Pathways Knowlegdes

Necessitatibus eius consequatur ex aliquid fuga eum quidem sint consectetur velit

Pathway DOIs Note
Metabolism and regulation

Accession ID: Plant Reactome:R-GMA-2744345		 -
Amino acid metabolism

Accession ID: Plant Reactome:R-GMA-2744343		 -
Metabolism and regulation

Accession ID: Plant Reactome:R-PDA-2744345		 -
Amino acid metabolism

Accession ID: Plant Reactome:R-PDA-2744343		 -
Metabolism and regulation

Accession ID: Plant Reactome:R-PVU-2744345		 -
Amino acid metabolism

Accession ID: Plant Reactome:R-PVU-2744343		 -
GABA shunt

Accession ID: Plant Reactome:R-BRA-1119458
  • 10.1002/jsfa.3866
  • 10.1016/j.jplph.2012.09.007
  • 10.1016/j.molp.2015.09.005
  • 10.1016/j.tplants.2004.01.006
  • 10.1016/s0167-4781(01)00324-4
  • 10.1016/s1360-1385(99)01486-7
  • 10.1073/pnas.1037532100
  • 10.1074/jbc.271.8.4148
  • 10.1093/jxb/erm121
  • 10.1093/jxb/eru171
  • 10.1104/pp.106.4.1381
  • 10.1104/pp.121.2.589
  • 10.1104/pp.124.4.1511
  • 10.1111/pbi.12050
  • 10.1186/s12864-017-3588-7
  • 10.3389/fpls.2015.00419
 Kan CC, Chung TY, Wu HY, Juo YA, Hsieh MH. Exogenous glutamate rapidly induces the expression of genes involved in metabolism and defense responses in rice roots. BMC Genomics. 2017 Feb 17;18(1):186. PMID: 28212609; PMCID: PMC5316172.; Hildebrandt TM, Nunes Nesi A, Araújo WL, Braun HP. Amino Acid Catabolism in Plants. Mol Plant. 2015 Nov 02;8(11):1563–79. doi: 10.1016/j.molp.2015.09.005. PMID: 26384576.; Michaeli S, Fromm H. Closing the loop on the GABA shunt in plants: are GABA metabolism and signaling entwined? Front Plant Sci. 2015;6():419. PMID: 26106401; PMCID: PMC4460296.; Yu GH, Zou J, Feng J, Peng XB, Wu JY, Wu YL, Palanivelu R, Sun MX. Exogenous ?-aminobutyric acid (GABA) affects pollen tube growth via modulating putative Ca2+-permeable membrane channels and is coupled to negative regulation on glutamate decarboxylase. J Exp Bot. 2014 Jul;65(12):3235–48. PMID: 24799560; PMCID: PMC4071839.; Shimajiri Y, Oonishi T, Ozaki K, Kainou K, Akama K. Genetic manipulation of the ?-aminobutyric acid (GABA) shunt in rice: overexpression of truncated glutamate decarboxylase (GAD2) and knockdown of ?-aminobutyric acid transaminase (GABA-T) lead to sustained and high levels of GABA accumulation in rice kernels. Plant Biotechnology Journal. 2013 Feb 20;11(5):594–604. doi: 10.1111/pbi.12050.; Shimajiri Y, Ozaki K, Kainou K, Akama K. Differential subcellular localization, enzymatic properties and expression patterns of ?-aminobutyric acid transaminases (GABA-Ts) in rice (Oryza sativa). J Plant Physiol. 2013 Jan 15;170(2):196–201. doi: 10.1016/j.jplph.2012.09.007. PMID: 23122787.; Wang L, Liu M, Lv YG, Zhang H. Purification of calmodulin from rice bran and activation of glutamate decarboxylase by Ca2+/calmodulin. J Sci Food Agric. 2010 Mar 15;90(4):669–75. doi: 10.1002/jsfa.3866. PMID: 20355097.; Forde BG, Lea PJ. Glutamate in plants: metabolism, regulation, and signalling. Journal of Experimental Botany. 2007 Mar 09;58(9):2339–58. doi: 10.1093/jxb/erm121.; Bouché N, Fromm H. GABA in plants: just a metabolite? Trends Plant Sci. 2004 Mar;9(3):110–5. doi: 10.1016/j.tplants.2004.01.006. PMID: 15003233.; Bouché N, Fait A, Bouchez D, Møller SG, Fromm H. Mitochondrial succinic-semialdehyde dehydrogenase of the gamma-aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6843–8. PMID: 12740438; PMCID: PMC164534.; Akama K, Akihiro T, Kitagawa M, Takaiwa F. Rice (Oryza sativa) contains a novel isoform of glutamate decarboxylase that lacks an authentic calmodulin-binding domain at the C-terminus. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 2001 Dec;1522(3):143–50. doi: 10.1016/s0167-4781(01)00324-4.; Dennison KL, Spalding EP. Glutamate-gated calcium fluxes in Arabidopsis. Plant Physiol. 2000 Dec;124(4):1511–4. PMID: 11115867; PMCID: PMC1539305.; Shelp, Bown, McLean. Metabolism and functions of gamma-aminobutyric acid. Trends Plant Sci. 1999 Nov;4(11):446–52. doi: 10.1016/s1360-1385(99)01486-7. PMID: 10529826.; Busch KB, Fromm H. Plant succinic semialdehyde dehydrogenase. Cloning, purification, localization in mitochondria, and regulation by adenine nucleotides. Plant Physiol. 1999 Oct;121(2):589–97. PMID: 10517851; PMCID: PMC59422.; Snedden WA, Koutsia N, Baum G, Fromm H. Activation of a Recombinant Petunia Glutamate Decarboxylase by Calcium/Calmodulin or by a Monoclonal Antibody Which Recognizes the Calmodulin Binding Domain. Journal of Biological Chemistry. 1996 Feb;271(8):4148–53. doi: 10.1074/jbc.271.8.4148.; Chen Y, Baum G, Fromm H. The 58-Kilodalton Calmodulin-Binding Glutamate Decarboxylase Is a Ubiquitous Protein in Petunia Organs and Its Expression Is Developmentally Regulated. Plant Physiol. 1994 Dec;106(4):1381–7. PMID: 12232415; PMCID: PMC159676.
GABA shunt

