Pathways Knowlegdes

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Pathway DOIs Note
Cytochrome P450 - arranged by substrate type

Accession ID: Reactome:R-GGA-211897
  • 10.1097/00008571-200401000-00001
  • 10.1208/aapsj080112
  • 10.1517/phgs.5.3.305.29827
  • 10.2174/1389200023337054
 Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Lewis DF. 57 varieties: the human cytochromes P450. Pharmacogenomics. 2004 Apr;5(3):305–18. doi: 10.1517/phgs.5.3.305.29827. PMID: 15102545.; Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenetics. 2004 Jan;14(1):1–18. doi: 10.1097/00008571-200401000-00001. PMID: 15128046.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Biological oxidations

Accession ID: Reactome:R-RNO-211859		 -
Fatty acids

Accession ID: Reactome:R-RNO-211935
  • 10.1016/j.pharmthera.2005.05.011
  • 10.1016/j.prostaglandins.2006.05.025
 Medhora M, Dhanasekaran A, Gruenloh SK, Dunn LK, Gabrilovich M, Falck JR, Harder DR, Jacobs ER, Pratt PF. Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids. Prostaglandins Other Lipid Mediat. 2007 Jan;82(1-4):19–29. doi: 10.1016/j.prostaglandins.2006.05.025. PMID: 17164129.; Elbekai RH, El-Kadi AO. Cytochrome P450 enzymes: central players in cardiovascular health and disease. Pharmacol Ther. 2006 Nov;112(2):564–87. doi: 10.1016/j.pharmthera.2005.05.011. PMID: 16824612.
Metabolism

Accession ID: Reactome:R-SSC-1430728		 -
Biological oxidations

Accession ID: Reactome:R-SSC-211859		 -
Fatty acids

Accession ID: Reactome:R-SSC-211935
  • 10.1016/j.pharmthera.2005.05.011
  • 10.1016/j.prostaglandins.2006.05.025
 Medhora M, Dhanasekaran A, Gruenloh SK, Dunn LK, Gabrilovich M, Falck JR, Harder DR, Jacobs ER, Pratt PF. Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids. Prostaglandins Other Lipid Mediat. 2007 Jan;82(1-4):19–29. doi: 10.1016/j.prostaglandins.2006.05.025. PMID: 17164129.; Elbekai RH, El-Kadi AO. Cytochrome P450 enzymes: central players in cardiovascular health and disease. Pharmacol Ther. 2006 Nov;112(2):564–87. doi: 10.1016/j.pharmthera.2005.05.011. PMID: 16824612.
Phase I - Functionalization of compounds

Accession ID: Reactome:R-XTR-211945
  • 10.1208/aapsj080112
  • 10.1517/17425255.2.6.895
  • 10.2174/1389200023337054
 Strolin Benedetti M, Whomsley R, Baltes E. Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics. Expert Opinion on Drug Metabolism & Toxicology. 2006 Nov 24;2(6):895–921. doi: 10.1517/17425255.2.6.895.; Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Cytochrome P450 - arranged by substrate type

Accession ID: Reactome:R-BTA-211897
  • 10.1097/00008571-200401000-00001
  • 10.1208/aapsj080112
  • 10.1517/phgs.5.3.305.29827
  • 10.2174/1389200023337054
 Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Lewis DF. 57 varieties: the human cytochromes P450. Pharmacogenomics. 2004 Apr;5(3):305–18. doi: 10.1517/phgs.5.3.305.29827. PMID: 15102545.; Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenetics. 2004 Jan;14(1):1–18. doi: 10.1097/00008571-200401000-00001. PMID: 15128046.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Biological oxidations

