Pathways Knowlegdes

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Pathway DOIs Note
Sensory Perception

Accession ID: Reactome:R-HSA-9709957
  • 10.1002/cphy.c160049
  • 10.1016/b978-0-444-63855-7.00005-8
  • 10.1016/bs.pmbts.2015.06.001
  • 10.1038/nrn.2017.68
  • 10.1242/jcs.175687
  • 10.3389/fncel.2020.595523
Lankford CK, Laird JG, Inamdar SM, Baker SA. A Comparison of the Primary Sensory Neurons Used in Olfaction and Vision. Front Cell Neurosci. 2020;14():595523. PMID: 33250719; PMCID: PMC7676898.; Glezer I, Malnic B. Olfactory receptor function. Handb Clin Neurol. 2019;164():67–78. doi: 10.1016/b978-0-444-63855-7.00005-8. PMID: 31604564.; Fettiplace R. Hair Cell Transduction, Tuning, and Synaptic Transmission in the Mammalian Cochlea. Comprehensive Physiology. 2017 Oct;7(4):1197–227. doi: 10.1002/j.2040-4603.2017.tb00783.x.; Roper SD, Chaudhari N. Taste buds: cells, signals and synapses. Nature Reviews Neuroscience. 2017 Jun 29;18(8):485–97. doi: 10.1038/nrn.2017.68.; Molday RS, Moritz OL. Photoreceptors at a glance. J Cell Sci. 2015 Nov 15;128(22):4039–45. PMID: 26574505; PMCID: PMC4712787.; Grossniklaus HE, Geisert EE, Nickerson JM. Introduction to the Retina. Prog Mol Biol Transl Sci. 2015;134():383–96. doi: 10.1016/bs.pmbts.2015.06.001. PMID: 26310166.
Olfactory Signaling Pathway

