-BTA-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-BTA-194138 Signaling by VEGF
Reactome:R-BTA-5218920 VEGFR2 mediated vascular permeability
Reactome:R-BTA-8863795 Downregulation of ERBB2 signaling
Reactome:R-BTA-8939211 ESR-mediated signaling
Reactome:R-GGA-1280215 Cytokine Signaling in Immune system
Reactome:R-HSA-432722 Golgi Associated Vesicle Biogenesis
Reactome:R-HSA-5620912 Anchoring of the basal body to the plasma membrane
Reactome:R-HSA-422475 Axon guidance
Reactome:R-HSA-114608 Platelet degranulation
Reactome:R-HSA-202131 Metabolism of nitric oxide: NOS3 activation and regulation
Reactome:R-HSA-611105 Respiratory electron transport
Reactome:R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Reactome:R-HSA-5675482 Regulation of necroptotic cell death
Reactome:R-HSA-1227986 Signaling by ERBB2
Reactome:R-HSA-8863795 Downregulation of ERBB2 signaling
Reactome:R-HSA-112315 Transmission across Chemical Synapses
Reactome:R-HSA-888590 GABA synthesis, release, reuptake and degradation
Reactome:R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
Reactome:R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
Reactome:R-HSA-68877 Mitotic Prometaphase
Reactome:R-HSA-392499 Metabolism of proteins
Reactome:R-HSA-597592 Post-translational protein modification
Reactome:R-HSA-381070 IRE1alpha activates chaperones
Reactome:R-HSA-1643685 Disease
Reactome:R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Reactome:R-HSA-168273 Influenza Viral RNA Transcription and Replication
Reactome:R-HSA-5339562 Uptake and actions of bacterial toxins
Reactome:R-HSA-74160 Gene expression (Transcription)
Reactome:R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Reactome:R-HSA-72172 mRNA Splicing
Reactome:R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements
Reactome:R-MMU-1640170 Cell Cycle
Reactome:R-MMU-380259 Loss of Nlp from mitotic centrosomes
Reactome:R-MMU-168256 Immune System
Reactome:R-MMU-168249 Innate Immune System
Reactome:R-MMU-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-202131 Metabolism of nitric oxide: NOS3 activation and regulation
Reactome:R-MMU-611105 Respiratory electron transport
Reactome:R-MMU-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Reactome:R-MMU-8953854 Metabolism of RNA
Reactome:R-MMU-72163 pre-mRNA splicing
Reactome:R-MMU-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
Reactome:R-MMU-5357801 Programmed Cell Death
Reactome:R-MMU-5675482 Regulation of necroptotic cell death
Reactome:R-MMU-3371497 HSP90 chaperone cycle for SHRs
Reactome:R-MMU-162582 Signaling Pathways
Reactome:R-MMU-8939211 ESR-mediated signaling
Reactome:R-MMU-8876725 Protein methylation
Reactome:R-MMU-432720 Lysosome Vesicle Biogenesis
Reactome:R-RNO-5620912 Anchoring of the basal body to the plasma membrane
Reactome:R-RNO-72203 Processing of Capped Intron-Containing Pre-mRNA
Reactome:R-RNO-202131 Metabolism of nitric oxide: NOS3 activation and regulation
Reactome:R-RNO-611105 Respiratory electron transport
Reactome:R-RNO-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Reactome:R-RNO-69275 G2/M Transition
Reactome:R-RNO-380287 Centrosome maturation
Reactome:R-RNO-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
Reactome:R-RNO-68886 M Phase
Reactome:R-RNO-380320 Recruitment of NuMA to mitotic centrosomes
