Secondary Metabolites: Methylerythritol Phosphate and Polyisoprenoid Biosynthesis

Metabolites

1-Deoxy-D-xylulose 5-phosphate

Formula: C5H11O7P (214.0242386)

CAS ID: 190079-18-6

ADP

Formula: C10H15N5O10P2 (427.02941500000003)

CAS ID: 58-64-0

ATP

Formula: C10H16N5O13P3 (506.9957476)

CAS ID: 56-65-5

CMP

Formula: C9H14N3O8P (323.05184940000004)

CAS ID: 63-37-6

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

CTP

Formula: C9H16N3O14P3 (482.9845146)

CAS ID: 65-47-4

Dimethylallyl diphosphate

Formula: C5H12O7P2 (246.0058262)

CAS ID: 358-72-5

Geranyl diphosphate

Formula: C10H20O7P2 (314.068423)

CAS ID: 763-10-0

Glyceraldehyde 3-phosphate

Formula: C3H7O6P (169.9980252)

CAS ID: 591-59-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Isopentenyl diphosphate

Formula: C5H12O7P2 (246.0058262)

CAS ID: 358-71-4

NADP+

Formula: C21H29N7O17P3 (744.0832754)

CAS ID: 53-59-8

diphosphate

Formula: O7P2 (173.911931)

CAS ID: 14000-31-8



Enzyme

EC Number name full name note
1.1.1.267 1-deoxy-D-xylulose-5-phosphate reductoisomerase 2-C-methyl-D-erythritol-4-phosphate:NADP+ oxidoreductase (isomerizing)
1.17.7.3 (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin) (E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:oxidized flavodoxin oxidoreductase
1.17.7.4 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase isopentenyl-diphosphate:ferredoxin oxidoreductase
2.2.1.7 1-deoxy-D-xylulose-5-phosphate synthase pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating)
2.5.1.10 (2E,6E)-farnesyl diphosphate synthase geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase
2.5.1.31 ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 8 isopentenyl units)
2.5.1.90 all-trans-octaprenyl-diphosphate synthase (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 5 isopentenyl units)
2.7.1.148 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase
2.7.7.60 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
4.6.1.12 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate-forming)
5.3.3.2 isopentenyl-diphosphate DELTA-isomerase 3-methylbut-3-en-1-yl-diphosphate DELTA3-DELTA2-isomerase


Proteins

Protein ID name full name
P0AD57 ispB Octaprenyl diphosphate synthase
P22939 ispA Farnesyl diphosphate synthase
P45568 dxr 1-deoxy-D-xylulose 5-phosphate reductoisomerase
P60472 ispU Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)
P62615 ispE 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
P62617 ispF 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
P62620 ispG 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)
P62623 ispH 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
P77488 dxs 1-deoxy-D-xylulose-5-phosphate synthase
Q46822 idi Isopentenyl-diphosphate Delta-isomerase
Q46893 ispD 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase