Pathways Knowlegdes

Necessitatibus eius consequatur ex aliquid fuga eum quidem sint consectetur velit

Pathway DOIs Note
methylglyoxal degradation III

Accession ID: BioCyc:HUMAN_PWY-5453
  • 10.1128/jb.187.16.5782-5789.2005
 Ko J, Kim I, Yoo S, Min B, Kim K, Park C. Conversion of Methylglyoxal to Acetol by Escherichia coli Aldo-Keto Reductases. J Bacteriol. 2005 Aug 15;187(16):5782–9. doi: 10.1128/jb.187.16.5782-5789.2005.
paerucumarin biosynthesis

Accession ID: BioCyc:META_PWY-7955
  • 10.1016/j.jmb.2008.09.027
  • 10.1186/1475-2859-11-42
 Lin Y, Yan Y. Biosynthesis of caffeic acid in Escherichia coli using its endogenous hydroxylase complex. Microbial Cell Factories. 2012 Apr 04;11(1):42. doi: 10.1186/1475-2859-11-42.; Drake EJ, Gulick AM. Three-dimensional Structures of Pseudomonas aeruginosa PvcA and PvcB, Two Proteins Involved in the Synthesis of 2-Isocyano-6,7-dihydroxycoumarin. Journal of Molecular Biology. 2008 Dec;384(1):193–205. doi: 10.1016/j.jmb.2008.09.027.
methylglyoxal degradation III

Accession ID: BioCyc:ECO_PWY-5453
  • 10.1128/jb.187.16.5782-5789.2005
 Ko J, Kim I, Yoo S, Min B, Kim K, Park C. Conversion of Methylglyoxal to Acetol by Escherichia coli Aldo-Keto Reductases. J Bacteriol. 2005 Aug 15;187(16):5782–9. doi: 10.1128/jb.187.16.5782-5789.2005.
detoxification of reactive carbonyls in chloroplasts

Accession ID: BioCyc:ARA_PWY-6786
  • 10.1016/j.jmb.2009.07.023
  • 10.1074/jbc.m110.202226
 Yamauchi Y, Hasegawa A, Taninaka A, Mizutani M, Sugimoto Y. NADPH-dependent Reductases Involved in the Detoxification of Reactive Carbonyls in Plants. Journal of Biological Chemistry. 2011 Mar;286(9):6999–7009. doi: 10.1074/jbc.m110.202226.; Simpson PJ, Tantitadapitak C, Reed AM, Mather OC, Bunce CM, White SA, Ride JP. Characterization of two novel aldo-keto reductases from Arabidopsis: expression patterns, broad substrate specificity, and an open active-site structure suggest a role in toxicant metabolism following stress. J Mol Biol. 2009 Sep 18;392(2):465–80. doi: 10.1016/j.jmb.2009.07.023. PMID: 19616008.
methylglyoxal degradation III

Accession ID: BioCyc:ECOL199310_PWY-5453		 -
methylglyoxal degradation III

Accession ID: BioCyc:ECOL413997_PWY-5453		 -
acetone degradation I (to methylglyoxal)

Accession ID: BioCyc:HUMAN_PWY-5451
  • 10.1016/s0021-9258(17)38768-9
  • 10.1016/s0021-9258(17)43646-5
 Koop DR, Casazza JP. Identification of ethanol-inducible P-450 isozyme 3a as the acetone and acetol monooxygenase of rabbit microsomes. Journal of Biological Chemistry. 1985 Nov;260(25):13607–12. doi: 10.1016/s0021-9258(17)38768-9.; Casazza JP, Felver ME, Veech RL. The metabolism of acetone in rat. Journal of Biological Chemistry. 1984 Jan;259(1):231–6. doi: 10.1016/s0021-9258(17)43646-5.
detoxification of reactive carbonyls in chloroplasts

Accession ID: BioCyc:META_PWY-6786
  • 10.1016/j.jmb.2009.07.023
  • 10.1074/jbc.m110.202226
 Yamauchi Y, Hasegawa A, Taninaka A, Mizutani M, Sugimoto Y. NADPH-dependent Reductases Involved in the Detoxification of Reactive Carbonyls in Plants. Journal of Biological Chemistry. 2011 Mar;286(9):6999–7009. doi: 10.1074/jbc.m110.202226.; Simpson PJ, Tantitadapitak C, Reed AM, Mather OC, Bunce CM, White SA, Ride JP. Characterization of two novel aldo-keto reductases from Arabidopsis: expression patterns, broad substrate specificity, and an open active-site structure suggest a role in toxicant metabolism following stress. J Mol Biol. 2009 Sep 18;392(2):465–80. doi: 10.1016/j.jmb.2009.07.023. PMID: 19616008.
propane degradation II

Accession ID: BioCyc:META_PWY-7775
  • 10.1074/jbc.m211943200
  • 10.1093/femsle/fnv136
 Furuya T, Nakao T, Kino K. Catalytic function of the mycobacterial binuclear iron monooxygenase in acetone metabolism. FEMS Microbiology Letters. 2015 Aug 19;362(19):fnv136. doi: 10.1093/femsle/fnv136.; Gidda SK, Miersch O, Levitin A, Schmidt J, Wasternack C, Varin L. Biochemical and Molecular Characterization of a Hydroxyjasmonate Sulfotransferase from Arabidopsis thaliana. Journal of Biological Chemistry. 2003 May;278(20):17895–900. doi: 10.1074/jbc.m211943200.
superpathway of methylglyoxal degradation

Accession ID: BioCyc:ECO_METHGLYUT-PWY
  • 10.1074/mcp.d500006-mcp200
 Lopez-Campistrous A, Semchuk P, Burke L, Palmer-Stone T, Brokx SJ, Broderick G, Bottorff D, Bolch S, Weiner JH, Ellison MJ. Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth. Mol Cell Proteomics. 2005 Aug;4(8):1205–9. doi: 10.1074/mcp.d500006-mcp200. PMID: 15911532.
methylglyoxal degradation III

Accession ID: BioCyc:ECOO157_PWY-5453		 -
superpathway of methylglyoxal degradation

Accession ID: BioCyc:CLOSSAC_METHGLYUT-PWY		 -
methylglyoxal degradation III

Accession ID: BioCyc:CLOSSAC_PWY-5453		 -
acetone degradation III (to propane-1,2-diol)

Accession ID: BioCyc:META_PWY-7466
  • 10.1016/s0021-9258(18)42844-x
 Vander Jagt DL, Robinson B, Taylor KK, Hunsaker LA. Reduction of trioses by NADPH-dependent aldo-keto reductases. Aldose reductase, methylglyoxal, and diabetic complications. Journal of Biological Chemistry. 1992 Mar;267(7):4364–9. doi: 10.1016/s0021-9258(18)42844-x.
12-epi-hapalindole biosynthesis

Accession ID: BioCyc:META_PWY-7959
  • 10.1002/anie.200501941
  • 10.1002/anie.200501942
  • 10.1021/acs.orglett.7b00258
  • 10.1021/cb400681n
  • 10.1021/jacs.5b10136
  • 10.1038/nchembio.2327
 Li S, Lowell AN, Newmister SA, Yu F, Williams RM, Sherman DH. Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids. Nature Chemical Biology. 2017 Mar 13;13(5):467–9. doi: 10.1038/nchembio.2327.; Chang WC, Sanyal D, Huang JL, Ittiamornkul K, Zhu Q, Liu X. In Vitro Stepwise Reconstitution of Amino Acid Derived Vinyl Isocyanide Biosynthesis: Detection of an Elusive Intermediate. Org Lett. 2017 Mar 03;19(5):1208–11. doi: 10.1021/acs.orglett.7b00258. PMID: 28212039.; Li S, Lowell AN, Yu F, Raveh A, Newmister SA, Bair N, Schaub JM, Williams RM, Sherman DH. Hapalindole/Ambiguine Biogenesis Is Mediated by a Cope Rearrangement, C–C Bond-Forming Cascade. J. Am. Chem. Soc. 2015 Dec 02;137(49):15366–9. doi: 10.1021/jacs.5b10136.; Hillwig ML, Zhu Q, Liu X. Biosynthesis of Ambiguine Indole Alkaloids in CyanobacteriumFischerella ambigua. ACS Chem. Biol. 2013 Nov 20;9(2):372–7. doi: 10.1021/cb400681n.; Brady SF, Clardy J. Systematic investigation of the Escherichia coli metabolome for the biosynthetic origin of an isocyanide carbon atom. Angew Chem Int Ed Engl. 2005 Nov 04;44(43):7045–8. doi: 10.1002/anie.200501942. PMID: 16217820.; Brady SF, Clardy J. Cloning and heterologous expression of isocyanide biosynthetic genes from environmental DNA. Angew Chem Int Ed Engl. 2005 Nov 04;44(43):7063–5. doi: 10.1002/anie.200501941. PMID: 16206308.
rhabduscin biosynthesis

