Pathways Knowlegdes

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Pathway DOIs Note
pyridine nucleotide cycling (plants)

Accession ID: BioCyc:LEISH_PWY-5381		 -
salvage pathways of pyrimidine ribonucleotides

Accession ID: BioCyc:LEISH_PWY0-163		 -
purine and pyrimidine metabolism

Accession ID: BioCyc:TRYPANO_P1-PWY		 -
aspartate superpathway

Accession ID: BioCyc:TRYPANO_PWY0-781		 -
superpathway of histidine, purine, and pyrimidine biosynthesis

Accession ID: BioCyc:TRYPANO_PRPP-PWY		 -
NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde

Accession ID: BioCyc:TRYPANO_PWY-5653		 -
salvage pathways of pyrimidine ribonucleotides

Accession ID: BioCyc:TRYPANO_PWY0-163		 -
PRPP biosynthesis I

Accession ID: BioCyc:TRYPANO_PWY0-662		 -
histidine biosynthesis

Accession ID: BioCyc:CALBI_HISTSYN-PWY
  • 10.1016/0378-1119(95)00492-o
 Pla J, Pérez-Díaz RM, Navarro-García F, Sánchez M, Nombela C. Cloning of the Candida albicans HIS1 gene by direct complementation of a C. albicans histidine auxotroph using an improved double-ARS shuttle vector. Gene. 1995 Nov 07;165(1):115–20. doi: 10.1016/0378-1119(95)00492-o. PMID: 7489899.
tryptophan degradation via kynurenine

Accession ID: BioCyc:CALBI_TRYPTOPHAN-DEGRADATION-1
  • 10.1002/jobm.19740140508
  • 10.1016/s0014-5793(02)02585-1
  • 10.1271/bbb.69.2358
 TSAI S, TSAI L, LI Y. An IsolatedCandida albicansTL3 Capable of Degrading Phenol at Large Concentration. Bioscience, Biotechnology, and Biochemistry. 2005 Jan;69(12):2358–67. doi: 10.1271/bbb.69.2358.; Panozzo C, Nawara M, Suski C, Kucharczyk R, Skoneczny M, Bécam A, Rytka J, Herbert CJ. Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae. FEBS Letters. 2002 Mar 22;517(1-3):97–102. doi: 10.1016/s0014-5793(02)02585-1.; Teuscher G, Karczewski P, Weide H. [Catabolism of tryptophan by Candida guilliermondii, strain H17]. Z Allg Mikrobiol. 1974;14(5):429–33. doi: 10.1002/jobm.3630140508. PMID: 4408763.
superpathway of phenylalanine, tyrosine and tryptophan biosynthesis

Accession ID: BioCyc:CALBI_COMPLETE-ARO-PWY		 -
superpathway of histidine, purine and pyrimidine biosynthesis

Accession ID: BioCyc:CALBI_PRPP-PWY		 -
tryptophan biosynthesis

Accession ID: BioCyc:CALBI_TRPSYN-PWY
  • 10.1002/(sici)1097-0061(200004)16:6<553::aid-yea554>3.0.co;2-7
  • 10.1016/s0021-9258(17)43193-0
  • 10.1128/ec.5.5.816-824.2006
  • 10.1128/jb.175.4.1061-1068.1993
  • 10.1128/mmbr.55.3.349-370.1991
 Kingsbury JM, Goldstein AL, McCusker JH. Role of Nitrogen and Carbon Transport, Regulation, and Metabolism Genes for Saccharomyces cerevisiae Survival In Vivo. Eukaryot Cell. 2006 May;5(5):816–24. doi: 10.1128/ec.5.5.816-824.2006.; Toyn JH, Gunyuzlu PL, White WH, Thompson LA, Hollis GF. A counterselection for the tryptophan pathway in yeast: 5-fluoroanthranilic acid resistance. Yeast. 2000 Apr;16(6):553–60. doi: 10.1002/(sici)1097-0061(200004)16:6<553::aid-yea554>3.0.co;2-7. PMID: 10790693.; Graf R, Mehmann B, Braus GH. Analysis of feedback-resistant anthranilate synthases from Saccharomyces cerevisiae. J Bacteriol. 1993 Feb;175(4):1061–8. doi: 10.1128/jb.175.4.1061-1068.1993.; Braus GH. Aromatic amino acid biosynthesis in the yeast Saccharomyces cerevisiae: a model system for the regulation of a eukaryotic biosynthetic pathway. Microbiol Rev. 1991 Sep;55(3):349–70. doi: 10.1128/mr.55.3.349-370.1991.; Zalkin H, Paluh JL, van Cleemput M, Moye WS, Yanofsky C. Nucleotide sequence of Saccharomyces cerevisiae genes TRP2 and TRP3 encoding bifunctional anthranilate synthase: indole-3-glycerol phosphate synthase. Journal of Biological Chemistry. 1984 Mar;259(6):3985–92. doi: 10.1016/s0021-9258(17)43193-0.
PRPP biosynthesis

