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Phosphoribosyl pyrophosphate, also known as PRPP or PRib-PP, belongs to the class of organic compounds known as pentose phosphates. These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups. Phosphoribosyl pyrophosphate is an extremely weak basic (essentially neutral) compound (based on its pKa). Phosphoribosyl pyrophosphate exists in all living species, ranging from bacteria to humans. Within humans, phosphoribosyl pyrophosphate participates in a number of enzymatic reactions. In particular, guanine and phosphoribosyl pyrophosphate can be biosynthesized from guanosine monophosphate through its interaction with the enzyme adenine phosphoribosyltransferase. In addition, guanine and phosphoribosyl pyrophosphate can be biosynthesized from guanosine monophosphate; which is catalyzed by the enzyme hypoxanthine-guanine phosphoribosyltransferase. In humans, phosphoribosyl pyrophosphate is involved in adenosine deaminase deficiency. Phosphoribosyl pyrophosphate is a pentosephosphate and it is the key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides. It is formed from ribose 5-phosphate by the enzyme ribose-phosphate diphosphokinase. It plays a role in transferring phosphate groups in several reactions.

5-O-phosphonato-alpha-D-ribofuranosyl Diphosphate(5-) is also known as 5-phospho-a-D-Ribose 1-diphosphoric acid or 5-Phosphonatoribosyl 1-pyrophosphate. 5-O-phosphonato-alpha-D-ribofuranosyl Diphosphate(5-) is considered to be soluble (in water) and acidic

5-O-phosphono-D-ribofuranosyl diphosphate is a 5-phosphoribosyl diphosphate.

A 5-O-phosphono-D-ribofuranosyl diphosphate with a beta-configuration at the anomeric position." []

A D-ribose 5-triphosphate in which the ribose is in the furanose form and has alpha-configuration at the anomeric centre." []