alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

Burdge GC. Metabolism of alpha-linolenic acid in humans. Prostaglandins Leukot Essent Fatty Acids. 2006 Sep;75(3):161–8. doi: 10.1016/j.plefa.2006.05.013. PMID: 16828546.; Sprecher H. The roles of anabolic and catabolic reactions in the synthesis and recycling of polyunsaturated fatty acids. Prostaglandins Leukot Essent Fatty Acids. 2002 Aug;67(2-3):79–83. doi: 10.1054/plef.2002.0402. PMID: 12324224.; Sprecher H. Metabolism of highly unsaturated n-3 and n-6 fatty acids. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2000 Jul;1486(2-3):219–31. doi: 10.1016/s1388-1981(00)00077-9.

Metabolites

(4Z,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoyl-CoA

Formula: C43H66N7O17P3S (1077.3448576)

CAS ID:

(6Z,9Z,12Z,15Z,18Z,21Z)-3-Oxotetracosahexaenoyl-CoA

Formula: C45H68N7O18P3S (1119.3554218)

CAS ID:

(9Z,12Z,15Z)-Octadecatrienoic acid

Formula: C18H30O2 (278.224568)

CAS ID: 463-40-1

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Linoleate

Formula: C18H32O2 (280.2402172)

CAS ID: 60-33-3

Linoleoyl-CoA

Formula: C39H66N7O17P3S (1029.3448576)

CAS ID: 6709-57-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA

Formula: C45H70N7O17P3S (1105.3761560000003)

CAS ID:

alpha-linolenoyl-CoA

Formula: C39H64N7O17P3S (1027.3292084)

CAS ID:

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.3.1.16 acetyl-CoA C-acyltransferase acyl-CoA:acetyl-CoA C-acyltransferase
3.1.2.2 palmitoyl-CoA hydrolase palmitoyl-CoA hydrolase
6.2.1.3 long-chain-fatty-acid-CoA ligase long-chain fatty acid:CoA ligase (AMP-forming)


Proteins

Protein ID name full name
P27796 POT1 3-ketoacyl-CoA thiolase, peroxisomal
P39518 FAA2 Long-chain-fatty-acid--CoA ligase 2
P41903 TES1 Peroxisomal acyl-coenzyme A thioester hydrolase 1