Lipopolysaccharide Biosynthesis II

Metabolites

Acetate

Formula: C2H4O2 (60.0211284)

CAS ID: 64-19-7

Acetyl-CoA

Formula: C23H38N7O17P3S (809.1257688000001)

CAS ID: 72-89-9

ADP

Formula: C10H15N5O10P2 (427.02941500000003)

CAS ID: 58-64-0

ATP

Formula: C10H16N5O13P3 (506.9957476)

CAS ID: 56-65-5

beta-D-Fructose

Formula: C6H12O6 (180.0633852)

CAS ID: 53188-23-1

CMP

Formula: C9H14N3O8P (323.05184940000004)

CAS ID: 63-37-6

CTP

Formula: C9H16N3O14P3 (482.9845146)

CAS ID: 65-47-4

D-Arabinose 5-phosphate

Formula: C5H11O8P (230.0191536)

CAS ID: 13137-52-5

D-Fructose 6-phosphate

Formula: C6H13O9P (260.0297178)

CAS ID: 643-13-0

D-Ribulose 5-phosphate

Formula: C5H11O8P (230.0191536)

CAS ID: 551-85-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

L-Glutamate

Formula: C5H9NO4 (147.0531554)

CAS ID: 56-86-0

L-Glutamine

Formula: C5H10N2O3 (146.069139)

CAS ID: 56-85-9

Phosphoenolpyruvate

Formula: C3H5O6P (167.98237600000002)

CAS ID: 138-08-9

UMP

Formula: C9H13N2O9P (324.03586580000007)

CAS ID: 58-97-9

UTP

Formula: C9H15N2O15P3 (483.968531)

CAS ID: 63-39-8

DG(16:0/16:0/0:0)

Formula: C35H68O5 (568.5066478)

CAS ID: 30334-71-5

PE(16:0/16:0)

Formula: C37H74NO8P (691.5151774)

CAS ID: 923-61-5

Cyclonite

Formula: C3H6N6O6 (222.0348816)

CAS ID: 121-82-4

diphosphate

Formula: O7P2 (173.911931)

CAS ID: 14000-31-8

phosphate(3-)

Formula: O4P (94.953423)

CAS ID: 14265-44-2

UDP(3-)

Formula: C9H11N2O12P2 (400.9787246)