Accession ID: Plant Reactome:R-OPU-1119458
  • 10.1002/jsfa.3866
  • 10.1016/j.jplph.2012.09.007
  • 10.1016/j.molp.2015.09.005
  • 10.1016/j.tplants.2004.01.006
  • 10.1016/s0167-4781(01)00324-4
  • 10.1016/s1360-1385(99)01486-7
  • 10.1073/pnas.1037532100
  • 10.1074/jbc.271.8.4148
  • 10.1093/jxb/erm121
  • 10.1093/jxb/eru171
  • 10.1104/pp.106.4.1381
  • 10.1104/pp.121.2.589
  • 10.1104/pp.124.4.1511
  • 10.1111/pbi.12050
  • 10.1186/s12864-017-3588-7
  • 10.3389/fpls.2015.00419
 Kan CC, Chung TY, Wu HY, Juo YA, Hsieh MH. Exogenous glutamate rapidly induces the expression of genes involved in metabolism and defense responses in rice roots. BMC Genomics. 2017 Feb 17;18(1):186. PMID: 28212609; PMCID: PMC5316172.; Hildebrandt TM, Nunes Nesi A, Araújo WL, Braun HP. Amino Acid Catabolism in Plants. Mol Plant. 2015 Nov 02;8(11):1563–79. doi: 10.1016/j.molp.2015.09.005. PMID: 26384576.; Michaeli S, Fromm H. Closing the loop on the GABA shunt in plants: are GABA metabolism and signaling entwined? Front Plant Sci. 2015;6():419. PMID: 26106401; PMCID: PMC4460296.; Yu GH, Zou J, Feng J, Peng XB, Wu JY, Wu YL, Palanivelu R, Sun MX. Exogenous ?-aminobutyric acid (GABA) affects pollen tube growth via modulating putative Ca2+-permeable membrane channels and is coupled to negative regulation on glutamate decarboxylase. J Exp Bot. 2014 Jul;65(12):3235–48. PMID: 24799560; PMCID: PMC4071839.; Shimajiri Y, Oonishi T, Ozaki K, Kainou K, Akama K. Genetic manipulation of the ?-aminobutyric acid (GABA) shunt in rice: overexpression of truncated glutamate decarboxylase (GAD2) and knockdown of ?-aminobutyric acid transaminase (GABA-T) lead to sustained and high levels of GABA accumulation in rice kernels. Plant Biotechnology Journal. 2013 Feb 20;11(5):594–604. doi: 10.1111/pbi.12050.; Shimajiri Y, Ozaki K, Kainou K, Akama K. Differential subcellular localization, enzymatic properties and expression patterns of ?-aminobutyric acid transaminases (GABA-Ts) in rice (Oryza sativa). J Plant Physiol. 2013 Jan 15;170(2):196–201. doi: 10.1016/j.jplph.2012.09.007. PMID: 23122787.; Wang L, Liu M, Lv YG, Zhang H. Purification of calmodulin from rice bran and activation of glutamate decarboxylase by Ca2+/calmodulin. J Sci Food Agric. 2010 Mar 15;90(4):669–75. doi: 10.1002/jsfa.3866. PMID: 20355097.; Forde BG, Lea PJ. Glutamate in plants: metabolism, regulation, and signalling. Journal of Experimental Botany. 2007 Mar 09;58(9):2339–58. doi: 10.1093/jxb/erm121.; Bouché N, Fromm H. GABA in plants: just a metabolite? Trends Plant Sci. 2004 Mar;9(3):110–5. doi: 10.1016/j.tplants.2004.01.006. PMID: 15003233.; Bouché N, Fait A, Bouchez D, Møller SG, Fromm H. Mitochondrial succinic-semialdehyde dehydrogenase of the gamma-aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6843–8. PMID: 12740438; PMCID: PMC164534.; Akama K, Akihiro T, Kitagawa M, Takaiwa F. Rice (Oryza sativa) contains a novel isoform of glutamate decarboxylase that lacks an authentic calmodulin-binding domain at the C-terminus. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 2001 Dec;1522(3):143–50. doi: 10.1016/s0167-4781(01)00324-4.; Dennison KL, Spalding EP. Glutamate-gated calcium fluxes in Arabidopsis. Plant Physiol. 2000 Dec;124(4):1511–4. PMID: 11115867; PMCID: PMC1539305.; Shelp, Bown, McLean. Metabolism and functions of gamma-aminobutyric acid. Trends Plant Sci. 1999 Nov;4(11):446–52. doi: 10.1016/s1360-1385(99)01486-7. PMID: 10529826.; Busch KB, Fromm H. Plant succinic semialdehyde dehydrogenase. Cloning, purification, localization in mitochondria, and regulation by adenine nucleotides. Plant Physiol. 1999 Oct;121(2):589–97. PMID: 10517851; PMCID: PMC59422.; Snedden WA, Koutsia N, Baum G, Fromm H. Activation of a Recombinant Petunia Glutamate Decarboxylase by Calcium/Calmodulin or by a Monoclonal Antibody Which Recognizes the Calmodulin Binding Domain. Journal of Biological Chemistry. 1996 Feb;271(8):4148–53. doi: 10.1074/jbc.271.8.4148.; Chen Y, Baum G, Fromm H. The 58-Kilodalton Calmodulin-Binding Glutamate Decarboxylase Is a Ubiquitous Protein in Petunia Organs and Its Expression Is Developmentally Regulated. Plant Physiol. 1994 Dec;106(4):1381–7. PMID: 12232415; PMCID: PMC159676.
Amino acid catabolism

