Thiamin Diphosphate Biosynthesis

Metabolites

5'-Deoxyadenosine

Formula: C10H13N5O3 (251.10183480000003)

CAS ID: 4754-39-6

ADP

Formula: C10H15N5O10P2 (427.02941500000003)

CAS ID: 58-64-0

Aminoimidazole ribotide

Formula: C8H14N3O7P (295.0569344)

CAS ID: 25635-88-5

ATP

Formula: C10H16N5O13P3 (506.9957476)

CAS ID: 56-65-5

CO

Formula: CO (27.994915)

CAS ID: 630-08-0

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

L-Glutamate

Formula: C5H9NO4 (147.0531554)

CAS ID: 56-86-0

L-Glutamine

Formula: C5H10N2O3 (146.069139)

CAS ID: 56-85-9

L-Methionine

Formula: C5H11NO2S (149.0510466)

CAS ID: 63-68-3

diphosphate

Formula: O7P2 (173.911931)

CAS ID: 14000-31-8

phosphate(3-)

Formula: O4P (94.953423)

CAS ID: 14265-44-2



Enzyme

EC Number name full name note
2.1.2.2 phosphoribosylglycinamide formyltransferase 1 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase
2.4.2.14 amidophosphoribosyltransferase 5-phospho-beta-D-ribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)
2.5.1.3 thiamine phosphate synthase 4-amino-2-methyl-5-diphosphomethylpyrimidine:2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate 4-amino-2-methylpyrimidine-5-methenyltransferase (decarboxylating)
2.7.1.49 hydroxymethylpyrimidine kinase ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase
2.7.4.16 thiamine-phosphate kinase ATP:thiamine-phosphate phosphotransferase
2.7.4.7 phosphooxymethylpyrimidine kinase ATP:4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine phosphotransferase
4.1.99.17 phosphomethylpyrimidine synthase 5-amino-1-(5-phospho-D-ribosyl)imidazole formate-lyase (decarboxylating, 4-amino-2-methyl-5-phosphomethylpyrimidine-forming)
6.3.1.21 phosphoribosylglycinamide formyltransferase 2 formate:N1-(5-phospho-beta-D-ribosyl)glycinamide ligase (ADP-forming)
6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)
6.3.4.13 phosphoribosylamine-glycine ligase 5-phospho-D-ribosylamine:glycine ligase (ADP-forming)
6.3.5.3 phosphoribosylformylglycinamidine synthase N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)


Proteins

Protein ID name full name
P08178 purM Phosphoribosylformylglycinamidine cyclo-ligase
P08179 purN Phosphoribosylglycinamide formyltransferase
P0AG16 purF Amidophosphoribosyltransferase
P0AGG0 thiL Thiamine-monophosphate kinase
P15254 purL Phosphoribosylformylglycinamidine synthase
P15640 purD Phosphoribosylamine--glycine ligase
P30136 thiC Phosphomethylpyrimidine synthase
P30137 thiE Thiamine-phosphate synthase
P33221 purT Formate-dependent phosphoribosylglycinamide formyltransferase
P76422 thiD Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase