EC: 1.2.4.1

pyruvate dehydrogenase (acetyl-transferring) (pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating))

enzyme lambda metabolic reaction experiment
- [Mg2+]

Coenzyme_A + NAD+ + Pyruvate -> Acetyl_CoA + H+ + NADH + CO2		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM TES, 3 mM cysteine, 0.05 mM chlorpromazine
PH: 7.7
Temperature: 36
- [Thiamine diphosphate]

Pyruvate + Coenzyme_A + NAD+ -> Acetyl_CoA + H+ + CO2 + NADH		 (( (Vmax * B) ) / (Km + B)) buffer: 50 mM potassium phosphate, 1 mM DTT, 1 mM MgCl2
PH: 7.5
Temperature: 30
- [Thiamine diphosphate]

Pyruvate + NAD+ + Coenzyme_A -> NADH + H+ + CO2 + Acetyl_CoA		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM potassium phosphate, 1 mM DTT, 1 mM MgCl2
PH: 7.5
Temperature: 30
- [Thiamine diphosphate]

Coenzyme_A + Pyruvate + NAD+ -> NADH + Acetyl_CoA + H+ + CO2		 (( (Vmax * C) ) / (Km + C)) buffer: 50 mM potassium phosphate, 1 mM DTT, 1 mM MgCl2
PH: 7.5
Temperature: 30
- [Mg2+]

Coenzyme_A + NAD+ + Pyruvate -> H+ + CO2 + NADH + Acetyl_CoA		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM TES, 3 mM cysteine, 0.05 mM chlorpromazine
PH: 7.7
Temperature: 36
- [Mg2+]

Pyruvate + Coenzyme_A + NAD+ -> NADH + H+ + CO2 + Acetyl_CoA		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM TES, 3 mM cysteine, 0.05 mM chlorpromazine
PH: 7.7
Temperature: 36
- [Thiamine diphosphate]

NAD+ + Coenzyme_A + Pyruvate -> NADH + CO2 + H+ + Acetyl_CoA		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Tris-HCl, 2.0 mM MgCl2, 2.6 mM DTT
PH: 8
Temperature: 27
- [Thiamine diphosphate]

Coenzyme_A + Pyruvate + NAD+ -> CO2 + H+ + NADH + Acetyl_CoA		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Tris-HCl, 2.0 mM MgCl2, 2.6 mM DTT
PH: 8
Temperature: 27
- [Thiamine diphosphate]

Coenzyme_A + NAD+ + Pyruvate -> H+ + CO2 + NADH + Acetyl_CoA		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Tris-HCl, 2.0 mM MgCl2, 2.6 mM DTT
PH: 8
Temperature: 27
- [Thiamine diphosphate]

Pyruvate + Coenzyme_A + NAD+ -> CO2 + H+ + Acetyl_CoA + NADH		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Tris-HCl, 2.0 mM MgCl2, 2.6 mM DTT
PH: 8
Temperature: 27
- [Thiamine diphosphate]

Coenzyme_A + Pyruvate + NAD+ -> H+ + NADH + CO2 + Acetyl_CoA		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Tris-HCl, 2.0 mM MgCl2, 2.6 mM DTT
PH: 8
Temperature: 27
- [Thiamine diphosphate]

Pyruvate + NAD+ + Coenzyme_A -> H+ + CO2 + NADH + Acetyl_CoA		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Tris-HCl, 1.0 mM MgCl2, 2.6 mM DTT
PH: 8
Temperature: 27
- [Thiamine diphosphate]

Pyruvate + Coenzyme_A + NAD+ -> NADH + H+ + CO2 + Acetyl_CoA		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Tris-HCl, 2.0 mM MgCl2, 2.6 mM DTT
PH: 8
Temperature: 27
- [Thiamine diphosphate]

NAD+ + Coenzyme_A + Pyruvate -> CO2 + H+ + Acetyl_CoA + NADH		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Tris-HCl, 1.0 mM MgCl2, 2.6 mM DTT
PH: 8
Temperature: 27
- [Thiamine diphosphate]