CAS ID: 86527-70-0



Enzyme

EC Number name full name note
2.4.1.-
2.3.1.129 acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase (3R)-3-hydroxyacyl-[acyl-carrier protein]:UDP-N-acetyl-alpha-D-glucosamine 3-O-(3-hydroxyacyl)transferase
2.3.1.157 glucosamine-1-phosphate N-acetyltransferase acetyl-CoA:alpha-D-glucosamine-1-phosphate N-acetyltransferase
2.3.1.191 UDP-3-O-(3-hydroxyacyl)glucosamine N-acyltransferase (3R)-3-hydroxyacyl-[acyl-carrier protein]:UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine N-acyltransferase
2.3.1.241 Kdo2-lipid IVA acyltransferase fatty acyl-[acyl-carrier protein]:alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-[lipid IVA] O-acyltransferase
2.3.1.243 acyl-Kdo2-lipid IVA acyltransferase fatty acyl-[acyl-carrier protein]:alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-[lipid IVA] O-acyltransferase
2.4.1.182 lipid-A-disaccharide synthase UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine:2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine 1-phosphate 2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosaminyltransferase
2.4.1.58 lipopolysaccharide glucosyltransferase I UDP-glucose:lipopolysaccharide glucosyltransferase
2.4.1.73 lipopolysaccharide glucosyltransferase II UDP-glucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase
2.4.99.12 lipid IVA 3-deoxy-D-manno-octulosonic acid transferase CMP-3-deoxy-D-manno-oct-2-ulosonate:lipid IVA 3-deoxy-D-manno-oct-2-ulosonate transferase
2.4.99.13 (Kdo)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase CMP-3-deoxy-beta-D-manno-oct-2-ulosonate:alpha-Kdo-(2->6)-[lipid IVA] 3-deoxy-D-manno-oct-2-ulosonate transferase (configuration-inverting)
2.4.99.23 lipopolysaccharide heptosyltransferase I ADP-L-glycero-beta-D-manno-heptose:an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-[lipid A] 5-alpha-heptosyltransferase
2.4.99.24 lipopolysaccharide heptosyltransferase II ADP-L-glycero-beta-D-manno-heptose:an alpha-L-glycero-D-manno-heptosyl-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[lipid A] 3-alpha-heptosyltransferase
2.4.99.25 lipopolysaccharide heptosyltransferase III ADP-L-glycero-beta-D-manno-heptose:an alpha-Hep-(1->3)-4-O-phospho-alpha-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[lipid A] heptoseI 7-alpha-heptosyltransferase
2.5.1.55 3-deoxy-8-phosphooctulonate synthase phosphoenolpyruvate:D-arabinose-5-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)
2.6.1.16 glutamine-fructose-6-phosphate transaminase (isomerizing) L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
2.7.1.130 tetraacyldisaccharide 4'-kinase ATP:2-deoxy-2-([(3R)-3-hydroxyacyl]amino)-3-O-[(3R)-3-hydroxyacyl]-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxyacyl]-2-([(3R)-3-hydroxyacyl]amino)-1-O-phospho-alpha-D-glucopyranose 4'-O-phosphotransferase
2.7.1.191 protein-Npi-phosphohistidine-D-mannose phosphotransferase protein-Npi-phospho-L-histidine:D-mannose Npi-phosphotransferase
2.7.1.235 lipopolysaccharide core heptose(I) kinase ATP:an alpha-Hep-(1->3)-alpha-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[lipid A] heptoseI 4-O-phosphotransferase
2.7.7.23 UDP-N-acetylglucosamine diphosphorylase UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase
2.7.7.38 3-deoxy-manno-octulosonate cytidylyltransferase CTP:3-deoxy-D-manno-octulosonate cytidylyltransferase
2.7.8.42 Kdo2-lipid A phosphoethanolamine 7''-transferase diacylphosphatidylethanolamine:alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid-A 7''-phosphoethanolaminetransferase
3.1.3.45 3-deoxy-manno-octulosonate-8-phosphatase 3-deoxy-D-manno-octulosonate-8-phosphate 8-phosphohydrolase
3.5.1.108 UDP-3-O-acyl-N-acetylglucosamine deacetylase UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine amidohydrolase
3.6.1.54 UDP-2,3-diacylglucosamine diphosphatase UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine 2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine-1-phosphate phosphohydrolase
5.3.1.13 arabinose-5-phosphate isomerase D-arabinose-5-phosphate aldose-ketose-isomerase
5.4.2.10 phosphoglucosamine mutase alpha-D-glucosamine 1,6-phosphomutase
7.5.2.6 ABC-type lipid A-core oligosaccharide transporter ATP phosphohydrolase (ABC-type, lipid A-core oligosaccharide-translocating)


Proteins

Protein ID name full name
P04951 kdsB 3-deoxy-manno-octulosonate cytidylyltransferase
P0A715 kdsA 2-dehydro-3-deoxyphosphooctonate aldolase
P0A722 lpxA Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
P0A725 lpxC UDP-3-O-acyl-N-acetylglucosamine deacetylase
P0A9V1 lptB Lipopolysaccharide export system ATP-binding protein LptB
P0ABZ4 kdsC 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC
P0AC75 waaA 3-deoxy-D-manno-octulosonic acid transferase
P0ACC7 glmU Bifunctional protein GlmU
P0ACV0 lpxL Lipid A biosynthesis lauroyltransferase
P10441 lpxB Lipid-A-disaccharide synthase
P17115 gutQ Arabinose 5-phosphate isomerase GutQ
P17169 glmS Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
P21645 lpxD UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase
P24173 waaC Lipopolysaccharide heptosyltransferase 1
P24205 lpxM Lipid A biosynthesis myristoyltransferase
P25740 waaG Lipopolysaccharide glucosyltransferase WaaG
P25741 waaP Lipopolysaccharide core heptose(I) kinase WaaP
P25742 waaQ Lipopolysaccharide heptosyltransferase 3
P27127 waaB Lipopolysaccharide 1,6-galactosyltransferase
P27128 waaO Lipopolysaccharide glucosyltransferase WaaO
P27129 waaJ Lipopolysaccharide 1,2-glucosyltransferase
P27240 waaY Lipopolysaccharide core heptose(II) kinase WaaY
P27242 waaU Putative lipopolysaccharide heptosyltransferase 4
P27300 lpxK Tetraacyldisaccharide 4'-kinase
P31120 glmM Phosphoglucosamine mutase
P37661 eptB Kdo(2)-lipid A phosphoethanolamine 7''-transferase
P37692 waaF Lipopolysaccharide heptosyltransferase 2
P43341 lpxH UDP-2,3-diacylglucosamine hydrolase
P45395 kdsD Arabinose 5-phosphate isomerase KdsD
P60752 msbA ATP-dependent lipid A-core flippase
P69797 manX PTS system mannose-specific EIIAB component