Accession ID: Plant Reactome:R-EGR-5655124		 -
GABA shunt

Accession ID: Plant Reactome:R-LPE-1119458
  • 10.1002/jsfa.3866
  • 10.1016/j.jplph.2012.09.007
  • 10.1016/j.molp.2015.09.005
  • 10.1016/j.tplants.2004.01.006
  • 10.1016/s0167-4781(01)00324-4
  • 10.1016/s1360-1385(99)01486-7
  • 10.1073/pnas.1037532100
  • 10.1074/jbc.271.8.4148
  • 10.1093/jxb/erm121
  • 10.1093/jxb/eru171
  • 10.1104/pp.106.4.1381
  • 10.1104/pp.121.2.589
  • 10.1104/pp.124.4.1511
  • 10.1111/pbi.12050
  • 10.1186/s12864-017-3588-7
  • 10.3389/fpls.2015.00419
 Kan CC, Chung TY, Wu HY, Juo YA, Hsieh MH. Exogenous glutamate rapidly induces the expression of genes involved in metabolism and defense responses in rice roots. BMC Genomics. 2017 Feb 17;18(1):186. PMID: 28212609; PMCID: PMC5316172.; Hildebrandt TM, Nunes Nesi A, Araújo WL, Braun HP. Amino Acid Catabolism in Plants. Mol Plant. 2015 Nov 02;8(11):1563–79. doi: 10.1016/j.molp.2015.09.005. PMID: 26384576.; Michaeli S, Fromm H. Closing the loop on the GABA shunt in plants: are GABA metabolism and signaling entwined? Front Plant Sci. 2015;6():419. PMID: 26106401; PMCID: PMC4460296.; Yu GH, Zou J, Feng J, Peng XB, Wu JY, Wu YL, Palanivelu R, Sun MX. Exogenous ?-aminobutyric acid (GABA) affects pollen tube growth via modulating putative Ca2+-permeable membrane channels and is coupled to negative regulation on glutamate decarboxylase. J Exp Bot. 2014 Jul;65(12):3235–48. PMID: 24799560; PMCID: PMC4071839.; Shimajiri Y, Oonishi T, Ozaki K, Kainou K, Akama K. Genetic manipulation of the ?-aminobutyric acid (GABA) shunt in rice: overexpression of truncated glutamate decarboxylase (GAD2) and knockdown of ?-aminobutyric acid transaminase (GABA-T) lead to sustained and high levels of GABA accumulation in rice kernels. Plant Biotechnology Journal. 2013 Feb 20;11(5):594–604. doi: 10.1111/pbi.12050.; Shimajiri Y, Ozaki K, Kainou K, Akama K. Differential subcellular localization, enzymatic properties and expression patterns of ?-aminobutyric acid transaminases (GABA-Ts) in rice (Oryza sativa). J Plant Physiol. 2013 Jan 15;170(2):196–201. doi: 10.1016/j.jplph.2012.09.007. PMID: 23122787.; Wang L, Liu M, Lv YG, Zhang H. Purification of calmodulin from rice bran and activation of glutamate decarboxylase by Ca2+/calmodulin. J Sci Food Agric. 2010 Mar 15;90(4):669–75. doi: 10.1002/jsfa.3866. PMID: 20355097.; Forde BG, Lea PJ. Glutamate in plants: metabolism, regulation, and signalling. Journal of Experimental Botany. 2007 Mar 09;58(9):2339–58. doi: 10.1093/jxb/erm121.; Bouché N, Fromm H. GABA in plants: just a metabolite? Trends Plant Sci. 2004 Mar;9(3):110–5. doi: 10.1016/j.tplants.2004.01.006. PMID: 15003233.; Bouché N, Fait A, Bouchez D, Møller SG, Fromm H. Mitochondrial succinic-semialdehyde dehydrogenase of the gamma-aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6843–8. PMID: 12740438; PMCID: PMC164534.; Akama K, Akihiro T, Kitagawa M, Takaiwa F. Rice (Oryza sativa) contains a novel isoform of glutamate decarboxylase that lacks an authentic calmodulin-binding domain at the C-terminus. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 2001 Dec;1522(3):143–50. doi: 10.1016/s0167-4781(01)00324-4.; Dennison KL, Spalding EP. Glutamate-gated calcium fluxes in Arabidopsis. Plant Physiol. 2000 Dec;124(4):1511–4. PMID: 11115867; PMCID: PMC1539305.; Shelp, Bown, McLean. Metabolism and functions of gamma-aminobutyric acid. Trends Plant Sci. 1999 Nov;4(11):446–52. doi: 10.1016/s1360-1385(99)01486-7. PMID: 10529826.; Busch KB, Fromm H. Plant succinic semialdehyde dehydrogenase. Cloning, purification, localization in mitochondria, and regulation by adenine nucleotides. Plant Physiol. 1999 Oct;121(2):589–97. PMID: 10517851; PMCID: PMC59422.; Snedden WA, Koutsia N, Baum G, Fromm H. Activation of a Recombinant Petunia Glutamate Decarboxylase by Calcium/Calmodulin or by a Monoclonal Antibody Which Recognizes the Calmodulin Binding Domain. Journal of Biological Chemistry. 1996 Feb;271(8):4148–53. doi: 10.1074/jbc.271.8.4148.; Chen Y, Baum G, Fromm H. The 58-Kilodalton Calmodulin-Binding Glutamate Decarboxylase Is a Ubiquitous Protein in Petunia Organs and Its Expression Is Developmentally Regulated. Plant Physiol. 1994 Dec;106(4):1381–7. PMID: 12232415; PMCID: PMC159676.
Amino acid catabolism

