MTHFD

K00288 MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]

Protein Function: methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]

DBLinks
Proteins
protein id name function taxonomy source
Reactions
reaction id name note
KEGG:R01220 5,10-methylenetetrahydrofolate:NADP+ oxidoreductase 5,10-Methylenetetrahydrofolate + NADP+ <=> 5,10-Methenyltetrahydrofolate + NADPH
BioCyc:METHYLENETHFDEHYDROG-NADP-RXN METHYLENE-THF-GLU-N + NADP<=>5-10-METHENYL-THF-GLU-N + NADPH
Rhea:RHEA:22813 (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP+ => (6R)-5,10-methenyltetrahydrofolate + NADPH
Rhea:RHEA:22814 (6R)-5,10-methenyltetrahydrofolate + NADPH => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP+
Rhea:RHEA:22815 (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP+ <=> (6R)-5,10-methenyltetrahydrofolate + NADPH
KEGG:R01655 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing) 5,10-Methenyltetrahydrofolate + H2O <=> 10-Formyltetrahydrofolate + H+
BioCyc:METHENYLTHFCYCLOHYDRO-RXN 5-10-METHENYL-THF-GLU-N + WATER<=>FORMYL-THF-GLU-N + PROTON
Rhea:RHEA:23701 (6R)-5,10-methenyltetrahydrofolate + H2O => (6R)-10-formyltetrahydrofolate + H+
Rhea:RHEA:23702 (6R)-10-formyltetrahydrofolate + H+ => (6R)-5,10-methenyltetrahydrofolate + H2O
Rhea:RHEA:23703 (6R)-5,10-methenyltetrahydrofolate + H2O <=> (6R)-10-formyltetrahydrofolate + H+