lipA, LIAS, LIP1, LIP5
K03644 lipA, LIAS, LIP1, LIP5; lipoyl synthase [EC:2.8.1.8]
Protein Function: lipoyl synthase [EC:2.8.1.8]
DBLinks
Proteins
| protein id | name | function | taxonomy source |
|---|
Reactions
| reaction id | name | note |
|---|---|---|
| KEGG:R07767 | [protein]-N6-(octanoyl)-L-lysine:an [Fe-S] cluster scaffold protein carrying a [4Fe-4S]2+ cluster sulfurtransferase | [Protein]-N6-(octanoyl)-L-lysine + [Fe-S] cluster scaffold protein carrying a [4Fe-4S]2+ cluster + 2 S-Adenosyl-L-methionine + 2 Reduced [2Fe-2S] ferredoxin + 8 H+ <=> [Protein]-N6-[(R)-dihydrolipoyl]-L-lysine + [Fe-S] cluster scaffold protein + 2 Hydrogen sulfide + 4 Fe2+ + 2 L-Methionine + 2 5'-Deoxyadenosine + 2 Oxidized [2Fe-2S] ferredoxin |
| KEGG:R12423 | [lipoyl-carrier protein E2]-N6-(octanoyl)-L-lysine:[Fe-S] cluster scaffold protein carrying a [4Fe-4S]2+ cluster sulfurtransferase | [Lipoyl-carrier protein E2]-N6-octanoyl-L-lysine + [Fe-S] cluster scaffold protein carrying a [4Fe-4S]2+ cluster + 2 S-Adenosyl-L-methionine + 2 Reduced [2Fe-2S] ferredoxin + 8 H+ <=> Enzyme N6-(dihydrolipoyl)lysine + [Fe-S] cluster scaffold protein + 2 Hydrogen sulfide + 4 Fe2+ + 2 L-Methionine + 2 5'-Deoxyadenosine + 2 Oxidized [2Fe-2S] ferredoxin |
| KEGG:R12424 | [glycine cleavage system H]-N6-octanoyl-L-lysine:[Fe-S] cluster scaffold protein carrying a [4Fe-4S]2+ cluster sulfurtransferase | [Glycine cleavage system H]-N6-octanoyl-L-lysine + [Fe-S] cluster scaffold protein carrying a [4Fe-4S]2+ cluster + 2 S-Adenosyl-L-methionine + 2 Reduced [2Fe-2S] ferredoxin + 8 H+ <=> Dihydrolipoylprotein + [Fe-S] cluster scaffold protein + 2 Hydrogen sulfide + 4 Fe2+ + 2 L-Methionine + 2 5'-Deoxyadenosine + 2 Oxidized [2Fe-2S] ferredoxin |
| BioCyc:RXN0-949 | 2 S-ADENOSYLMETHIONINE + Octanoylated-domains + Fe4S4-Cluster-Protein + 6 PROTON + 2 Reduced-ferredoxins --> Dihydro-Lipoyl-Proteins + 2 CH33ADO + 2 MET + Iron-Sulfur-Cluster-Scaffold-Proteins + 2 CPD-7046 + 4 FE+2 + 2 Oxidized-ferredoxins | |
| Rhea:RHEA:16586 | [[Fe-S] cluster scaffold protein carrying a second [4Fe-4S]2+ cluster] + N6-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H+ => [[Fe-S] cluster scaffold protein] + N6-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe3+ + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin] | |
| Rhea:RHEA:16587 | [[Fe-S] cluster scaffold protein] + N6-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe3+ + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin] => [[Fe-S] cluster scaffold protein carrying a second [4Fe-4S]2+ cluster] + N6-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H+ | |
| Rhea:RHEA:16588 | [[Fe-S] cluster scaffold protein carrying a second [4Fe-4S]2+ cluster] + N6-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H+ <=> [[Fe-S] cluster scaffold protein] + N6-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe3+ + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin] | |
| BioCyc:RXN-14957 | 2 S-ADENOSYLMETHIONINE + a-pyruvate-dehydrogenase-E2-protein-Nsup + 2 Sulfurated-Sulfur-Acceptors + 2 Reduced-2Fe-2S-Ferredoxins --> Pyruvate-dehydrogenase-lipoate + 2 MET + 2 CH33ADO + 2 Unsulfurated-Sulfur-Acceptors + 2 Oxidized-2Fe-2S-Ferredoxins | |
| BioCyc:RXN-14950 | 2 S-ADENOSYLMETHIONINE + Octanoylated-Gcv-H + 2 Sulfurated-Sulfur-Acceptors + 2 Reduced-2Fe-2S-Ferredoxins --> PROTEIN-LIPOYLLYSINE + 2 MET + 2 CH33ADO + 2 Unsulfurated-Sulfur-Acceptors + 2 Oxidized-2Fe-2S-Ferredoxins | |
| BioCyc:RXN-14959 | 2 S-ADENOSYLMETHIONINE + a-2-oxoglutarate-dehydrogenase-E2-protei + 2 Sulfurated-Sulfur-Acceptors + 2 Reduced-2Fe-2S-Ferredoxins --> Oxo-glutarate-dehydrogenase-lipoyl + 2 MET + 2 CH33ADO + 2 Unsulfurated-Sulfur-Acceptors + 2 Oxidized-2Fe-2S-Ferredoxins |