EC: 2.3.3.14

homocitrate synthase (acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming))

enzyme lambda metabolic reaction experiment
- [homocitrate synthase(Enzyme) wildtype]

Oxaloacetate + Acetyl_CoA + H2O -> Citrate + Coenzyme_A
(( (( (( (Et * kcat) ) * A) ) * B) ) / (( (( (( (Kia * Kb) ) + (Ka * B)) ) + (Kb * A)) ) + (A * B))) buffer: 50 mM Hepes
PH: 7.5
Temperature: 25
- [homocitrate synthase(Enzyme) wildtype]

H2O + Acetyl_CoA + 2_Oxoglutarate -> Homocitrate + Coenzyme_A
(( (( (( (Et * kcat) ) * A) ) * B) ) / (( (( (( (Kia * Kb) ) + (Ka * B)) ) + (Kb * A)) ) + (A * B))) buffer: 50 mM Hepes
PH: 7.5
Temperature: 25
- [Citrate]

2_Oxoglutarate + Acetyl_CoA + H2O -> Coenzyme_A + Homocitrate
(( (V * A) ) / (( (Ka * (1 + (I / Kis))) ) + (A * (1 + (I / Kii))))) buffer: 50 mM Hepes
PH: 7.5
Temperature: 25
- [Citrate]

2_Oxoglutarate + Acetyl_CoA + H2O -> Homocitrate + Coenzyme_A
(( (V * A) ) / (( (Ka * (1 + (I / Kis))) ) + A)) buffer: 50 mM Hepes
PH: 7.5
Temperature: 25
- [desulfo-CoA]

2_Oxoglutarate + H2O + Acetyl_CoA -> Homocitrate + Coenzyme_A
(( (V * A) ) / (( (Ka * (1 + (I / Kis))) ) + (A * (1 + (I / Kii))))) buffer: 50 mM Hepes
PH: 7.5
Temperature: 25
- [desulfo-CoA]

Acetyl_CoA + 2_Oxoglutarate + H2O -> Coenzyme_A + Homocitrate
(( (V * A) ) / (Ka + (A * (1 + (I / Kii))))) buffer: 50 mM Hepes
PH: 7.5
Temperature: 25
- [desulfo-CoA]

2_Oxoglutarate + H2O + Acetyl_CoA -> Homocitrate + Coenzyme_A
(( (V * A) ) / (Ka + (A * (1 + (I / Kii))))) buffer: 50 mM Hepes
PH: 7.5
Temperature: 25
- [homocitrate synthase(Enzyme) wildtype]

2_Oxoglutarate + Acetyl_CoA + H2O -> Coenzyme_A + Homocitrate
(( (V * A) ) / (( (Ka * (1 + (I / Kis))) ) + (A * (1 + (I / Kii))))) buffer: 50 mM Hepes
PH: 7.5
Temperature: 25

Pathways

pathway id name
BioCyc:META_PWY-7710 FeMo cofactor biosynthesis
BioCyc:META_LYSINE-AMINOAD-PWY L-lysine biosynthesis IV
BioCyc:YEAST_LYSINE-AMINOAD-PWY L-lysine biosynthesis IV
BioCyc:META_PWY-3081 L-lysine biosynthesis V
PathBank:SMP0002337 Lysine Metabolism
PathBank:SMP0002355 Pyruvate Metabolism