superpathway of polyamine biosynthesis I
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K. Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli. Molecular Microbiology. 2004 Jan 13;51(5):1401–12. doi: 10.1046/j.1365-2958.2003.03913.x.; Igarashi K, Kashiwagi K, Hamasaki H, Miura A, Kakegawa T, Hirose S, Matsuzaki S. Formation of a compensatory polyamine by Escherichia coli polyamine-requiring mutants during growth in the absence of polyamines. J Bacteriol. 1986 Apr;166(1):128–34. doi: 10.1128/jb.166.1.128-134.1986.; Dion AS, Cohen SS. Polyamine stimulation of nucleic acid synthesis in an uninfected and phage-infected polyamine auxotroph of Escherichia coli K12 (arginine-agmatine ureohydrolase-putrescine-spermidine-lysine-cadaverine). Proc Natl Acad Sci U S A. 1972 Jan;69(1):213–7. PMID: 4550506; PMCID: PMC427578.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 2.5.1.- | |||
| 2.5.1.16 | spermidine synthase | S-adenosyl 3-(methylthio)propylamine:putrescine 3-aminopropyltransferase | |
| 2.5.1.22 | spermine synthase | S-adenosyl 3-(methylthio)propylamine:spermidine 3-aminopropyltransferase | |
| 2.5.1.79 | thermospermine synthase | S-adenosyl 3-(methylthio)propylamine:spermidine 3-aminopropyltransferase (thermospermine synthesizing) | |
| 3.5.3.11 | agmatinase | agmatine amidinohydrolase | |
| 4.1.1.17 | ornithine decarboxylase | L-ornithine carboxy-lyase (putrescine-forming) | |
| 4.1.1.18 | lysine decarboxylase | L-lysine carboxy-lyase (cadaverine-forming) | |
| 4.1.1.19 | arginine decarboxylase | L-arginine carboxy-lyase (agmatine-forming) | |
| 4.1.1.50 | adenosylmethionine decarboxylase | S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium-salt-forming] |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P09158 | speE | Polyamine aminopropyltransferase |
| P0A7F6 | speD | S-adenosylmethionine decarboxylase proenzyme |
| P0A9H3 | cadA | Inducible lysine decarboxylase |
| P21169 | speC | Constitutive ornithine decarboxylase |
| P21170 | speA | Biosynthetic arginine decarboxylase |
| P52095 | ldcC | Constitutive lysine decarboxylase |
| P60651 | speB | Agmatinase |