Accession ID: Plant Reactome:R-PAB-5655124		 -
Metabolism and regulation

Accession ID: Plant Reactome:R-CSI-2744345		 -
Amino acid metabolism

Accession ID: Plant Reactome:R-CSI-2744343		 -
GABA shunt

Accession ID: Plant Reactome:R-VAN-1119458
  • 10.1002/jsfa.3866
  • 10.1016/j.jplph.2012.09.007
  • 10.1016/j.molp.2015.09.005
  • 10.1016/j.tplants.2004.01.006
  • 10.1016/s0167-4781(01)00324-4
  • 10.1016/s1360-1385(99)01486-7
  • 10.1073/pnas.1037532100
  • 10.1074/jbc.271.8.4148
  • 10.1093/jxb/erm121
  • 10.1093/jxb/eru171
  • 10.1104/pp.106.4.1381
  • 10.1104/pp.121.2.589
  • 10.1104/pp.124.4.1511
  • 10.1111/pbi.12050
  • 10.1186/s12864-017-3588-7
  • 10.3389/fpls.2015.00419
 Kan CC, Chung TY, Wu HY, Juo YA, Hsieh MH. Exogenous glutamate rapidly induces the expression of genes involved in metabolism and defense responses in rice roots. BMC Genomics. 2017 Feb 17;18(1):186. PMID: 28212609; PMCID: PMC5316172.; Hildebrandt TM, Nunes Nesi A, Araújo WL, Braun HP. Amino Acid Catabolism in Plants. Mol Plant. 2015 Nov 02;8(11):1563–79. doi: 10.1016/j.molp.2015.09.005. PMID: 26384576.; Michaeli S, Fromm H. Closing the loop on the GABA shunt in plants: are GABA metabolism and signaling entwined? Front Plant Sci. 2015;6():419. PMID: 26106401; PMCID: PMC4460296.; Yu GH, Zou J, Feng J, Peng XB, Wu JY, Wu YL, Palanivelu R, Sun MX. Exogenous ?-aminobutyric acid (GABA) affects pollen tube growth via modulating putative Ca2+-permeable membrane channels and is coupled to negative regulation on glutamate decarboxylase. J Exp Bot. 2014 Jul;65(12):3235–48. PMID: 24799560; PMCID: PMC4071839.; Shimajiri Y, Oonishi T, Ozaki K, Kainou K, Akama K. Genetic manipulation of the ?-aminobutyric acid (GABA) shunt in rice: overexpression of truncated glutamate decarboxylase (GAD2) and knockdown of ?-aminobutyric acid transaminase (GABA-T) lead to sustained and high levels of GABA accumulation in rice kernels. Plant Biotechnology Journal. 2013 Feb 20;11(5):594–604. doi: 10.1111/pbi.12050.; Shimajiri Y, Ozaki K, Kainou K, Akama K. Differential subcellular localization, enzymatic properties and expression patterns of ?-aminobutyric acid transaminases (GABA-Ts) in rice (Oryza sativa). J Plant Physiol. 2013 Jan 15;170(2):196–201. doi: 10.1016/j.jplph.2012.09.007. PMID: 23122787.; Wang L, Liu M, Lv YG, Zhang H. Purification of calmodulin from rice bran and activation of glutamate decarboxylase by Ca2+/calmodulin. J Sci Food Agric. 2010 Mar 15;90(4):669–75. doi: 10.1002/jsfa.3866. PMID: 20355097.; Forde BG, Lea PJ. Glutamate in plants: metabolism, regulation, and signalling. Journal of Experimental Botany. 2007 Mar 09;58(9):2339–58. doi: 10.1093/jxb/erm121.; Bouché N, Fromm H. GABA in plants: just a metabolite? Trends Plant Sci. 2004 Mar;9(3):110–5. doi: 10.1016/j.tplants.2004.01.006. PMID: 15003233.; Bouché N, Fait A, Bouchez D, Møller SG, Fromm H. Mitochondrial succinic-semialdehyde dehydrogenase of the gamma-aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6843–8. PMID: 12740438; PMCID: PMC164534.; Akama K, Akihiro T, Kitagawa M, Takaiwa F. Rice (Oryza sativa) contains a novel isoform of glutamate decarboxylase that lacks an authentic calmodulin-binding domain at the C-terminus. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 2001 Dec;1522(3):143–50. doi: 10.1016/s0167-4781(01)00324-4.; Dennison KL, Spalding EP. Glutamate-gated calcium fluxes in Arabidopsis. Plant Physiol. 2000 Dec;124(4):1511–4. PMID: 11115867; PMCID: PMC1539305.; Shelp, Bown, McLean. Metabolism and functions of gamma-aminobutyric acid. Trends Plant Sci. 1999 Nov;4(11):446–52. doi: 10.1016/s1360-1385(99)01486-7. PMID: 10529826.; Busch KB, Fromm H. Plant succinic semialdehyde dehydrogenase. Cloning, purification, localization in mitochondria, and regulation by adenine nucleotides. Plant Physiol. 1999 Oct;121(2):589–97. PMID: 10517851; PMCID: PMC59422.; Snedden WA, Koutsia N, Baum G, Fromm H. Activation of a Recombinant Petunia Glutamate Decarboxylase by Calcium/Calmodulin or by a Monoclonal Antibody Which Recognizes the Calmodulin Binding Domain. Journal of Biological Chemistry. 1996 Feb;271(8):4148–53. doi: 10.1074/jbc.271.8.4148.; Chen Y, Baum G, Fromm H. The 58-Kilodalton Calmodulin-Binding Glutamate Decarboxylase Is a Ubiquitous Protein in Petunia Organs and Its Expression Is Developmentally Regulated. Plant Physiol. 1994 Dec;106(4):1381–7. PMID: 12232415; PMCID: PMC159676.
Amino acid catabolism

