Pathways Knowlegdes

Necessitatibus eius consequatur ex aliquid fuga eum quidem sint consectetur velit

Pathway DOIs Note
Metabolism

Accession ID: Reactome:R-BTA-1430728		 -
Phase I - Functionalization of compounds

Accession ID: Reactome:R-BTA-211945
  • 10.1208/aapsj080112
  • 10.1517/17425255.2.6.895
  • 10.2174/1389200023337054
 Strolin Benedetti M, Whomsley R, Baltes E. Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics. Expert Opinion on Drug Metabolism & Toxicology. 2006 Nov 24;2(6):895–921. doi: 10.1517/17425255.2.6.895.; Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Ethanol oxidation

Accession ID: Reactome:R-BTA-71384
  • 10.1016/0005-2744(79)90046-9
  • 10.1016/0741-8329(85)90017-5
  • 10.1016/s0021-9258(18)57033-2
  • 10.1021/bi00666a023
  • 10.1086/302540
  • 10.1111/j.1440-1746.2006.04643.x
  • 10.1111/j.1469-1809.1989.tb01116.x
 Lemasters JJ. Modulation of mitochondrial membrane permeability in pathogenesis, autophagy and control of metabolism. J Gastroenterol Hepatol. 2007 Jun;22 Suppl 1():S31–7. doi: 10.1111/j.1440-1746.2006.04643.x. PMID: 17567461.; Chen C, Lu R, Chen Y, Wang M, Chang Y, Li T, Yin S. Interaction between the Functional Polymorphisms of the Alcohol-Metabolism Genes in Protection against Alcoholism. The American Journal of Human Genetics. 1999 Sep;65(3):795–807. doi: 10.1086/302540.; Yoshida A, Davé V, Ward RJ, Peters TJ. Cytosolic aldehyde dehydrogenase (ALDH1) variants found in alcohol flushers. Ann Hum Genet. 1989 Jan;53(1):1–7. doi: 10.1111/j.1469-1809.1989.tb01116.x. PMID: 2729894.; Jörnvall H. Alcohol dehydrogenases, aldehyde dehydrogenases, and related enzymes. Alcohol. 1985 Jan;2(1):61–6. doi: 10.1016/0741-8329(85)90017-5. PMID: 3893466.; Inoue K, Nishimukai H, Yamasawa K. Purification and partial characterization of aldehyde dehydrogenase from human erythrocytes. Biochimica et Biophysica Acta (BBA) - Enzymology. 1979 Aug;569(2):117–23. doi: 10.1016/0005-2744(79)90046-9.; Lange LG, Sytkowski AJ, Vallee BL. Human liver alcohol dehydrogenase: purification, composition, and catalytic features. Biochemistry. 1976 Oct 19;15(21):4687–93. doi: 10.1021/bi00666a023. PMID: 9982.; Racker E. ALDEHYDE DEHYDROGENASE, A DIPHOSPHOPYRIDINE NUCLEOTIDE-LINKED ENZYME. Journal of Biological Chemistry. 1949 Feb;177(2):883–92. doi: 10.1016/s0021-9258(18)57033-2.
Biological oxidations

