EC: 3.1.4.11

phosphoinositide phospholipase C (1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase)

enzyme lambda metabolic reaction experiment
uniprot:P10688 [Ca2+]

1_Phosphatidyl_D_myo_inositol_4,5_bisphosphate + H2O -> 1,2_Diacyl_sn_glycerol + D_myo_Inositol_1,4,5_trisphosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM Tris-HCl, 100 mM NaCl, 0.5% Sodium cholate, 5 mM 2-Mercaptoethanol, 0.4 mg/ml Bovine serum albumin
PH: 6.8
Temperature: 37
uniprot:P10688 [Ca2+]

H2O + 1_Phosphatidyl_D_myo_inositol_4,5_bisphosphate -> 1,2_Diacyl_sn_glycerol + D_myo_Inositol_1,4,5_trisphosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM Tris-HCl, 100 mM NaCl, 0.5% Sodium cholate, 5 mM 2-Mercaptoethanol, 0.4 mg/ml Bovine serum albumin
PH: 6.8
Temperature: 37
uniprot:P10688 [Ca2+]

H2O + 1_Phosphatidyl_D_myo_inositol_4,5_bisphosphate -> D_myo_Inositol_1,4,5_trisphosphate + 1,2_Diacyl_sn_glycerol		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM Tris-HCl, 100 mM NaCl, 0.5% Sodium cholate, 5 mM 2-Mercaptoethanol, 0.4 mg/ml Bovine serum albumin
PH: 6.8
Temperature: 37
uniprot:P10688 [Ca2+]

1_Phosphatidyl_D_myo_inositol_4,5_bisphosphate + H2O -> D_myo_Inositol_1,4,5_trisphosphate + 1,2_Diacyl_sn_glycerol		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM Tris-HCl, 100 mM NaCl, 0.5% Sodium cholate, 5 mM 2-Mercaptoethanol, 0.4 mg/ml Bovine serum albumin
PH: 6.8
Temperature: 37
uniprot:P10688 [Ca2+]

1_Phosphatidyl_D_myo_inositol_4,5_bisphosphate + H2O -> D_myo_Inositol_1,4,5_trisphosphate + 1,2_Diacyl_sn_glycerol		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM Tris-HCl, 100 mM NaCl, 0.5% Sodium cholate, 5 mM 2-Mercaptoethanol, 0.4 mg/ml Bovine serum albumin
PH: 6.8
Temperature: 37
uniprot:Q00722 [phosphoinositide phospholipase C(Enzyme) wildtype PLC-beta2]

1_Phosphatidyl_D_myo_inositol_4,5_bisphosphate + H2O -> 1,2_Diacyl_sn_glycerol + D_myo_Inositol_1,4,5_trisphosphate		 (( (Vmax * S) ) / (Km + S)) buffer: 10 mM Hepes, 0.5% (w/v) sodium cholate, 120 mM KCl, 10 mM NaCl, 2 mM EGTA, 2.1 mM CaCl2, 0.5 mg/ml fatty acid-free BSA
PH: 7.2
Temperature: 30
uniprot:P10894 [phosphoinositide phospholipase C(Enzyme) wildtype PLC-beta1]

1_Phosphatidyl_D_myo_inositol_4,5_bisphosphate + H2O -> 1,2_Diacyl_sn_glycerol + D_myo_Inositol_1,4,5_trisphosphate		 (( (Vmax * S) ) / (Km + S)) buffer: 10 mM Hepes, 0.5% (w/v) sodium cholate, 120 mM KCl, 10 mM NaCl, 2.1 mM CaCl2, 2 mM EGTA, 0.5 mg/ml fatty acid-free BSA
PH: 7.2
Temperature: 30
uniprot:P10687 [phosphoinositide phospholipase C(Enzyme) wildtype PLC-beta1]

1_Phosphatidyl_D_myo_inositol_4,5_bisphosphate + H2O -> D_myo_Inositol_1,4,5_trisphosphate + 1,2_Diacyl_sn_glycerol		 (( (Vmax * S) ) / (Km + S)) buffer: 10 mM Hepes, 0.5% (w/v) sodium cholate, 120 mM KCl, 10 mM NaCl, 2 mM EGTA, 2.1 mM CaCl2, 0.5 mg/ml fatty acid-free BSA
PH: 7.2
Temperature: 30
uniprot:Q00722 [phosphoinositide phospholipase C(Enzyme) wildtype PLC-beta2]

1_Phosphatidyl_D_myo_inositol_4,5_bisphosphate + H2O -> 1,2_Diacyl_sn_glycerol + D_myo_Inositol_1,4,5_trisphosphate		 (( (Vmax * S) ) / (Km + S)) buffer: 10 mM Hepes, 0.5% (w/v) sodium cholate, 120 mM KCl, 10 mM NaCl, 2 mM EGTA, 2.1 mM CaCl2, 0.5 mg/ml fatty acid-free BSA
PH: 7.2
Temperature: 30
uniprot:Q99P84 [Ca2+]

H2O + 1_Phosphatidyl_D_myo_inositol_4,5_bisphosphate -> 1,2_Diacyl_sn_glycerol + D_myo_Inositol_1,4,5_trisphosphate		 (( (Vmax * S) ) / (Km + S)) buffer: 20 mM HEPES, 70 mM KCl, 3 mM EGTA, 2 mM dithiothreitol, 0.16 mg/ml fatty acid-free bovine serum albumin
PH: 7.4
Temperature: 25
- [phosphoinositide phospholipase C(Enzyme) wildtype isozyme PHbeta2-PLCdelta1]

H2O + 1_Phosphatidyl_D_myo_inositol_4,5_bisphosphate -> 1,2_Diacyl_sn_glycerol + D_myo_Inositol_1,4,5_trisphosphate		 (( (Vmax * (A ^ n)) ) / (( (S_h ^ n) ) + (A ^ n))) buffer: 50 mM Hepes, 160 mM KCl, 3 mM EGTA, 1 mM DTT, 1000 nM Ca2+
PH: 7.2
Temperature: 37
- [phosphoinositide phospholipase C(Enzyme) wildtype isozyme PHbeta2-PLCdelta1]

H2O + 1_Phosphatidyl_D_myo_inositol_4,5_bisphosphate -> 1,2_Diacyl_sn_glycerol + D_myo_Inositol_1,4,5_trisphosphate		 (( (Vmax * (A ^ n)) ) / (( (S_h ^ n) ) + (A ^ n))) buffer: 50 mM Hepes, 160 mM KCl, 3 mM EGTA, 1 mM DTT, 1000 nM Ca2+, 3 mM D-myo-Inositol 1,4,5-trisphosphate
PH: 7.2
Temperature: 37
- [phosphoinositide phospholipase C(Enzyme) wildtype isozyme PHbeta2-PLCdelta1]

1_Phosphatidyl_D_myo_inositol_4,5_bisphosphate + H2O -> D_myo_Inositol_1,4,5_trisphosphate + 1,2_Diacyl_sn_glycerol		 (( (Vmax * (A ^ n)) ) / (( (S_h ^ n) ) + (A ^ n))) buffer: 50 mM Hepes, 160 mM KCl, 3 mM EGTA, 1 mM DTT, 1000 nM Ca2+
PH: 7.2
Temperature: 37
- [phosphoinositide phospholipase C(Enzyme) wildtype isozyme PHbeta2-PLCdelta1]

1_Phosphatidyl_D_myo_inositol_4,5_bisphosphate + H2O -> D_myo_Inositol_1,4,5_trisphosphate + 1,2_Diacyl_sn_glycerol		 (( (Vmax * (A ^ n)) ) / (( (S_h ^ n) ) + (A ^ n))) buffer: 50 mM Hepes, 160 mM KCl, 3 mM EGTA, 1 mM DTT, 1000 nM Ca2+, 3 mM D-myo-Inositol 1,4,5-trisphosphate
PH: 7.2
Temperature: 37
- [phosphoinositide phospholipase C(Enzyme) wildtype]

1_Phosphatidyl_D_myo_inositol_4,5_bisphosphate + H2O -> 1,2_Diacyl_sn_glycerol + D_myo_Inositol_1,4,5_trisphosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 45 mM Tris-HCl, 0.72 mM Cetyltrimethylammonium bromide
PH: 7.2
Temperature: 37

