Peptidoglycan Biosynthesis I

Metabolites

Acetyl-CoA

Formula: C23H38N7O17P3S (809.1257688000001)

CAS ID: 72-89-9

ADP

Formula: C10H15N5O10P2 (427.02941500000003)

CAS ID: 58-64-0

ATP

Formula: C10H16N5O13P3 (506.9957476)

CAS ID: 56-65-5

beta-D-Glucose 6-phosphate

Formula: C6H13O9P (260.0297178)

CAS ID: 15209-12-8

D-Alanine

Formula: C3H7NO2 (89.0476762)

CAS ID: 338-69-2

D-Alanyl-D-alanine

Formula: C6H12N2O3 (160.0847882)

CAS ID: 923-16-0

D-Glutamate

Formula: C5H9NO4 (147.0531554)

CAS ID: 6893-26-1

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

L-Alanine

Formula: C3H7NO2 (89.0476762)

CAS ID: 56-41-7

L-Glutamate

Formula: C5H9NO4 (147.0531554)

CAS ID: 56-86-0

L-Glutamine

Formula: C5H10N2O3 (146.069139)

CAS ID: 56-85-9

NADP+

Formula: C21H29N7O17P3 (744.0832754)

CAS ID: 53-59-8

Phosphoenolpyruvate

Formula: C3H5O6P (167.98237600000002)

CAS ID: 138-08-9

Sodium cation

Formula: Na (22.98977)

CAS ID: 17341-25-2

UDP

Formula: C9H14N2O12P2 (404.0021984)

CAS ID: 58-98-0

UMP

Formula: C9H13N2O9P (324.03586580000007)

CAS ID: 58-97-9

UTP

Formula: C9H15N2O15P3 (483.968531)

CAS ID: 63-39-8

Lorglumide

Formula: C22H32Cl2N2O4 (458.1739012)

CAS ID: 97964-56-2

diphosphate

Formula: O7P2 (173.911931)

CAS ID: 14000-31-8

phosphate(3-)

Formula: O4P (94.953423)

CAS ID: 14265-44-2



Enzyme

EC Number name full name note
1.3.1.98 UDP-N-acetylmuramate dehydrogenase UDP-N-acetyl-alpha-D-muramate:NADP+ oxidoreductase
2.3.1.157 glucosamine-1-phosphate N-acetyltransferase acetyl-CoA:alpha-D-glucosamine-1-phosphate N-acetyltransferase
2.4.1.227 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase UDP-N-acetyl-D-glucosamine:N-acetyl-alpha-D-muramyl(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase
2.4.99.28 peptidoglycan glycosyltransferase [poly-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide)]-diphosphoundecaprenol:[N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide]-diphosphoundecaprenol disaccharidetransferase
2.5.1.7 UDP-N-acetylglucosamine 1-carboxyvinyltransferase phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase
2.6.1.16 glutamine-fructose-6-phosphate transaminase (isomerizing) L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
2.7.1.191 protein-Npi-phosphohistidine-D-mannose phosphotransferase protein-Npi-phospho-L-histidine:D-mannose Npi-phosphotransferase
2.7.7.23 UDP-N-acetylglucosamine diphosphorylase UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase
2.7.8.13 phospho-N-acetylmuramoyl-pentapeptide-transferase UDP-MurAc(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala):undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide-transferase
3.4.16.4 serine-type D-Ala-D-Ala carboxypeptidase
5.1.1.3 glutamate racemase glutamate racemase
5.3.1.9 glucose-6-phosphate isomerase alpha-D-glucose-6-phosphate aldose-ketose-isomerase (configuration-inverting)
5.4.2.10 phosphoglucosamine mutase alpha-D-glucosamine 1,6-phosphomutase
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine:D-alanyl-D-alanine ligase (ADP-forming)
6.3.2.13 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2,6-diaminopimelate ligase UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:(L)-meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming)
6.3.2.4 D-Alanine-D-alanine ligase D-alanine:D-alanine ligase (ADP-forming)
6.3.2.8 UDP-N-acetylmuramate-L-alanine ligase UDP-N-acetylmuramate:L-alanine ligase (ADP-forming)
6.3.2.9 UDP-N-acetylmuramoyl-L-alanine-D-glutamate ligase UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (ADP-forming)


Proteins

Protein ID name full name
P02918 mrcA Penicillin-binding protein 1A
P02919 mrcB Penicillin-binding protein 1B
P07862 ddlB D-alanine--D-alanine ligase B
P08373 murB UDP-N-acetylenolpyruvoylglucosamine reductase
P0A6J8 ddlA D-alanine--D-alanine ligase A
P0A6T1 pgi Glucose-6-phosphate isomerase
P0A6W3 mraY Phospho-N-acetylmuramoyl-pentapeptide-transferase
P0A749 murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase
P0ABG4 ftsW Probable peptidoglycan glycosyltransferase FtsW
P0ACC7 glmU Bifunctional protein GlmU
P0AD65 mrdA Peptidoglycan D,D-transpeptidase MrdA
P0AD68 ftsI Peptidoglycan D,D-transpeptidase FtsI
P11880 murF UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
P14900 murD UDP-N-acetylmuramoylalanine--D-glutamate ligase
P17169 glmS Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
P17443 murG UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
P17952 murC UDP-N-acetylmuramate--L-alanine ligase
P22188 murE UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
P22634 murI Glutamate racemase
P31120 glmM Phosphoglucosamine mutase
P46022 mtgA Biosynthetic peptidoglycan transglycosylase
P69797 manX PTS system mannose-specific EIIAB component
P76577 pbpC Penicillin-binding protein 1C