Reactome:R-RNO-112316 Neuronal System
Reactome:R-RNO-597592 Post-translational protein modification
Reactome:R-RNO-162582 Signaling Pathways
Reactome:R-RNO-4420097 VEGFA-VEGFR2 Pathway
Reactome:R-RNO-9006931 Signaling by Nuclear Receptors
Reactome:R-RNO-9018519 Estrogen-dependent gene expression
Reactome:R-RNO-199991 Membrane Trafficking
Reactome:R-RNO-5213460 RIPK1-mediated regulated necrosis
Reactome:R-SCE-8953897 Cellular responses to stimuli
Reactome:R-SCE-3371556 Cellular response to heat stress
Reactome:R-SCE-3371453 Regulation of HSF1-mediated heat shock response
Reactome:R-SCE-611105 Respiratory electron transport
Reactome:R-SPO-1430728 Metabolism
Reactome:R-SPO-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-SPO-3371453 Regulation of HSF1-mediated heat shock response
Reactome:R-SSC-8953897 Cellular responses to stimuli
Reactome:R-SSC-2262752 Cellular responses to stress
Reactome:R-SSC-3371511 HSF1 activation
Reactome:R-SSC-69278 Cell Cycle, Mitotic
Reactome:R-SSC-380270 Recruitment of mitotic centrosome proteins and complexes
Reactome:R-SSC-8854518 AURKA Activation by TPX2
Reactome:R-SSC-68877 Mitotic Prometaphase
Reactome:R-SSC-5357801 Programmed Cell Death
Reactome:R-SSC-5675482 Regulation of necroptotic cell death
Reactome:R-SSC-1227986 Signaling by ERBB2
Reactome:R-SSC-168256 Immune System
Reactome:R-SSC-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome:R-BTA-8876725 Protein methylation
Reactome:R-BTA-453274 Mitotic G2-G2/M phases
Reactome:R-BTA-2565942 Regulation of PLK1 Activity at G2/M Transition
Reactome:R-BTA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
Reactome:R-BTA-68877 Mitotic Prometaphase
Reactome:R-BTA-168249 Innate Immune System
Reactome:R-BTA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome:R-BTA-1280215 Cytokine Signaling in Immune system
Reactome:R-BTA-72203 Processing of Capped Intron-Containing Pre-mRNA
Reactome:R-BTA-202131 Metabolism of nitric oxide: NOS3 activation and regulation
Reactome:R-BTA-611105 Respiratory electron transport
Reactome:R-BTA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Reactome:R-BTA-5675482 Regulation of necroptotic cell death
Reactome:R-BTA-3371556 Cellular response to heat stress
Reactome:R-BTA-3371453 Regulation of HSF1-mediated heat shock response
Reactome:R-BTA-5653656 Vesicle-mediated transport
Reactome:R-BTA-112316 Neuronal System
Reactome:R-BTA-5620912 Anchoring of the basal body to the plasma membrane
Reactome:R-BTA-162582 Signaling Pathways
Reactome:R-BTA-4420097 VEGFA-VEGFR2 Pathway
Reactome:R-DME-8953897 Cellular responses to stimuli
Reactome:R-DME-3371556 Cellular response to heat stress
Reactome:R-DME-3371453 Regulation of HSF1-mediated heat shock response
Reactome:R-HSA-199991 Membrane Trafficking
Reactome:R-HSA-1592230 Mitochondrial biogenesis
Reactome:R-HSA-5617833 Cilium Assembly
Reactome:R-HSA-1266738 Developmental Biology
Reactome:R-HSA-76002 Platelet activation, signaling and aggregation
Reactome:R-HSA-196854 Metabolism of vitamins and cofactors
Reactome:R-HSA-5213460 RIPK1-mediated regulated necrosis
Reactome:R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-HSA-194138 Signaling by VEGF
Reactome:R-HSA-5218920 VEGFR2 mediated vascular permeability
Reactome:R-HSA-9006931 Signaling by Nuclear Receptors
Reactome:R-HSA-9018519 Estrogen-dependent gene expression
Reactome:R-HSA-2262752 Cellular responses to stress
Reactome:R-HSA-3371511 HSF1 activation
Reactome:R-HSA-1640170 Cell Cycle
Reactome:R-HSA-453274 Mitotic G2-G2/M phases
Reactome:R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
Reactome:R-HSA-8854518 AURKA Activation by TPX2
Reactome:R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
Reactome:R-HSA-8876725 Protein methylation
Reactome:R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes
Reactome:R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer
Reactome:R-HSA-5336415 Uptake and function of diphtheria toxin
Reactome:R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome:R-HSA-913531 Interferon Signaling
Reactome:R-HSA-449147 Signaling by Interleukins
Reactome:R-HSA-9020591 Interleukin-12 signaling
Reactome:R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
Reactome:R-MMU-453274 Mitotic G2-G2/M phases
Reactome:R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
Reactome:R-MMU-380284 Loss of proteins required for interphase microtubule organization from the centrosome
Reactome:R-MMU-196854 Metabolism of vitamins and cofactors
Reactome:R-MMU-72172 mRNA Splicing
Reactome:R-MMU-450531 Regulation of mRNA stability by proteins that bind AU-rich elements
Reactome:R-MMU-5213460 RIPK1-mediated regulated necrosis
Reactome:R-MMU-1227986 Signaling by ERBB2
Reactome:R-MMU-432722 Golgi Associated Vesicle Biogenesis
Reactome:R-MMU-8856828 Clathrin-mediated endocytosis
Reactome:R-MMU-112310 Neurotransmitter release cycle
Reactome:R-RNO-1852241 Organelle biogenesis and maintenance
Reactome:R-RNO-5617833 Cilium Assembly
Reactome:R-RNO-196854 Metabolism of vitamins and cofactors
Reactome:R-RNO-1640170 Cell Cycle
Reactome:R-RNO-380259 Loss of Nlp from mitotic centrosomes
Reactome:R-RNO-112315 Transmission across Chemical Synapses
Reactome:R-RNO-888590 GABA synthesis, release, reuptake and degradation
Reactome:R-RNO-392499 Metabolism of proteins
Reactome:R-RNO-8876725 Protein methylation
Reactome:R-RNO-8953897 Cellular responses to stimuli
Reactome:R-RNO-2262752 Cellular responses to stress
Reactome:R-RNO-3371511 HSF1 activation
Reactome:R-RNO-8939211 ESR-mediated signaling
Reactome:R-RNO-5653656 Vesicle-mediated transport
Reactome:R-RNO-199992 trans-Golgi Network Vesicle Budding
Reactome:R-RNO-5218859 Regulated Necrosis
Reactome:R-RNO-168256 Immune System
Reactome:R-RNO-168249 Innate Immune System
Reactome:R-SCE-1430728 Metabolism
Reactome:R-SPO-611105 Respiratory electron transport
Reactome:R-SPO-2262752 Cellular responses to stress
Reactome:R-SSC-3371556 Cellular response to heat stress
Reactome:R-SSC-5620912 Anchoring of the basal body to the plasma membrane
Reactome:R-SSC-69275 G2/M Transition
Reactome:R-SSC-380287 Centrosome maturation
Reactome:R-SSC-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
Reactome:R-SSC-68886 M Phase
Reactome:R-SSC-380320 Recruitment of NuMA to mitotic centrosomes
Reactome:R-SSC-5213460 RIPK1-mediated regulated necrosis
Reactome:R-SSC-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-SSC-194138 Signaling by VEGF
Reactome:R-SSC-8863795 Downregulation of ERBB2 signaling
Reactome:R-SSC-168249 Innate Immune System
Reactome:R-BTA-392499 Metabolism of proteins