Pathways

pathway id name
BioCyc:YEAST_LIPASYN-PWY-1 phospholipids degradation
BioCyc:MOUSE_PWY3DJ-219 PIP metabolism
BioCyc:META_PWY-6367 D-myo-inositol-5-phosphate metabolism
BioCyc:YEAST_PWY3O-402 inositol phosphate biosynthesis
BioCyc:ARA_PWY-7039 phosphatidate metabolism, as a signaling molecule
BioCyc:ARA_PWY-6367 D-myo-inositol-5-phosphate metabolism
BioCyc:HUMAN_PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis
BioCyc:META_PWY-7039 phosphatidate metabolism, as a signaling molecule
BioCyc:ARA_LIPASYN-PWY phospholipases
BioCyc:ARA_PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis
BioCyc:MOUSE_PWY-6367 D-myo-inositol-5-phosphate metabolism
BioCyc:HUMAN_LIPASYN-PWY phospholipases
BioCyc:HUMAN_PWY-6371 superpathway of inositol phosphate compounds
BioCyc:HUMAN_PWY-6367 D-myo-inositol-5-phosphate metabolism
BioCyc:META_LIPASYN-PWY phospholipases
BioCyc:META_PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis
BioCyc:YEAST_PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis
BioCyc:MOUSE_LIPASYN-PWY phospholipases
BioCyc:MOUSE_PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis
PlantCyc:ARA_LIPASYN-PWY phospholipases
PlantCyc:ARA_PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis
PlantCyc:ARA_PWY-7039 phosphatidate metabolism, as a signaling molecule
PlantCyc:PLANT_PWY-7039 phosphatidate metabolism, as a signaling molecule
PlantCyc:PLANT_PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis
PlantCyc:PLANT_PWY-6367 D-myo-inositol-5-phosphate metabolism
PlantCyc:ARA_PWY-6367 D-myo-inositol-5-phosphate metabolism
PlantCyc:PLANT_LIPASYN-PWY phospholipases
Reactome:R-HSA-9664565 Signaling by ERBB2 KD Mutants
Reactome:R-HSA-1227990 Signaling by ERBB2 in Cancer
Reactome:R-HSA-9679506 SARS-CoV Infections
Reactome:R-HSA-9679191 Potential therapeutics for SARS
Reactome:R-MMU-201556 Signaling by ALK
Reactome:R-HSA-9700206 Signaling by ALK in cancer
Reactome:R-HSA-9717189 Sensory perception of taste
Reactome:R-MMU-9675108 Nervous system development
Reactome:R-HSA-9675108 Nervous system development
Reactome:R-HSA-9709957 Sensory Perception
Reactome:R-HSA-9665348 Signaling by ERBB2 ECD mutants
Reactome:R-RNO-201556 Signaling by ALK
Reactome:R-HSA-9725370 Signaling by ALK fusions and activated point mutants
Reactome:R-HSA-201556 Signaling by ALK
Reactome:R-HSA-9717207 Sensory perception of sweet, bitter, and umami (glutamate) taste
Reactome:R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells
Reactome:R-HSA-9824446 Viral Infection Pathways
Reactome:R-RNO-9675108 Nervous system development
Reactome:R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants
Reactome:R-CEL-5654221 Phospholipase C-mediated cascade; FGFR2
Reactome:R-CEL-5654716 Downstream signaling of activated FGFR4
Reactome:R-CEL-186763 Downstream signal transduction
Reactome:R-RNO-210990 PECAM1 interactions
Reactome:R-DDI-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome:R-CEL-5654687 Downstream signaling of activated FGFR1
Reactome:R-CEL-5654743 Signaling by FGFR4
Reactome:R-CEL-186797 Signaling by PDGF
Reactome:R-DDI-202433 Generation of second messenger molecules
Reactome:R-CEL-5654219 Phospholipase C-mediated cascade: FGFR1
Reactome:R-CEL-5654227 Phospholipase C-mediated cascade; FGFR3
Reactome:R-SPO-202433 Generation of second messenger molecules
Reactome:R-SPO-5621481 C-type lectin receptors (CLRs)
Reactome:R-MMU-5621480 Dectin-2 family
Reactome:R-CEL-212718 EGFR interacts with phospholipase C-gamma
Reactome:R-CEL-5654228 Phospholipase C-mediated cascade; FGFR4
Reactome:R-RNO-5621480 Dectin-2 family
Reactome:R-SPO-5607764 CLEC7A (Dectin-1) signaling
Reactome:R-BTA-1430728 Metabolism
Reactome:R-CEL-1280218 Adaptive Immune System
Reactome:R-CEL-5654736 Signaling by FGFR1
Reactome:R-CEL-388396 GPCR downstream signalling
Reactome:R-DRE-1855204 Synthesis of IP3 and IP4 in the cytosol
Reactome:R-DDI-76002 Platelet activation, signaling and aggregation
Reactome:R-DDI-1483249 Inositol phosphate metabolism
Reactome:R-DDI-418594 G alpha (i) signalling events
Reactome:R-DDI-112043 PLC beta mediated events
Reactome:R-DDI-416476 G alpha (q) signalling events
Reactome:R-DDI-168256 Immune System
Reactome:R-DME-1483249 Inositol phosphate metabolism
Reactome:R-GGA-1855204 Synthesis of IP3 and IP4 in the cytosol
Reactome:R-HSA-422475 Axon guidance
