10-Formyltetrahydrofolate (BioCAD00000001737)
Metabolite Card
Formula: C20H23N7O7 (473.1659)
SMILES: NC1=NC(=O)C2=C(NCC(CN(C=O)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N2)N1
Synonyms [en]
10-Formyltetrahydrofolate; 10-Formyl-THF; N10-Formyltetrahydrofolic acid; 10-formyl-tetrahydrofolate; 10-Formyltetrahydropteroylglutamate; 10-FTHF
Last reviewed on 2024-06-28.
Cite this Page
10-Formyltetrahydrofolate. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China.
https://biocad_registry.innovation.ac.cn/s/(-)-arctiin
(retrieved
2026-01-03) (CAD Registry RN: BioCAD00000001737). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Note
10-Formyltetrahydrofolate (10-CHO-THF) is form of tetrahydrofolate that acts as a donor of formyl groups in anabolism. In particular, 10-CHO-THF is used as a substrate in a number of formyltransferase reactions. It plays an important role in purine biosynthesis, where 10-CHO-THF is a substrate for phosphoribosylaminoimidazolecarboxamide formyltransferase, as well as in the formylation of the methionyl initiator tRNA (fMet-tRNA), when 10-CHO-THF is a substrate for methionyl-tRNA formyltransferase. 10-Formyltetrahydrofolate is a substrate for Trifunctional purine biosynthetic protein adenosine-3, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase (mitochondrial), 10-formyltetrahydrofolate dehydrogenase, Folylpolyglutamate synthase (mitochondrial), Bifunctional purine biosynthesis protein PURH and C-1-tetrahydrofolate synthase (cytoplasmic).
DBLinks
- CAS Registry Number: 2800-34-2
- PubChem CID: 122347
- ChEBI: 15637
- HMDB: HMDB0000972
- LipidMaps:
- KEGG: C00234
- BioCyc:
- NCBI MeSH: 10-formyltetrahydropteroylglutamic acid
- Wikipedia: 10-Formyltetrahydrofolate
Other DBLinks
- CAS Registry Number: 2800-34-2
- PubChem: 122347
- PubChem: 135398556
- PubChem: 135450591
- ChEBI: ChEBI:134412
- ChEBI: ChEBI:15637
- ChEBI: ChEBI:195364
- HMDB: HMDB0000972
- KEGG: C00234
- NCBI MeSH: 10-formyltetrahydropteroylglutamic acid
- Wikipedia: 10-Formyltetrahydrofolate
- RefMet: RM0030050
- Metlin: METLIN_715
- Coconut NaturalProduct: CNP0169938.1
- Coconut NaturalProduct: CNP0507737.1
- Coconut NaturalProduct: CNP0589112.0
Class / Ontology
- WishartLab ClassyFire: [Pterins and derivatives] Pterins and derivatives
- RefMet: [Tetrahydrofolic acids] Tetrahydrofolic acids
- Coconut NaturalProduct: [pteridine alkaloids] pteridine alkaloids
| ID | EC Number | Name |
|---|---|---|
| KEGG:R00941 | 1.5.1.6 | 10-formyltetrahydrofolate:NADP+ oxidoreductase |
| KEGG:R00943 | 6.3.4.3 | formate:tetrahydrofolate ligase (ADP-forming) |
| KEGG:R00944 | 3.5.1.10 | 10-formyltetrahydrofolate amidohydrolase |
| KEGG:R01654 | 6.3.2.12 | 10-formyltetrahydrofolate:L-glutamate ligase (ADP-forming) |
| KEGG:R01655 | 3.5.4.9 | 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing) |
| KEGG:R03940 | 2.1.2.9 | 10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase |
| KEGG:R04325 | 2.1.2.2 | 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase |
| KEGG:R04560 | 2.1.2.3 | 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase |
| KEGG:R07660 | 2.1.2.13 | C00234 + C16153<=>C00101 + C16154 |
| KEGG:R12790 | 2.1.2.14 | 10-formyltetrahydrofolate:GDP-alpha-D-perosamine N-formyltransferase |
Taxonomy Source
- Arabidopsis thaliana [ncbi taxid: 3702]
- Escherichia coli [ncbi taxid: 562]
- Herba dendrobii [ncbi taxid: ]
Pathway Synthetic
| pathway id | name |
|---|---|
| PathBank:SMP0000914 | Amino Sugar and Nucleotide Sugar Metabolism III |
| PathBank:SMP0000927 | Purine Nucleotides De Novo Biosynthesis |
| PathBank:SMP0001750 | One Carbon Pool by Folate |
| PathBank:SMP0002047 | Purine Nucleotides De Novo Biosynthesis 2 |
| PathBank:SMP0002065 | Polymyxin Resistance |
| PathBank:SMP0120670 | Adenylosuccinate Lyase Deficiency |
| PathBank:SMP0120718 | Hypermethioninemia |
| PathBank:SMP0120742 | Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) |
| PathBank:SMP0120448 | Adenosine Deaminase Deficiency |
| PathBank:SMP0120452 | AICA-Ribosiduria |
| PathBank:SMP0120508 | Lesch-Nyhan Syndrome (LNS) |
| PathBank:SMP0120532 | Molybdenum Cofactor Deficiency |
| PathBank:SMP0120536 | Purine Nucleoside Phosphorylase Deficiency |
| PathBank:SMP0120577 | Xanthinuria Type I |
| PathBank:SMP0120601 | Mitochondrial DNA Depletion Syndrome |
| PathBank:SMP0122040 | One Carbon Pool by Folate |
| PathBank:SMP0000167 | Adenylosuccinate Lyase Deficiency |
| PathBank:SMP0000220 | Xanthine Dehydrogenase Deficiency (Xanthinuria) |
| PathBank:SMP0000177 | Cystathionine beta-Synthase Deficiency |
| PathBank:SMP0000340 | Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) |