Pathways Knowlegdes

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Pathway DOIs Note
D-galactarate degradation I

Accession ID: BioCyc:ECO_GALACTARDEG-PWY		 -
superpathway of D-glucarate and D-galactarate degradation

Accession ID: BioCyc:ECO_GLUCARGALACTSUPER-PWY		 -
superpathway of microbial D-galacturonate and D-glucuronate degradation

Accession ID: BioCyc:META_PWY-6516
  • 10.1016/j.fgb.2008.08.002
  • 10.1038/nbt777
  • 10.1074/jbc.m111.335240
  • 10.1271/bbb.60327
 Andberg M, Maaheimo H, Boer H, Penttilä M, Koivula A, Richard P. Characterization of a novel Agrobacterium tumefaciens Galactarolactone Cycloisomerase Enzyme for Direct Conversion of d-Galactarolactone to 3-Deoxy-2-keto-l-threo-hexarate. Journal of Biological Chemistry. 2012 May;287(21):17662–71. doi: 10.1074/jbc.m111.335240.; Martens-Uzunova ES, Schaap PJ. An evolutionary conserved d-galacturonic acid metabolic pathway operates across filamentous fungi capable of pectin degradation. Fungal Genet Biol. 2008 Nov;45(11):1449–57. doi: 10.1016/j.fgb.2008.08.002. PMID: 18768163.; ISHIKAWA T, MASUMOTO I, IWASA N, NISHIKAWA H, SAWA Y, SHIBATA H, NAKAMURA A, YABUTA Y, SHIGEOKA S. Functional Characterization ofD-Galacturonic Acid Reductase, a Key Enzyme of the Ascorbate Biosynthesis Pathway, fromEuglena gracilis. Bioscience, Biotechnology, and Biochemistry. 2006 Nov 23;70(11):2720–6. doi: 10.1271/bbb.60327.; Agius F, González-Lamothe R, Caballero JL, Muñoz-Blanco J, Botella MA, Valpuesta V. Engineering increased vitamin C levels in plants by overexpression of a D-galacturonic acid reductase. Nat Biotechnol. 2003 Feb;21(2):177–81. doi: 10.1038/nbt777. PMID: 12524550.
D-galactarate degradation I

Accession ID: BioCyc:META_GALACTARDEG-PWY		 -
superpathway of D-glucarate and D-galactarate degradation

Accession ID: BioCyc:META_GLUCARGALACTSUPER-PWY
  • 10.1021/bi981124f
 Hubbard BK, Koch M, Palmer DRJ, Babbitt PC, Gerlt JA. Evolution of Enzymatic Activities in the Enolase Superfamily: Characterization of the (D)-Glucarate/Galactarate Catabolic Pathway in Escherichia coli. Biochemistry. 1998 Sep 25;37(41):14369–75. doi: 10.1021/bi981124f.
Metabolism

Accession ID: Reactome:R-BTA-1430728		 -
Phase II - Conjugation of compounds

Accession ID: Reactome:R-GGA-156580
  • 10.1124/jpet.300.2.361
 McCarver DG, Hines RN. The Ontogeny of Human Drug-Metabolizing Enzymes: Phase II Conjugation Enzymes and Regulatory Mechanisms. The Journal of Pharmacology and Experimental Therapeutics. 2002 Feb;300(2):361–6. doi: 10.1124/jpet.300.2.361.
Biological oxidations

Accession ID: Reactome:R-HSA-211859		 -
Methylation

Accession ID: Reactome:R-HSA-156581
  • 10.1016/j.tibs.2004.03.007
  • 10.1146/annurev.pharmtox.39.1.19
  • 10.1152/ajpgi.2000.279.1.g178
 Fontecave M, Atta M, Mulliez E. S-adenosylmethionine: nothing goes to waste. Trends Biochem Sci. 2004 May;29(5):243–9. doi: 10.1016/j.tibs.2004.03.007. PMID: 15130560.; Lu SC, Huang Z, Yang H, Mato JM, Avila MA, Tsukamoto H. Changes in methionine adenosyltransferase andS-adenosylmethionine homeostasis in alcoholic rat liver. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2000 Jul 01;279(1):G178–85. doi: 10.1152/ajpgi.2000.279.1.g178.; Weinshilboum RM, Otterness DM, Szumlanski CL. Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase. Annu Rev Pharmacol Toxicol. 1999;39():19–52. doi: 10.1146/annurev.pharmtox.39.1.19. PMID: 10331075.
Metabolism

