Pathways Knowlegdes
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| Pathway | DOIs | Note |
|---|---|---|
| uridine-5'-phosphate biosynthesis Accession ID: BioCyc:TRYPANO_PWY-5686 |
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| NAD biosynthesis (from tryptophan) Accession ID: BioCyc:CALBI_NADSYN-PWY |
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Li YF, Bao WG. Why do some yeast species require niacin for growth? Different modes of NAD synthesis. FEMS Yeast Res. 2007 Aug;7(5):657–64. doi: 10.1111/j.1567-1364.2007.00231.x. PMID: 17425674.; Belenky P, Bogan KL, Brenner C. NAD+ metabolism in health and disease. Trends Biochem Sci. 2007 Jan;32(1):12–9. doi: 10.1016/j.tibs.2006.11.006. PMID: 17161604.; Chaffin WL, Barton RA, Jacobson EL, Jacobson MK. Nicotinamide adenine dinucleotide metabolism in Candida albicans. J Bacteriol. 1979 Sep;139(3):883–8. doi: 10.1128/jb.139.3.883-888.1979. |
| salvage pathways of guanine, xanthine, and their nucleosides Accession ID: BioCyc:CALBI_SALVPURINE2-PWY |
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Rolfes RJ. Regulation of purine nucleotide biosynthesis: in yeast and beyond. Biochem Soc Trans. 2006 Nov;34(Pt 5):786–90. doi: 10.1042/bst0340786. PMID: 17052198.; Escobar-Henriques M, Daignan-Fornier B. Transcriptional Regulation of the Yeast GMP Synthesis Pathway by Its End Products. Journal of Biological Chemistry. 2001 Jan;276(2):1523–30. doi: 10.1074/jbc.m007926200. |
| salvage pathways of purine nucleosides Accession ID: BioCyc:CALBI_P121-PWY |
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Rolfes RJ. Regulation of purine nucleotide biosynthesis: in yeast and beyond. Biochem Soc Trans. 2006 Nov;34(Pt 5):786–90. doi: 10.1042/bst0340786. PMID: 17052198.; Challa A, Johnson S, Robertson K, Gunasekaran M. Properties of adenosine deaminase from Candida albicans. J Basic Microbiol. 1999;39(2):97–101. doi: 10.1002/(sici)1521-4028(199905)39:2<97::aid-jobm97>3.0.co;2-n. PMID: 10335602. |
| NAD salvage pathway Accession ID: BioCyc:CALBI_PWY3O-4107 |
|
Li YF, Bao WG. Why do some yeast species require niacin for growth? Different modes of NAD synthesis. FEMS Yeast Res. 2007 Aug;7(5):657–64. doi: 10.1111/j.1567-1364.2007.00231.x. PMID: 17425674.; Belenky P, Bogan KL, Brenner C. NAD+ metabolism in health and disease. Trends Biochem Sci. 2007 Jan;32(1):12–9. doi: 10.1016/j.tibs.2006.11.006. PMID: 17161604.; Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Cohen H, Lin SS, Manchester JK, Gordon JI, Sinclair DA. Manipulation of a Nuclear NAD+ Salvage Pathway Delays Aging without Altering Steady-state NAD+ Levels. Journal of Biological Chemistry. 2002 May;277(21):18881–90. doi: 10.1074/jbc.m111773200.; Chaffin WL, Barton RA, Jacobson EL, Jacobson MK. Nicotinamide adenine dinucleotide metabolism in Candida albicans. J Bacteriol. 1979 Sep;139(3):883–8. doi: 10.1128/jb.139.3.883-888.1979. |
| NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde Accession ID: BioCyc:LEISH_PWY-5653 |
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| salvage pathways of purine nucleosides Accession ID: BioCyc:LEISH_PWY3IU-402 |
