EC: 2.8.2.1

aryl sulfotransferase (3'-phosphoadenylyl-sulfate:phenol sulfotransferase)

enzyme lambda metabolic reaction experiment
uniprot:P50225 [aryl sulfotransferase(Enzyme) wildtype HAST1]

Dopamine + 3'_Phosphoadenylyl_sulfate -> Dopamine_sulfate + Adenosine_3',5'_bisphosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Potassium phosphate, 1 mM Pargyline
PH: 7
Temperature: 37
uniprot:P50224 [aryl sulfotransferase(Enzyme) wildtype HAST3]

Dopamine + 3'_Phosphoadenylyl_sulfate -> Adenosine_3',5'_bisphosphate + Dopamine_sulfate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Potassium phosphate, 1 mM Pargyline
PH: 7
Temperature: 37
uniprot:P50224 [aryl sulfotransferase(Enzyme) wildtype HAST3]

3'_Phosphoadenylyl_sulfate + Dopamine -> Dopamine_sulfate + Adenosine_3',5'_bisphosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Potassium phosphate, 1 mM Pargyline
PH: 7
Temperature: 37
uniprot:P50225 [aryl sulfotransferase(Enzyme) wildtype HAST1]

3'_Phosphoadenylyl_sulfate + p_Nitrophenol -> 4_Nitrophenyl_sulfate + Adenosine_3',5'_bisphosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Potassium phosphate
PH: 7
Temperature: 37
uniprot:P50224 [aryl sulfotransferase(Enzyme) wildtype HAST3]

p_Nitrophenol + 3'_Phosphoadenylyl_sulfate -> 4_Nitrophenyl_sulfate + Adenosine_3',5'_bisphosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Potassium phosphate
PH: 7
Temperature: 37
uniprot:P50225 [aryl sulfotransferase(Enzyme) wildtype HAST1]

3'_Phosphoadenylyl_sulfate + p_Nitrophenol -> Adenosine_3',5'_bisphosphate + 4_Nitrophenyl_sulfate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Potassium phosphate
PH: 7
Temperature: 37
uniprot:P50225 [aryl sulfotransferase(Enzyme) wildtype SULT1A1]

Dopamine + 3'_Phosphoadenylyl_sulfate -> Dopamine_sulfate + Adenosine_3',5'_bisphosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Phosphate
PH: 7
Temperature: 37
uniprot:P50225 [aryl sulfotransferase(Enzyme) wildtype SULT1A1]

p_Nitrophenol + 3'_Phosphoadenylyl_sulfate -> Adenosine_3',5'_bisphosphate + 4_Nitrophenyl_sulfate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Phosphate
PH: 7
Temperature: 37
uniprot:P50225 [aryl sulfotransferase(Enzyme) wildtype SULT1A1]

4_Cresol + 3'_Phosphoadenylyl_sulfate -> Adenosine_3',5'_bisphosphate + p_Cresyl_sulfate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Phosphate
PH: 7
Temperature: 37
uniprot:P50225 [aryl sulfotransferase(Enzyme) wildtype SULT1A1]

4_Hydroxyaniline + 3'_Phosphoadenylyl_sulfate -> Adenosine_3',5'_bisphosphate + p_Aminophenyl_sulfate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Phosphate
PH: 7
Temperature: 37
uniprot:P50225 [aryl sulfotransferase(Enzyme) wildtype SULT1A1]

Tyramine + 3'_Phosphoadenylyl_sulfate -> Adenosine_3',5'_bisphosphate + Tyramine_sulfate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Phosphate
PH: 7
Temperature: 37
uniprot:P50225 [aryl sulfotransferase(Enzyme) wildtype SULT1A1]

4_Ethylphenol + 3'_Phosphoadenylyl_sulfate -> Adenosine_3',5'_bisphosphate + 4_Ethylphenyl_sulfate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Phosphate
PH: 7
Temperature: 37
uniprot:P50225 [aryl sulfotransferase(Enzyme) wildtype SULT1A1]

