5'-Phosphoribosyl-N-formylglycinamide (BioCAD00000005033)

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Metabolite Card

Formula: C8H15N2O9P (314.0515)
SMILES: O[C@H]1[C@@H](O)[C@H](NC(=O)CNC=O)O[C@@H]1COP(O)(O)=O

Synonyms [en]

5'-Phosphoribosyl-N-formylglycinamide; N-Formyl-GAR; N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide; N-Formylglycinamide ribonucleotide; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide; 2-(Formylamino)-N-(5-O-phosphono-beta-D-ribofuranosyl)acetamide

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

5'-Phosphoribosyl-N-formylglycinamide. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000005033). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

5'-Phosphoribosyl-N-formylglycinamide, also known as FGAR or N-formyl-GAR, belongs to the class of organic compounds known as glycinamide ribonucleotides. Glycinamide ribonucleotides are compounds in which the amide N atom of glycineamide is linked to the C-1 of a ribosyl (or deoxyribosyl) moiety. FGAR is an extremely weak basic (essentially neutral) compound (based on its pKa). FGAR is a substrate for phosphoribosylformylglycinamidine synthase. It is involved in aminoimidazole ribonucleotide biosynthesis and plays a vital role in purine metabolism as well as in the conversion of glutamine to glutamate.

Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 349-34-8
  • PubChem: 130805
  • PubChem: 151
  • PubChem: 16048611
  • ChEBI: ChEBI:18272
  • HMDB: HMDB0001308
  • KEGG: C04376
  • NCBI MeSH: phosphoribosyl-N-formylglycineamide
  • Wikipedia: Phosphoribosyl-N-formylglycineamide
  • RefMet: RM0033450
  • Metlin: METLIN_3443
  • Coconut NaturalProduct: CNP0359509.1
  • Coconut NaturalProduct: CNP0359509.3

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R04325 2.1.2.2 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase
KEGG:R04326 2.1.2.2 C03838 + C00445 + C00001<=>C04376 + C00101
KEGG:R04463 6.3.5.3 5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)
KEGG:R06974 6.3.1.21 formate:N1-(5-phospho-beta-D-ribosyl)glycinamide ligase (ADP-forming)
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Organism Source

Taxonomy Source

Pathway Synthetic

pathway id name
BioCyc:TRYPANO_PRPP-PWY superpathway of histidine, purine, and pyrimidine biosynthesis
BioCyc:TRYPANO_DENOVOPURINE2-PWY purine nucleotides de novo biosynthesis I
BioCyc:TRYPANO_PWY-6122 5-aminoimidazole ribonucleotide biosynthesis II
BioCyc:TRYPANO_PWY-841 purine nucleotides de novo biosynthesis II
BioCyc:TRYPANO_PWY-6121 5-aminoimidazole ribonucleotide biosynthesis I
PathBank:SMP0000927 Purine Nucleotides De Novo Biosynthesis
PathBank:SMP0001750 One Carbon Pool by Folate
PathBank:SMP0002042 Thiamin Diphosphate Biosynthesis
PathBank:SMP0002047 Purine Nucleotides De Novo Biosynthesis 2
WikiPathways:WP2185 Purine metabolism
WikiPathways:WP3604 Biochemical pathways: part I
PathBank:SMP0120670 Adenylosuccinate Lyase Deficiency
PathBank:SMP0120448 Adenosine Deaminase Deficiency
PathBank:SMP0120452 AICA-Ribosiduria
PathBank:SMP0120508 Lesch-Nyhan Syndrome (LNS)
PathBank:SMP0120532 Molybdenum Cofactor Deficiency
PathBank:SMP0120536 Purine Nucleoside Phosphorylase Deficiency
PathBank:SMP0120577 Xanthinuria Type I
PathBank:SMP0120601 Mitochondrial DNA Depletion Syndrome
PathBank:SMP0122040 One Carbon Pool by Folate
View All Pathways