epoxysqualene biosynthesis

Hata S, Sanmiya K, Kouchi H, Matsuoka M, Yamamoto N, Izui K. cDNA cloning of squalene synthase genes from mono- and dicotyledonous plants, and expression of the gene in rice. Plant Cell Physiol. 1997 Dec;38(12):1409–13. doi: 10.1093/oxfordjournals.pcp.a029137. PMID: 9522471.; Abe I, Tomesch JC, Wattanasin S, Prestwich GD. Inhibitors of squalene biosynthesis and metabolism. Nat Prod Rep. 1994 Jun;11(3):279–302. doi: 10.1039/np9941100279. PMID: 15200015.; Cattel L, Ceruti M, Viola F, Delprino L, Balliano G, Duriatti A, Bouvier-Navé P. The squalene-2,3-epoxide cyclase as a model for the development of new drugs. Lipids. 1986 Jan;21(1):31–8. doi: 10.1007/bf02534300. PMID: 3515096.; Popják G. Conversion of mevalonic acid into prenyl hydrocarbons as exemplified by the synthesis of squalene. Biochem Soc Symp. 1970;29():17–33. PMID: 4332649.

Metabolites

(S)-2,3-Epoxysqualene

Formula: C30H50O (426.386145)

CAS ID: 54910-48-4

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.14.14.17 squalene monooxygenase squalene,NADPH-hemoprotein:oxygen oxidoreductase (2,3-epoxidizing


Proteins

Protein ID name full name