Methanearsonous acid (BioCAD00000013936)
Metabolite Card
Formula: CH5AsO2 (123.9505)
SMILES: C[As](O)O
Synonyms [en]
Methanearsonous acid; methylarsonous acid; Methylarsonite; monomethylarsonous acid; Mma(III); MeAs(OH)2
Last reviewed on 2024-06-28.
Cite this Page
Methanearsonous acid. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China.
https://biocad_registry.innovation.ac.cn/s/(-)-arctiin
(retrieved
2026-01-03) (CAD Registry RN: BioCAD00000013936). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Note
Methylarsonite is found in the arsenate detoxification I pathway. Two molecules of glutathione reacts with methylarsonate to produce glutathione disulfide and methylarsonite. Methylarsonate reductase catalyzes this reaction. Methylarsonite reacts with S-adenosyl-L-methionine to produce S-adenosyl-L-homocysteine and dimethylarsinate. Methylarsonite methyltransferase catalyzes this reaction.
DBLinks
- CAS Registry Number: 25400-23-1
- PubChem CID: 161491
- ChEBI: 17826
- HMDB: HMDB0012259
- LipidMaps:
- KEGG: C07295
- BioCyc: METHYLARSONITE
- NCBI MeSH:
- Wikipedia:
Other DBLinks
- CAS Registry Number: 25400-23-1
- PubChem: 161491
- ChEBI: ChEBI:14597
- ChEBI: ChEBI:17826
- HMDB: HMDB0012259
- HMDB: HMDB12259
- KEGG: C07295
- BioCyc: METHYLARSONITE
- RefMet: RM0136378
- Metlin: METLIN_62895
- Coconut NaturalProduct: CNP0579708.0
Class / Ontology
- WishartLab ClassyFire: [Organoarsenic compounds] Organoarsenic compounds
- RefMet: [Organoarsenic compounds] Organoarsenic compounds
- ChEBI: [CHEBI:17826] methylarsonous acid
| ID | EC Number | Name |
|---|---|---|
| KEGG:R05748 | 1.20.4.2 | gluthathione:methylarsonate oxidoreductase |
| KEGG:R12917 | 2.1.1.137 | S-adenosyl-L-methionine:arsenous acid As-methyltransferase |
| Rhea:RHEA:11685 | methylarsonous acid + S-adenosyl-L-methionine => dimethylarsinate + S-adenosyl-L-homocysteine + 2 H+ | |
| Rhea:RHEA:11686 | dimethylarsinate + S-adenosyl-L-homocysteine + 2 H+ => methylarsonous acid + S-adenosyl-L-methionine | |
| Rhea:RHEA:11687 | methylarsonous acid + S-adenosyl-L-methionine <=> dimethylarsinate + S-adenosyl-L-homocysteine + 2 H+ | |
| Rhea:RHEA:15970 | 1.20.4.2 | methylarsonate + 2 glutathione + H+ => methylarsonous acid + glutathione disulfide + H2O |
| Rhea:RHEA:15971 | 1.20.4.2 | methylarsonous acid + glutathione disulfide + H2O => methylarsonate + 2 glutathione + H+ |
| Rhea:RHEA:15972 | 1.20.4.2 | methylarsonate + 2 glutathione + H+ <=> methylarsonous acid + glutathione disulfide + H2O |
| Rhea:RHEA:69461 | 2.1.1.137 | arsenic triglutathione + [thioredoxin]-dithiol + S-adenosyl-L-methionine + 2 H2O => methylarsonous acid + [thioredoxin]-disulfide + 3 glutathione + S-adenosyl-L-homocysteine + H+ |
| Rhea:RHEA:69462 | 2.1.1.137 | methylarsonous acid + [thioredoxin]-disulfide + 3 glutathione + S-adenosyl-L-homocysteine + H+ => arsenic triglutathione + [thioredoxin]-dithiol + S-adenosyl-L-methionine + 2 H2O |
| Rhea:RHEA:69463 | 2.1.1.137 | arsenic triglutathione + [thioredoxin]-dithiol + S-adenosyl-L-methionine + 2 H2O <=> methylarsonous acid + [thioredoxin]-disulfide + 3 glutathione + S-adenosyl-L-homocysteine + H+ |
| Rhea:RHEA:82324 | methylarsonous acid + AH2 + O2 => arsenite + methanol + A + H+ | |
| Rhea:RHEA:82325 | arsenite + methanol + A + H+ => methylarsonous acid + AH2 + O2 | |
| Rhea:RHEA:82326 | methylarsonous acid + AH2 + O2 <=> arsenite + methanol + A + H+ | |
| BioCyc:1.20.4.2-RXN | 1.20.4.2 | 2 GLUTATHIONE + METHYLARSONATE + PROTON --> OXIDIZED-GLUTATHIONE + METHYLARSONITE + WATER |
| BioCyc:RXN-21018 | 1.20.1.- | OXYGEN-MOLECULE + METHYLARSONITE + NADPH --> WATER + METHYLARSONATE + NADP |
| BioCyc:RXN-22372 | 1.13.11.- | METHYLARSONITE + OXYGEN-MOLECULE + Donor-H2 --> CPD0-2040 + METOH + Acceptor |
| BioCyc:RXN-22329 | Methylarsenite-Arsenite-Methyltranferase + 2 WATER --> METHYLARSONITE + Arsenite-methyltransferases | |
| BioCyc:RXN-22330 | 2.1.1.137 | S-ADENOSYLMETHIONINE + CPD-22658 + Red-Thioredoxin + 2 WATER --> ADENOSYL-HOMO-CYS + METHYLARSONITE + Ox-Thioredoxin + PROTON + 3 GLUTATHIONE |
| BioCyc:RXN-22323 | METHYLARSONITE + 2 GLUTATHIONE --> CPD-24323 + 2 WATER |
Taxonomy Source
Pathway Synthetic
| pathway id | name |
|---|---|
| Reactome:R-BTA-1430728 | Metabolism |
| Reactome:R-CEL-211859 | Biological oxidations |
| Reactome:R-CFA-1430728 | Metabolism |
| Reactome:R-CFA-156580 | Phase II - Conjugation of compounds |
| Reactome:R-CFA-156581 | Methylation |
| Reactome:R-DDI-211859 | Biological oxidations |
| Reactome:R-HSA-211859 | Biological oxidations |
| Reactome:R-HSA-156581 | Methylation |
| Reactome:R-MMU-1430728 | Metabolism |
| Reactome:R-MMU-211859 | Biological oxidations |
| Reactome:R-MMU-156581 | Methylation |
| Reactome:R-PFA-211859 | Biological oxidations |
| Reactome:R-SPO-1430728 | Metabolism |
| Reactome:R-BTA-211859 | Biological oxidations |
| Reactome:R-BTA-156581 | Methylation |
| Reactome:R-DME-1430728 | Metabolism |
| Reactome:R-HSA-156580 | Phase II - Conjugation of compounds |
| Reactome:R-MMU-156580 | Phase II - Conjugation of compounds |
| Reactome:R-PFA-156580 | Phase II - Conjugation of compounds |
| Reactome:R-SCE-1430728 | Metabolism |