Reactome:R-BTA-69275 G2/M Transition
Reactome:R-BTA-380287 Centrosome maturation
Reactome:R-BTA-68886 M Phase
Reactome:R-BTA-8953854 Metabolism of RNA
Reactome:R-BTA-72163 pre-mRNA splicing
Reactome:R-BTA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
Reactome:R-BTA-203615 eNOS activation
Reactome:R-BTA-5218859 Regulated Necrosis
Reactome:R-BTA-8856828 Clathrin-mediated endocytosis
Reactome:R-BTA-1227986 Signaling by ERBB2
Reactome:R-BTA-9006931 Signaling by Nuclear Receptors
Reactome:R-BTA-9018519 Estrogen-dependent gene expression
Reactome:R-DME-2262752 Cellular responses to stress
Reactome:R-GGA-913531 Interferon Signaling
Reactome:R-HSA-432720 Lysosome Vesicle Biogenesis
Reactome:R-HSA-8856828 Clathrin-mediated endocytosis
Reactome:R-HSA-373760 L1CAM interactions
Reactome:R-HSA-447041 CHL1 interactions
Reactome:R-HSA-109582 Hemostasis
Reactome:R-HSA-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-HSA-6799198 Complex I biogenesis
Reactome:R-HSA-8978934 Metabolism of cofactors
Reactome:R-HSA-5357801 Programmed Cell Death
Reactome:R-HSA-3371497 HSP90 chaperone cycle for SHRs
Reactome:R-HSA-112316 Neuronal System
Reactome:R-HSA-69278 Cell Cycle, Mitotic
Reactome:R-HSA-69275 G2/M Transition
Reactome:R-HSA-380259 Loss of Nlp from mitotic centrosomes
Reactome:R-HSA-381119 Unfolded Protein Response (UPR)
Reactome:R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
Reactome:R-HSA-5637812 Signaling by EGFRvIII in Cancer
Reactome:R-HSA-192905 vRNP Assembly
Reactome:R-HSA-9609507 Protein localization
Reactome:R-HSA-211000 Gene Silencing by RNA
Reactome:R-HSA-168256 Immune System
Reactome:R-HSA-168249 Innate Immune System
Reactome:R-HSA-8953854 Metabolism of RNA
Reactome:R-HSA-72163 pre-mRNA splicing
Reactome:R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
Reactome:R-MMU-69275 G2/M Transition
Reactome:R-MMU-380287 Centrosome maturation
Reactome:R-MMU-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
Reactome:R-MMU-68886 M Phase
Reactome:R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
Reactome:R-MMU-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-MMU-6799198 Complex I biogenesis
Reactome:R-MMU-8978934 Metabolism of cofactors
Reactome:R-MMU-3371556 Cellular response to heat stress
Reactome:R-MMU-3371453 Regulation of HSF1-mediated heat shock response
Reactome:R-MMU-1852241 Organelle biogenesis and maintenance
Reactome:R-MMU-5617833 Cilium Assembly
Reactome:R-MMU-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-MMU-4420097 VEGFA-VEGFR2 Pathway
Reactome:R-MMU-9006931 Signaling by Nuclear Receptors
Reactome:R-MMU-9018519 Estrogen-dependent gene expression
Reactome:R-MMU-392499 Metabolism of proteins
Reactome:R-MMU-597592 Post-translational protein modification
Reactome:R-MMU-5653656 Vesicle-mediated transport
Reactome:R-MMU-199992 trans-Golgi Network Vesicle Budding
Reactome:R-MMU-112315 Transmission across Chemical Synapses
Reactome:R-MMU-888590 GABA synthesis, release, reuptake and degradation
Reactome:R-RNO-72172 mRNA Splicing
Reactome:R-RNO-450531 Regulation of mRNA stability by proteins that bind AU-rich elements
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-RNO-6799198 Complex I biogenesis
Reactome:R-RNO-8978934 Metabolism of cofactors
Reactome:R-RNO-69278 Cell Cycle, Mitotic
