EC: 3.5.4.16

GTP cyclohydrolase I (GTP 7,8-8,9-dihydrolase)

enzyme lambda metabolic reaction experiment
uniprot:O25613 [GTP cyclohydrolase I(Enzyme) wildtype]

GTP + H2O -> Formate + 7,8_Dihydroneopterin_3'_triphosphate		 (( (( (kcat * E) ) * S) ) / (Km + S)) buffer: 100 mM sodium citrate, 2.5 mM EDTA, 0.05 M KCl, 10% (v/v) glycerin
PH: 4
Temperature: 30
uniprot:P22288 [GTP cyclohydrolase I(Enzyme) wildtype]

H2O + GTP -> Formate + 7,8_Dihydroneopterin_3'_triphosphate		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 20 mM potassium phosphate, 0.1 M KCl
PH: 7.5
Temperature: 37

Pathways

pathway id name
BioCyc:META_PWY-6703 preQ0 biosynthesis
BioCyc:META_ALL-CHORISMATE-PWY superpathway of chorismate metabolism
BioCyc:ECO_PWY0-1433 tetrahydromonapterin biosynthesis
BioCyc:ECO_PWY-6703 preQ0 biosynthesis
BioCyc:ECO_PWY-6612 superpathway of tetrahydrofolate biosynthesis
BioCyc:YEAST_FOLSYN-PWY superpathway of tetrahydrofolate biosynthesis and salvage
BioCyc:ARA_PWY-6612 superpathway of tetrahydrofolate biosynthesis
BioCyc:ARA_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
BioCyc:MTBH37RV_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
BioCyc:MTBH37RV_PWY-6612 superpathway of tetrahydrofolate biosynthesis
BioCyc:ECOO157_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
BioCyc:CAULO_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
BioCyc:CAULO_PWY-6612 superpathway of tetrahydrofolate biosynthesis
BioCyc:AGRO_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
BioCyc:BSUB_PWY-6703 preQ0 biosynthesis
BioCyc:ECOL316407_ALL-CHORISMATE-PWY superpathway of chorismate metabolism
BioCyc:PDIF272563_PWY-6612 superpathway of tetrahydrofolate biosynthesis
BioCyc:META_PWY-6612 superpathway of tetrahydrofolate biosynthesis
BioCyc:META_PWY-5664 erythro-tetrahydrobiopterin biosynthesis II
BioCyc:YEAST_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
BioCyc:ARA_PWY-3742 tetrahydrofolate biosynthesis II
BioCyc:MTBH37RV_FOLSYN-PWY superpathway of tetrahydrofolate biosynthesis and salvage
BioCyc:MTBCDC1551_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
BioCyc:ECOO157_FOLSYN-PWY superpathway of tetrahydrofolate biosynthesis and salvage
BioCyc:ECOL199310_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
BioCyc:ECOL199310_FOLSYN-PWY superpathway of tetrahydrofolate biosynthesis and salvage
BioCyc:CAULO_FOLSYN-PWY superpathway of tetrahydrofolate biosynthesis and salvage
BioCyc:ANTHRA_FOLSYN-PWY superpathway of tetrahydrofolate biosynthesis and salvage
BioCyc:AGRO_FOLSYN-PWY superpathway of tetrahydrofolate biosynthesis and salvage
BioCyc:BSUB_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
BioCyc:BSUB_PWY-6612 superpathway of tetrahydrofolate biosynthesis
BioCyc:SYNEL_PWY-6983 tetrahydrobiopterin biosynthesis III
BioCyc:ECOL316407_PWY-6612 superpathway of tetrahydrofolate biosynthesis
BioCyc:CORYNE_PWY-6612 superpathway of tetrahydrofolate biosynthesis
BioCyc:GCF_000013425_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
BioCyc:GCF_000013425_PWY-6612 superpathway of tetrahydrofolate biosynthesis
BioCyc:HUMAN_PWY-5663 tetrahydrobiopterin de novo biosynthesis
BioCyc:META_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
BioCyc:META_PWY-7442 drosopterin and aurodrosopterin biosynthesis
BioCyc:META_PWY0-1433 tetrahydromonapterin biosynthesis
BioCyc:YEAST_PWY-6612 superpathway of tetrahydrofolate biosynthesis
BioCyc:ANTHRA_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
BioCyc:ANTHRA_PWY-6612 superpathway of tetrahydrofolate biosynthesis
BioCyc:AGRO_PWY-6612 superpathway of tetrahydrofolate biosynthesis
BioCyc:MOUSE_PWY-5663 tetrahydrobiopterin biosynthesis I
BioCyc:SYNEL_PWY-6612 superpathway of tetrahydrofolate biosynthesis
BioCyc:SYNEL_FOLSYN-PWY superpathway of tetrahydrofolate biosynthesis and salvage
BioCyc:ECOL316407_PWY-6703 preQ0 biosynthesis
BioCyc:PDIF272563_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
BioCyc:BTHE_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
BioCyc:CORYNE_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
BioCyc:CORYNE_FOLSYN-PWY superpathway of tetrahydrofolate biosynthesis and salvage
BioCyc:GCF_000013425_FOLSYN-PWY superpathway of tetrahydrofolate biosynthesis and salvage
BioCyc:GCF_000013425_PWY-6703 preQ0 biosynthesis