Pyruvate + Coenzyme_A + NAD+ -> Acetyl_CoA + NADH + H+ + CO2		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Tris-HCl, 1.0 mM MgCl2, 2.6 mM DTT
PH: 8
Temperature: 27
- [Mg2+]

Pyruvate + NAD+ + Coenzyme_A -> Acetyl_CoA + NADH + H+ + CO2		 (( (( (kcat * E) ) * (S ^ n)) ) / (( (Km ^ n) ) + (S ^ n))) buffer: 0.1 M Tris-HCl, 2.6 mM dithiothreitol
PH: 8
Temperature: 30
- [Mg2+]

NAD+ + Coenzyme_A + Pyruvate -> CO2 + Acetyl_CoA + H+ + NADH		 (( (( (kcat * E) ) * (S ^ n)) ) / (( (Km ^ n) ) + (S ^ n))) buffer: 0.1 M Tris-HCl, 2.6 mM dithiothreitol
PH: 8
Temperature: 30
- [Enzyme wildtype]

NAD+ + Coenzyme_A + Pyruvate -> CO2 + NADH + Acetyl_CoA		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM potassium phosphate, 0.5 mM thiamine pyrophosphate, 1.25 mM MgCl2, 1.5 mM dithiothreitol
PH: 7
Temperature: 25
- [Enzyme wildtype]

Coenzyme_A + NAD+ + Pyruvate -> Acetyl_CoA + CO2 + NADH		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM HEPES
PH: 7
Temperature: 25
- [Thiamine diphosphate]

Pyruvate + NAD+ + Coenzyme_A -> Acetyl_CoA + H+ + CO2 + NADH		 (( (Vmax * (A ^ h)) ) / (( (Km ^ h) ) + (A ^ h))) buffer: *
PH: 7
Temperature: 36
uniprot:F1N206 [Enzyme wildtype]

Pyruvate + NAD+ + Coenzyme_A -> CO2 + H+ + NADH + Acetyl_CoA		 (V / (( (( (1 + (Ka / A)) ) + (Kb / B)) ) + (Kc / C))) buffer: 50 mM potassium phosphate, 1 mM MgCl2, 0.2 mM Thiamine pyrophosphate, 2.6 mM cysteine hydrochloride
PH: 7.5
Temperature: 30
- [Thiamine diphosphate]

NAD+ + Pyruvate + Coenzyme_A -> CO2 + Acetyl_CoA + H+ + NADH		 (( (Vmax * S) ) / (( (Km * (1 + (I / Ki))) ) + S)) buffer: 80 mM Mops, 3 mM MgCl2, 3 mM DTT
PH: 7.5
Temperature: 25
- [Thiamine diphosphate]

NAD+ + Pyruvate + Coenzyme_A -> CO2 + NADH + Acetyl_CoA + H+		 (( (Vmax * S) ) / (( (Km * (1 + (I / Ki))) ) + S)) buffer: 80 mM Mops, 3 mM MgCl2, 3 mM DTT
PH: 7.5
Temperature: 25
- [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) wildtype]

Coenzyme_A + Pyruvate + NAD+ -> NADH + CO2 + H+ + Acetyl_CoA		 (( (Vmax * A) ) / (Km + A)) buffer: 100 mM Tris-HCl, 1 mM MgCl2, 0.5 mM CaCl2, 0.5 mM EDTA, 0.2 mM thiamin diphosphate, 2 mM cysteine hydrochloride
PH: 8.1
Temperature: 30
uniprot:Q8NNF6 [Mg2+]

Pyruvate + 2,6_Dichloroindophenol -> CO2 + Acetaldehyde + Reduced_2,6_dichlorophenolindophenol		 (( (Vmax * S) ) / (Km + S)) buffer: 80 mM potassium phosphate, 3 mM KCN, 2.2 mM phenazine methosulfate
PH: 7.5
Temperature: 36
- [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) wildtype PDH E1]

