EC: 1.14.14.17

squalene monooxygenase (squalene,NADPH-hemoprotein:oxygen oxidoreductase (2,3-epoxidizing)

enzyme lambda metabolic reaction experiment
uniprot:Q14534 [FAD]

O2 + Squalene + NADPH + H+ -> NADP+ + H2O + (S)_2,3_Epoxysqualene		 (( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 20 mM Tris-HCl, 0.1 % Triton X-100
PH: 7.4
Temperature: 37
uniprot:Q14534 [FAD]

Squalene + O2 + H+ + NADPH -> NADP+ + (S)_2,3_Epoxysqualene + H2O		 (( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 20 mM Tris-HCl, 0.1 % Triton X-100, 140 nM cytochrome P450 reductase
PH: 7.4
Temperature: 37
uniprot:Q14534 [FAD]

H+ + O2 + NADPH + Squalene -> H2O + NADP+ + (S)_2,3_Epoxysqualene		 (( (( (kcat * E) ) * M) ) / (Km + M)) buffer: 20 mM Tris-HCl, 0.1 % Triton X-100, 140 nM cytochrome P450 reductase
PH: 7.4
Temperature: 37

Pathways

pathway id name
BioCyc:YEAST_PWY-5670 epoxysqualene biosynthesis
BioCyc:MOUSE_PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
BioCyc:MOUSE_PWY-5670 epoxysqualene biosynthesis
BioCyc:HUMAN_PWY66-5 superpathway of cholesterol biosynthesis
BioCyc:HUMAN_PWY66-341 cholesterol biosynthesis I
BioCyc:META_PWY-5670 epoxysqualene biosynthesis
BioCyc:META_PWY66-341 cholesterol biosynthesis I
BioCyc:META_PWY66-4 cholesterol biosynthesis III (via desmosterol)
BioCyc:YEAST_ERGOSTEROL-SYN-PWY superpathway of ergosterol biosynthesis
BioCyc:ARA_PWY-2541 plant sterol biosynthesis
BioCyc:MOUSE_PWY66-341 cholesterol biosynthesis I
BioCyc:HUMAN_PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
BioCyc:HUMAN_PWY-5670 epoxysqualene biosynthesis
BioCyc:META_PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
BioCyc:ARA_PWY-5670 epoxysqualene biosynthesis
BioCyc:ARA_PWY-6663 plant sterol biosynthesis II
BioCyc:HUMAN_PWY66-4 cholesterol biosynthesis III (via desmosterol)
BioCyc:META_ERGOSTEROL-SYN-PWY superpathway of ergosterol biosynthesis I
BioCyc:META_PWY66-5 superpathway of cholesterol biosynthesis
BioCyc:META_PWY-2541 plant sterol biosynthesis
BioCyc:MOUSE_PWY66-4 cholesterol biosynthesis III (via desmosterol)
PlantCyc:ARA_PWY-5670 epoxysqualene biosynthesis
PlantCyc:PLANT_PWY66-341 cholesterol biosynthesis I
PlantCyc:PLANT_PWY-6663 plant sterol biosynthesis II
PlantCyc:ARA_PWY-6663 plant sterol biosynthesis II
PlantCyc:PLANT_PWY-5670 epoxysqualene biosynthesis
Reactome:R-HSA-9969896 Lanosterol biosynthesis
Reactome:R-MMU-9969896 Lanosterol biosynthesis
Reactome:R-SPO-9969896 Lanosterol biosynthesis
Reactome:R-RNO-9969896 Lanosterol biosynthesis
Reactome:R-SCE-9969896 Lanosterol biosynthesis
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-556833 Metabolism of lipids
Reactome:R-MMU-8957322 Metabolism of steroids
Reactome:R-SCE-8957322 Metabolism of steroids
Reactome:R-SPO-1430728 Metabolism
Reactome:R-HSA-556833 Metabolism of lipids
Reactome:R-HSA-191273 Cholesterol biosynthesis
Reactome:R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
Reactome:R-SCE-1430728 Metabolism
Reactome:R-MMU-191273 Cholesterol biosynthesis
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-556833 Metabolism of lipids
Reactome:R-RNO-8957322 Metabolism of steroids
Reactome:R-SCE-556833 Metabolism of lipids
Reactome:R-SCE-191273 Cholesterol biosynthesis
Reactome:R-SPO-8957322 Metabolism of steroids
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-8957322 Metabolism of steroids
Reactome:R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
Reactome:R-RNO-191273 Cholesterol biosynthesis
Reactome:R-SPO-556833 Metabolism of lipids
Reactome:R-SPO-191273 Cholesterol biosynthesis
PathBank:SMP0121207 Triterpenoid Biosynthesis
PathBank:SMP0000023 Steroid Biosynthesis
PathBank:SMP0000387 CHILD Syndrome
PathBank:SMP0000112 Risedronate Action Pathway
PathBank:SMP0000508 Cholesteryl Ester Storage Disease
PathBank:SMP0002438 Cholesterol Biosynthesis and Metabolism CE(12:0)
PathBank:SMP0012042 Epoxysqualene Biosynthesis
PathBank:SMP0121055 Mevalonate Pathway
PathBank:SMP0000389 Smith-Lemli-Opitz Syndrome (SLOS)
PathBank:SMP0000319 Lysosomal Acid Lipase Deficiency (Wolman Disease)
PathBank:SMP0000082 Simvastatin Action Pathway
PathBank:SMP0000111 Cerivastatin Action Pathway
PathBank:SMP0000131 Atorvastatin Action Pathway
PathBank:SMP0000511 Wolman Disease
PathBank:SMP0002381 Steroid Biosynthesis
PathBank:SMP0002436 Cholesterol biosynthesis and metabolism CE(10:0)
PathBank:SMP0002441 Cholesterol biosynthesis and metabolism CE(18:0)
PathBank:SMP0070041 Cholesterol Biosynthesis and Metabolism
PathBank:SMP0000386 Desmosterolosis
PathBank:SMP0000089 Pravastatin Action Pathway
PathBank:SMP0000095 Alendronate Action Pathway
PathBank:SMP0000099 Lovastatin Action Pathway
PathBank:SMP0000117 Pamidronate Action Pathway
PathBank:SMP0000509 Hyper-IgD Syndrome
PathBank:SMP0121205 Sesquiterpenoid Biosynthesis
PathBank:SMP0121236 Steroid Biosynthesis
PathBank:SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2)
PathBank:SMP0000079 Ibandronate Action Pathway
PathBank:SMP0000092 Rosuvastatin Action Pathway
PathBank:SMP0000209 Hypercholesterolemia
PathBank:SMP0000107 Zoledronate Action Pathway
PathBank:SMP0000119 Fluvastatin Action Pathway
PathBank:SMP0000510 Mevalonic Aciduria
PathBank:SMP0002435 Cholesterol biosynthesis and metabolism CE(14:0)
PathBank:SMP0002440 Cholesterol Biosynthesis and Metabolism CE(16:0)