BioCyc:META_FOLSYN-PWY superpathway of tetrahydrofolate biosynthesis and salvage
BioCyc:META_PWY-5663 erythro-tetrahydrobiopterin biosynthesis I
BioCyc:ECO_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
BioCyc:ECO_ALL-CHORISMATE-PWY superpathway of chorismate metabolism
BioCyc:MTBCDC1551_PWY-6612 superpathway of tetrahydrofolate biosynthesis
BioCyc:MTBCDC1551_FOLSYN-PWY superpathway of tetrahydrofolate biosynthesis and salvage
BioCyc:ECOO157_PWY-6612 superpathway of tetrahydrofolate biosynthesis
BioCyc:ECOL199310_PWY-6612 superpathway of tetrahydrofolate biosynthesis
BioCyc:ECOL199310_ALL-CHORISMATE-PWY superpathway of chorismate metabolism
BioCyc:MOUSE_PWY-5664 tetrahydrobiopterin biosynthesis II
BioCyc:BSUB_FOLSYN-PWY superpathway of tetrahydrofolate biosynthesis and salvage
BioCyc:SYNEL_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
BioCyc:SYNEL_PWY-5663 tetrahydrobiopterin biosynthesis I
BioCyc:ECOL316407_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
BioCyc:PDIF272563_FOLSYN-PWY superpathway of tetrahydrofolate biosynthesis and salvage
BioCyc:BTHE_PWY-6612 superpathway of tetrahydrofolate biosynthesis
PathBank:SMP0000925 Folate Biosynthesis
PathBank:SMP0001902 GTP Degradation and Molybdenum Cofactor Biosynthesis
PathBank:SMP0001907 PreQ0 Metabolism
PathBank:SMP0001985 Flavin Biosynthesis
PathBank:SMP0002057 Tetrahydromonapterin Biosynthesis
PlantCyc:ARA_PWY-3742 tetrahydrofolate biosynthesis II
PlantCyc:ARA_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
PlantCyc:PLANT_PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
PlantCyc:ARA_PWY-6612 superpathway of tetrahydrofolate biosynthesis
PlantCyc:PLANT_PWY-3742 tetrahydrofolate biosynthesis II
PlantCyc:PLANT_PWY-6612 superpathway of tetrahydrofolate biosynthesis
Reactome:R-CEL-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Reactome:R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Reactome:R-RNO-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Reactome:R-SCE-8978934 Metabolism of cofactors
Reactome:R-SPO-1430728 Metabolism
Reactome:R-DDI-196854 Metabolism of vitamins and cofactors
Reactome:R-DDI-8978934 Metabolism of cofactors
Reactome:R-DME-1430728 Metabolism
Reactome:R-DME-8978934 Metabolism of cofactors
Reactome:R-HSA-196854 Metabolism of vitamins and cofactors
Reactome:R-MMU-196854 Metabolism of vitamins and cofactors
Reactome:R-RNO-196854 Metabolism of vitamins and cofactors
Reactome:R-SCE-1430728 Metabolism
Reactome:R-SCE-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Reactome:R-SPO-8978934 Metabolism of cofactors
Reactome:R-CEL-8978934 Metabolism of cofactors
Reactome:R-HSA-8978934 Metabolism of cofactors
Reactome:R-MMU-8978934 Metabolism of cofactors
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-8978934 Metabolism of cofactors
Reactome:R-SPO-196854 Metabolism of vitamins and cofactors
Reactome:R-CEL-1430728 Metabolism
Reactome:R-CEL-196854 Metabolism of vitamins and cofactors
Reactome:R-DDI-1430728 Metabolism
Reactome:R-DDI-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Reactome:R-DME-196854 Metabolism of vitamins and cofactors
Reactome:R-DME-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Reactome:R-HSA-1430728 Metabolism
Reactome:R-SCE-196854 Metabolism of vitamins and cofactors
Reactome:R-SPO-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
WikiPathways:WP4156 Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine
PathBank:SMP0120774 Hyperphenylalaninemia Due to DHPR-Deficiency
PathBank:SMP0000005 Pterine Biosynthesis
PathBank:SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps)
PathBank:SMP0087486 Pterine Biosynthesis
PathBank:SMP0120773 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps)
PathBank:SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency
PathBank:SMP0000491 Sepiapterin Reductase Deficiency
PathBank:SMP0012013 Pterin Biosynthesis (Folate Precursor)
PathBank:SMP0120772 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency
PathBank:SMP0120776 Sepiapterin Reductase Deficiency
PathBank:SMP0000489 Hyperphenylalaninemia Due to DHPR-Deficiency
PathBank:SMP0002334 Tetrahydrofolate Biosynthesis
PathBank:SMP0120771 DOPA-Responsive Dystonia
PathBank:SMP0120775 Segawa Syndrome
PathBank:SMP0000486 DOPA-Responsive Dystonia
PathBank:SMP0000490 Segawa Syndrome
PathBank:SMP0087343 Pterine Biosynthesis