Pyruvate + Thiamine_diphosphate -> CO2 + 2_(alpha_Hydroxyethyl)thiamine_diphosphate		 (( (Vmax * S) ) / (Km + S)) buffer: 85.0 mM Na-phosphate, 10 mM MgCl2, 0.2 mM phenazine methosulfate, 0.1 mM 2,6-DCPIP
PH: 7
Temperature: 22
uniprot:Q06437 [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) wildtype PDH E1 (rat testis E1alpha + human liver E1beta)]

Pyruvate + Thiamine_diphosphate -> CO2 + 2_(alpha_Hydroxyethyl)thiamine_diphosphate		 (( (Vmax * S) ) / (Km + S)) buffer: 85.0 mM Na-phosphate, 10 mM MgCl2, 0.2 mM phenazine methosulfate, 0.1 mM 2,6-DCPIP
PH: 7
Temperature: 22
uniprot:Q06437 [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) wildtype PDH E1 (rat testis E1alpha + human liver E1beta)]

Thiamine_diphosphate + Pyruvate -> 2_(alpha_Hydroxyethyl)thiamine_diphosphate + CO2		 (( (Vmax * S) ) / (Km + S)) buffer: 85.0 mM Na-phosphate, 10 mM MgCl2, 0.2 mM phenazine methosulfate, 0.1 mM 2,6-DCPIP
PH: 7
Temperature: 22
uniprot:P0AFG8 [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) wildtype E1 in 3-lip PDHc (three lipoyl domains per E2 chain)]

Pyruvate + Thiamine_diphosphate -> 2_(alpha_Hydroxyethyl)thiamine_diphosphate + CO2		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.05 M Tris-HCl, 12 mM MgCl2, 2.6 mM DTT, 1.25 mM 4,4'-dithiodipyridine, 1.25 mM 4-mercaptopyridine
PH: 7.7
Temperature: 27
uniprot:P0AFG8 [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) wildtype E1 resolved from 3-lip PDHc (three lipoyl domains per E2 chain)]

Pyruvate + Thiamine_diphosphate -> 2_(alpha_Hydroxyethyl)thiamine_diphosphate + CO2		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.05 M Tris-HCl, 12 mM MgCl2, 2.6 mM DTT, 1.25 mM 4,4'-dithiodipyridine, 1.25 mM 4-mercaptopyridine
PH: 7.7
Temperature: 27
- [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) wildtype PDH E1]

Pyruvate + Thiamine_diphosphate -> CO2 + 2_(alpha_Hydroxyethyl)thiamine_diphosphate		 (( (Vmax * S) ) / (Km + S)) buffer: 85.0 mM Na-phosphate, 10 mM MgCl2, 0.2 mM phenazine methosulfate, 0.1 mM 2,6-DCPIP
PH: 7
Temperature: 22
uniprot:P0AFG8 [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) wildtype E1 resolved from 1-lip PDHc (single lipoyl domain per E2 chain)]

Pyruvate + Thiamine_diphosphate -> CO2 + 2_(alpha_Hydroxyethyl)thiamine_diphosphate		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.05 M Tris-HCl, 12 mM MgCl2, 2.6 mM DTT, 1.25 mM 4,4'-dithiodipyridine, 1.25 mM 4-mercaptopyridine
PH: 7.7
Temperature: 27
uniprot:P0AFG8 [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) wildtype E1 in 1-lip PDHc (single lipoyl domain per E2 chain)]

Thiamine_diphosphate + Pyruvate -> CO2 + 2_(alpha_Hydroxyethyl)thiamine_diphosphate		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.05 M Tris-HCl, 12 mM MgCl2, 2.6 mM DTT, 1.25 mM 4,4'-dithiodipyridine, 1.25 mM 4-mercaptopyridine
PH: 7.7
Temperature: 27
- [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) mutant subunit alpha F266A]