Accession ID: Reactome:R-CEL-211859		 -
Metabolism

Accession ID: Reactome:R-CFA-1430728		 -
Biological oxidations

Accession ID: Reactome:R-DDI-211859		 -
Ethanol oxidation

Accession ID: Reactome:R-DDI-71384
  • 10.1016/0005-2744(79)90046-9
  • 10.1016/0741-8329(85)90017-5
  • 10.1016/s0021-9258(18)57033-2
  • 10.1021/bi00666a023
  • 10.1086/302540
  • 10.1111/j.1440-1746.2006.04643.x
  • 10.1111/j.1469-1809.1989.tb01116.x
 Lemasters JJ. Modulation of mitochondrial membrane permeability in pathogenesis, autophagy and control of metabolism. J Gastroenterol Hepatol. 2007 Jun;22 Suppl 1():S31–7. doi: 10.1111/j.1440-1746.2006.04643.x. PMID: 17567461.; Chen C, Lu R, Chen Y, Wang M, Chang Y, Li T, Yin S. Interaction between the Functional Polymorphisms of the Alcohol-Metabolism Genes in Protection against Alcoholism. The American Journal of Human Genetics. 1999 Sep;65(3):795–807. doi: 10.1086/302540.; Yoshida A, Davé V, Ward RJ, Peters TJ. Cytosolic aldehyde dehydrogenase (ALDH1) variants found in alcohol flushers. Ann Hum Genet. 1989 Jan;53(1):1–7. doi: 10.1111/j.1469-1809.1989.tb01116.x. PMID: 2729894.; Jörnvall H. Alcohol dehydrogenases, aldehyde dehydrogenases, and related enzymes. Alcohol. 1985 Jan;2(1):61–6. doi: 10.1016/0741-8329(85)90017-5. PMID: 3893466.; Inoue K, Nishimukai H, Yamasawa K. Purification and partial characterization of aldehyde dehydrogenase from human erythrocytes. Biochimica et Biophysica Acta (BBA) - Enzymology. 1979 Aug;569(2):117–23. doi: 10.1016/0005-2744(79)90046-9.; Lange LG, Sytkowski AJ, Vallee BL. Human liver alcohol dehydrogenase: purification, composition, and catalytic features. Biochemistry. 1976 Oct 19;15(21):4687–93. doi: 10.1021/bi00666a023. PMID: 9982.; Racker E. ALDEHYDE DEHYDROGENASE, A DIPHOSPHOPYRIDINE NUCLEOTIDE-LINKED ENZYME. Journal of Biological Chemistry. 1949 Feb;177(2):883–92. doi: 10.1016/s0021-9258(18)57033-2.
Biological oxidations

Accession ID: Reactome:R-HSA-211859		 -
Metabolism

Accession ID: Reactome:R-MMU-1430728		 -
Biological oxidations

Accession ID: Reactome:R-MMU-211859		 -
Phase I - Functionalization of compounds

Accession ID: Reactome:R-RNO-211945
  • 10.1208/aapsj080112
  • 10.1517/17425255.2.6.895
  • 10.2174/1389200023337054
 Strolin Benedetti M, Whomsley R, Baltes E. Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics. Expert Opinion on Drug Metabolism & Toxicology. 2006 Nov 24;2(6):895–921. doi: 10.1517/17425255.2.6.895.; Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Ethanol oxidation

Accession ID: Reactome:R-RNO-71384
  • 10.1016/0005-2744(79)90046-9
  • 10.1016/0741-8329(85)90017-5
  • 10.1016/s0021-9258(18)57033-2
  • 10.1021/bi00666a023
  • 10.1086/302540
  • 10.1111/j.1440-1746.2006.04643.x
  • 10.1111/j.1469-1809.1989.tb01116.x
 Lemasters JJ. Modulation of mitochondrial membrane permeability in pathogenesis, autophagy and control of metabolism. J Gastroenterol Hepatol. 2007 Jun;22 Suppl 1():S31–7. doi: 10.1111/j.1440-1746.2006.04643.x. PMID: 17567461.; Chen C, Lu R, Chen Y, Wang M, Chang Y, Li T, Yin S. Interaction between the Functional Polymorphisms of the Alcohol-Metabolism Genes in Protection against Alcoholism. The American Journal of Human Genetics. 1999 Sep;65(3):795–807. doi: 10.1086/302540.; Yoshida A, Davé V, Ward RJ, Peters TJ. Cytosolic aldehyde dehydrogenase (ALDH1) variants found in alcohol flushers. Ann Hum Genet. 1989 Jan;53(1):1–7. doi: 10.1111/j.1469-1809.1989.tb01116.x. PMID: 2729894.; Jörnvall H. Alcohol dehydrogenases, aldehyde dehydrogenases, and related enzymes. Alcohol. 1985 Jan;2(1):61–6. doi: 10.1016/0741-8329(85)90017-5. PMID: 3893466.; Inoue K, Nishimukai H, Yamasawa K. Purification and partial characterization of aldehyde dehydrogenase from human erythrocytes. Biochimica et Biophysica Acta (BBA) - Enzymology. 1979 Aug;569(2):117–23. doi: 10.1016/0005-2744(79)90046-9.; Lange LG, Sytkowski AJ, Vallee BL. Human liver alcohol dehydrogenase: purification, composition, and catalytic features. Biochemistry. 1976 Oct 19;15(21):4687–93. doi: 10.1021/bi00666a023. PMID: 9982.; Racker E. ALDEHYDE DEHYDROGENASE, A DIPHOSPHOPYRIDINE NUCLEOTIDE-LINKED ENZYME. Journal of Biological Chemistry. 1949 Feb;177(2):883–92. doi: 10.1016/s0021-9258(18)57033-2.
Ethanol oxidation

Accession ID: Reactome:R-SCE-71384
  • 10.1016/0005-2744(79)90046-9
  • 10.1016/0741-8329(85)90017-5
  • 10.1016/s0021-9258(18)57033-2
  • 10.1021/bi00666a023
  • 10.1086/302540
  • 10.1111/j.1440-1746.2006.04643.x
  • 10.1111/j.1469-1809.1989.tb01116.x
 Lemasters JJ. Modulation of mitochondrial membrane permeability in pathogenesis, autophagy and control of metabolism. J Gastroenterol Hepatol. 2007 Jun;22 Suppl 1():S31–7. doi: 10.1111/j.1440-1746.2006.04643.x. PMID: 17567461.; Chen C, Lu R, Chen Y, Wang M, Chang Y, Li T, Yin S. Interaction between the Functional Polymorphisms of the Alcohol-Metabolism Genes in Protection against Alcoholism. The American Journal of Human Genetics. 1999 Sep;65(3):795–807. doi: 10.1086/302540.; Yoshida A, Davé V, Ward RJ, Peters TJ. Cytosolic aldehyde dehydrogenase (ALDH1) variants found in alcohol flushers. Ann Hum Genet. 1989 Jan;53(1):1–7. doi: 10.1111/j.1469-1809.1989.tb01116.x. PMID: 2729894.; Jörnvall H. Alcohol dehydrogenases, aldehyde dehydrogenases, and related enzymes. Alcohol. 1985 Jan;2(1):61–6. doi: 10.1016/0741-8329(85)90017-5. PMID: 3893466.; Inoue K, Nishimukai H, Yamasawa K. Purification and partial characterization of aldehyde dehydrogenase from human erythrocytes. Biochimica et Biophysica Acta (BBA) - Enzymology. 1979 Aug;569(2):117–23. doi: 10.1016/0005-2744(79)90046-9.; Lange LG, Sytkowski AJ, Vallee BL. Human liver alcohol dehydrogenase: purification, composition, and catalytic features. Biochemistry. 1976 Oct 19;15(21):4687–93. doi: 10.1021/bi00666a023. PMID: 9982.; Racker E. ALDEHYDE DEHYDROGENASE, A DIPHOSPHOPYRIDINE NUCLEOTIDE-LINKED ENZYME. Journal of Biological Chemistry. 1949 Feb;177(2):883–92. doi: 10.1016/s0021-9258(18)57033-2.
Metabolism

Accession ID: Reactome:R-SPO-1430728		 -
Phase I - Functionalization of compounds

Accession ID: Reactome:R-SPO-211945
  • 10.1208/aapsj080112
  • 10.1517/17425255.2.6.895
  • 10.2174/1389200023337054
 Strolin Benedetti M, Whomsley R, Baltes E. Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics. Expert Opinion on Drug Metabolism & Toxicology. 2006 Nov 24;2(6):895–921. doi: 10.1517/17425255.2.6.895.; Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Ethanol oxidation