Accession ID: Plant Reactome:R-CSA-5655124		 -
Amino acid catabolism

Accession ID: Plant Reactome:R-PPE-5655124		 -
Amino acid metabolism

Accession ID: Plant Reactome:R-PTA-2744343		 -
GABA shunt

Accession ID: Plant Reactome:R-PTA-1119458
  • 10.1002/jsfa.3866
  • 10.1016/j.jplph.2012.09.007
  • 10.1016/j.molp.2015.09.005
  • 10.1016/j.tplants.2004.01.006
  • 10.1016/s0167-4781(01)00324-4
  • 10.1016/s1360-1385(99)01486-7
  • 10.1073/pnas.1037532100
  • 10.1074/jbc.271.8.4148
  • 10.1093/jxb/erm121
  • 10.1093/jxb/eru171
  • 10.1104/pp.106.4.1381
  • 10.1104/pp.121.2.589
  • 10.1104/pp.124.4.1511
  • 10.1111/pbi.12050
  • 10.1186/s12864-017-3588-7
  • 10.3389/fpls.2015.00419
 Kan CC, Chung TY, Wu HY, Juo YA, Hsieh MH. Exogenous glutamate rapidly induces the expression of genes involved in metabolism and defense responses in rice roots. BMC Genomics. 2017 Feb 17;18(1):186. PMID: 28212609; PMCID: PMC5316172.; Hildebrandt TM, Nunes Nesi A, Araújo WL, Braun HP. Amino Acid Catabolism in Plants. Mol Plant. 2015 Nov 02;8(11):1563–79. doi: 10.1016/j.molp.2015.09.005. PMID: 26384576.; Michaeli S, Fromm H. Closing the loop on the GABA shunt in plants: are GABA metabolism and signaling entwined? Front Plant Sci. 2015;6():419. PMID: 26106401; PMCID: PMC4460296.; Yu GH, Zou J, Feng J, Peng XB, Wu JY, Wu YL, Palanivelu R, Sun MX. Exogenous ?-aminobutyric acid (GABA) affects pollen tube growth via modulating putative Ca2+-permeable membrane channels and is coupled to negative regulation on glutamate decarboxylase. J Exp Bot. 2014 Jul;65(12):3235–48. PMID: 24799560; PMCID: PMC4071839.; Shimajiri Y, Oonishi T, Ozaki K, Kainou K, Akama K. Genetic manipulation of the ?-aminobutyric acid (GABA) shunt in rice: overexpression of truncated glutamate decarboxylase (GAD2) and knockdown of ?-aminobutyric acid transaminase (GABA-T) lead to sustained and high levels of GABA accumulation in rice kernels. Plant Biotechnology Journal. 2013 Feb 20;11(5):594–604. doi: 10.1111/pbi.12050.; Shimajiri Y, Ozaki K, Kainou K, Akama K. Differential subcellular localization, enzymatic properties and expression patterns of ?-aminobutyric acid transaminases (GABA-Ts) in rice (Oryza sativa). J Plant Physiol. 