aksA
K10977 aksA; methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-]
Protein Function: methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-]
DBLinks
Proteins
| protein id | name | function | taxonomy source |
|---|
Reactions
| reaction id | name | note |
|---|---|---|
| KEGG:R08331 | acetyl-CoA:2-oxoadipate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming) | 2-Oxoadipate + Acetyl-CoA + H2O <=> (R)-(Homo)2-citrate + CoA |
| KEGG:R08332 | acetyl-CoA:2-oxopimelate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming) | 2-Oxopimelate + Acetyl-CoA + H2O <=> (R)-(Homo)3-citrate + CoA |
| KEGG:R08680 | acetyl-CoA:2-oxo-acid C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming) | a part of chain-elongation cycle (see R08792) |
| KEGG:R10500 | acetyl-CoA:phenylpyruvate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming) | Phenylpyruvate + Acetyl-CoA + H2O <=> 2-Benzylmalic acid + CoA |
| BioCyc:RXN-9171 | CPD-9735 + ACETYL-COA + WATER --> PROTON + CPD-9736 + CO-A | This reaction is hypothesized to occur in ackee plants |FRAME: TAX-259381| as part of hypoglycinbiosynthesis, but, there is no direct evidence for this reaction. In this plant, the authors hypothesizethat the acetyl co-A is derived from acetate, based on the finding that radio-labeled acetate isincorporated into hypoglycin |CITS: [kean81]|. Pyruvate may also serve as a source of the acetyl-coAin this reaction, but much lower rates of incorporation are observed for pyruvate than for acetatein radiotracer experiments |CITS: [kean81]|. |
| BioCyc:RXN-22116 | CPD-24091 + ACETYL-COA + WATER --> CPD-24092 + CO-A | To complete the strychnidine backbone from the intermediate |FRAME: CPD-24091|, two additional carbons are required. Robinson et al has suggested that they originate from acetate |CITS: [Anet53]|. This proposal was proven by Schlatter in 1969 |CITS: [Schlatter69]|. It is believed that the process proceeds via |FRAME: CPD-24092|, formed by an aldol condensation involving acetyl-CoA |CITS: [11777429]|. |
| BioCyc:RXN-18333 | PROPIONYL-COA + WATER + GLYOX --> CPD-7066 + CO-A + PROTON | |
| BioCyc:R215-RXN | CPD-291 + ACETYL-COA + WATER --> CPD-301 + CO-A + PROTON | |
| BioCyc:RXN-14462 | PHENYL-PYRUVATE + ACETYL-COA + WATER --> CPD-15323 + CO-A + PROTON | |
| BioCyc:RXN-20469 | Acetyl-BryU-ACP + Monobranched-Heptadecenoyl-BryB-PKS + WATER --> 3-Ac-Heptadecenoyl-BryB-PKS + BryU-ACP + PROTON |