Accession ID: Reactome:R-MMU-1430728		 -
Biological oxidations

Accession ID: Reactome:R-MMU-211859		 -
Methylation

Accession ID: Reactome:R-MMU-156581
  • 10.1016/j.tibs.2004.03.007
  • 10.1146/annurev.pharmtox.39.1.19
  • 10.1152/ajpgi.2000.279.1.g178
 Fontecave M, Atta M, Mulliez E. S-adenosylmethionine: nothing goes to waste. Trends Biochem Sci. 2004 May;29(5):243–9. doi: 10.1016/j.tibs.2004.03.007. PMID: 15130560.; Lu SC, Huang Z, Yang H, Mato JM, Avila MA, Tsukamoto H. Changes in methionine adenosyltransferase andS-adenosylmethionine homeostasis in alcoholic rat liver. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2000 Jul 01;279(1):G178–85. doi: 10.1152/ajpgi.2000.279.1.g178.; Weinshilboum RM, Otterness DM, Szumlanski CL. Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase. Annu Rev Pharmacol Toxicol. 1999;39():19–52. doi: 10.1146/annurev.pharmtox.39.1.19. PMID: 10331075.
Biological oxidations

Accession ID: Reactome:R-BTA-211859		 -
Methylation

Accession ID: Reactome:R-BTA-156581
  • 10.1016/j.tibs.2004.03.007
  • 10.1146/annurev.pharmtox.39.1.19
  • 10.1152/ajpgi.2000.279.1.g178
 Fontecave M, Atta M, Mulliez E. S-adenosylmethionine: nothing goes to waste. Trends Biochem Sci. 2004 May;29(5):243–9. doi: 10.1016/j.tibs.2004.03.007. PMID: 15130560.; Lu SC, Huang Z, Yang H, Mato JM, Avila MA, Tsukamoto H. Changes in methionine adenosyltransferase andS-adenosylmethionine homeostasis in alcoholic rat liver. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2000 Jul 01;279(1):G178–85. doi: 10.1152/ajpgi.2000.279.1.g178.; Weinshilboum RM, Otterness DM, Szumlanski CL. Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase. Annu Rev Pharmacol Toxicol. 1999;39():19–52. doi: 10.1146/annurev.pharmtox.39.1.19. PMID: 10331075.
Phase II - Conjugation of compounds

Accession ID: Reactome:R-HSA-156580
  • 10.1124/jpet.300.2.361
 McCarver DG, Hines RN. The Ontogeny of Human Drug-Metabolizing Enzymes: Phase II Conjugation Enzymes and Regulatory Mechanisms. The Journal of Pharmacology and Experimental Therapeutics. 2002 Feb;300(2):361–6. doi: 10.1124/jpet.300.2.361.
Phase II - Conjugation of compounds

Accession ID: Reactome:R-MMU-156580
  • 10.1124/jpet.300.2.361
 McCarver DG, Hines RN. The Ontogeny of Human Drug-Metabolizing Enzymes: Phase II Conjugation Enzymes and Regulatory Mechanisms. The Journal of Pharmacology and Experimental Therapeutics. 2002 Feb;300(2):361–6. doi: 10.1124/jpet.300.2.361.
Biological oxidations

Accession ID: Reactome:R-RNO-211859		 -
Methylation

Accession ID: Reactome:R-RNO-156581
  • 10.1016/j.tibs.2004.03.007
  • 10.1146/annurev.pharmtox.39.1.19
  • 10.1152/ajpgi.2000.279.1.g178
 Fontecave M, Atta M, Mulliez E. S-adenosylmethionine: nothing goes to waste. Trends Biochem Sci. 2004 May;29(5):243–9. doi: 10.1016/j.tibs.2004.03.007. PMID: 15130560.; Lu SC, Huang Z, Yang H, Mato JM, Avila MA, Tsukamoto H. Changes in methionine adenosyltransferase andS-adenosylmethionine homeostasis in alcoholic rat liver. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2000 Jul 01;279(1):G178–85. doi: 10.1152/ajpgi.2000.279.1.g178.; Weinshilboum RM, Otterness DM, Szumlanski CL. Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase. Annu Rev Pharmacol Toxicol. 1999;39():19–52. doi: 10.1146/annurev.pharmtox.39.1.19. PMID: 10331075.
Metabolism

Accession ID: Reactome:R-SSC-1430728		 -
Biological oxidations

Accession ID: Reactome:R-SSC-211859		 -