Reactome:R-RNO-380270 Recruitment of mitotic centrosome proteins and complexes
Reactome:R-RNO-68877 Mitotic Prometaphase
Reactome:R-RNO-112310 Neurotransmitter release cycle
Reactome:R-RNO-3371497 HSP90 chaperone cycle for SHRs
Reactome:R-RNO-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-RNO-194138 Signaling by VEGF
Reactome:R-RNO-5218920 VEGFR2 mediated vascular permeability
Reactome:R-RNO-8863795 Downregulation of ERBB2 signaling
Reactome:R-RNO-432722 Golgi Associated Vesicle Biogenesis
Reactome:R-RNO-8856828 Clathrin-mediated endocytosis
Reactome:R-RNO-5357801 Programmed Cell Death
Reactome:R-RNO-5675482 Regulation of necroptotic cell death
Reactome:R-SCE-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-SPO-8953897 Cellular responses to stimuli
Reactome:R-SPO-3371556 Cellular response to heat stress
Reactome:R-SSC-453274 Mitotic G2-G2/M phases
Reactome:R-SSC-2565942 Regulation of PLK1 Activity at G2/M Transition
Reactome:R-SSC-380284 Loss of proteins required for interphase microtubule organization from the centrosome
Reactome:R-SSC-8939211 ESR-mediated signaling
Reactome:R-BTA-69278 Cell Cycle, Mitotic
Reactome:R-BTA-380270 Recruitment of mitotic centrosome proteins and complexes
Reactome:R-BTA-8854518 AURKA Activation by TPX2
Reactome:R-BTA-380320 Recruitment of NuMA to mitotic centrosomes
Reactome:R-BTA-196854 Metabolism of vitamins and cofactors
Reactome:R-BTA-5357801 Programmed Cell Death
Reactome:R-BTA-5213460 RIPK1-mediated regulated necrosis
Reactome:R-BTA-3371497 HSP90 chaperone cycle for SHRs
Reactome:R-BTA-112315 Transmission across Chemical Synapses
Reactome:R-BTA-888590 GABA synthesis, release, reuptake and degradation
Reactome:R-BTA-1852241 Organelle biogenesis and maintenance
Reactome:R-BTA-5617833 Cilium Assembly
Reactome:R-GGA-168256 Immune System
Reactome:R-HSA-5653656 Vesicle-mediated transport
Reactome:R-HSA-199992 trans-Golgi Network Vesicle Budding
Reactome:R-HSA-1852241 Organelle biogenesis and maintenance
Reactome:R-HSA-8949613 Cristae formation
Reactome:R-HSA-76005 Response to elevated platelet cytosolic Ca2+
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-203615 eNOS activation
Reactome:R-HSA-5218859 Regulated Necrosis
Reactome:R-HSA-162582 Signaling Pathways
Reactome:R-HSA-4420097 VEGFA-VEGFR2 Pathway
Reactome:R-HSA-8939211 ESR-mediated signaling
Reactome:R-HSA-8953897 Cellular responses to stimuli
Reactome:R-HSA-1632852 Macroautophagy
Reactome:R-HSA-3371556 Cellular response to heat stress
Reactome:R-HSA-3371453 Regulation of HSF1-mediated heat shock response
Reactome:R-HSA-112310 Neurotransmitter release cycle
Reactome:R-HSA-380287 Centrosome maturation
Reactome:R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
Reactome:R-HSA-68886 M Phase
Reactome:R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones
Reactome:R-HSA-381042 PERK regulates gene expression
Reactome:R-HSA-1643713 Signaling by EGFR in Cancer
Reactome:R-HSA-5637810 Constitutive Signaling by EGFRvIII
Reactome:R-HSA-5663205 Infectious disease
Reactome:R-HSA-168255 Influenza Infection
Reactome:R-HSA-1268020 Mitochondrial protein import
Reactome:R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis
Reactome:R-HSA-1280215 Cytokine Signaling in Immune system
Reactome:R-HSA-447115 Interleukin-12 family signaling
Reactome:R-MMU-69278 Cell Cycle, Mitotic
