Methanearsonous acid
Methylarsonite is found in the arsenate detoxification I pathway. Two molecules of glutathione reacts with methylarsonate to produce glutathione disulfide and methylarsonite. Methylarsonate reductase catalyzes this reaction. Methylarsonite reacts with S-adenosyl-L-methionine to produce S-adenosyl-L-homocysteine and dimethylarsinate. Methylarsonite methyltransferase catalyzes this reaction.
| ID | EC Number | Name |
|---|---|---|
| KEGG:R05748 | 1.20.4.2 | gluthathione:methylarsonate oxidoreductase |
| KEGG:R12917 | 2.1.1.137 | S-adenosyl-L-methionine:arsenous acid As-methyltransferase |
| Rhea:RHEA:11685 | methylarsonous acid + S-adenosyl-L-methionine => dimethylarsinate + S-adenosyl-L-homocysteine + 2 H+ | |
| Rhea:RHEA:11686 | dimethylarsinate + S-adenosyl-L-homocysteine + 2 H+ => methylarsonous acid + S-adenosyl-L-methionine | |
| Rhea:RHEA:11687 | methylarsonous acid + S-adenosyl-L-methionine <=> dimethylarsinate + S-adenosyl-L-homocysteine + 2 H+ | |
| Rhea:RHEA:15970 | 1.20.4.2 | methylarsonate + 2 glutathione + H+ => methylarsonous acid + glutathione disulfide + H2O |
| Rhea:RHEA:15971 | 1.20.4.2 | methylarsonous acid + glutathione disulfide + H2O => methylarsonate + 2 glutathione + H+ |
| Rhea:RHEA:15972 | 1.20.4.2 | methylarsonate + 2 glutathione + H+ <=> methylarsonous acid + glutathione disulfide + H2O |
| Rhea:RHEA:69461 | 2.1.1.137 | arsenic triglutathione + [thioredoxin]-dithiol + S-adenosyl-L-methionine + 2 H2O => methylarsonous acid + [thioredoxin]-disulfide + 3 glutathione + S-adenosyl-L-homocysteine + H+ |
| Rhea:RHEA:69462 | 2.1.1.137 | methylarsonous acid + [thioredoxin]-disulfide + 3 glutathione + S-adenosyl-L-homocysteine + H+ => arsenic triglutathione + [thioredoxin]-dithiol + S-adenosyl-L-methionine + 2 H2O |
| Rhea:RHEA:69463 | 2.1.1.137 | arsenic triglutathione + [thioredoxin]-dithiol + S-adenosyl-L-methionine + 2 H2O <=> methylarsonous acid + [thioredoxin]-disulfide + 3 glutathione + S-adenosyl-L-homocysteine + H+ |
| Rhea:RHEA:82324 | methylarsonous acid + AH2 + O2 => arsenite + methanol + A + H+ | |
| Rhea:RHEA:82325 | arsenite + methanol + A + H+ => methylarsonous acid + AH2 + O2 | |
| Rhea:RHEA:82326 | methylarsonous acid + AH2 + O2 <=> arsenite + methanol + A + H+ | |
| BioCyc:1.20.4.2-RXN | 1.20.4.2 | 2 GLUTATHIONE + METHYLARSONATE + PROTON --> OXIDIZED-GLUTATHIONE + METHYLARSONITE + WATER |
| BioCyc:RXN-21018 | 1.20.1.- | OXYGEN-MOLECULE + METHYLARSONITE + NADPH --> WATER + METHYLARSONATE + NADP |
| BioCyc:RXN-22372 | 1.13.11.- | METHYLARSONITE + OXYGEN-MOLECULE + Donor-H2 --> CPD0-2040 + METOH + Acceptor |
| BioCyc:RXN-22329 | Methylarsenite-Arsenite-Methyltranferase + 2 WATER --> METHYLARSONITE + Arsenite-methyltransferases | |
| BioCyc:RXN-22330 | 2.1.1.137 | S-ADENOSYLMETHIONINE + CPD-22658 + Red-Thioredoxin + 2 WATER --> ADENOSYL-HOMO-CYS + METHYLARSONITE + Ox-Thioredoxin + PROTON + 3 GLUTATHIONE |
| BioCyc:RXN-22323 | METHYLARSONITE + 2 GLUTATHIONE --> CPD-24323 + 2 WATER | |
| BioCyc:RXN-21023 | METHYLARSONITE + PROTON --> METHYLARSONITE + PROTON | |
| BioCyc:RXN-22386 | METHYLARSONITE --> METHYLARSONITE | |
| BioCyc:RXN-22318 | METHYLARSONITE<=>CPD-24334 + 2 PROTON | |
| BioCyc:RXN-22337 | 2 METHYLARSONITE + OXYGEN-MOLECULE --> 2 METHYLARSONATE + 2 PROTON |