Tryptophan metabolism
Han Q, Cai T, Tagle DA, Li J. Structure, expression, and function of kynurenine aminotransferases in human and rodent brains. Cellular and Molecular Life Sciences. 2009 Oct 15;67(3):353–68. doi: 10.1007/s00018-009-0166-4.
Metabolites
4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
Formula: C10H9NO5 (223.04807039999997)
CAS ID: 857760-67-9
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.13.11.- | |||
| 1.1.1.110 | aromatic 2-oxoacid reductase | aromatic 2-oxoacid:NAD+ oxidoreductase | |
| 1.1.1.35 | 3-hydroxyacyl-CoA dehydrogenase | (S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase | |
| 1.13.11.11 | tryptophan 2,3-dioxygenase | L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) | |
| 1.13.11.52 | indoleamine 2,3-dioxygenase | D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) | |
| 1.14.16.4 | tryptophan 5-monooxygenase | L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) | |
| 1.2.1.3 | aldehyde dehydrogenase (NAD+) | aldehyde:NAD+ oxidoreductase | |
| 1.3.8.15 | 3-(aryl)acrylate reductase | 3-(phenyl)propanoate:electron-transfer flavoprotein 2,3-oxidoreductase | |
| 1.4.3.2 | L-amino-acid oxidase | L-amino-acid:oxygen oxidoreductase (deaminating) | |
| 1.4.3.25 | L-arginine oxidase | L-arginine:oxygen oxidoreductase (deaminating) | |
| 2.6.1.1 | aspartate transaminase | L-aspartate:2-oxoglutarate aminotransferase | |
| 2.6.1.39 | 2-aminoadipate transaminase | L-2-aminoadipate:2-oxoglutarate aminotransferase | |
| 2.6.1.4 | glycine transaminase | glycine:2-oxoglutarate aminotransferase | |
| 2.6.1.63 | kynurenine-glyoxylate transaminase | L-kynurenine:glyoxylate aminotransferase (cyclizing) | |
| 2.6.1.64 | glutamine-phenylpyruvate transaminase | L-glutamine:phenylpyruvate aminotransferase | |
| 2.6.1.7 | kynurenine-oxoglutarate transaminase | L-kynurenine:2-oxoglutarate aminotransferase | |
| 2.6.1.73 | methionine-glyoxylate transaminase | L-methionine:glyoxylate aminotransferase | |
| 4.1.99.1 | tryptophanase | L-tryptophan indole-lyase (deaminating; pyruvate-forming) | |
| 4.2.1.175 | (R)-3-(aryl)lactoyl-CoA dehydratase | (R)-3-phenyllactyl-CoA hydro-lyase | |
| 4.4.1.13 | cysteine-S-conjugate beta-lyase | L-cysteine-S-conjugate thiol-lyase (deaminating; pyruvate-forming) |
Proteins
| Protein ID | name | full name |
|---|---|---|
| G9EZR6 | fldH | Aromatic 2-oxoacid reductase |
| J7SHB8 | fldH | Aromatic 2-oxoacid reductase |
| J7TF92 | acdA | 3-(aryl)acrylate reductase |
| O07674 | tnaA | Tryptophanase |
| P31014 | tnaA1 | Tryptophanase 1 |
| P31015 | tnaA2 | Tryptophanase 2 |
| P45867 | acdA | Acyl-CoA dehydrogenase |
| Q93AL8 | fldC | (R)-phenyllactyl-CoA dehydratase beta subunit |
| Q93AL9 | fldB | (R)-phenyllactyl-CoA dehydratase alpha subunit |
| Q9ZNA8 | tnaA | Tryptophanase |