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Boitz JM, Ullman B. A Conditional Mutant Deficient in Hypoxanthine-guanine Phosphoribosyltransferase and Xanthine Phosphoribosyltransferase Validates the Purine Salvage Pathway of Leishmania donovani. Journal of Biological Chemistry. 2006 Jun;281(23):16084–9. doi: 10.1074/jbc.m600188200.; Jardim A, Bergeson SE, Shih S, Carter N, Lucas RW, Merlin G, Myler PJ, Stuart K, Ullman B. Xanthine phosphoribosyltransferase from Leishmania donovani. Molecular cloning, biochemical characterization, and genetic analysis. J Biol Chem. 1999 Nov 26;274(48):34403–10. doi: 10.1074/jbc.274.48.34403. PMID: 10567419.; Rainey PM, Spithill TW, McMahon-Pratt D, Pan AA. Biochemical and molecular characterization ofLeishmania pifanoi amastigotes in continuous axenic culture. Molecular and Biochemical Parasitology. 1991 Nov;49(1):111–8. doi: 10.1016/0166-6851(91)90134-r.; LaFon SW, Nelson DJ, Berens RL, Marr JJ. Purine and pyrimidine salvage pathways in Leishmania donovani. Biochem Pharmacol. 1982 Jan 15;31(2):231–8. doi: 10.1016/0006-2952(82)90216-7. PMID: 7059364. |
| salvage pathways of adenine, hypoxanthine, and their nucleosides Accession ID: BioCyc:TRYPANO_SALVADEHYPOX-PWY |
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| purine nucleotides de novo biosynthesis I Accession ID: BioCyc:TRYPANO_DENOVOPURINE2-PWY |
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| 5-aminoimidazole ribonucleotide biosynthesis II Accession ID: BioCyc:TRYPANO_PWY-6122 |
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| salvage pathways of purine nucleosides I Accession ID: BioCyc:TRYPANO_P121-PWY |
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| PRPP biosynthesis II Accession ID: BioCyc:TRYPANO_PWY0-661 |
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| salvage pathways of pyrimidine ribonucleotides Accession ID: BioCyc:CALBI_PWY0-163 |
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Hope WW, Tabernero L, Denning DW, Anderson MJ. Molecular Mechanisms of Primary Resistance to Flucytosine in Candida albicans. Antimicrob Agents Chemother. 2004 Nov;48(11):4377–86. doi: 10.1128/aac.48.11.4377-4386.2004.; Kurtz JE, Exinger F, Erbs P, Jund R. New insights into the pyrimidine salvage pathway of Saccharomyces cerevisiae: requirement of six genes for cytidine metabolism. Curr Genet. 1999 Sep;36(3):130–6. doi: 10.1007/s002940050482. PMID: 10501935.; Kern L, de Montigny J, Lacroute F, Jund R. Regulation of the pyrimidine salvage pathway by the FUR1 gene product of Saccharomyces cerevisiae. Curr Genet. 1991 May;19(5):333–7. doi: 10.1007/bf00309592. PMID: 1913872.; Kern L, de Montigny J, Jund R, Lacroute F. The FUR1 gene of Saccharomyces cerevisiae: cloning, structure and expression of wild-type and mutant alleles. Gene. 1990 Apr 16;88(2):149–57. doi: 10.1016/0378-1119(90)90026-n. PMID: 2189783. |
| NAD biosynthesis II (from tryptophan) Accession ID: BioCyc:LEISH_NADSYN-PWY |
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| pyrimidine ribonucleotides de novo biosynthesis Accession ID: BioCyc:LEISH_PWY0-162 |
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Opperdoes FR, Szikora J. In silico prediction of the glycosomal enzymes of Leishmania major and trypanosomes. Molecular and Biochemical Parasitology. 2006 Jun;147(2):193–206. doi: 10.1016/j.molbiopara.2006.02.010. |
| purine nucleotides de novo biosynthesis II Accession ID: BioCyc:TRYPANO_PWY-841 |
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| pyrimidine ribonucleotides de novo biosynthesis Accession ID: BioCyc:TRYPANO_PWY0-162 |
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| pyridine nucleotide cycling Accession ID: BioCyc:TRYPANO_PYRNUCYC-PWY |
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| 5-aminoimidazole ribonucleotide biosynthesis I Accession ID: BioCyc:TRYPANO_PWY-6121 |
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| salvage pathways of guanine, xanthine, and their nucleosides Accession ID: BioCyc:TRYPANO_SALVPURINE2-PWY |
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