Reactome:R-HSA-210990 PECAM1 interactions
Reactome:R-HSA-6814848 Glycerophospholipid catabolism
Reactome:R-HSA-177929 Signaling by EGFR
Reactome:R-HSA-5654738 Signaling by FGFR2
Reactome:R-HSA-5654716 Downstream signaling of activated FGFR4
Reactome:R-HSA-167021 PLC-gamma1 signalling
Reactome:R-HSA-9034015 Signaling by NTRK3 (TRKC)
Reactome:R-HSA-5218921 VEGFR2 mediated cell proliferation
Reactome:R-HSA-1227986 Signaling by ERBB2
Reactome:R-HSA-1251932 PLCG1 events in ERBB2 signaling
Reactome:R-HSA-9006925 Intracellular signaling by second messengers
Reactome:R-HSA-1489509 DAG and IP3 signaling
Reactome:R-HSA-1643685 Disease
Reactome:R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Reactome:R-HSA-5655253 Signaling by FGFR2 in disease
Reactome:R-HSA-5655291 Signaling by FGFR4 in disease
Reactome:R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
Reactome:R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
Reactome:R-HSA-5607764 CLEC7A (Dectin-1) signaling
Reactome:R-HSA-5621480 Dectin-2 family
Reactome:R-MMU-168256 Immune System
Reactome:R-MMU-168249 Innate Immune System
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-76002 Platelet activation, signaling and aggregation
Reactome:R-MMU-8853659 RET signaling
Reactome:R-MMU-162582 Signaling Pathways
Reactome:R-MMU-190236 Signaling by FGFR
Reactome:R-MMU-5654228 Phospholipase C-mediated cascade; FGFR4
Reactome:R-MMU-166520 Signaling by NTRKs
Reactome:R-MMU-9006115 Signaling by NTRK2 (TRKB)
Reactome:R-MMU-186797 Signaling by PDGF
Reactome:R-RNO-1855204 Synthesis of IP3 and IP4 in the cytosol
Reactome:R-RNO-162582 Signaling Pathways
Reactome:R-RNO-190236 Signaling by FGFR
Reactome:R-RNO-5654228 Phospholipase C-mediated cascade; FGFR4
Reactome:R-RNO-166520 Signaling by NTRKs
Reactome:R-RNO-9026527 Activated NTRK2 signals through PLCG1
Reactome:R-RNO-9034015 Signaling by NTRK3 (TRKC)
Reactome:R-RNO-186763 Downstream signal transduction
Reactome:R-RNO-4420097 VEGFA-VEGFR2 Pathway
Reactome:R-RNO-109582 Hemostasis
Reactome:R-RNO-202733 Cell surface interactions at the vascular wall
Reactome:R-RNO-1280218 Adaptive Immune System
Reactome:R-RNO-202433 Generation of second messenger molecules
Reactome:R-RNO-983705 B Cell Activation
Reactome:R-RNO-168898 Toll-like Receptor Cascades
Reactome:R-RNO-5621481 C-type lectin receptors (CLRs)
Reactome:R-RNO-1266738 Developmental Biology
Reactome:R-SCE-76002 Platelet activation, signaling and aggregation
Reactome:R-SCE-202403 TCR signaling
Reactome:R-SCE-1483249 Inositol phosphate metabolism
Reactome:R-SPO-1430728 Metabolism
Reactome:R-BTA-1855204 Synthesis of IP3 and IP4 in the cytosol
Reactome:R-CEL-168256 Immune System
Reactome:R-CEL-177929 Signaling by EGFR
Reactome:R-CEL-190236 Signaling by FGFR
Reactome:R-CEL-5654738 Signaling by FGFR2
Reactome:R-CEL-111885 Opioid Signalling
Reactome:R-CEL-1855204 Synthesis of IP3 and IP4 in the cytosol
Reactome:R-DRE-1483249 Inositol phosphate metabolism
Reactome:R-DDI-372790 Signaling by GPCR
Reactome:R-DDI-112040 G-protein mediated events
Reactome:R-DDI-168249 Innate Immune System
Reactome:R-DME-1430728 Metabolism
Reactome:R-GGA-1483249 Inositol phosphate metabolism
Reactome:R-HSA-1266738 Developmental Biology
Reactome:R-HSA-373752 Netrin-1 signaling
Reactome:R-HSA-76002 Platelet activation, signaling and aggregation
Reactome:R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol
Reactome:R-HSA-556833 Metabolism of lipids
Reactome:R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-HSA-5654736 Signaling by FGFR1
Reactome:R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1
Reactome:R-HSA-5654221 Phospholipase C-mediated cascade; FGFR2
Reactome:R-HSA-5654741 Signaling by FGFR3
Reactome:R-HSA-5654708 Downstream signaling of activated FGFR3
Reactome:R-HSA-194138 Signaling by VEGF
Reactome:R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer
Reactome:R-HSA-202403 TCR signaling
Reactome:R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome:R-HSA-2029485 Role of phospholipids in phagocytosis
Reactome:R-HSA-5621481 C-type lectin receptors (CLRs)
Reactome:R-MMU-166016 Toll Like Receptor 4 (TLR4) Cascade
Reactome:R-MMU-5607764 CLEC7A (Dectin-1) signaling
Reactome:R-MMU-1855204 Synthesis of IP3 and IP4 in the cytosol
Reactome:R-MMU-114604 GPVI-mediated activation cascade
