S-(Hydroxymethyl)glutathione

S-Hydroxymethylglutathione is a critical component of the binding site for activating fatty acids in glutathione-dependent formaldehyde dehydrogenase activity (OMIM: 103710). Formaldehyde dehydrogenase (FDH; EC 1.2.1.1), a widely occurring enzyme, catalyzes the oxidation of S-hydroxymethylglutathione into S-formylglutathione in the presence of NAD (PMID: 2806555).

ID EC Number Name
KEGG:R06982 4.4.1.22 S-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming);
KEGG:R06983 1.1.1.284 S-(hydroxymethyl)glutathione dehydrogenase
KEGG:R07140 1.1.1.284 S-(hydroxymethyl)glutathione:NADP+ oxidoreductase