Accession ID: Reactome:R-HSA-381753
  • 10.1007/s00424-009-0684-9
  • 10.1007/s00441-020-03391-7
  • 10.1016/0092-8674(91)90418-x
  • 10.1016/0896-6273(94)90029-9
  • 10.1016/j.ajhg.2013.12.005
  • 10.1016/j.cell.2004.11.021
  • 10.1016/j.cell.2005.11.047
  • 10.1016/j.conb.2008.09.020
  • 10.1016/s0021-9258(19)39853-9
  • 10.1016/s0092-8674(00)81173-3
  • 10.1016/s0169-328x(97)00099-5
  • 10.1016/s0896-6273(00)80435-3
  • 10.1038/355453a0
  • 10.1038/nature06162
  • 10.1038/nrm2299
  • 10.1038/sdata.2015.2
  • 10.1038/sj.bjp.0706405
  • 10.1073/pnas.0307882100
  • 10.1073/pnas.0903304106
  • 10.1074/jbc.m005433200
  • 10.1074/jbc.m513637200
  • 10.1124/mol.116.104745
  • 10.1126/science.2255909
  • 10.1172/jci40979
  • 10.1186/gb-2007-8-5-r86
  • 10.1371/annotation/6f86410c-63c3-4fcd-b1cb-9fd8d2ea95d0
  • 10.1371/journal.pbio.0050284
Boccaccio A, Menini A, Pifferi S. The cyclic AMP signaling pathway in the rodent main olfactory system. Cell Tissue Res. 2021 Jan;383(1):429–43. doi: 10.1007/s00441-020-03391-7. PMID: 33447881.; Nagai MH, Armelin-Correa LM, Malnic B. Monogenic and Monoallelic Expression of Odorant Receptors. Mol Pharmacol. 2016 Nov;90(5):633–9. doi: 10.1124/mol.116.104745. PMID: 27587538.; Mainland JD, Li YR, Zhou T, Liu WLL, Matsunami H. Human olfactory receptor responses to odorants. Scientific Data. 2015 Feb 03;2(1):150002. doi: 10.1038/sdata.2015.2.; Esteves T, Durr A, Mundwiller E, Loureiro J, Boutry M, Gonzalez M, Gauthier J, El-Hachimi K, Depienne C, Muriel M, Acosta Lebrigio R, Gaussen M, Noreau A, Speziani F, Dionne-Laporte A, Deleuze J, Dion P, Coutinho P, Rouleau G, Zuchner S, Brice A, Stevanin G, Darios F. Loss of Association of REEP2 with Membranes Leads to Hereditary Spastic Paraplegia. The American Journal of Human Genetics. 2014 Feb;94(2):268–77. doi: 10.1016/j.ajhg.2013.12.005.; Björk S, Hurt CM, Ho VK, Angelotti T. Correction: REEPs Are Membrane Shaping Adapter Proteins That Modulate Specific G Protein-Coupled Receptor Trafficking by Affecting ER Cargo Capacity. PLoS ONE. 2013 Dec 17;8(12). doi: 10.1371/annotation/6f86410c-63c3-4fcd-b1cb-9fd8d2ea95d0.; Park SH, Zhu PP, Parker RL, Blackstone C. Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network. J Clin Invest. 2010 Apr;120(4):1097–110. PMID: 20200447; PMCID: PMC2846052.; Stephan AB, Shum EY, Hirsh S, Cygnar KD, Reisert J, Zhao H. ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11776–81. PMID: 19561302; PMCID: PMC2702256.; Pifferi S, Dibattista M, Menini A. TMEM16B induces chloride currents activated by calcium in mammalian cells. Pflügers Archiv - European Journal of Physiology. 2009 May 28;458(6):1023–38. doi: 10.1007/s00424-009-0684-9.; Keller A, Vosshall LB. Better smelling through genetics: mammalian odor perception. Current Opinion in Neurobiology. 2008 Aug;18(4):364–9. doi: 10.1016/j.conb.2008.09.020.; Oldham WM, Hamm HE. Heterotrimeric G protein activation by G-protein-coupled receptors. Nature Reviews Molecular Cell Biology. 2008 Jan;9(1):60–71. doi: 10.1038/nrm2299.; Menashe I, Abaffy T, Hasin Y, Goshen S, Yahalom V, Luetje CW, Lancet D. Genetic Elucidation of Human Hyperosmia to Isovaleric Acid. PLoS Biol. 2007 Oct 30;5(11):e284. doi: 10.1371/journal.pbio.0050284.; Keller A, Zhuang H, Chi Q, Vosshall LB, Matsunami H. Genetic variation in a human odorant receptor alters odour perception. Nature. 2007 Sep 27;449(7161):468–72. doi: 10.1038/nature06162. PMID: 17873857.; Zhang X, De la Cruz O, Pinto JM, Nicolae D, Firestein S, Gilad Y. Characterizing the expression of the human olfactory receptor gene family using a novel DNA microarray. Genome Biology. 2007 May 17;8(5):r86. doi: 10.1186/gb-2007-8-5-r86.; Behrens M, Bartelt J, Reichling C, Winnig M, Kuhn C, Meyerhof W. Members of RTP and REEP Gene Families Influence Functional Bitter Taste Receptor Expression. Journal of Biological Chemistry. 2006 Jul;281(29):20650–9. doi: 10.1074/jbc.m513637200.; Voeltz GK, Prinz WA, Shibata Y, Rist JM, Rapoport TA. A class of membrane proteins shaping the tubular endoplasmic reticulum. Cell. 2006 Feb 10;124(3):573–86. doi: 10.1016/j.cell.2005.11.047. PMID: 16469703.; Milligan G, Kostenis E. Heterotrimeric G-proteins: a short history. Br J Pharmacol. 2006 Jan;147 Suppl 1():S46–55. PMID: 16402120; PMCID: PMC1760735.; Saito H, Kubota M, Roberts RW, Chi Q, Matsunami H. RTP family members induce functional expression of mammalian odorant receptors. Cell. 2004 Nov 24;119(5):679–91. doi: 10.1016/j.cell.2004.11.021. PMID: 15550249.; Malnic B, Godfrey PA, Buck LB. The human olfactory receptor gene family. Proc. Natl. Acad. Sci. U.S.A. 2004 Feb 13;101(8):2584–9. doi: 10.1073/pnas.0307882100.; Gimelbrant AA, Haley SL, McClintock TS. Olfactory Receptor Trafficking Involves Conserved Regulatory Steps. Journal of Biological Chemistry. 2001 Mar;276(10):7285–90. doi: 10.1074/jbc.m005433200.; Dwyer ND, Troemel ER, Sengupta P, Bargmann CI. Odorant receptor localization to olfactory cilia is mediated by ODR-4, a novel membrane-associated protein. Cell. 1998 May 01;93(3):455–66. doi: 10.1016/s0092-8674(00)81173-3. PMID: 9590179.; Belluscio L, Gold GH, Nemes A, Axel R. Mice deficient in G(olf) are anosmic. Neuron. 1998 Jan;20(1):69–81. doi: 10.1016/s0896-6273(00)80435-3. PMID: 9459443.; McClintock TS, Landers TM, Gimelbrant AA, Fuller LZ, Jackson BA, Jayawickreme CK, Lerner MR. Functional expression of olfactory-adrenergic receptor chimeras and intracellular retention of heterologously expressed olfactory receptors. Brain Res Mol Brain Res. 1997 Sep;48(2):270–8. doi: 10.1016/s0169-328x(97)00099-5. PMID: 9332724.; Liman ER, Buck LB. A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP. Neuron. 1994 Sep;13(3):611–21. doi: 10.1016/0896-6273(94)90029-9. PMID: 7522482.; Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gérard C, Perret J, Grootegoed A, Vassart G. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. Nature. 1992 Jan;355(6359):453–5. doi: 10.1038/355453a0.; Buck L, Axel R. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell. 1991 Apr 05;65(1):175–87. doi: 10.1016/0092-8674(91)90418-x. PMID: 1840504.; Bakalyar HA, Reed RR. Identification of a specialized adenylyl cyclase that may mediate odorant detection. Science. 1990 Dec 07;250(4986):1403–6. doi: 10.1126/science.2255909. PMID: 2255909.; Jones DT, Masters SB, Bourne HR, Reed RR. Biochemical characterization of three stimulatory GTP-binding proteins. The large and small forms of Gs and the olfactory-specific G-protein, Golf. Journal of Biological Chemistry. 1990 Feb;265(5):2671–6. doi: 10.1016/s0021-9258(19)39853-9.