Reactome:R-MMU-202733 Cell surface interactions at the vascular wall
Reactome:R-MMU-212718 EGFR interacts with phospholipase C-gamma
Reactome:R-MMU-5654687 Downstream signaling of activated FGFR1
Reactome:R-MMU-5654696 Downstream signaling of activated FGFR2
Reactome:R-MMU-5654227 Phospholipase C-mediated cascade; FGFR3
Reactome:R-MMU-5654743 Signaling by FGFR4
Reactome:R-MMU-9034793 Activated NTRK3 signals through PLCG1
Reactome:R-MMU-5218921 VEGFR2 mediated cell proliferation
Reactome:R-RNO-1483249 Inositol phosphate metabolism
Reactome:R-RNO-212718 EGFR interacts with phospholipase C-gamma
Reactome:R-RNO-5654687 Downstream signaling of activated FGFR1
Reactome:R-RNO-5654696 Downstream signaling of activated FGFR2
Reactome:R-RNO-5654227 Phospholipase C-mediated cascade; FGFR3
Reactome:R-RNO-5654743 Signaling by FGFR4
Reactome:R-RNO-9006115 Signaling by NTRK2 (TRKB)
Reactome:R-RNO-186797 Signaling by PDGF
Reactome:R-RNO-168256 Immune System
Reactome:R-RNO-168249 Innate Immune System
Reactome:R-RNO-166016 Toll Like Receptor 4 (TLR4) Cascade
Reactome:R-RNO-8853659 RET signaling
Reactome:R-SCE-109582 Hemostasis
Reactome:R-SCE-114604 GPVI-mediated activation cascade
Reactome:R-SCE-1280218 Adaptive Immune System
Reactome:R-SCE-5607764 CLEC7A (Dectin-1) signaling
Reactome:R-SCE-1430728 Metabolism
Reactome:R-SPO-202403 TCR signaling
Reactome:R-SSC-1430728 Metabolism
Reactome:R-CEL-109582 Hemostasis
Reactome:R-CEL-76002 Platelet activation, signaling and aggregation
Reactome:R-CEL-202403 TCR signaling
Reactome:R-CEL-5621481 C-type lectin receptors (CLRs)
Reactome:R-CEL-162582 Signaling Pathways
Reactome:R-CEL-5654696 Downstream signaling of activated FGFR2
Reactome:R-CEL-5654741 Signaling by FGFR3
Reactome:R-CEL-112040 G-protein mediated events
Reactome:R-DRE-1430728 Metabolism
Reactome:R-DDI-109582 Hemostasis
Reactome:R-DDI-114604 GPVI-mediated activation cascade
Reactome:R-DDI-1855204 Synthesis of IP3 and IP4 in the cytosol
Reactome:R-DDI-111885 Opioid Signalling
Reactome:R-DDI-1280218 Adaptive Immune System
Reactome:R-DDI-983705 B Cell Activation
Reactome:R-DDI-5621481 C-type lectin receptors (CLRs)
Reactome:R-DME-1855204 Synthesis of IP3 and IP4 in the cytosol
Reactome:R-GGA-1430728 Metabolism
Reactome:R-HSA-8853659 RET signaling
Reactome:R-HSA-109582 Hemostasis
Reactome:R-HSA-1483257 Phospholipid metabolism
Reactome:R-HSA-1483255 PI Metabolism
Reactome:R-HSA-212718 EGFR interacts with phospholipase C-gamma
Reactome:R-HSA-5654687 Downstream signaling of activated FGFR1
Reactome:R-HSA-5654696 Downstream signaling of activated FGFR2
Reactome:R-HSA-5654227 Phospholipase C-mediated cascade; FGFR3
Reactome:R-HSA-5654743 Signaling by FGFR4
Reactome:R-HSA-187037 Signaling by NTRK1 (TRKA)
Reactome:R-HSA-9006115 Signaling by NTRK2 (TRKB)
Reactome:R-HSA-186797 Signaling by PDGF
Reactome:R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
Reactome:R-HSA-5637812 Signaling by EGFRvIII in Cancer
Reactome:R-HSA-1226099 Signaling by FGFR in disease
Reactome:R-HSA-168256 Immune System
Reactome:R-HSA-168249 Innate Immune System
Reactome:R-MMU-1280218 Adaptive Immune System
Reactome:R-MMU-202433 Generation of second messenger molecules
Reactome:R-MMU-983705 B Cell Activation
Reactome:R-MMU-168898 Toll-like Receptor Cascades
Reactome:R-MMU-210990 PECAM1 interactions
Reactome:R-MMU-1266738 Developmental Biology
Reactome:R-MMU-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-MMU-5654736 Signaling by FGFR1
Reactome:R-MMU-5654219 Phospholipase C-mediated cascade: FGFR1
Reactome:R-MMU-5654221 Phospholipase C-mediated cascade; FGFR2
Reactome:R-MMU-5654741 Signaling by FGFR3
Reactome:R-MMU-5654708 Downstream signaling of activated FGFR3
Reactome:R-MMU-9026527 Activated NTRK2 signals through PLCG1
Reactome:R-MMU-9034015 Signaling by NTRK3 (TRKC)
Reactome:R-MMU-186763 Downstream signal transduction
Reactome:R-MMU-4420097 VEGFA-VEGFR2 Pathway
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-RNO-5654736 Signaling by FGFR1
Reactome:R-RNO-5654219 Phospholipase C-mediated cascade: FGFR1
Reactome:R-RNO-5654221 Phospholipase C-mediated cascade; FGFR2
Reactome:R-RNO-5654741 Signaling by FGFR3
Reactome:R-RNO-5654708 Downstream signaling of activated FGFR3
Reactome:R-RNO-194138 Signaling by VEGF
Reactome:R-RNO-114604 GPVI-mediated activation cascade
