Beta-oxidation of pristanoyl-CoA

Wanders RJ, Waterham HR. Biochemistry of mammalian peroxisomes revisited. Annu Rev Biochem. 2006;75():295–332. doi: 10.1146/annurev.biochem.74.082803.133329. PMID: 16756494.; Ferdinandusse S, Mulders J, IJlst L, Denis S, Dacremont G, Waterham HR, Wanders RJA. Molecular Cloning and Expression of Human Carnitine Octanoyltransferase: Evidence for Its Role in the Peroxisomal ß-Oxidation of Branched-Chain Fatty Acids. Biochemical and Biophysical Research Communications. 1999 Sep;263(1):213–8. doi: 10.1006/bbrc.1999.1340.; Verhoeven NM, Roe DS, Kok RM, Wanders RJA, Jakobs C, Roe CR. Phytanic acid and pristanic acid are oxidized by sequential peroxisomal and mitochondrial reactions in cultured fibroblasts. Journal of Lipid Research. 1998 Jan;39(1):66–74. doi: 10.1016/s0022-2275(20)34204-8.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen peroxide

Formula: H2O2 (34.0054792)

CAS ID: 7722-84-1

L-Carnitine

Formula: C7H15NO3 (161.105188)

CAS ID: 541-15-1

O-Propanoylcarnitine

Formula: C10H19NO4 (217.1314014)

CAS ID: 20064-19-1

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Acetyl-L-carnitine

Formula: C9H17NO4 (203.1157522)

CAS ID: 3040-38-8

acetate

Formula: C2H3O2 (59.0133038)

CAS ID: 71-50-1



Enzyme

EC Number name full name note
1.3.3.6 acyl-CoA oxidase acyl-CoA:oxygen 2-oxidoreductase
2.3.1.7 carnitine O-acetyltransferase acetyl-CoA:carnitine O-acetyltransferase
3.1.2.2 palmitoyl-CoA hydrolase palmitoyl-CoA hydrolase


Proteins

Protein ID name full name
P13711 POX1 Acyl-coenzyme A oxidase
P32796 CAT2 Carnitine O-acetyltransferase, mitochondrial
P41903 TES1 Peroxisomal acyl-coenzyme A thioester hydrolase 1