serotonin degradation

Squires LN, Talbot KN, Rubakhin SS, Sweedler JV. Serotonin catabolism in the central and enteric nervous systems of rats upon induction of serotonin syndrome. Journal of Neurochemistry. 2007 Jun 03;103(1):174–80. doi: 10.1111/j.1471-4159.2007.04739.x.; Slominski A, Wortsman J, Tobin DJ. The cutaneous serotoninergic/melatoninergic system: securing a place under the sun. FASEB J. 2005 Feb;19(2):176–94. doi: 10.1096/fj.04-2079rev. PMID: 15677341.

Metabolites

5-Hydroxyindoleacetaldehyde

Formula: C10H9NO2 (175.0633254)

CAS ID: 1892-21-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen peroxide

Formula: H2O2 (34.0054792)

CAS ID: 7722-84-1

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

5-Hydroxytryptophol

Formula: C10H11NO2 (177.0789746)

CAS ID: 154-02-9

Serotonin O-sulfate

Formula: C10H12N2O4S (256.0517752)

CAS ID: 16310-20-6

5-hydroxyindole thiazolidine carboxylate

Formula: C13H14N2O3S (278.0725094)

CAS ID: 121514-30-5

5-Hydroxytryptophol sulfate

Formula: C10H10NO5S (256.02796700000005)

CAS ID:

(5-hydroxyindol-3-yl)acetate

Formula: C10H8NO3 (190.0504158)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

UDP(3-)

Formula: C9H11N2O12P2 (400.9787246)

CAS ID: 86527-70-0

serotonin(1+)

Formula: C10H13N2O (177.1027828)

CAS ID:



Enzyme

EC Number name full name note
1.1.1.105 all-trans-retinol dehydrogenase (NAD+) all-trans retinol:NAD+ oxidoreductase
1.2.1.3 aldehyde dehydrogenase (NAD+) aldehyde:NAD+ oxidoreductase
1.2.1.94 farnesal dehydrogenase farnesal:NAD+ oxidoreductase
1.4.3.21 primary-amine oxidase primary-amine:oxygen oxidoreductase (deaminating)
1.4.3.4 monoamine oxidase amine:oxygen oxidoreductase (deaminating)
2.8.2.1 aryl sulfotransferase 3'-phosphoadenylyl-sulfate:phenol sulfotransferase


Proteins

Protein ID name full name