Interconversion of nucleotide di- and triphosphates

Van Rompay AR, Johansson M, Karlsson A. Phosphorylation of nucleosides and nucleoside analogs by mammalian nucleoside monophosphate kinases. Pharmacol Ther. 2000 Aug;87(2-3):189–98. doi: 10.1016/s0163-7258(00)00048-6. PMID: 11008000.; Wilson DE, Povey S, Harris H. Adenylate kinases in man: evidence for a third locus. Ann Hum Genet. 1976 Jan;39(3):305–13. doi: 10.1111/j.1469-1809.1976.tb00134.x. PMID: 5940.; Jamil T, Fisher RA, Harris H. Studies on the properties and tissue distribution of the isozymes of guanylate kinase in man. Hum Hered. 1975;25(5):402–13. doi: 10.1159/000152753. PMID: 177353.

Metabolites

Fe3+

Formula: Fe (55.934939)

CAS ID: 7439-89-6

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8

dTMP(2-)

Formula: C10H13N2O8P (320.0409508)

CAS ID: 14057-65-9



Enzyme

EC Number name full name note
3.5.1.-
1.17.4.1 ribonucleoside-diphosphate reductase 2'-deoxyribonucleoside-5'-diphosphate:thioredoxin-disulfide 2'-oxidoreductase
2.7.4.14 UMP/CMP kinase ATP:CMP(UMP) phosphotransferase
2.7.4.3 adenylate kinase ATP:AMP phosphotransferase
2.7.4.6 nucleoside-diphosphate kinase ATP:nucleoside-diphosphate phosphotransferase
2.7.4.9 dTMP kinase ATP:dTMP phosphotransferase
6.3.4.2 CTP synthase (glutamine hydrolysing) UTP:ammonia ligase (ADP-forming)


Proteins

Protein ID name full name