Thiamine_diphosphate + Pyruvate -> CO2 + 2_(alpha_Hydroxyethyl)thiamine_diphosphate		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 100 mM potassium phosphate, 2 mM MgCl2, 50 µM 2,6-dichlorophenolindophenol
PH: 7
Temperature: 30
- [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) mutant subunit alpha Y281A]

Pyruvate + Thiamine_diphosphate -> 2_(alpha_Hydroxyethyl)thiamine_diphosphate + CO2		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 100 mM potassium phosphate, 2 mM MgCl2, 50 µM 2,6-dichlorophenolindophenol
PH: 7
Temperature: 30
- [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) mutant subunit alpha S283C]

Pyruvate + Thiamine_diphosphate -> 2_(alpha_Hydroxyethyl)thiamine_diphosphate + CO2		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 100 mM potassium phosphate, 2 mM MgCl2, 50 µM 2,6-dichlorophenolindophenol
PH: 7
Temperature: 30
- [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) wildtype]

Pyruvate + Thiamine_diphosphate -> 2_(alpha_Hydroxyethyl)thiamine_diphosphate + CO2		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 100 mM potassium phosphate, 2 mM MgCl2, 50 µM 2,6-dichlorophenolindophenol
PH: 7
Temperature: 30
- [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) mutant subunit alpha R267A]

Thiamine_diphosphate + Pyruvate -> CO2 + 2_(alpha_Hydroxyethyl)thiamine_diphosphate		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 100 mM potassium phosphate, 2 mM MgCl2, 50 µM 2,6-dichlorophenolindophenol
PH: 7
Temperature: 30
- [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) mutant subunit alpha R282A]

Thiamine_diphosphate + Pyruvate -> 2_(alpha_Hydroxyethyl)thiamine_diphosphate + CO2		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 100 mM potassium phosphate, 2 mM MgCl2, 50 µM 2,6-dichlorophenolindophenol
PH: 7
Temperature: 30
- [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) mutant subunit alpha Y281S/R282S]

Pyruvate + Thiamine_diphosphate -> CO2 + 2_(alpha_Hydroxyethyl)thiamine_diphosphate		 (( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 100 mM potassium phosphate, 2 mM MgCl2, 50 µM 2,6-dichlorophenolindophenol
PH: 7
Temperature: 30
- [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) mutant subunit alpha D276A]

Pyruvate + Thiamine_diphosphate -> 2_(alpha_Hydroxyethyl)thiamine_diphosphate + CO2		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 100 mM potassium phosphate, 2 mM MgCl2, 50 µM 2,6-dichlorophenolindophenol
PH: 7
Temperature: 30
- [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) mutant subunit alpha Y281A/R282A]

Thiamine_diphosphate + Pyruvate -> 2_(alpha_Hydroxyethyl)thiamine_diphosphate + CO2		 (( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 100 mM potassium phosphate, 2 mM MgCl2, 50 µM 2,6-dichlorophenolindophenol
PH: 7
Temperature: 30
- [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) wildtype]

Coenzyme_A + NAD+ + Pyruvate -> H+ + NADH + Acetyl_CoA + CO2		 (( (Vmax * A) ) / (Km + A)) buffer: 0.3 M Mannitol, 10 mM KCl, 5 mM MgCl2, 10 mM KH2PO4, 0.1 % Triton X-100, 1 mM cysteine, 200 µM thiamine pyrophosphate
PH: 7.8
Temperature: 37
- [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) mutant subunit alpha D276A]

Thiamine_diphosphate + Pyruvate -> 2_(alpha_Hydroxyethyl)thiamine_diphosphate + CO2		 (( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 100 mM potassium phosphate, 2 mM MgCl2, 50 µM 2,6-dichlorophenolindophenol
PH: 7
Temperature: 30
- [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) mutant subunit alpha R282A]