Accession ID: Reactome:R-CFA-211859		 -
Fatty acids

Accession ID: Reactome:R-CFA-211935
  • 10.1016/j.pharmthera.2005.05.011
  • 10.1016/j.prostaglandins.2006.05.025
 Medhora M, Dhanasekaran A, Gruenloh SK, Dunn LK, Gabrilovich M, Falck JR, Harder DR, Jacobs ER, Pratt PF. Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids. Prostaglandins Other Lipid Mediat. 2007 Jan;82(1-4):19–29. doi: 10.1016/j.prostaglandins.2006.05.025. PMID: 17164129.; Elbekai RH, El-Kadi AO. Cytochrome P450 enzymes: central players in cardiovascular health and disease. Pharmacol Ther. 2006 Nov;112(2):564–87. doi: 10.1016/j.pharmthera.2005.05.011. PMID: 16824612.
Metabolism

Accession ID: Reactome:R-DRE-1430728		 -
Metabolism

Accession ID: Reactome:R-GGA-1430728		 -
Biological oxidations

Accession ID: Reactome:R-GGA-211859		 -
Fatty acids

Accession ID: Reactome:R-GGA-211935
  • 10.1016/j.pharmthera.2005.05.011
  • 10.1016/j.prostaglandins.2006.05.025
 Medhora M, Dhanasekaran A, Gruenloh SK, Dunn LK, Gabrilovich M, Falck JR, Harder DR, Jacobs ER, Pratt PF. Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids. Prostaglandins Other Lipid Mediat. 2007 Jan;82(1-4):19–29. doi: 10.1016/j.prostaglandins.2006.05.025. PMID: 17164129.; Elbekai RH, El-Kadi AO. Cytochrome P450 enzymes: central players in cardiovascular health and disease. Pharmacol Ther. 2006 Nov;112(2):564–87. doi: 10.1016/j.pharmthera.2005.05.011. PMID: 16824612.
Phase I - Functionalization of compounds

Accession ID: Reactome:R-HSA-211945
  • 10.1208/aapsj080112
  • 10.1517/17425255.2.6.895
  • 10.2174/1389200023337054
 Strolin Benedetti M, Whomsley R, Baltes E. Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics. Expert Opinion on Drug Metabolism & Toxicology. 2006 Nov 24;2(6):895–921. doi: 10.1517/17425255.2.6.895.; Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Phase I - Functionalization of compounds

Accession ID: Reactome:R-MMU-211945
  • 10.1208/aapsj080112
  • 10.1517/17425255.2.6.895
  • 10.2174/1389200023337054
 Strolin Benedetti M, Whomsley R, Baltes E. Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics. Expert Opinion on Drug Metabolism & Toxicology. 2006 Nov 24;2(6):895–921. doi: 10.1517/17425255.2.6.895.; Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Metabolism

Accession ID: Reactome:R-RNO-1430728		 -
Cytochrome P450 - arranged by substrate type

Accession ID: Reactome:R-RNO-211897
  • 10.1097/00008571-200401000-00001
  • 10.1208/aapsj080112
  • 10.1517/phgs.5.3.305.29827
  • 10.2174/1389200023337054
 Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Lewis DF. 57 varieties: the human cytochromes P450. Pharmacogenomics. 2004 Apr;5(3):305–18. doi: 10.1517/phgs.5.3.305.29827. PMID: 15102545.; Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenetics. 2004 Jan;14(1):1–18. doi: 10.1097/00008571-200401000-00001. PMID: 15128046.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Cytochrome P450 - arranged by substrate type

Accession ID: Reactome:R-SSC-211897
  • 10.1097/00008571-200401000-00001
  • 10.1208/aapsj080112
  • 10.1517/phgs.5.3.305.29827
  • 10.2174/1389200023337054
 Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Lewis DF. 57 varieties: the human cytochromes P450. Pharmacogenomics. 2004 Apr;5(3):305–18. doi: 10.1517/phgs.5.3.305.29827. PMID: 15102545.; Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenetics. 2004 Jan;14(1):1–18. doi: 10.1097/00008571-200401000-00001. PMID: 15128046.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Metabolism

Accession ID: Reactome:R-XTR-1430728		 -