Accession ID: BioCyc:META_PWY-7960
  • 10.1016/j.cub.2009.10.059
  • 10.1016/j.jmb.2008.09.027
 Crawford JM, Kontnik R, Clardy J. Regulating Alternative Lifestyles in Entomopathogenic Bacteria. Current Biology. 2010 Jan;20(1):69–74. doi: 10.1016/j.cub.2009.10.059.; Drake EJ, Gulick AM. Three-dimensional Structures of Pseudomonas aeruginosa PvcA and PvcB, Two Proteins Involved in the Synthesis of 2-Isocyano-6,7-dihydroxycoumarin. Journal of Molecular Biology. 2008 Dec;384(1):193–205. doi: 10.1016/j.jmb.2008.09.027.
hapalindole H biosynthesis

Accession ID: BioCyc:META_PWY-7957
  • 10.1002/anie.200501941
  • 10.1002/anie.200501942
  • 10.1021/acs.orglett.7b00258
  • 10.1021/cb400681n
  • 10.1021/jacs.5b10136
  • 10.1038/nchembio.2327
 Li S, Lowell AN, Newmister SA, Yu F, Williams RM, Sherman DH. Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids. Nature Chemical Biology. 2017 Mar 13;13(5):467–9. doi: 10.1038/nchembio.2327.; Chang WC, Sanyal D, Huang JL, Ittiamornkul K, Zhu Q, Liu X. In Vitro Stepwise Reconstitution of Amino Acid Derived Vinyl Isocyanide Biosynthesis: Detection of an Elusive Intermediate. Org Lett. 2017 Mar 03;19(5):1208–11. doi: 10.1021/acs.orglett.7b00258. PMID: 28212039.; Li S, Lowell AN, Yu F, Raveh A, Newmister SA, Bair N, Schaub JM, Williams RM, Sherman DH. Hapalindole/Ambiguine Biogenesis Is Mediated by a Cope Rearrangement, C–C Bond-Forming Cascade. J. Am. Chem. Soc. 2015 Dec 02;137(49):15366–9. doi: 10.1021/jacs.5b10136.; Hillwig ML, Zhu Q, Liu X. Biosynthesis of Ambiguine Indole Alkaloids in CyanobacteriumFischerella ambigua. ACS Chem. Biol. 2013 Nov 20;9(2):372–7. doi: 10.1021/cb400681n.; Brady SF, Clardy J. Systematic investigation of the Escherichia coli metabolome for the biosynthetic origin of an isocyanide carbon atom. Angew Chem Int Ed Engl. 2005 Nov 04;44(43):7045–8. doi: 10.1002/anie.200501942. PMID: 16217820.; Brady SF, Clardy J. Cloning and heterologous expression of isocyanide biosynthetic genes from environmental DNA. Angew Chem Int Ed Engl. 2005 Nov 04;44(43):7063–5. doi: 10.1002/anie.200501941. PMID: 16206308.
methylglyoxal degradation III

Accession ID: BioCyc:META_PWY-5453
  • 10.1128/jb.187.16.5782-5789.2005
 Ko J, Kim I, Yoo S, Min B, Kim K, Park C. Conversion of Methylglyoxal to Acetol by Escherichia coli Aldo-Keto Reductases. J Bacteriol. 2005 Aug 15;187(16):5782–9. doi: 10.1128/jb.187.16.5782-5789.2005.
methylglyoxal degradation III

Accession ID: BioCyc:SHIGELLA_PWY-5453		 -
superpathway of methylglyoxal degradation

Accession ID: BioCyc:ECOL316407_METHGLYUT-PWY		 -