Pyruvate + Thiamine_diphosphate -> 2_(alpha_Hydroxyethyl)thiamine_diphosphate + CO2		 (( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 100 mM potassium phosphate, 2 mM MgCl2, 50 µM 2,6-dichlorophenolindophenol
PH: 7
Temperature: 30
- [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) mutant subunit alpha R267A]

Thiamine_diphosphate + Pyruvate -> CO2 + 2_(alpha_Hydroxyethyl)thiamine_diphosphate		 (( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 100 mM potassium phosphate, 2 mM MgCl2, 50 µM 2,6-dichlorophenolindophenol
PH: 7
Temperature: 30
- [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) mutant subunit alpha Y281A]

Pyruvate + Thiamine_diphosphate -> CO2 + 2_(alpha_Hydroxyethyl)thiamine_diphosphate		 (( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 100 mM potassium phosphate, 2 mM MgCl2, 50 µM 2,6-dichlorophenolindophenol
PH: 7
Temperature: 30
- [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) mutant subunit alpha Y281A/R282A/S283A]

Thiamine_diphosphate + Pyruvate -> CO2 + 2_(alpha_Hydroxyethyl)thiamine_diphosphate		 (( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 100 mM potassium phosphate, 2 mM MgCl2, 50 µM 2,6-dichlorophenolindophenol
PH: 7
Temperature: 30
- [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) wildtype]

Pyruvate + Thiamine_diphosphate -> 2_(alpha_Hydroxyethyl)thiamine_diphosphate + CO2		 (( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 100 mM potassium phosphate, 2 mM MgCl2, 50 µM 2,6-dichlorophenolindophenol
PH: 7
Temperature: 30
- [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) mutant subunit alpha F266A]

Pyruvate + Thiamine_diphosphate -> CO2 + 2_(alpha_Hydroxyethyl)thiamine_diphosphate		 (( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 100 mM potassium phosphate, 2 mM MgCl2, 50 µM 2,6-dichlorophenolindophenol
PH: 7
Temperature: 30
- [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) mutant subunit alpha S283C]

Thiamine_diphosphate + Pyruvate -> 2_(alpha_Hydroxyethyl)thiamine_diphosphate + CO2		 (( (( (kcat * E) ) * A) ) / (Km + A)) buffer: 100 mM potassium phosphate, 2 mM MgCl2, 50 µM 2,6-dichlorophenolindophenol
PH: 7
Temperature: 30
- [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) mutant subunit alpha Y281A/R282A/S283A]

Thiamine_diphosphate + Pyruvate -> 2_(alpha_Hydroxyethyl)thiamine_diphosphate + CO2		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 100 mM potassium phosphate, 2 mM MgCl2, 50 µM 2,6-dichlorophenolindophenol
PH: 7
Temperature: 30
- [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) mutant subunit alpha Y281A/R282A]

Pyruvate + Thiamine_diphosphate -> 2_(alpha_Hydroxyethyl)thiamine_diphosphate + CO2		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 100 mM potassium phosphate, 2 mM MgCl2, 50 µM 2,6-dichlorophenolindophenol
PH: 7
Temperature: 30
- [pyruvate dehydrogenase (acetyl-transferring)(Enzyme) mutant subunit alpha Y281S/R282S]

Pyruvate + Thiamine_diphosphate -> CO2 + 2_(alpha_Hydroxyethyl)thiamine_diphosphate		 (( (( (kcat * E) ) * B) ) / (Km + B)) buffer: 100 mM potassium phosphate, 2 mM MgCl2, 50 µM 2,6-dichlorophenolindophenol
PH: 7
Temperature: 30

Pathways

pathway id name
BioCyc:META_PWY-7384 anaerobic energy metabolism (invertebrates, mitochondrial)
BioCyc:MTBH37RV_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:MTBH37RV_PWY-5482 pyruvate fermentation to acetate II
BioCyc:MTBCDC1551_GLYCOLYSIS-TCA-GLYOX-BYPASS superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass
BioCyc:ECOO157_P41-PWY pyruvate fermentation to acetate and lactate I
BioCyc:ECOO157_GLYCOLYSIS-TCA-GLYOX-BYPASS superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass
BioCyc:ECOL316407_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:META_PWY-5482 pyruvate fermentation to acetate II
BioCyc:META_PWY-7389 superpathway of anaerobic energy metabolism (invertebrates)
BioCyc:ECO_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:BSUB_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:ECOL316407_ANARESP1-PWY respiration (anaerobic)
BioCyc:CORYNE_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:HUMAN_PWY66-407 superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
BioCyc:HUMAN_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:META_P41-PWY pyruvate fermentation to acetate and lactate I
BioCyc:META_PWY-7218 photosynthetic 3-hydroxybutanoate biosynthesis (engineered)
BioCyc:ECO_GLYCOLYSIS-TCA-GLYOX-BYPASS superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass
BioCyc:ARA_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:MTBCDC1551_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:MTBCDC1551_PWY-5482 pyruvate fermentation to acetate II
BioCyc:ECOO157_PWY-5482 pyruvate fermentation to acetate II
BioCyc:ECOO157_PYRUVOX-PWY pyruvate oxidation pathway
BioCyc:ECOL316407_GLYCOLYSIS-TCA-GLYOX-BYPASS superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass
BioCyc:META_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
BioCyc:META_GLYCOLYSIS-TCA-GLYOX-BYPASS superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass
BioCyc:YEAST_PYRUVDEHYD-PWY pyruvate dehydrogenase complex
BioCyc:ECOO157_ANARESP1-PWY respiration (anaerobic)
BioCyc:ECOO157_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
WikiPathways:WP2472 Escherichia coli K-12 peripherome
PathBank:SMP0002095 Pyruvate Decarboxylation to Acetyl-CoA
PlantCyc:ARA_PWY-5464 superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle
PlantCyc:ARA_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA
PlantCyc:ARA_PWY-5173 superpathway of acetyl-CoA biosynthesis
Reactome:R-DME-9861718 Regulation of pyruvate metabolism
Reactome:R-HSA-9861718 Regulation of pyruvate metabolism
Reactome:R-SPO-9861718 Regulation of pyruvate metabolism
Reactome:R-BTA-9861718 Regulation of pyruvate metabolism
Reactome:R-CEL-9861718 Regulation of pyruvate metabolism
Reactome:R-DME-9861559 PDH complex synthesizes acetyl-CoA from PYR
Reactome:R-HSA-9861559 PDH complex synthesizes acetyl-CoA from PYR
Reactome:R-SCE-9861559 PDH complex synthesizes acetyl-CoA from PYR
Reactome:R-SPO-9861559 PDH complex synthesizes acetyl-CoA from PYR
Reactome:R-DDI-9861559 PDH complex synthesizes acetyl-CoA from PYR
Reactome:R-MMU-9861559 PDH complex synthesizes acetyl-CoA from PYR
Reactome:R-RNO-9861559 PDH complex synthesizes acetyl-CoA from PYR
Reactome:R-BTA-9861559 PDH complex synthesizes acetyl-CoA from PYR
Reactome:R-CEL-9861559 PDH complex synthesizes acetyl-CoA from PYR
Reactome:R-MMU-9861718 Regulation of pyruvate metabolism
Reactome:R-RNO-9861718 Regulation of pyruvate metabolism
Reactome:R-BTA-1430728 Metabolism
Reactome:R-BTA-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-CEL-5362517 Signaling by Retinoic Acid
Reactome:R-CEL-204174 Regulation of pyruvate dehydrogenase (PDH) complex
Reactome:R-DDI-70268 Pyruvate metabolism
Reactome:R-DME-9006931 Signaling by Nuclear Receptors
Reactome:R-DME-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex
Reactome:R-HSA-5362517 Signaling by Retinoic Acid
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-204174 Regulation of pyruvate dehydrogenase (PDH) complex
Reactome:R-MMU-162582 Signaling Pathways
Reactome:R-RNO-204174 Regulation of pyruvate dehydrogenase (PDH) complex
Reactome:R-RNO-162582 Signaling Pathways
Reactome:R-RNO-9006931 Signaling by Nuclear Receptors
Reactome:R-SPO-1430728 Metabolism
Reactome:R-SPO-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-BTA-204174 Regulation of pyruvate dehydrogenase (PDH) complex
Reactome:R-BTA-162582 Signaling Pathways
Reactome:R-CEL-9006931 Signaling by Nuclear Receptors
Reactome:R-CEL-70268 Pyruvate metabolism
Reactome:R-DME-162582 Signaling Pathways
Reactome:R-DME-1430728 Metabolism
Reactome:R-DME-204174 Regulation of pyruvate dehydrogenase (PDH) complex
Reactome:R-HSA-70268 Pyruvate metabolism
Reactome:R-HSA-9006931 Signaling by Nuclear Receptors
Reactome:R-MMU-70268 Pyruvate metabolism
Reactome:R-RNO-70268 Pyruvate metabolism
Reactome:R-SCE-1430728 Metabolism
Reactome:R-SCE-70268 Pyruvate metabolism
Reactome:R-SPO-204174 Regulation of pyruvate dehydrogenase (PDH) complex
Reactome:R-BTA-9006931 Signaling by Nuclear Receptors
Reactome:R-CEL-162582 Signaling Pathways
Reactome:R-CEL-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-DME-5362517 Signaling by Retinoic Acid
Reactome:R-HSA-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-MMU-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-MMU-9006931 Signaling by Nuclear Receptors
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-RNO-5362517 Signaling by Retinoic Acid
Reactome:R-SCE-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-SPO-162582 Signaling Pathways
Reactome:R-SPO-9006931 Signaling by Nuclear Receptors
Reactome:R-BTA-70268 Pyruvate metabolism
Reactome:R-BTA-5362517 Signaling by Retinoic Acid
Reactome:R-CEL-1430728 Metabolism
Reactome:R-DDI-1430728 Metabolism
Reactome:R-DDI-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-DME-70268 Pyruvate metabolism
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-162582 Signaling Pathways
Reactome:R-MMU-5362517 Signaling by Retinoic Acid
Reactome:R-SPO-70268 Pyruvate metabolism
Reactome:R-SPO-5362517 Signaling by Retinoic Acid
WikiPathways:WP2624 TCA cycle (Krebs cycle)
WikiPathways:WP3614 Photodynamic therapy-induced HIF-1 survival signaling
WikiPathways:WP5220 Metabolic reprogramming in pancreatic cancer
PathBank:SMP0120726 Leigh Syndrome
PathBank:SMP0120830 Fumarase Deficiency
PathBank:SMP0120834 Pyruvate Dehydrogenase Deficiency (E2)
PathBank:SMP0120842 Pyruvate Kinase Deficiency
PathBank:SMP0120440 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency
PathBank:SMP0120444 3-Methylglutaconic Aciduria Type IV
PathBank:SMP0120516 Maple Syrup Urine Disease
PathBank:SMP0120528 Methylmalonic Aciduria Due to Cobalamin-Related Disorders
PathBank:SMP0120589 Isovaleric Acidemia
PathBank:SMP0121182 Citrate Cycle
PathBank:SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)
PathBank:SMP0000548 Mitochondrial Complex II Deficiency