Reactome:R-RNO-202403 TCR signaling
Reactome:R-RNO-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome:R-RNO-5607764 CLEC7A (Dectin-1) signaling
Reactome:R-RNO-422475 Axon guidance
Reactome:R-SCE-202433 Generation of second messenger molecules
Reactome:R-SCE-168249 Innate Immune System
Reactome:R-SCE-1855204 Synthesis of IP3 and IP4 in the cytosol
Reactome:R-SPO-109582 Hemostasis
Reactome:R-SPO-76002 Platelet activation, signaling and aggregation
Reactome:R-SPO-168256 Immune System
Reactome:R-SPO-1483249 Inositol phosphate metabolism
Reactome:R-SSC-1483249 Inositol phosphate metabolism
Reactome:R-BTA-1483249 Inositol phosphate metabolism
Reactome:R-CEL-114604 GPVI-mediated activation cascade
Reactome:R-CEL-202433 Generation of second messenger molecules
Reactome:R-CEL-168249 Innate Immune System
Reactome:R-CEL-5607764 CLEC7A (Dectin-1) signaling
Reactome:R-CEL-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-CEL-5654708 Downstream signaling of activated FGFR3
Reactome:R-CEL-372790 Signaling by GPCR
Reactome:R-CEL-418594 G alpha (i) signalling events
Reactome:R-CEL-112043 PLC beta mediated events
Reactome:R-CEL-416476 G alpha (q) signalling events
Reactome:R-CEL-1430728 Metabolism
Reactome:R-CEL-1483249 Inositol phosphate metabolism
Reactome:R-DDI-1430728 Metabolism
Reactome:R-DDI-162582 Signaling Pathways
Reactome:R-DDI-388396 GPCR downstream signalling
Reactome:R-DDI-202403 TCR signaling
Reactome:R-DDI-5607764 CLEC7A (Dectin-1) signaling
Reactome:R-HSA-418890 Role of second messengers in netrin-1 signaling
Reactome:R-HSA-114604 GPVI-mediated activation cascade
Reactome:R-HSA-202733 Cell surface interactions at the vascular wall
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-1483249 Inositol phosphate metabolism
Reactome:R-HSA-162582 Signaling Pathways
Reactome:R-HSA-190236 Signaling by FGFR
Reactome:R-HSA-5654228 Phospholipase C-mediated cascade; FGFR4
Reactome:R-HSA-166520 Signaling by NTRKs
Reactome:R-HSA-9026527 Activated NTRK2 signals through PLCG1
Reactome:R-HSA-9034793 Activated NTRK3 signals through PLCG1
Reactome:R-HSA-186763 Downstream signal transduction
Reactome:R-HSA-4420097 VEGFA-VEGFR2 Pathway
Reactome:R-HSA-1643713 Signaling by EGFR in Cancer
Reactome:R-HSA-5637810 Constitutive Signaling by EGFRvIII
Reactome:R-HSA-5655302 Signaling by FGFR1 in disease
Reactome:R-HSA-5655332 Signaling by FGFR3 in disease
Reactome:R-HSA-5663205 Infectious disease
Reactome:R-HSA-1280218 Adaptive Immune System
Reactome:R-HSA-202433 Generation of second messenger molecules
Reactome:R-HSA-983705 B Cell Activation
Reactome:R-HSA-168898 Toll-like Receptor Cascades
Reactome:R-HSA-1280215 Cytokine Signaling in Immune system
Reactome:R-MMU-202403 TCR signaling
Reactome:R-MMU-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome:R-MMU-5621481 C-type lectin receptors (CLRs)
Reactome:R-MMU-1483249 Inositol phosphate metabolism
Reactome:R-MMU-109582 Hemostasis
Reactome:R-MMU-422475 Axon guidance
Reactome:R-MMU-177929 Signaling by EGFR
Reactome:R-MMU-5654738 Signaling by FGFR2
Reactome:R-MMU-5654716 Downstream signaling of activated FGFR4
Reactome:R-MMU-194138 Signaling by VEGF
Reactome:R-RNO-177929 Signaling by EGFR
Reactome:R-RNO-5654738 Signaling by FGFR2
Reactome:R-RNO-5654716 Downstream signaling of activated FGFR4
Reactome:R-RNO-9034793 Activated NTRK3 signals through PLCG1
Reactome:R-RNO-5218921 VEGFR2 mediated cell proliferation
Reactome:R-RNO-76002 Platelet activation, signaling and aggregation
Reactome:R-SCE-168256 Immune System
Reactome:R-SCE-5621481 C-type lectin receptors (CLRs)
Reactome:R-SPO-114604 GPVI-mediated activation cascade
Reactome:R-SPO-1280218 Adaptive Immune System
Reactome:R-SPO-168249 Innate Immune System
Reactome:R-SPO-1855204 Synthesis of IP3 and IP4 in the cytosol
Reactome:R-SSC-1855204 Synthesis of IP3 and IP4 in the cytosol
WikiPathways:WP4971 Phosphoinositides metabolism
WikiPathways:WP2889 Oxytocin signaling
WikiPathways:WP5098 T-cell activation SARS-CoV-2
WikiPathways:WP5312 Metabolic pathways of fibroblasts
PathBank:SMP0108193 Lysophosphatidic Acid LPA2 Signalling
PathBank:SMP0108209 Phospholipase C Signaling Pathway
PathBank:SMP0108229 Lysophosphatidic Acid LPA4 Signalling
PathBank:SMP0119378 Muscle/Heart Contraction
PathBank:SMP0120923 Growth Hormone Signaling Pathway
PathBank:SMP0120935 T Cell Receptor Signaling Pathway
PathBank:SMP0120943 G-Protein Signaling Through Tubby Proteins
PathBank:SMP0120947 Growth Hormone Signaling Pathway
PathBank:SMP0120959 T Cell Receptor Signaling Pathway
PathBank:SMP0120967 G-Protein Signaling Through Tubby Proteins
PathBank:SMP0002397 Inositol Metabolism
PathBank:SMP0087258 Phosphatidylinositol Phosphate Metabolism
PathBank:SMP0056661 Chlorphenamine H1-Antihistamine Action
PathBank:SMP0057581 Triprolidine H1-Antihistamine Action
PathBank:SMP0057585 Chloropyramine H1-Antihistamine Action
PathBank:SMP0058908 Diphenylpyraline H1-Antihistamine Action
PathBank:SMP0058916 Phenyltoloxamine H1-Antihistamine Action
PathBank:SMP0058936 Hydroxyzine H1-Antihistamine Action
PathBank:SMP0059058 Cetirizine H1-Antihistamine Action
PathBank:SMP0059110 Cinnarizine H1-Antihistamine Action
PathBank:SMP0059114 Levocetirizine H1-Antihistamine Action
PathBank:SMP0059716 Isothipendyl H1-Antihistamine Action
PathBank:SMP0059720 Mequitazine H1-Antihistamine Action
PathBank:SMP0059868 Ketotifen H1-Antihistamine Action
PathBank:SMP0059872 Doxepin H1-Antihistamine Action
PathBank:SMP0060201 Desloratadine H1-Antihistamine Action
PathBank:SMP0060741 Azelastine H1-Antihistamine Action
PathBank:SMP0062621 Tolpropamine H1-Antihistamine Action
PathBank:SMP0062625 Propiomazine H1-Antihistamine Action
PathBank:SMP0062882 Bamipine H1-Antihistamine Action
PathBank:SMP0062886 Pimethixene H1-Antihistamine Action
PathBank:SMP0062894 Thenalidine H1-Antihistamine Action
PathBank:SMP0063753 Lysophosphatidic Acid LPA2 Signalling
PathBank:SMP0063783 Phospholipase C Signaling Pathway
PathBank:SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages
PathBank:SMP0063810 EGF Signalling Pathway
PathBank:SMP0066977 T Cell Receptor Signaling Pathway
PathBank:SMP0120865 Joubert Syndrome
PathBank:SMP0108002 Histamine H1 Receptor Activation
PathBank:SMP0108196 Lysophosphatidic Acid LPA4 Signalling
PathBank:SMP0108212 Cadmium Induces DNA Synthesis and Proliferation in Macrophages
PathBank:SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells
PathBank:SMP0108228 Lysophosphatidic Acid LPA3 Signalling
PathBank:SMP0108240 Cadmium Induces DNA Synthesis and Proliferation in Macrophages
PathBank:SMP0120888 Succinate Signalling During Inflammation
PathBank:SMP0120938 EPO Signaling Pathway
PathBank:SMP0120962 EPO Signaling Pathway
PathBank:SMP0000011 Inositol Metabolism
PathBank:SMP0000463 Phosphatidylinositol Phosphate Metabolism
PathBank:SMP0012029 D-myo-Inositol (1,4,5)-Trisphosphate Biosynthesis
PathBank:SMP0089843 G-Protein Signaling Through Tubby Proteins
PathBank:SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway
PathBank:SMP0057580 Dexbrompheniramine H1-Antihistamine Action
PathBank:SMP0057584 Antazoline H1-Antihistamine Action
PathBank:SMP0058741 Methapyrilene H1-Antihistamine Action
PathBank:SMP0058769 Thonzylamine H1-Antihistamine Action
PathBank:SMP0058785 Diphenhydramine H1-Antihistamine Action
PathBank:SMP0058797 Carbinoxamine H1-Antihistamine Action
PathBank:SMP0058813 Bromodiphenhydramine H1-Antihistamine Action
PathBank:SMP0058903 Chlorphenoxamine H1-Antihistamine Action
PathBank:SMP0058923 Cyclizine H1-Antihistamine Action
PathBank:SMP0058931 Chlorcyclizine H1-Antihistamine Action
PathBank:SMP0058956 Meclizine H1-Antihistamine Action
PathBank:SMP0058964 Buclizine H1-Antihistamine Action
PathBank:SMP0059044 Oxatomide H1-Antihistamine Action
PathBank:SMP0059707 Fenethazine H1-Antihistamine Action
PathBank:SMP0060204 Ebastine H1-Antihistamine Action
PathBank:SMP0060208 Terfenadine H1-Antihistamine Action
PathBank:SMP0060224 Levocabastine H1-Antihistamine Action
PathBank:SMP0060740 Olopatadine H1-Antihistamine Action
PathBank:SMP0060744 Betahistine H1-Antihistamine Action
PathBank:SMP0061040 Emedastine H1-Antihistamine Action
PathBank:SMP0061052 Mebhydrolin H1-Antihistamine Action
PathBank:SMP0062624 Thenyldiamine H1-Antihistamine Action
PathBank:SMP0062788 Clocinizine H1-Antihistamine Action
PathBank:SMP0062881 Alcaftadine H1-Antihistamine Action
PathBank:SMP0062885 Mirtazapine H1-Antihistamine Action
PathBank:SMP0063452 Histamine H1 Receptor Activation
PathBank:SMP0063629 Inositol Metabolism
PathBank:SMP0063746 Lysophosphatidic Acid LPA1 Signalling
PathBank:SMP0063757 Lysophosphatidic Acid LPA5 Signalling
