10-Formyltetrahydrofolate
10-Formyltetrahydrofolate (10-CHO-THF) is form of tetrahydrofolate that acts as a donor of formyl groups in anabolism. In particular, 10-CHO-THF is used as a substrate in a number of formyltransferase reactions. It plays an important role in purine biosynthesis, where 10-CHO-THF is a substrate for phosphoribosylaminoimidazolecarboxamide formyltransferase, as well as in the formylation of the methionyl initiator tRNA (fMet-tRNA), when 10-CHO-THF is a substrate for methionyl-tRNA formyltransferase. 10-Formyltetrahydrofolate is a substrate for Trifunctional purine biosynthetic protein adenosine-3, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase (mitochondrial), 10-formyltetrahydrofolate dehydrogenase, Folylpolyglutamate synthase (mitochondrial), Bifunctional purine biosynthesis protein PURH and C-1-tetrahydrofolate synthase (cytoplasmic).
| ID | EC Number | Name |
|---|---|---|
| KEGG:R00941 | 1.5.1.6 | 10-formyltetrahydrofolate:NADP+ oxidoreductase |
| KEGG:R00943 | 6.3.4.3 | formate:tetrahydrofolate ligase (ADP-forming) |
| KEGG:R00944 | 3.5.1.10 | 10-formyltetrahydrofolate amidohydrolase |
| KEGG:R01654 | 6.3.2.12 | 10-formyltetrahydrofolate:L-glutamate ligase (ADP-forming) |
| KEGG:R01655 | 3.5.4.9 | 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing) |
| KEGG:R03940 | 2.1.2.9 | 10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase |
| KEGG:R04325 | 2.1.2.2 | 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase |
| KEGG:R04560 | 2.1.2.3 | 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase |
| KEGG:R07660 | 2.1.2.13 | C00234 + C16153<=>C00101 + C16154 |
| KEGG:R12790 | 2.1.2.14 | 10-formyltetrahydrofolate:GDP-alpha-D-perosamine N-formyltransferase |