PathBank:SMP0002295 The Oncogenic Action of Fumarate
PathBank:SMP0002358 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria
PathBank:SMP0087254 Transfer of Acetyl Groups into Mitochondria
PathBank:SMP0087270 Warburg Effect
PathBank:SMP0087274 Citric Acid Cycle
PathBank:SMP0087394 Pyruvate Metabolism
PathBank:SMP0087406 Transfer of Acetyl Groups into Mitochondria
PathBank:SMP0063656 Propanoate Metabolism
PathBank:SMP0120753 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)
PathBank:SMP0120829 Congenital Lactic Acidosis
PathBank:SMP0120833 Pyruvate Dehydrogenase Deficiency (E3)
PathBank:SMP0120841 Primary Hyperoxaluria II, PH2
PathBank:SMP0108771 The Oncogenic Action of 2-Hydroxyglutarate
PathBank:SMP0120439 2-Methyl-3-hydroxybutryl-CoA Dehydrogenase Deficiency
PathBank:SMP0120443 3-Methylglutaconic Aciduria Type III
PathBank:SMP0120459 beta-Ketothiolase Deficiency
PathBank:SMP0120503 Isovaleric Aciduria
PathBank:SMP0120523 Methylmalonate Semialdehyde Dehydrogenase Deficiency
PathBank:SMP0120588 Isobutyryl-CoA Dehydrogenase Deficiency
PathBank:SMP0000196 Leigh Syndrome
PathBank:SMP0000547 Fumarase Deficiency
PathBank:SMP0000551 Pyruvate Dehydrogenase Deficiency (E2)
PathBank:SMP0000559 Pyruvate Kinase Deficiency
PathBank:SMP0002292 The Oncogenic Action of Succinate
PathBank:SMP0087325 Pyruvate Metabolism
PathBank:SMP0087449 Pyruvate Metabolism
PathBank:SMP0063678 Threonine and 2-Oxobutanoate Degradation
PathBank:SMP0063689 Valine, Leucine, and Isoleucine Degradation
PathBank:SMP0120832 2-Ketoglutarate Dehydrogenase Complex Deficiency
PathBank:SMP0108773 Glutaminolysis and Cancer
PathBank:SMP0120441 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I
PathBank:SMP0120525 Methylmalonic Aciduria
PathBank:SMP0120537 Propionic Acidemia
PathBank:SMP0120586 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency
PathBank:SMP0000057 Citric Acid Cycle
PathBank:SMP0000212 Pyruvate Dehydrogenase Complex Deficiency
PathBank:SMP0000549 2-Ketoglutarate Dehydrogenase Complex Deficiency
PathBank:SMP0000654 Warburg Effect
PathBank:SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria
PathBank:SMP0002414 TCA Cycle
PathBank:SMP0087163 Citric Acid Cycle
PathBank:SMP0087231 Pyruvate Metabolism
PathBank:SMP0087420 Warburg Effect
PathBank:SMP0087424 Citric Acid Cycle
PathBank:SMP0087480 Propanoate Metabolism
PathBank:SMP0087492 Transfer of Acetyl Groups into Mitochondria
PathBank:SMP0087516 Threonine and 2-Oxobutanoate Degradation
PathBank:SMP0120751 Pyruvate Dehydrogenase Complex Deficiency
PathBank:SMP0120831 Mitochondrial Complex II Deficiency
PathBank:SMP0120442 3-Methylglutaconic Aciduria Type I
PathBank:SMP0120514 Malonic Aciduria
PathBank:SMP0120567 Malonyl-CoA Decarboxylase Deficiency
PathBank:SMP0120587 3-Hydroxyisobutyric Aciduria
PathBank:SMP0000060 Pyruvate Metabolism
PathBank:SMP0000466 Transfer of Acetyl Groups into Mitochondria
PathBank:SMP0000546 Congenital Lactic Acidosis
PathBank:SMP0000550 Pyruvate Dehydrogenase Deficiency (E3)
PathBank:SMP0000558 Primary Hyperoxaluria II, PH2
PathBank:SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate
PathBank:SMP0002298 Glutaminolysis and Cancer
PathBank:SMP0002304 TCA Cycle
PathBank:SMP0002355 Pyruvate Metabolism
PathBank:SMP0087347 Transfer of Acetyl Groups into Mitochondria
PathBank:SMP0087363 Warburg Effect
PathBank:SMP0087367 Citric Acid Cycle
PathBank:SMP0087527 Warburg Effect