Inositol phosphate metabolism

Monserrate JP, York JD. Inositol phosphate synthesis and the nuclear processes they affect. Curr Opin Cell Biol. 2010 Jun;22(3):365–73. doi: 10.1016/j.ceb.2010.03.006. PMID: 20359876.; Bunney TD, Katan M. Phosphoinositide signalling in cancer: beyond PI3K and PTEN. Nat Rev Cancer. 2010 May;10(5):342–52. doi: 10.1038/nrc2842. PMID: 20414202.; Alcázar-Román AR, Wente SR. Inositol polyphosphates: a new frontier for regulating gene expression. Chromosoma. 2008 Feb;117(1):1–13. doi: 10.1007/s00412-007-0126-4. PMID: 17943301.; York JD. Regulation of nuclear processes by inositol polyphosphates. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2006 May;1761(5-6):552–9. doi: 10.1016/j.bbalip.2006.04.014.; Irvine RF, Schell MJ. Back in the water: the return of the inositol phosphates. Nature Reviews Molecular Cell Biology. 2001 May;2(5):327–38. doi: 10.1038/35073015.

Metabolites

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

myo-Inositol

Formula: C6H12O6 (180.0633852)

CAS ID: 87-89-8

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

1D-myo-inositol (1,2,3,4,6)-pentakisphosphate

Formula: C6H7O21P5 (569.8168022)

CAS ID:

D-myo-inositol (1,2,4,5,6)-pentakisphosphate

Formula: C6H7O21P5 (569.8168022)

CAS ID:

D-myo-inositol (1,3,4)-trisphosphate

Formula: C6H9O15P3 (413.91543540000004)

CAS ID:

D-glucopyranuronate

Formula: C6H9O7 (193.0348264)

CAS ID: 148-00-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)

Formula: C6H8O18P4 (491.86611880000004)

CAS ID:

5-diphospho-1D-myo-inositol pentakisphosphate(13-)

Formula: C6H6O27P7 (726.7259936)

CAS ID:



Enzyme

EC Number name full name note
3.1.3.-
1.13.99.1 inositol oxygenase myo-Inositol:oxygen oxidoreductase
2.7.1.127 inositol-trisphosphate 3-kinase ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase
2.7.1.134 inositol-tetrakisphosphate 1-kinase ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase
2.7.1.140 inositol-tetrakisphosphate 5-kinase ATP:1D-myo-inositol-1,3,4,6-tetrakisphosphate 5-phosphotransferase
2.7.1.151 inositol-polyphosphate multikinase ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase
2.7.1.153 phosphatidylinositol-4,5-bisphosphate 3-kinase ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase
2.7.1.158 inositol-pentakisphosphate 2-kinase ATP:1D-myo-inositol 1,3,4,5,6-pentakisphosphate 2-phosphotransferase
2.7.1.159 inositol-1,3,4-trisphosphate 5/6-kinase ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase
3.1.16.1 spleen exonuclease
3.1.3.16 protein-serine/threonine phosphatase protein-serine/threonine-phosphate phosphohydrolase
3.1.3.48 protein-tyrosine-phosphatase protein-tyrosine-phosphate phosphohydrolase
3.1.3.57 inositol-1,4-bisphosphate 1-phosphatase 1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase
3.1.3.62 multiple inositol-polyphosphate phosphatase myo-inositol-hexakisphosphate phosphohydrolase
3.1.3.64 phosphatidylinositol-3-phosphatase 1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase
3.1.3.67 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase
3.1.3.80 2,3-bisphosphoglycerate 3-phosphatase 2,3-bisphospho-D-glycerate 3-phosphohydrolase
3.1.4.11 phosphoinositide phospholipase C 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase
3.6.1.10 endopolyphosphatase polyphosphate polyphosphohydrolase
3.6.1.52 diphosphoinositol-polyphosphate diphosphatase diphospho-myo-inositol-polyphosphate diphosphohydrolase
3.6.1.59 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] N7-methylguanosine 5'-phosphate phosphohydrolase
3.6.1.60 diadenosine hexaphosphate hydrolase (AMP-forming) P1,P6-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (AMP-forming)
3.6.1.61 diadenosine hexaphosphate hydrolase (ATP-forming) P1,P6-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (ATP-forming)
3.6.1.62 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] N7-methylguanosine-5'-diphosphate phosphohydrolase
5.5.1.4 inositol-3-phosphate synthase 1D-myo-inositol-3-phosphate lyase (isomerizing)


Proteins

Protein ID name full name