Accession ID: Reactome:R-SPO-71384
  • 10.1016/0005-2744(79)90046-9
  • 10.1016/0741-8329(85)90017-5
  • 10.1016/s0021-9258(18)57033-2
  • 10.1021/bi00666a023
  • 10.1086/302540
  • 10.1111/j.1440-1746.2006.04643.x
  • 10.1111/j.1469-1809.1989.tb01116.x
 Lemasters JJ. Modulation of mitochondrial membrane permeability in pathogenesis, autophagy and control of metabolism. J Gastroenterol Hepatol. 2007 Jun;22 Suppl 1():S31–7. doi: 10.1111/j.1440-1746.2006.04643.x. PMID: 17567461.; Chen C, Lu R, Chen Y, Wang M, Chang Y, Li T, Yin S. Interaction between the Functional Polymorphisms of the Alcohol-Metabolism Genes in Protection against Alcoholism. The American Journal of Human Genetics. 1999 Sep;65(3):795–807. doi: 10.1086/302540.; Yoshida A, Davé V, Ward RJ, Peters TJ. Cytosolic aldehyde dehydrogenase (ALDH1) variants found in alcohol flushers. Ann Hum Genet. 1989 Jan;53(1):1–7. doi: 10.1111/j.1469-1809.1989.tb01116.x. PMID: 2729894.; Jörnvall H. Alcohol dehydrogenases, aldehyde dehydrogenases, and related enzymes. Alcohol. 1985 Jan;2(1):61–6. doi: 10.1016/0741-8329(85)90017-5. PMID: 3893466.; Inoue K, Nishimukai H, Yamasawa K. Purification and partial characterization of aldehyde dehydrogenase from human erythrocytes. Biochimica et Biophysica Acta (BBA) - Enzymology. 1979 Aug;569(2):117–23. doi: 10.1016/0005-2744(79)90046-9.; Lange LG, Sytkowski AJ, Vallee BL. Human liver alcohol dehydrogenase: purification, composition, and catalytic features. Biochemistry. 1976 Oct 19;15(21):4687–93. doi: 10.1021/bi00666a023. PMID: 9982.; Racker E. ALDEHYDE DEHYDROGENASE, A DIPHOSPHOPYRIDINE NUCLEOTIDE-LINKED ENZYME. Journal of Biological Chemistry. 1949 Feb;177(2):883–92. doi: 10.1016/s0021-9258(18)57033-2.
Phase I - Functionalization of compounds

Accession ID: Reactome:R-SSC-211945
  • 10.1208/aapsj080112
  • 10.1517/17425255.2.6.895
  • 10.2174/1389200023337054
 Strolin Benedetti M, Whomsley R, Baltes E. Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics. Expert Opinion on Drug Metabolism & Toxicology. 2006 Nov 24;2(6):895–921. doi: 10.1517/17425255.2.6.895.; Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Ethanol oxidation

