Microbial Natural Product
Microbial natural products, primarily secondary metabolites produced by bacteria, fungi, and other microorganisms, remain a cornerstone of modern medicine and biotechnology. They form the foundation of numerous antibiotics (e.g., penicillin, streptomycin), anticancer agents, and immunosuppressants, addressing critical global health challenges like infectious diseases and cancer. Despite historical challenges such as compound rediscovery and complex biosynthesis, advances in genomics, metabolomics, and synthetic biology are unlocking novel chemical diversity from underexplored microbial sources. Consequently, microbial natural products continue to represent an unparalleled reservoir for discovering next-generation therapeutics, underscoring their enduring significance in drug development and sustainable bioprospecting. (98 words)
2-O-Methylxylose
2-o-methylxylose is a member of the class of compounds known as pentoses. Pentoses are monosaccharides in which the carbohydrate moiety contains five ...
gamma-Carotene
gamma-Carotene is a cyclic carotene obtained by the cyclization of lycopene. It is found in human serum and breast milk (PMID: 9164160). Carotenoids a...
15-cis-Phytoene
15-cis-Phytoene is found in cauliflower. 15-cis-Phytoene is isolated from tomato (Lycopersicon esculentum var. `Tangella'). 7,7',8,8',11,11',12,12'-Oc...
Antimycin A1
Formula: C28H40N2O9 (548.2734)
A nine-membered bis-lactone having methyl substituents at the 2- and 6-positions, an n-hexyl substituent at the 8-position, an acyloxy substituent at ...
Purothionin AII
Formula: C26H36N2O9 (520.2421)
Purothionin AII is found in cereals and cereal products. Purothionin AII is isolated from wheat (Triticum monococcum). Toxic to brewers' yeast.
6-Acetophenazine-1-carboxylic acid
Formula: C15H10N2O3 (266.0691)
6-Acetophenazine-1-carboxylic acid is a member of phenazines. 6-Acetylphenazine-1-carboxylic acid is a natural product found in Streptomyces and Stre...
Epothilone C
Formula: C26H39NO5S (477.2549)
An epothilone that is 1-oxacyclohexadec-13-ene-2,6-dione which is substituted by hydroxy groups at positions 4 and 9, methyl groups at positions 5, 5,...
3-Hydroxy-4-methylanthranilate
An aminobenzoic acid that is anthranilic acid substituted by a hydroxy group at position 3 and a methyl group at position 4." []
Isopentenyl phosphate
Isopentenyl phosphate is a monoalkyl phosphate that is isopentenyl alcohol in which the hydroxyl hydrogen is substituted by a phosphate group. It is f...
Deoxycoformycin
Formula: C11H16N4O4 (268.1171)
Pentostatin is only found in individuals that have used or taken this drug. It is a potent inhibitor of adenosine deaminase. The drug is effective in ...
Saphenic acid
Formula: C15H12N2O3 (268.0848)
Geranylgeranyl diphosphate
Formula: C20H36O7P2 (450.1936)
Geranylgeranyl pyrophosphate, also known as geranylgeranyl-PP or GGPP, is an intermediate in the HMG-CoA reductase pathway used by organisms in the bi...
Myxochelin A
Formula: C20H24N2O7 (404.1583)
Myxochelin A is a member of salicylamides. N,N'-Bis(2,3-dihydroxybenzoyl)lysinol is a natural product found in Archangium disciforme with data availa...
Myxochelin B
Formula: C20H25N3O6 (403.1743)
A member of the class of benzamides obtained by formal condensation of the 1- and 6-amino groups of hexane-1,2,6-triamine with the carboxy groups fro...
Aurachin C
Aurachin C is a C-type aurachin that is quinolin-4-one which is substituted by a hydroxy group at positions 1, a methyl group at position 2, and a tri...
Aurachin B
Aurachin B is an A-type aurachin that is quinoline N-oxide which is substituted by a methyl group at position 2, a hydroxy group at position 3, and a ...
Aurachin A
Aurachin A is an A-type aurichin that is 1,2-dihydrofuro[2,3-c]quinoline 5-oxide which is substituted at position 2 by a (6E)-10-hydroxy-2,6-dimethylu...
5alpha-Campestan-3-one
5alpha-Campestan-3-one, also known as 3-dehydro-campestanol or methylcholestanone, belongs to the class of organic compounds known as ergosterols and ...
5alpha-Cholestan-3-one
5alpha-Cholestanone, also known as 5α-cholestanone, belongs to the class of organic compounds known as cholesterols and derivatives. Cholesterols and ...
(-)-beta-Phellandrene
(-)-beta-Phellandrene is found in pine nut. Phellandrene is the name for a pair of organic compounds that have a similar molecular structure and simil...
(R)-(-)-alpha-Phellandrene
(R)-alpha-Phellandrene is found in herbs and spices. (R)-alpha-Phellandrene is a constituent of oils of pimento, bay, Citrus, Juniperus, Mentha, and o...
Tubulysin E
Formula: C42H63N5O9S (813.4346)
1,4-Dimethoxybenzene
1,4-Dimethoxybenzene is found in peppermint. 1,4-Dimethoxybenzene is a flavouring ingredien
(E)-beta-Ocimene
trans-Ocimene is found in allspice. trans-Ocimene is a constituent of the pheromones of Anastrepha suspensa, Euploea tulliolus koxinga, and Labidus sp...
Terpinolene
Terpinolene (TPO), also known as alpha-terpinolene or isoterpinene, belongs to the class of organic compounds known as menthane monoterpenoids. These ...
(S)-(+)-alpha-Phellandrene
(S)-alpha-Phellandrene is found in ceylan cinnamon. (S)-alpha-Phellandrene is a flavouring agent. (S)-alpha-Phellandrene is a constituent of many ess...
Chondrochloren B
Formula: C28H42ClNO7 (539.265)
Chondrochloren B is a monocarboxylic acid amide with formula C28H42ClNO7, that is produced by Chondromyces crocatus and exhibits antibiotic properties...
Chondrochloren A
Formula: C27H40ClNO7 (525.2493)
Chondrochloren A is a monocarboxylic acid amide with formula C27H40ClNO7, that is produced by Chondromyces crocatus and exhibits antibiotic properties...
2-Methoxy-3-methylpyrazine
2-Methoxy-3-methylpyrazine is found in burdock. 2-Methoxy-3-methylpyrazine is reported in sherry and krill. 2-Methoxy-3-methylpyrazine is a flavouring...
Sandaracopimaric Acid
Sandaracopimaric acid is a pimarane diterpenoid that is (1S,4aS,4bS,7R,10aS)-1,4a,7-trimethyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydrophenanthrene car...
Gnaphaliin
Gnaphaliin is found in herbs and spices. Gnaphaliin is a constituent of Helichrysum italicum (curry plant)
Soraphen A
A macrolide and an agent highly effective against plant-pathogenic fungi. It was extensively researched for agricultural use until it was discovered t...
3,5,7-Trihydroxy-6,8-dimethoxyflavone
3,5,7-Trihydroxy-6,8-dimethoxyflavone
(S)-Isoboldine
Isoboldine is an aporphine alkaloid. (+)-Isoboldine has been reported in Aconitum sanyoense, Corydalis solida, and other organisms with data availabl...