Accession ID: BioCyc:CALBI_PWY0-662
  • 10.1007/bf01146517
 Alloush HM, Kerridge D. Characterisation of a partially purified uracil phosphoribosyltransferase from the opportunistic pathogen Candida albicans. Mycopathologia. 1994 Mar;125(3):129–41. doi: 10.1007/bf01146517. PMID: 8047103.
salvage pathways of adenine, hypoxanthine, and their nucleosides

Accession ID: BioCyc:CALBI_SALVADEHYPOX-PWY
  • 10.1002/(sici)1521-4028(199905)39:2<97::aid-jobm97>3.0.co;2-n
  • 10.1042/bst0340786
  • 10.1074/jbc.m007926200
  • 10.1093/genetics/147.2.383
  • 10.1128/jb.174.10.3102-3110.1992
  • 10.1186/1471-2091-4-4
 Rolfes RJ. Regulation of purine nucleotide biosynthesis: in yeast and beyond. Biochem Soc Trans. 2006 Nov;34(Pt 5):786–90. doi: 10.1042/bst0340786. PMID: 17052198.; Itoh R, Saint-Marc C, Chaignepain S, Katahira R, Schmitter J, Daignan-Fornier B. The yeast ISN1 (YOR155c) gene encodes a new type of IMP-specific 5'-nucleotidase. BMC Molecular and Cell Biology. 2003 May 07;4(1):4. doi: 10.1186/1471-2091-4-4.; Escobar-Henriques M, Daignan-Fornier B. Transcriptional Regulation of the Yeast GMP Synthesis Pathway by Its End Products. Journal of Biological Chemistry. 2001 Jan;276(2):1523–30. doi: 10.1074/jbc.m007926200.; Challa A, Johnson S, Robertson K, Gunasekaran M. Properties of adenosine deaminase from Candida albicans. J Basic Microbiol. 1999;39(2):97–101. doi: 10.1002/(sici)1521-4028(199905)39:2<97::aid-jobm97>3.0.co;2-n. PMID: 10335602.; Guetsova ML, Lecoq K, Daignan-Fornier B. The isolation and characterization of Saccharomyces cerevisiae mutants that constitutively express purine biosynthetic genes. Genetics. 1997 Oct;147(2):383–97. PMID: 9335580; PMCID: PMC1208165.; Deeley MC. Adenine deaminase and adenine utilization in Saccharomyces cerevisiae. J Bacteriol. 1992 May;174(10):3102–10. doi: 10.1128/jb.174.10.3102-3110.1992.
purine nucleotides de novo biosynthesis

Accession ID: BioCyc:CALBI_DENOVOPURINE2-PWY
  • 10.1016/j.chembiol.2007.09.009
  • 10.1042/bst0340786
  • 10.1128/jb.156.3.1066-1077.1983
  • 10.1128/jb.179.7.2331-2338.1997
 Rodriguez-Suarez R, Xu D, Veillette K, Davison J, Sillaots S, Kauffman S, Hu W, Bowman J, Martel N, Trosok S, Wang H, Zhang L, Huang LY, Li Y, Rahkhoodaee F, Ransom T, Gauvin D, Douglas C, Youngman P, Becker J, Jiang B, Roemer T. Mechanism-of-action determination of GMP synthase inhibitors and target validation in Candida albicans and Aspergillus fumigatus. Chem Biol. 2007 Oct;14(10):1163–75. doi: 10.1016/j.chembiol.2007.09.009. PMID: 17961828.; Rolfes RJ. Regulation of purine nucleotide biosynthesis: in yeast and beyond. Biochem Soc Trans. 2006 Nov;34(Pt 5):786–90. doi: 10.1042/bst0340786. PMID: 17052198.; Köhler GA, White TC, Agabian N. Overexpression of a cloned IMP dehydrogenase gene of Candida albicans confers resistance to the specific inhibitor mycophenolic acid. J Bacteriol. 1997 Apr;179(7):2331–8. doi: 10.1128/jb.179.7.2331-2338.1997.; Poulter RT, Rikkerink EH. Genetic analysis of red, adenine-requiring mutants of Candida albicans. J Bacteriol. 1983 Dec;156(3):1066–77. doi: 10.1128/jb.156.3.1066-1077.1983.
uridine-5'-phosphate biosynthesis

Accession ID: BioCyc:LEISH_PWY-5686		 -
PRPP biosynthesis I

Accession ID: BioCyc:LEISH_PWY0-662		 -
NAD biosynthesis II (from tryptophan)

Accession ID: BioCyc:TRYPANO_NADSYN-PWY		 -
NAD biosynthesis I (from aspartate)

Accession ID: BioCyc:TRYPANO_PYRIDNUCSYN-PWY		 -