PathBank:SMP0108012 Activation of PKC Through G Protein-Coupled Receptor
PathBank:SMP0108186 Fc Epsilon Receptor I Signaling in Mast Cells
PathBank:SMP0108194 Lysophosphatidic Acid LPA3 Signalling
PathBank:SMP0108198 Lysophosphatidic Acid LPA5 Signalling
PathBank:SMP0108226 Lysophosphatidic Acid LPA1 Signalling
PathBank:SMP0108230 Lysophosphatidic Acid LPA5 Signalling
PathBank:SMP0108238 Phospholipase C Signaling Pathway
PathBank:SMP0069678 EPO Signaling Pathway
PathBank:SMP0069871 BCR Signaling Pathway
PathBank:SMP0119395 Muscle/Heart Contraction
PathBank:SMP0120886 Succinate Signalling During Inflammation
PathBank:SMP0120924 EGF Signalling Pathway
PathBank:SMP0120940 BCR Signaling Pathway
PathBank:SMP0120948 EGF Signalling Pathway
PathBank:SMP0120964 BCR Signaling Pathway
PathBank:SMP0121018 Pancreas Function - Beta Cell
PathBank:SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells
PathBank:SMP0056811 Dexchlorpheniramine H1-Antihistamine Action
PathBank:SMP0057579 Brompheniramine H1-Antihistamine Action
PathBank:SMP0057583 Mepyramine H1-Antihistamine Action
PathBank:SMP0057587 Tripelennamine H1-Antihistamine Action
PathBank:SMP0058732 Histapyrrodine H1-Antihistamine Action
PathBank:SMP0058808 Orphenadrine H1-Antihistamine Action
PathBank:SMP0059694 Cyproheptadine H1-Antihistamine Action
PathBank:SMP0059702 Phenbenzamine H1-Antihistamine Action
PathBank:SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action
PathBank:SMP0059730 Methdilazine H1-Antihistamine Action
PathBank:SMP0059738 Oxomemazine H1-Antihistamine Action
PathBank:SMP0060058 Bepotastine H1-Antihistamine Action
PathBank:SMP0060195 Loratadine H1-Antihistamine Action
PathBank:SMP0060235 Rupatadine H1-Antihistamine Action
PathBank:SMP0060743 Quifenadine H1-Antihistamine Action
PathBank:SMP0061047 Flunarizine H1-Antihistamine Action
PathBank:SMP0061191 Epinastine H1-Antihistamine Action
PathBank:SMP0062623 Latrepirdine H1-Antihistamine Action
PathBank:SMP0062795 Homochlorcyclizine H1-Antihistamine Action
PathBank:SMP0062880 Temelastine H1-Antihistamine Action
PathBank:SMP0062884 Quetiapine H1-Antihistamine Action
PathBank:SMP0063756 Lysophosphatidic Acid LPA4 Signalling
PathBank:SMP0108001 Activation of PKC Through G Protein-Coupled Receptor
PathBank:SMP0108013 Histamine H1 Receptor Activation
PathBank:SMP0108191 Lysophosphatidic Acid LPA1 Signalling
PathBank:SMP0108227 Lysophosphatidic Acid LPA2 Signalling
PathBank:SMP0120925 GnRH Signaling Pathway
PathBank:SMP0120933 CXCR4 Signaling Pathway
PathBank:SMP0120945 Ion Channel and Phorbal Esters Signaling Pathway
PathBank:SMP0120949 GnRH Signaling Pathway
PathBank:SMP0120957 CXCR4 Signaling Pathway
PathBank:SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway
PathBank:SMP0000582 Joubert Syndrome
PathBank:SMP0000749 Activation of PKC Through G Protein-Coupled Receptor
PathBank:SMP0084634 Succinate Signalling During Inflammation
PathBank:SMP0087351 Phosphatidylinositol Phosphate Metabolism
PathBank:SMP0056662 Pheniramine H1-Antihistamine Action
PathBank:SMP0057582 Dimetindene H1-Antihistamine Action
PathBank:SMP0057586 Talastine H1-Antihistamine Action
PathBank:SMP0058803 Doxylamine H1-Antihistamine Action
PathBank:SMP0058891 Clemastine H1-Antihistamine Action
PathBank:SMP0059211 Promethazine H1-Antihistamine Action
PathBank:SMP0059689 Alimemazine H1-Antihistamine Action
PathBank:SMP0059865 Azatadine H1-Antihistamine Action
PathBank:SMP0059881 Acrivastine H1-Antihistamine Action
PathBank:SMP0059897 Astemizole H1-Antihistamine Action
PathBank:SMP0060170 Bilastine H1-Antihistamine Action
PathBank:SMP0060218 Fexofenadine H1-Antihistamine Action
PathBank:SMP0060230 Mizolastine H1-Antihistamine Action
PathBank:SMP0060742 Thiazinamium H1-Antihistamine Action
PathBank:SMP0061190 Phenindamine H1-Antihistamine Action
PathBank:SMP0062622 Embramine H1-Antihistamine Action
PathBank:SMP0062883 Deptropine H1-Antihistamine Action
PathBank:SMP0062887 Pyrrobutamine H1-Antihistamine Action
PathBank:SMP0062895 Tritoqualine H1-Antihistamine Action
PathBank:SMP0063755 Lysophosphatidic Acid LPA3 Signalling
PathBank:SMP0063807 Growth Hormone Signaling Pathway
PathBank:SMP0063811 GnRH Signaling Pathway
PathBank:SMP0064625 CXCR4 Signaling Pathway
PathBank:SMP0100480 Phospholipase C Signaling Pathway
PathBank:SMP0100495 Phospholipase C Signaling Pathway