3'_Phosphoadenylyl_sulfate + 3_Nitrophenol -> m_Nitrophenyl_sulfate + Adenosine_3',5'_bisphosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Phosphate
PH: 7
Temperature: 37
uniprot:P50225 [aryl sulfotransferase(Enzyme) wildtype SULT1A1]

3'_Phosphoadenylyl_sulfate + 4_Nitrocatechol -> 4_Nitrocatechol_sulfate + Adenosine_3',5'_bisphosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Phosphate
PH: 7
Temperature: 37
uniprot:P50225 [aryl sulfotransferase(Enzyme) mutant SULT1A1 A146E]

Dopamine + 3'_Phosphoadenylyl_sulfate -> Adenosine_3',5'_bisphosphate + Dopamine_sulfate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Phosphate
PH: 7
Temperature: 37
uniprot:P50225 [aryl sulfotransferase(Enzyme) mutant SULT1A1 A146E]

3'_Phosphoadenylyl_sulfate + p_Nitrophenol -> Adenosine_3',5'_bisphosphate + 4_Nitrophenyl_sulfate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Phosphate
PH: 7
Temperature: 37
uniprot:P50225 [aryl sulfotransferase(Enzyme) mutant SULT1A1 A146E]

4_Cresol + 3'_Phosphoadenylyl_sulfate -> Adenosine_3',5'_bisphosphate + p_Cresyl_sulfate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Phosphate
PH: 7
Temperature: 37
uniprot:P50225 [aryl sulfotransferase(Enzyme) mutant SULT1A1 A146E]

3'_Phosphoadenylyl_sulfate + 4_Hydroxyaniline -> Adenosine_3',5'_bisphosphate + p_Aminophenyl_sulfate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Phosphate
PH: 7
Temperature: 37
uniprot:P50225 [aryl sulfotransferase(Enzyme) mutant SULT1A1 A146E]

3'_Phosphoadenylyl_sulfate + 4_Ethylphenol -> 4_Ethylphenyl_sulfate + Adenosine_3',5'_bisphosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Phosphate
PH: 7
Temperature: 37
uniprot:P50225 [aryl sulfotransferase(Enzyme) mutant SULT1A1 A146E]

Tyramine + 3'_Phosphoadenylyl_sulfate -> Tyramine_sulfate + Adenosine_3',5'_bisphosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Phosphate
PH: 7
Temperature: 37
uniprot:P50225 [aryl sulfotransferase(Enzyme) mutant SULT1A1 A146E]

4_Nitrocatechol + 3'_Phosphoadenylyl_sulfate -> Adenosine_3',5'_bisphosphate + 4_Nitrocatechol_sulfate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Phosphate
PH: 7
Temperature: 37
uniprot:P50225 [aryl sulfotransferase(Enzyme) mutant SULT1A1 A146E]

3'_Phosphoadenylyl_sulfate + 3_Nitrophenol -> Adenosine_3',5'_bisphosphate + m_Nitrophenyl_sulfate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM Phosphate
PH: 7
Temperature: 37
uniprot:Q80VR3 [aryl sulfotransferase(Enzyme) wildtype]

N_Hydroxy_2_acetamidofluorene + 3'_Phosphoadenylyl_sulfate -> 2_Acetamidofluorene_N_sulfate + Adenosine_3',5'_bisphosphate		 (( (Vmax * A) ) / (Km + A)) buffer: 50 mM bicine/KOH
PH: 7.8
Temperature: 37
uniprot:Q80VR3 [aryl sulfotransferase(Enzyme) wildtype]

Guaiacol + 3'_Phosphoadenylyl_sulfate -> Adenosine_3',5'_bisphosphate + Guaiacol_sulfate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM phosphate
PH: 6.4
Temperature: 37
uniprot:Q80VR3 [aryl sulfotransferase(Enzyme) wildtype]

3'_Phosphoadenylyl_sulfate + beta_Naphthol -> Adenosine_3',5'_bisphosphate + 2_Naphthyl_sulfate		 (( (Vmax * A) ) / (Km + A)) buffer: 10 mM phosphate
PH: 6.4
Temperature: 37

