Metabolism of cofactors

Lipmann F. A long life in times of great upheaval. Annu Rev Biochem. 1984;53():1–33. doi: 10.1146/annurev.bi.53.070184.000245. PMID: 6383192.

Metabolites

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

Ubiquinol-10

Formula: C59H92O4 (864.6995231999999)

CAS ID: 5677-55-4

formate

Formula: CHO2 (44.997654600000004)

CAS ID: 71-47-6

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

4-hydroxybenzoate

Formula: C7H5O3 (137.023868)

CAS ID: 456-23-5

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
2.1.1.-
1.1.1.42 isocitrate dehydrogenase (NADP+) isocitrate:NADP+ oxidoreductase (decarboxylating)
1.14.15.45 4-hydroxy-3-polyprenylbenzoate 5-hydroxylase 4-hydroxy-3-all-trans-polyprenylbenzoate,ferredoxin:oxygen oxidoreductase (5-hydroxylating)
1.14.15.46 2-methoxy-6-polyprenylphenol 4-hydroxylase 2-methoxy-6-(all-trans-polyprenyl)phenol,ferredoxin:oxygen oxidoreductase (4-hydroxylating)
1.6.2.4 NADPH-hemoprotein reductase NADPH:hemoprotein oxidoreductase
2.1.1.114 polyprenyldihydroxybenzoate methyltransferase S-adenosyl-L-methionine:3,4-dihydroxy-5-all-trans-polyprenylbenzoate 3-O-methyltransferase
2.1.1.201 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase S-adenosyl-L-methionine:2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol 5-C-methyltransferase
2.1.1.64 3-demethylubiquinol 3-O-methyltransferase S-adenosyl-L-methionine:3-hydroxy-2-methoxy-5-methyl-6-(all-trans-polyprenyl)-1,4-benzoquinol 3-O-methyltransferase
2.5.1.39 4-hydroxybenzoate polyprenyltransferase polyprenyl-diphosphate:4-hydroxybenzoate polyprenyltransferase
2.5.1.91 all-trans-decaprenyl-diphosphate synthase (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 7 isopentenyl units)
3.5.4.16 GTP cyclohydrolase I GTP 7,8-8,9-dihydrolase
4.1.1.130 4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase 4-hydroxy-3-methoxy-5-all-trans-polyprenylbenzoate carboxy-lyase


Proteins

Protein ID name full name
O13774 GCH1_SCHPO GTP cyclohydrolase 1
O14254 idp1 Probable isocitrate dehydrogenase [NADP], mitochondrial
O43091 dps1 Decaprenyl-diphosphate synthase subunit 1
O74421 coq3 Ubiquinone biosynthesis O-methyltransferase, mitochondrial
O94453 coq4 Ubiquinone biosynthesis protein coq4, mitochondrial
P36587 ccr1 NADPH--cytochrome P450 reductase
P87230 coq5 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
Q10252 ppt1 4-hydroxybenzoate polyprenyltransferase, mitochondrial
Q92338 coq8 Atypical kinase COQ8, mitochondrial
Q9Y7Z9 coq6 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial