Fe3+

Iron is a metallic element found in certain minerals, in nearly all soils, and in mineral waters. Iron is required for life. It exists in all living species, ranging from bacteria to humans. It can be found primarily in blood and it is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletion of iron stores may result in iron-deficiency anemia. Iron is used to build up the blood in anemia. In humans, iron is involved in several metabolic pathways, some of which include the rofecoxib pathway, magnesium salicylate action pathway, etodolac pathway, and diclofenac pathway. Iron is also involved in several metabolic disorders, some of which include adenine phosphoribosyltransferase deficiency (APRT), porphyria variegata (PV), adenylosuccinate lyase deficiency, and AICA-ribosiduria. The major activity of supplemental iron is in the prevention and treatment of iron-deficiency anemia. Iron has putative immune-enhancing, anticarcinogenic, and cognition-enhancing activities. Iron can be found in a number of food items such as chinese water chestnut, hyssop, daikon radish, and peppermint, which makes it a potential biomarker for the consumption of these food products.

ID EC Number Name
KEGG:R00078 1.16.3.1 Fe(II):oxygen oxidoreductase;
KEGG:R00092 1.16.1.7 Fe2+:NAD+ oxidoreductase;
KEGG:R04155 C03179<=>C05780 + 2 C14819
KEGG:R05318 1.9.98.1 ferrocytochrome-c:Fe3+ oxidoreductase
KEGG:R09422 C05779 + C14819<=>C19608
KEGG:R09541 1.16.1.9 Fe(II):NADP+ oxidoreductase
KEGG:R09739 7.2.1.3 Fe(III):ascorbate oxidorectuctase (electron-translocating)
BioCyc:RXN-14387 CD-2S-SP-Complex + 2 FE+3 --> CD-SP-2Fe2S-Complex
BioCyc:RXN-12540 Fenton reaction
BioCyc:RXN0-1483 1.16.3.1 4 FE+2 + 4 PROTON + OXYGEN-MOLECULE --> 4 FE+3 + 2 WATER
BioCyc:RXN-12541 2 OXYGEN-MOLECULE + 2 FE+2 --> 2 SUPER-OXIDE + 2 FE+3
BioCyc:RXN-20002 ENTEROBACTIN + FE+3 --> FERRIC-ENTEROBACTIN-COMPLEX + 6 PROTON
Rhea:RHEA:11149 1.16.3.1 4 Fe2+ + O2 + 4 H+ => 4 Fe3+ + 2 H2O
Rhea:RHEA:11150 1.16.3.1 4 Fe3+ + 2 H2O => 4 Fe2+ + O2 + 4 H+
Rhea:RHEA:11151 1.16.3.1 4 Fe2+ + O2 + 4 H+ <=> 4 Fe3+ + 2 H2O
Rhea:RHEA:12333 7.2.2.7 Fe3+(out) + ATP + H2O => Fe3+(in) + ADP + phosphate + H+
Rhea:RHEA:12334 7.2.2.7 Fe3+(in) + ADP + phosphate + H+ => Fe3+(out) + ATP + H2O
Rhea:RHEA:12335 7.2.2.7 Fe3+(out) + ATP + H2O <=> Fe3+(in) + ADP + phosphate + H+
Rhea:RHEA:15618 1.9.98.1 Fe3+ + Fe(II)-[cytochrome c] => Fe2+ + Fe(III)-[cytochrome c]
Rhea:RHEA:15619 1.9.98.1 Fe2+ + Fe(III)-[cytochrome c] => Fe3+ + Fe(II)-[cytochrome c]
Rhea:RHEA:15620 1.9.98.1 Fe3+ + Fe(II)-[cytochrome c] <=> Fe2+ + Fe(III)-[cytochrome c]
Rhea:RHEA:16586 2.8.1.8 [[Fe-S] cluster scaffold protein carrying a second [4Fe-4S]2+ cluster] + N6-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H+ => [[Fe-S] cluster scaffold protein] + N6-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe3+ + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]
Rhea:RHEA:16587 2.8.1.8 [[Fe-S] cluster scaffold protein] + N6-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe3+ + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin] => [[Fe-S] cluster scaffold protein carrying a second [4Fe-4S]2+ cluster] + N6-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H+
Rhea:RHEA:16588 2.8.1.8 [[Fe-S] cluster scaffold protein carrying a second [4Fe-4S]2+ cluster] + N6-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H+ <=> [[Fe-S] cluster scaffold protein] + N6-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe3+ + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]
Rhea:RHEA:30156 2 Fe3+ + FADH2 => 2 Fe2+ + FAD + 3 H+
Rhea:RHEA:30157 2 Fe2+ + FAD + 3 H+ => 2 Fe3+ + FADH2
Rhea:RHEA:30158 2 Fe3+ + FADH2 <=> 2 Fe2+ + FAD + 3 H+
Rhea:RHEA:30404 7.2.1.3 Fe3+(out) + L-ascorbate(in) => monodehydro-L-ascorbate radical(in) + Fe2+(out) + H+
Rhea:RHEA:30405 7.2.1.3 monodehydro-L-ascorbate radical(in) + Fe2+(out) + H+ => Fe3+(out) + L-ascorbate(in)
Rhea:RHEA:30406 7.2.1.3 Fe3+(out) + L-ascorbate(in) <=> monodehydro-L-ascorbate radical(in) + Fe2+(out) + H+