S-(Hydroxymethyl)glutathione (BioCAD00000017428)

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Metabolite Card

Formula: C11H19N3O7S (337.0944)
SMILES: N[C@@H](CCC(=O)N[C@@H](CSCO)C(=O)NCC(O)=O)C(O)=O

Synonyms [en]

S-(Hydroxymethyl)glutathione; S-hydroxymethylglutathione; L-gamma-glutamyl-S-(hydroxymethyl)-L-cysteinylglycine; (2S)-2-amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-[(hydroxymethyl)sulfanyl]ethyl]carbamoyl}butanoic acid; serGSH; S-HYDROXYMETHYL GLUTATHIONE

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

S-(Hydroxymethyl)glutathione. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000017428). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

S-Hydroxymethylglutathione is a critical component of the binding site for activating fatty acids in glutathione-dependent formaldehyde dehydrogenase activity (OMIM: 103710). Formaldehyde dehydrogenase (FDH; EC 1.2.1.1), a widely occurring enzyme, catalyzes the oxidation of S-hydroxymethylglutathione into S-formylglutathione in the presence of NAD (PMID: 2806555).

Cytoplasm
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 32260-87-0
  • PubChem: 447123
  • ChEBI: ChEBI:48926
  • HMDB: HMDB0004662
  • HMDB: HMDB04662
  • KEGG: C14180
  • NCBI MeSH: S-hydroxymethylglutathione
  • DrugBank: DB04153
  • RefMet: RM0042959
  • Metlin: METLIN_7068
  • Coconut NaturalProduct: CNP0083444.1

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R06982 4.4.1.22 S-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming);
KEGG:R06983 1.1.1.284 S-(hydroxymethyl)glutathione dehydrogenase
KEGG:R07140 1.1.1.284 S-(hydroxymethyl)glutathione:NADP+ oxidoreductase
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Organism Source

Taxonomy Source

Pathway Synthetic

pathway id name
Reactome:R-BTA-1430728 Metabolism
Reactome:R-BTA-211945 Phase I - Functionalization of compounds
Reactome:R-BTA-71384 Ethanol oxidation
Reactome:R-CEL-211859 Biological oxidations
Reactome:R-CFA-1430728 Metabolism
Reactome:R-DDI-211859 Biological oxidations
Reactome:R-DDI-71384 Ethanol oxidation
Reactome:R-HSA-211859 Biological oxidations
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-211859 Biological oxidations
Reactome:R-RNO-211945 Phase I - Functionalization of compounds
Reactome:R-RNO-71384 Ethanol oxidation
Reactome:R-SCE-71384 Ethanol oxidation
Reactome:R-SPO-1430728 Metabolism
Reactome:R-SPO-211945 Phase I - Functionalization of compounds
Reactome:R-SPO-71384 Ethanol oxidation
Reactome:R-SSC-211945 Phase I - Functionalization of compounds
Reactome:R-SSC-71384 Ethanol oxidation
Reactome:R-BTA-211859 Biological oxidations
Reactome:R-CEL-71384 Ethanol oxidation
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