Reactome:R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
Reactome:R-MMU-8854518 AURKA Activation by TPX2
Reactome:R-MMU-68877 Mitotic Prometaphase
Reactome:R-MMU-203615 eNOS activation
Reactome:R-MMU-72203 Processing of Capped Intron-Containing Pre-mRNA
Reactome:R-MMU-5218859 Regulated Necrosis
Reactome:R-MMU-8953897 Cellular responses to stimuli
Reactome:R-MMU-2262752 Cellular responses to stress
Reactome:R-MMU-3371511 HSF1 activation
Reactome:R-MMU-5620912 Anchoring of the basal body to the plasma membrane
Reactome:R-MMU-194138 Signaling by VEGF
Reactome:R-MMU-5218920 VEGFR2 mediated vascular permeability
Reactome:R-MMU-8863795 Downregulation of ERBB2 signaling
Reactome:R-MMU-199991 Membrane Trafficking
Reactome:R-MMU-112316 Neuronal System
Reactome:R-RNO-8953854 Metabolism of RNA
Reactome:R-RNO-72163 pre-mRNA splicing
Reactome:R-RNO-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
Reactome:R-RNO-203615 eNOS activation
Reactome:R-RNO-453274 Mitotic G2-G2/M phases
Reactome:R-RNO-2565942 Regulation of PLK1 Activity at G2/M Transition
Reactome:R-RNO-380284 Loss of proteins required for interphase microtubule organization from the centrosome
Reactome:R-RNO-3371556 Cellular response to heat stress
Reactome:R-RNO-3371453 Regulation of HSF1-mediated heat shock response
Reactome:R-RNO-1227986 Signaling by ERBB2
Reactome:R-RNO-432720 Lysosome Vesicle Biogenesis
Reactome:R-RNO-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome:R-SCE-2262752 Cellular responses to stress
Reactome:R-SSC-3371497 HSP90 chaperone cycle for SHRs
Reactome:R-SSC-1852241 Organelle biogenesis and maintenance
Reactome:R-SSC-5617833 Cilium Assembly
Reactome:R-SSC-1640170 Cell Cycle
Reactome:R-SSC-380259 Loss of Nlp from mitotic centrosomes
Reactome:R-SSC-5218859 Regulated Necrosis
Reactome:R-SSC-162582 Signaling Pathways
Reactome:R-SSC-4420097 VEGFA-VEGFR2 Pathway
Reactome:R-SSC-9006931 Signaling by Nuclear Receptors
Reactome:R-SSC-9018519 Estrogen-dependent gene expression
WikiPathways:WP4861 Endoplasmic reticulum stress response in coronavirus infection
WikiPathways:WP5356 Disturbed pathways in Duchenne Muscular Dystrophy
PathBank:SMP0030406 Androstenedione Metabolism
PathBank:SMP0000327 Phenytoin (Antiarrhythmic) Action Pathway
PathBank:SMP0000406 Morphine Action Pathway
PathBank:SMP0000601 Etoposide Metabolism Pathway
PathBank:SMP0000086 Ibuprofen Action Pathway
PathBank:SMP0000441 Prednisolone Action Pathway
PathBank:SMP0000600 Irinotecan Metabolism Pathway
PathBank:SMP0000632 Prednisolone Metabolism Pathway
PathBank:SMP0000640 Acetaminophen Metabolism Pathway
PathBank:SMP0000648 Sorafenib Metabolism Pathway
PathBank:SMP0087353 Retinol Metabolism
PathBank:SMP0087365 Estrone Metabolism
PathBank:SMP0120720 Vitamin A Deficiency
PathBank:SMP0108202 Ahr Signal Transduction Pathway
PathBank:SMP0000074 Retinol Metabolism
PathBank:SMP0000336 Vitamin A Deficiency
PathBank:SMP0000442 Etoposide Action Pathway
PathBank:SMP0000590 Ibuprofen Metabolism Pathway
PathBank:SMP0000622 Morphine Metabolism Pathway
PathBank:SMP0087364 Androstenedione Metabolism
PathBank:SMP0063771 Ahr Signal Transduction Pathway
PathBank:SMP0030880 Estrone Metabolism
PathBank:SMP0108155 Ahr Signal Transduction Pathway
PathBank:SMP0000433 Irinotecan Action Pathway