Pathways

pathway id name
BioCyc:HUMAN_PWY66-401 superpathway of tryptophan utilization
BioCyc:HUMAN_PWY-6402 superpathway of melatonin degradation
BioCyc:META_PWY6666-2 dopamine degradation
BioCyc:META_PWY-6313 serotonin degradation
BioCyc:HUMAN_PWY-6398 melatonin degradation I
BioCyc:META_PWY-6261 thyroid hormone metabolism II (via conjugation and/or degradation)
BioCyc:HUMAN_PWY-6261 thyroid hormone metabolism II (via conjugation and/or degradation)
BioCyc:HUMAN_PWY-6313 serotonin degradation
BioCyc:META_PWY-6398 melatonin degradation I
BioCyc:MOUSE_PWY6666-2 dopamine degradation
BioCyc:HUMAN_PWY6666-2 dopamine degradation
BioCyc:META_PWY-6402 superpathway of melatonin degradation
Reactome:R-BTA-9748784 Drug ADME
Reactome:R-CEL-9753281 APAP ADME
Reactome:R-MMU-9753281 APAP ADME
Reactome:R-RNO-9748784 Drug ADME
Reactome:R-BTA-9753281 APAP ADME
Reactome:R-CFA-9748784 Drug ADME
Reactome:R-RNO-9753281 APAP ADME
Reactome:R-CEL-9748784 Drug ADME
Reactome:R-HSA-9753281 APAP ADME
Reactome:R-MMU-9748784 Drug ADME
Reactome:R-CFA-9753281 APAP ADME
Reactome:R-HSA-9748784 Drug ADME
Reactome:R-BTA-1430728 Metabolism
Reactome:R-CEL-211859 Biological oxidations
Reactome:R-CEL-156584 Cytosolic sulfonation of small molecules
Reactome:R-CFA-1430728 Metabolism
Reactome:R-CFA-156580 Phase II - Conjugation of compounds
Reactome:R-HSA-211859 Biological oxidations
Reactome:R-HSA-381070 IRE1alpha activates chaperones
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-211859 Biological oxidations
Reactome:R-BTA-211859 Biological oxidations
Reactome:R-CFA-156584 Cytosolic sulfonation of small molecules
Reactome:R-HSA-156580 Phase II - Conjugation of compounds
Reactome:R-HSA-2262752 Cellular responses to stress
Reactome:R-MMU-156580 Phase II - Conjugation of compounds
Reactome:R-RNO-211859 Biological oxidations
Reactome:R-BTA-156584 Cytosolic sulfonation of small molecules
Reactome:R-CEL-156580 Phase II - Conjugation of compounds
Reactome:R-CFA-211859 Biological oxidations
Reactome:R-HSA-381119 Unfolded Protein Response (UPR)
Reactome:R-HSA-381038 XBP1(S) activates chaperone genes
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-156584 Cytosolic sulfonation of small molecules
Reactome:R-BTA-156580 Phase II - Conjugation of compounds
Reactome:R-CEL-1430728 Metabolism
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-156584 Cytosolic sulfonation of small molecules
Reactome:R-HSA-8953897 Cellular responses to stimuli
Reactome:R-MMU-156584 Cytosolic sulfonation of small molecules
Reactome:R-RNO-156580 Phase II - Conjugation of compounds
WikiPathways:WP5320 Male steroid hormones in cardiomyocyte energy metabolism
PathBank:SMP0000041 Sulfate/Sulfite Metabolism
PathBank:SMP0000532 Sulfite Oxidase Deficiency
PathBank:SMP0000649 Lamivudine Metabolism Pathway
PathBank:SMP0000640 Acetaminophen Metabolism Pathway
PathBank:SMP0087489 Androgen and Estrogen Metabolism
PathBank:SMP0000606 Tamoxifen Metabolism Pathway
PathBank:SMP0087444 Sulfate/Sulfite Metabolism
PathBank:SMP0087532 Estrone Metabolism
PathBank:SMP0000471 Tamoxifen Action Pathway