2013 Jan 15;170(2):196–201. doi: 10.1016/j.jplph.2012.09.007. PMID: 23122787.; Wang L, Liu M, Lv YG, Zhang H. Purification of calmodulin from rice bran and activation of glutamate decarboxylase by Ca2+/calmodulin. J Sci Food Agric. 2010 Mar 15;90(4):669–75. doi: 10.1002/jsfa.3866. PMID: 20355097.; Forde BG, Lea PJ. Glutamate in plants: metabolism, regulation, and signalling. Journal of Experimental Botany. 2007 Mar 09;58(9):2339–58. doi: 10.1093/jxb/erm121.; Bouché N, Fromm H. GABA in plants: just a metabolite? Trends Plant Sci. 2004 Mar;9(3):110–5. doi: 10.1016/j.tplants.2004.01.006. PMID: 15003233.; Bouché N, Fait A, Bouchez D, Møller SG, Fromm H. Mitochondrial succinic-semialdehyde dehydrogenase of the gamma-aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6843–8. PMID: 12740438; PMCID: PMC164534.; Akama K, Akihiro T, Kitagawa M, Takaiwa F. Rice (Oryza sativa) contains a novel isoform of glutamate decarboxylase that lacks an authentic calmodulin-binding domain at the C-terminus. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 2001 Dec;1522(3):143–50. doi: 10.1016/s0167-4781(01)00324-4.; Dennison KL, Spalding EP. Glutamate-gated calcium fluxes in Arabidopsis. Plant Physiol. 2000 Dec;124(4):1511–4. PMID: 11115867; PMCID: PMC1539305.; Shelp, Bown, McLean. Metabolism and functions of gamma-aminobutyric acid. Trends Plant Sci. 1999 Nov;4(11):446–52. doi: 10.1016/s1360-1385(99)01486-7. PMID: 10529826.; Busch KB, Fromm H. Plant succinic semialdehyde dehydrogenase. Cloning, purification, localization in mitochondria, and regulation by adenine nucleotides. Plant Physiol. 1999 Oct;121(2):589–97. PMID: 10517851; PMCID: PMC59422.; Snedden WA, Koutsia N, Baum G, Fromm H. Activation of a Recombinant Petunia Glutamate Decarboxylase by Calcium/Calmodulin or by a Monoclonal Antibody Which Recognizes the Calmodulin Binding Domain. Journal of Biological Chemistry. 1996 Feb;271(8):4148–53. doi: 10.1074/jbc.271.8.4148.; Chen Y, Baum G, Fromm H. The 58-Kilodalton Calmodulin-Binding Glutamate Decarboxylase Is a Ubiquitous Protein in Petunia Organs and Its Expression Is Developmentally Regulated. Plant Physiol. 1994 Dec;106(4):1381–7. PMID: 12232415; PMCID: PMC159676.
Metabolism and regulation

Accession ID: Plant Reactome:R-MDO-2744345		 -
Amino acid metabolism

Accession ID: Plant Reactome:R-MDO-2744343		 -