Accession ID: Reactome:R-SSC-71384
  • 10.1016/0005-2744(79)90046-9
  • 10.1016/0741-8329(85)90017-5
  • 10.1016/s0021-9258(18)57033-2
  • 10.1021/bi00666a023
  • 10.1086/302540
  • 10.1111/j.1440-1746.2006.04643.x
  • 10.1111/j.1469-1809.1989.tb01116.x
 Lemasters JJ. Modulation of mitochondrial membrane permeability in pathogenesis, autophagy and control of metabolism. J Gastroenterol Hepatol. 2007 Jun;22 Suppl 1():S31–7. doi: 10.1111/j.1440-1746.2006.04643.x. PMID: 17567461.; Chen C, Lu R, Chen Y, Wang M, Chang Y, Li T, Yin S. Interaction between the Functional Polymorphisms of the Alcohol-Metabolism Genes in Protection against Alcoholism. The American Journal of Human Genetics. 1999 Sep;65(3):795–807. doi: 10.1086/302540.; Yoshida A, Davé V, Ward RJ, Peters TJ. Cytosolic aldehyde dehydrogenase (ALDH1) variants found in alcohol flushers. Ann Hum Genet. 1989 Jan;53(1):1–7. doi: 10.1111/j.1469-1809.1989.tb01116.x. PMID: 2729894.; Jörnvall H. Alcohol dehydrogenases, aldehyde dehydrogenases, and related enzymes. Alcohol. 1985 Jan;2(1):61–6. doi: 10.1016/0741-8329(85)90017-5. PMID: 3893466.; Inoue K, Nishimukai H, Yamasawa K. Purification and partial characterization of aldehyde dehydrogenase from human erythrocytes. Biochimica et Biophysica Acta (BBA) - Enzymology. 1979 Aug;569(2):117–23. doi: 10.1016/0005-2744(79)90046-9.; Lange LG, Sytkowski AJ, Vallee BL. Human liver alcohol dehydrogenase: purification, composition, and catalytic features. Biochemistry. 1976 Oct 19;15(21):4687–93. doi: 10.1021/bi00666a023. PMID: 9982.; Racker E. ALDEHYDE DEHYDROGENASE, A DIPHOSPHOPYRIDINE NUCLEOTIDE-LINKED ENZYME. Journal of Biological Chemistry. 1949 Feb;177(2):883–92. doi: 10.1016/s0021-9258(18)57033-2.
Biological oxidations

Accession ID: Reactome:R-BTA-211859		 -
Ethanol oxidation

Accession ID: Reactome:R-CEL-71384
  • 10.1016/0005-2744(79)90046-9
  • 10.1016/0741-8329(85)90017-5
  • 10.1016/s0021-9258(18)57033-2
  • 10.1021/bi00666a023
  • 10.1086/302540
  • 10.1111/j.1440-1746.2006.04643.x
  • 10.1111/j.1469-1809.1989.tb01116.x
 Lemasters JJ. Modulation of mitochondrial membrane permeability in pathogenesis, autophagy and control of metabolism. J Gastroenterol Hepatol. 2007 Jun;22 Suppl 1():S31–7. doi: 10.1111/j.1440-1746.2006.04643.x. PMID: 17567461.; Chen C, Lu R, Chen Y, Wang M, Chang Y, Li T, Yin S. Interaction between the Functional Polymorphisms of the Alcohol-Metabolism Genes in Protection against Alcoholism. The American Journal of Human Genetics. 1999 Sep;65(3):795–807. doi: 10.1086/302540.; Yoshida A, Davé V, Ward RJ, Peters TJ. Cytosolic aldehyde dehydrogenase (ALDH1) variants found in alcohol flushers. Ann Hum Genet. 1989 Jan;53(1):1–7. doi: 10.1111/j.1469-1809.1989.tb01116.x. PMID: 2729894.; Jörnvall H. Alcohol dehydrogenases, aldehyde dehydrogenases, and related enzymes. Alcohol. 1985 Jan;2(1):61–6. doi: 10.1016/0741-8329(85)90017-5. PMID: 3893466.; Inoue K, Nishimukai H, Yamasawa K. Purification and partial characterization of aldehyde dehydrogenase from human erythrocytes. Biochimica et Biophysica Acta (BBA) - Enzymology. 1979 Aug;569(2):117–23. doi: 10.1016/0005-2744(79)90046-9.; Lange LG, Sytkowski AJ, Vallee BL. Human liver alcohol dehydrogenase: purification, composition, and catalytic features. Biochemistry. 1976 Oct 19;15(21):4687–93. doi: 10.1021/bi00666a023. PMID: 9982.; Racker E. ALDEHYDE DEHYDROGENASE, A DIPHOSPHOPYRIDINE NUCLEOTIDE-LINKED ENZYME. Journal of Biological Chemistry. 1949 Feb;177(2):883–92. doi: 10.1016/s0021-9258(18)57033-2.