EC: 1.4.4.2

glycine dehydrogenase (aminomethyl-transferring) (glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating))

enzyme lambda metabolic reaction experiment
uniprot:Q9WUP5 [glycine dehydrogenase (decarboxylating)(Enzyme) wildtype]

Lipoylprotein + Glycine -> CO2 + S_Aminomethyldihydrolipoylprotein		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM potassium phosphate, 1 mM DTT, 0.1 mM pyridoxal phosphate
PH: 6.2
Temperature: 37
uniprot:Q9WUP5 [glycine dehydrogenase (decarboxylating)(Enzyme) wildtype]

Lipoylprotein + Glycine -> S_Aminomethyldihydrolipoylprotein + CO2		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM potassium phosphate, 1 mM DTT, 0.1 mM pyridoxal phosphate
PH: 6.2
Temperature: 37
- [Pyridoxal phosphate]

CO2 + S_Aminomethyldihydrolipoylprotein -> Glycine + Lipoylprotein		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM potassium phosphate, 1 mM dithiothreitol
PH: 6.6
Temperature: 37
- [Pyridoxal phosphate]

Lipoylprotein + Glycine -> S_Aminomethyldihydrolipoylprotein + CO2		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM potassium phosphate, 1 mM dithiothreitol
PH: 6.6
Temperature: 37

Pathways

pathway id name
BioCyc:META_1CMET2-PWY N10-formyl-tetrahydrofolate biosynthesis
BioCyc:META_PWY-2201 folate transformations I
BioCyc:META_GLYCLEAV-PWY glycine cleavage
BioCyc:YEAST_GLYCLEAV-PWY glycine cleavage
BioCyc:YEAST_GLYCINE-SYN2-PWY glycine biosynthesis II
BioCyc:MTBCDC1551_GLYCLEAV-PWY glycine cleavage
BioCyc:MTBCDC1551_PWY-2201 folate transformations I
BioCyc:ECOL199310_GLYCLEAV-PWY glycine cleavage
BioCyc:BSUB_GLYCLEAV-PWY glycine cleavage
BioCyc:META_GLYCINE-SYN2-PWY glycine biosynthesis II
BioCyc:YEAST_PWY3O-697 folate interconversions
BioCyc:MTBCDC1551_1CMET2-PWY N10-formyl-tetrahydrofolate biosynthesis
BioCyc:ECOL199310_GLYCINE-SYN2-PWY glycine biosynthesis II
BioCyc:MOUSE_GLYCLEAV-PWY glycine cleavage complex
BioCyc:MOUSE_PWY-2201 folate transformations I
BioCyc:BTHE_GLYCINE-SYN2-PWY glycine biosynthesis II
BioCyc:BTHE_GLYCLEAV-PWY glycine cleavage
BioCyc:GCF_000013425_PWY-2201 folate transformations I
BioCyc:ECO_1CMET2-PWY N10-formyl-tetrahydrofolate biosynthesis
BioCyc:ARA_GLYCLEAV-PWY glycine cleavage
BioCyc:MTBH37RV_1CMET2-PWY N10-formyl-tetrahydrofolate biosynthesis
BioCyc:ECOO157_PWY-2201 folate transformations I
BioCyc:MOUSE_PWY3DJ-35778 Serine degradation II
BioCyc:GCF_000013425_1CMET2-PWY N10-formyl-tetrahydrofolate biosynthesis
BioCyc:GCF_000013425_GLYCLEAV-PWY glycine cleavage
BioCyc:HUMAN_GLYCLEAV-PWY glycine cleavage
BioCyc:ECO_GLYCLEAV-PWY glycine cleavage
BioCyc:YEAST_PWY-2201 folate transformations
BioCyc:MTBH37RV_GLYCLEAV-PWY glycine cleavage
BioCyc:MTBCDC1551_GLYCINE-SYN2-PWY glycine biosynthesis II
BioCyc:ECOO157_1CMET2-PWY formylTHF biosynthesis
BioCyc:ECOO157_GLYCLEAV-PWY glycine cleavage
BioCyc:AGRO_PWY-2201 folate transformations I
BioCyc:AGRO_1CMET2-PWY N10-formyl-tetrahydrofolate biosynthesis
BioCyc:MOUSE_PWY-3841 folate transformations II (plants)
BioCyc:CAULONA1000_GLYCLEAV-PWY glycine cleavage complex
WikiPathways:WP2472 Escherichia coli K-12 peripherome
PlantCyc:ARA_GLYCLEAV-PWY glycine cleavage
Reactome:R-DDI-6783984 Glycine degradation
Reactome:R-HSA-389661 Glyoxylate metabolism and glycine degradation
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-389661 Glyoxylate metabolism and glycine degradation
Reactome:R-SCE-71291 Amino acid and derivative metabolism
Reactome:R-SPO-1430728 Metabolism
Reactome:R-SPO-389661 Glyoxylate metabolism and glycine degradation
Reactome:R-DDI-71291 Amino acid and derivative metabolism
Reactome:R-DDI-389661 Glyoxylate metabolism and glycine degradation
Reactome:R-SCE-1430728 Metabolism
Reactome:R-SPO-71291 Amino acid and derivative metabolism
Reactome:R-HSA-71291 Amino acid and derivative metabolism
Reactome:R-HSA-6783984 Glycine degradation
Reactome:R-MMU-71291 Amino acid and derivative metabolism
Reactome:R-MMU-6783984 Glycine degradation
Reactome:R-SCE-389661 Glyoxylate metabolism and glycine degradation
Reactome:R-SPO-6783984 Glycine degradation
Reactome:R-DDI-1430728 Metabolism
Reactome:R-HSA-1430728 Metabolism
Reactome:R-SCE-6783984 Glycine degradation
PathBank:SMP0000009 Ammonia Recycling
PathBank:SMP0000242 Dimethylglycine Dehydrogenase Deficiency
PathBank:SMP0000223 Non-Ketotic Hyperglycinemia
PathBank:SMP0000484 Dimethylglycine Dehydrogenase Deficiency
PathBank:SMP0063579 Ammonia Recycling
PathBank:SMP0120653 3-Phosphoglycerate Dehydrogenase Deficiency
PathBank:SMP0120475 Dimethylglycine Dehydrogenase Deficiency
PathBank:SMP0000004 Glycine and Serine Metabolism
PathBank:SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency
PathBank:SMP0120521 Sarcosinemia
PathBank:SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD)
PathBank:SMP0000485 Hyperglycinemia, Non-Ketotic
PathBank:SMP0120474 Dihydropyrimidine Dehydrogenase Deficiency (DHPD)
PathBank:SMP0120534 Non-Ketotic Hyperglycinemia
PathBank:SMP0120550 Hyperglycinemia, Non-Ketotic
PathBank:SMP0000244 Sarcosinemia
PathBank:SMP0063626 Glycine and Serine Metabolism