EC: 2.7.11.13

protein kinase C (ATP:protein phosphotransferase (diacylglycerol-dependent))

enzyme lambda metabolic reaction experiment
uniprot:P41743 [protein kinase C(Enzyme) wildtype aPKC-iota (RGS-His6 tagged)]

Protein + ATP -> Phosphoprotein + ADP
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 20 mM MgCl2
PH: 7.5
Temperature: 30
uniprot:P41743 [protein kinase C(Enzyme) mutant K274R aPKC-iota (RGS-His6 tagged)]

Protein + ATP -> Phosphoprotein + ADP
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 20 mM MgCl2
PH: 7.5
Temperature: 30
uniprot:P17252 [protein kinase C(Enzyme) wildtype PKC-alpha-AE]

ATP + Protein -> Phosphoprotein + ADP
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM Tris-HCl, 20 mM MgCl2
PH: 7.5
Temperature: 30

Pathways

pathway id name
Reactome:R-RNO-9648002 RAS processing
Reactome:R-DME-9648002 RAS processing
Reactome:R-RNO-9711123 Cellular response to chemical stress
Reactome:R-DME-9711123 Cellular response to chemical stress
Reactome:R-HSA-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-DRE-9755511 KEAP1-NFE2L2 pathway
Reactome:R-RNO-9755511 KEAP1-NFE2L2 pathway
Reactome:R-CEL-9675108 Nervous system development
Reactome:R-MMU-9675108 Nervous system development
Reactome:R-HSA-9675108 Nervous system development
Reactome:R-HSA-9648002 RAS processing
Reactome:R-DRE-9711123 Cellular response to chemical stress
Reactome:R-RNO-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-MMU-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-CEL-9755511 KEAP1-NFE2L2 pathway
Reactome:R-MMU-9755511 KEAP1-NFE2L2 pathway
Reactome:R-MMU-9648002 RAS processing
Reactome:R-CEL-9711123 Cellular response to chemical stress
Reactome:R-MMU-9711123 Cellular response to chemical stress
Reactome:R-HSA-9755511 KEAP1-NFE2L2 pathway
Reactome:R-RNO-9675108 Nervous system development
Reactome:R-DME-9675108 Nervous system development
Reactome:R-CEL-9648002 RAS processing
Reactome:R-BTA-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-DME-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-SCE-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3
Reactome:R-HSA-9711123 Cellular response to chemical stress
Reactome:R-DME-9755511 KEAP1-NFE2L2 pathway
Reactome:R-DME-9855142 Cellular responses to mechanical stimuli
Reactome:R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Reactome:R-MMU-9860931 Response of endothelial cells to shear stress
Reactome:R-RNO-9855142 Cellular responses to mechanical stimuli
Reactome:R-SCE-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Reactome:R-DRE-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Reactome:R-HSA-9860931 Response of endothelial cells to shear stress
Reactome:R-MMU-9855142 Cellular responses to mechanical stimuli
Reactome:R-SCE-9860931 Response of endothelial cells to shear stress
Reactome:R-DRE-9855142 Cellular responses to mechanical stimuli
Reactome:R-DME-9860931 Response of endothelial cells to shear stress
Reactome:R-MMU-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Reactome:R-RNO-9860931 Response of endothelial cells to shear stress
Reactome:R-DRE-9860931 Response of endothelial cells to shear stress
Reactome:R-DME-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Reactome:R-HSA-9855142 Cellular responses to mechanical stimuli
Reactome:R-RNO-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Reactome:R-SCE-9855142 Cellular responses to mechanical stimuli
Reactome:R-RNO-9634635 Estrogen-stimulated signaling through PRKCZ
Reactome:R-DME-9634635 Estrogen-stimulated signaling through PRKCZ
Reactome:R-SCE-9634635 Estrogen-stimulated signaling through PRKCZ
Reactome:R-CEL-9634635 Estrogen-stimulated signaling through PRKCZ
Reactome:R-RNO-9009391 Extra-nuclear estrogen signaling
Reactome:R-DME-9009391 Extra-nuclear estrogen signaling
Reactome:R-SCE-9009391 Extra-nuclear estrogen signaling
Reactome:R-MMU-9634635 Estrogen-stimulated signaling through PRKCZ
Reactome:R-SPO-114516 Disinhibition of SNARE formation
Reactome:R-HSA-9009391 Extra-nuclear estrogen signaling
Reactome:R-CEL-9009391 Extra-nuclear estrogen signaling
Reactome:R-MMU-9009391 Extra-nuclear estrogen signaling
Reactome:R-HSA-9634635 Estrogen-stimulated signaling through PRKCZ
Reactome:R-BTA-1640170 Cell Cycle
Reactome:R-BTA-109582 Hemostasis
Reactome:R-BTA-168256 Immune System
Reactome:R-BTA-1169091 Activation of NF-kappaB in B cells
Reactome:R-BTA-416993 Trafficking of GluR2-containing AMPA receptors
Reactome:R-BTA-4086400 PCP/CE pathway
Reactome:R-CEL-68875 Mitotic Prophase
Reactome:R-CEL-4419969 Depolymerization of the Nuclear Lamina
Reactome:R-CEL-1280218 Adaptive Immune System
Reactome:R-CEL-1169091 Activation of NF-kappaB in B cells
Reactome:R-CEL-2454202 Fc epsilon receptor (FCERI) signaling
Reactome:R-CEL-8953897 Cellular responses to stimuli
Reactome:R-CEL-1433559 Regulation of KIT signaling
Reactome:R-CEL-388396 GPCR downstream signalling
Reactome:R-CEL-2179392 EGFR Transactivation by Gastrin
Reactome:R-CEL-157118 Signaling by NOTCH
Reactome:R-CEL-5683057 MAPK family signaling cascades
Reactome:R-CEL-422475 Axon guidance
Reactome:R-CEL-1474244 Extracellular matrix organization
Reactome:R-DRE-1912408 Pre-NOTCH Transcription and Translation
Reactome:R-DRE-5099900 WNT5A-dependent internalization of FZD4
Reactome:R-DRE-73887 Death Receptor Signaling
Reactome:R-DRE-209543 p75NTR recruits signalling complexes
Reactome:R-DRE-112315 Transmission across Chemical Synapses
Reactome:R-DRE-112314 Neurotransmitter receptors and postsynaptic signal transmission
Reactome:R-DRE-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity
Reactome:R-DRE-1500931 Cell-Cell communication
Reactome:R-DRE-1280218 Adaptive Immune System
Reactome:R-DRE-1168372 Downstream signaling events of B Cell Receptor (BCR)
Reactome:R-DME-8953854 Metabolism of RNA
Reactome:R-DME-111465 Apoptotic cleavage of cellular proteins
Reactome:R-DME-168256 Immune System
Reactome:R-DME-202424 Downstream TCR signaling
Reactome:R-DME-2454202 Fc epsilon receptor (FCERI) signaling
Reactome:R-DME-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-DME-9006931 Signaling by Nuclear Receptors
Reactome:R-DME-194315 Signaling by Rho GTPases
Reactome:R-DME-416993 Trafficking of GluR2-containing AMPA receptors
Reactome:R-DME-1266738 Developmental Biology
Reactome:R-DME-114516 Disinhibition of SNARE formation
Reactome:R-HSA-422475 Axon guidance
Reactome:R-HSA-376176 Signaling by ROBO receptors
Reactome:R-HSA-9010642 ROBO receptors bind AKAP5
Reactome:R-HSA-111465 Apoptotic cleavage of cellular proteins
Reactome:R-HSA-1227986 Signaling by ERBB2
Reactome:R-HSA-9006936 Signaling by TGFB family members
Reactome:R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Reactome:R-HSA-157118 Signaling by NOTCH
Reactome:R-HSA-4086400 PCP/CE pathway
Reactome:R-HSA-4086398 Ca2+ pathway
Reactome:R-HSA-5683057 MAPK family signaling cascades
Reactome:R-HSA-112315 Transmission across Chemical Synapses
Reactome:R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
Reactome:R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity
Reactome:R-HSA-74160 Gene expression (Transcription)
Reactome:R-HSA-73857 RNA Polymerase II Transcription
Reactome:R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
Reactome:R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR)
Reactome:R-HSA-5607764 CLEC7A (Dectin-1) signaling
Reactome:R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements
Reactome:R-MMU-168256 Immune System
Reactome:R-MMU-1169091 Activation of NF-kappaB in B cells
Reactome:R-MMU-168249 Innate Immune System
Reactome:R-MMU-2871837 FCERI mediated NF-kB activation
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-422356 Regulation of insulin secretion
Reactome:R-MMU-8953854 Metabolism of RNA
Reactome:R-MMU-76002 Platelet activation, signaling and aggregation
Reactome:R-MMU-114516 Disinhibition of SNARE formation
Reactome:R-MMU-5357801 Programmed Cell Death
Reactome:R-MMU-162582 Signaling Pathways
Reactome:R-MMU-1250196 SHC1 events in ERBB2 signaling
Reactome:R-MMU-388396 GPCR downstream signalling
Reactome:R-MMU-2179392 EGFR Transactivation by Gastrin
Reactome:R-MMU-4086400 PCP/CE pathway
Reactome:R-MMU-8939211 ESR-mediated signaling
Reactome:R-MMU-5673001 RAF/MAP kinase cascade
Reactome:R-MMU-209543 p75NTR recruits signalling complexes
Reactome:R-RNO-163685 Integration of energy metabolism
Reactome:R-RNO-112316 Neuronal System
Reactome:R-RNO-399719 Trafficking of AMPA receptors
Reactome:R-RNO-421270 Cell-cell junction organization
Reactome:R-RNO-162582 Signaling Pathways
Reactome:R-RNO-1433557 Signaling by SCF-KIT
Reactome:R-RNO-372790 Signaling by GPCR
Reactome:R-RNO-416476 G alpha (q) signalling events
Reactome:R-RNO-2179392 EGFR Transactivation by Gastrin
Reactome:R-RNO-4086400 PCP/CE pathway
Reactome:R-RNO-9006931 Signaling by Nuclear Receptors
Reactome:R-RNO-194315 Signaling by Rho GTPases
Reactome:R-RNO-73887 Death Receptor Signaling
Reactome:R-RNO-193704 p75 NTR receptor-mediated signalling
Reactome:R-RNO-3000171 Non-integrin membrane-ECM interactions
Reactome:R-RNO-109582 Hemostasis
Reactome:R-RNO-76005 Response to elevated platelet cytosolic Ca2+
Reactome:R-RNO-111465 Apoptotic cleavage of cellular proteins
Reactome:R-RNO-1280218 Adaptive Immune System
Reactome:R-RNO-983705 B Cell Activation
Reactome:R-RNO-5621481 C-type lectin receptors (CLRs)
Reactome:R-RNO-1266738 Developmental Biology
Reactome:R-RNO-373752 Netrin-1 signaling
Reactome:R-SCE-76002 Platelet activation, signaling and aggregation
Reactome:R-SCE-114508 Effects of PIP2 hydrolysis
Reactome:R-SCE-8953897 Cellular responses to stimuli
Reactome:R-SCE-202403 TCR signaling
Reactome:R-SCE-983705 B Cell Activation
Reactome:R-SCE-2029485 Role of phospholipids in phagocytosis
Reactome:R-SCE-2871837 FCERI mediated NF-kB activation
Reactome:R-SCE-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-SCE-4420097 VEGFA-VEGFR2 Pathway
Reactome:R-SCE-2179392 EGFR Transactivation by Gastrin
Reactome:R-SCE-9006931 Signaling by Nuclear Receptors
Reactome:R-SCE-9006925 Intracellular signaling by second messengers
Reactome:R-SCE-194315 Signaling by Rho GTPases
Reactome:R-SCE-422356 Regulation of insulin secretion
Reactome:R-SCE-1640170 Cell Cycle
Reactome:R-XTR-76002 Platelet activation, signaling and aggregation
Reactome:R-XTR-114516 Disinhibition of SNARE formation
Reactome:R-XTR-1168372 Downstream signaling events of B Cell Receptor (BCR)
Reactome:R-XTR-195721 Signaling by WNT
Reactome:R-BTA-1168372 Downstream signaling events of B Cell Receptor (BCR)
Reactome:R-BTA-112316 Neuronal System
Reactome:R-BTA-399719 Trafficking of AMPA receptors
Reactome:R-BTA-162582 Signaling Pathways
Reactome:R-BTA-3858494 Beta-catenin independent WNT signaling
Reactome:R-BTA-195258 RHO GTPase Effectors
Reactome:R-BTA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome:R-CEL-69278 Cell Cycle, Mitotic
Reactome:R-CEL-68886 M Phase
Reactome:R-CEL-2980766 Nuclear Envelope Breakdown
Reactome:R-CEL-114516 Disinhibition of SNARE formation
Reactome:R-CEL-168256 Immune System
Reactome:R-CEL-202424 Downstream TCR signaling
Reactome:R-CEL-1168372 Downstream signaling events of B Cell Receptor (BCR)
Reactome:R-CEL-2871837 FCERI mediated NF-kB activation
Reactome:R-CEL-1433557 Signaling by SCF-KIT
Reactome:R-CEL-881907 Gastrin-CREB signalling pathway via PKC and MAPK
Reactome:R-CEL-4086400 PCP/CE pathway
Reactome:R-CEL-9006931 Signaling by Nuclear Receptors
Reactome:R-CEL-422356 Regulation of insulin secretion
Reactome:R-CEL-1266738 Developmental Biology
Reactome:R-CEL-373752 Netrin-1 signaling
Reactome:R-CEL-3000170 Syndecan interactions
Reactome:R-DRE-162582 Signaling Pathways
Reactome:R-DRE-1912422 Pre-NOTCH Expression and Processing
Reactome:R-DRE-195721 Signaling by WNT
Reactome:R-DRE-193704 p75 NTR receptor-mediated signalling
Reactome:R-DRE-193639 p75NTR signals via NF-kB
Reactome:R-DRE-8953897 Cellular responses to stimuli
Reactome:R-DRE-76002 Platelet activation, signaling and aggregation
Reactome:R-DRE-168256 Immune System
Reactome:R-DME-75153 Apoptotic execution phase
Reactome:R-DME-168249 Innate Immune System
Reactome:R-DME-2871837 FCERI mediated NF-kB activation
Reactome:R-DME-162582 Signaling Pathways
Reactome:R-DME-8939211 ESR-mediated signaling
Reactome:R-DME-5673001 RAF/MAP kinase cascade
Reactome:R-DME-112315 Transmission across Chemical Synapses
Reactome:R-DME-399719 Trafficking of AMPA receptors
Reactome:R-DME-8953897 Cellular responses to stimuli
Reactome:R-DME-109582 Hemostasis
Reactome:R-DME-76002 Platelet activation, signaling and aggregation
Reactome:R-DME-76005 Response to elevated platelet cytosolic Ca2+
Reactome:R-HSA-1266738 Developmental Biology
Reactome:R-HSA-373752 Netrin-1 signaling
Reactome:R-HSA-421270 Cell-cell junction organization
Reactome:R-HSA-76002 Platelet activation, signaling and aggregation
Reactome:R-HSA-114516 Disinhibition of SNARE formation
Reactome:R-HSA-422356 Regulation of insulin secretion
Reactome:R-HSA-75153 Apoptotic execution phase
Reactome:R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-HSA-1433559 Regulation of KIT signaling
Reactome:R-HSA-372790 Signaling by GPCR
Reactome:R-HSA-2179392 EGFR Transactivation by Gastrin
Reactome:R-HSA-195721 Signaling by WNT
Reactome:R-HSA-3858494 Beta-catenin independent WNT signaling
Reactome:R-HSA-9006931 Signaling by Nuclear Receptors
Reactome:R-HSA-195258 RHO GTPase Effectors
Reactome:R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome:R-HSA-2262752 Cellular responses to stress
Reactome:R-HSA-202403 TCR signaling
Reactome:R-HSA-202424 Downstream TCR signaling
Reactome:R-HSA-5621481 C-type lectin receptors (CLRs)
Reactome:R-MMU-1168372 Downstream signaling events of B Cell Receptor (BCR)
Reactome:R-MMU-5607764 CLEC7A (Dectin-1) signaling
Reactome:R-MMU-163685 Integration of energy metabolism
Reactome:R-MMU-450531 Regulation of mRNA stability by proteins that bind AU-rich elements
Reactome:R-MMU-450520 HuR (ELAVL1) binds and stabilizes mRNA
Reactome:R-MMU-1474244 Extracellular matrix organization
Reactome:R-MMU-3000170 Syndecan interactions
Reactome:R-MMU-76005 Response to elevated platelet cytosolic Ca2+
Reactome:R-MMU-111465 Apoptotic cleavage of cellular proteins
Reactome:R-MMU-421270 Cell-cell junction organization
Reactome:R-MMU-1227986 Signaling by ERBB2
Reactome:R-MMU-881907 Gastrin-CREB signalling pathway via PKC and MAPK
Reactome:R-MMU-1912408 Pre-NOTCH Transcription and Translation
Reactome:R-MMU-3858494 Beta-catenin independent WNT signaling
Reactome:R-MMU-5684996 ERK1/ERK2 pathway
Reactome:R-MMU-195258 RHO GTPase Effectors
Reactome:R-MMU-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome:R-MMU-193639 p75NTR signals via NF-kB
Reactome:R-MMU-416993 Trafficking of GluR2-containing AMPA receptors
Reactome:R-RNO-399997 Acetylcholine regulates insulin secretion
Reactome:R-RNO-112315 Transmission across Chemical Synapses
Reactome:R-RNO-112314 Neurotransmitter receptors and postsynaptic signal transmission
Reactome:R-RNO-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity
Reactome:R-RNO-446728 Cell junction organization
Reactome:R-RNO-420029 Tight junction interactions
Reactome:R-RNO-8953897 Cellular responses to stimuli
Reactome:R-RNO-2262752 Cellular responses to stress
Reactome:R-RNO-1250196 SHC1 events in ERBB2 signaling
Reactome:R-RNO-388396 GPCR downstream signalling
Reactome:R-RNO-881907 Gastrin-CREB signalling pathway via PKC and MAPK
Reactome:R-RNO-1912408 Pre-NOTCH Transcription and Translation
Reactome:R-RNO-3858494 Beta-catenin independent WNT signaling
Reactome:R-RNO-8939211 ESR-mediated signaling
Reactome:R-RNO-5673001 RAF/MAP kinase cascade
Reactome:R-RNO-209543 p75NTR recruits signalling complexes
Reactome:R-RNO-75153 Apoptotic execution phase
Reactome:R-RNO-168256 Immune System
Reactome:R-RNO-1169091 Activation of NF-kappaB in B cells
Reactome:R-RNO-168249 Innate Immune System
Reactome:R-RNO-2454202 Fc epsilon receptor (FCERI) signaling
Reactome:R-SCE-109582 Hemostasis
Reactome:R-SCE-114516 Disinhibition of SNARE formation
Reactome:R-SCE-1280218 Adaptive Immune System
Reactome:R-SCE-5607764 CLEC7A (Dectin-1) signaling
Reactome:R-SCE-162582 Signaling Pathways
Reactome:R-SCE-194138 Signaling by VEGF
Reactome:R-SCE-388396 GPCR downstream signalling
Reactome:R-SCE-881907 Gastrin-CREB signalling pathway via PKC and MAPK
Reactome:R-SCE-8939211 ESR-mediated signaling
Reactome:R-SCE-1489509 DAG and IP3 signaling
Reactome:R-SCE-5668599 RHO GTPases Activate NADPH Oxidases
Reactome:R-SCE-1430728 Metabolism
Reactome:R-SCE-163685 Integration of energy metabolism
Reactome:R-SCE-4419969 Depolymerization of the Nuclear Lamina
Reactome:R-XTR-76005 Response to elevated platelet cytosolic Ca2+
Reactome:R-XTR-69278 Cell Cycle, Mitotic
Reactome:R-XTR-4086400 PCP/CE pathway
Reactome:R-BTA-68886 M Phase
Reactome:R-BTA-76005 Response to elevated platelet cytosolic Ca2+
Reactome:R-BTA-1280218 Adaptive Immune System
Reactome:R-BTA-983705 B Cell Activation
Reactome:R-BTA-195721 Signaling by WNT
Reactome:R-BTA-194315 Signaling by Rho GTPases
Reactome:R-CEL-1640170 Cell Cycle
Reactome:R-CEL-109582 Hemostasis
Reactome:R-CEL-76002 Platelet activation, signaling and aggregation
Reactome:R-CEL-202403 TCR signaling
Reactome:R-CEL-983705 B Cell Activation
Reactome:R-CEL-5621481 C-type lectin receptors (CLRs)
Reactome:R-CEL-162582 Signaling Pathways
Reactome:R-CEL-1912422 Pre-NOTCH Expression and Processing
Reactome:R-CEL-195721 Signaling by WNT
Reactome:R-CEL-5099900 WNT5A-dependent internalization of FZD4
Reactome:R-CEL-5684996 ERK1/ERK2 pathway
Reactome:R-CEL-399997 Acetylcholine regulates insulin secretion
Reactome:R-DRE-3858494 Beta-catenin independent WNT signaling
Reactome:R-DRE-112316 Neuronal System
Reactome:R-DRE-399719 Trafficking of AMPA receptors
Reactome:R-DRE-2262752 Cellular responses to stress
Reactome:R-DRE-446728 Cell junction organization
Reactome:R-DRE-420029 Tight junction interactions
Reactome:R-DRE-109582 Hemostasis
Reactome:R-DRE-76005 Response to elevated platelet cytosolic Ca2+
Reactome:R-DRE-1169091 Activation of NF-kappaB in B cells
Reactome:R-DME-5357801 Programmed Cell Death
Reactome:R-DME-1280218 Adaptive Immune System
Reactome:R-DME-5621481 C-type lectin receptors (CLRs)
Reactome:R-DME-1227986 Signaling by ERBB2
Reactome:R-DME-5683057 MAPK family signaling cascades
Reactome:R-DME-5625740 RHO GTPases activate PKNs
Reactome:R-DME-2262752 Cellular responses to stress
Reactome:R-DME-422475 Axon guidance
Reactome:R-DME-373752 Netrin-1 signaling
Reactome:R-HSA-1500931 Cell-Cell communication
Reactome:R-HSA-3000171 Non-integrin membrane-ECM interactions
Reactome:R-HSA-109582 Hemostasis
Reactome:R-HSA-399997 Acetylcholine regulates insulin secretion
Reactome:R-HSA-5357801 Programmed Cell Death
Reactome:R-HSA-1250196 SHC1 events in ERBB2 signaling
Reactome:R-HSA-170834 Signaling by TGF-beta Receptor Complex
Reactome:R-HSA-416476 G alpha (q) signalling events
Reactome:R-HSA-1912422 Pre-NOTCH Expression and Processing
Reactome:R-HSA-5684996 ERK1/ERK2 pathway
Reactome:R-HSA-194315 Signaling by Rho GTPases
Reactome:R-HSA-193639 p75NTR signals via NF-kB
Reactome:R-HSA-112316 Neuronal System
Reactome:R-HSA-399719 Trafficking of AMPA receptors
Reactome:R-HSA-212436 Generic Transcription Pathway
Reactome:R-HSA-8878171 Transcriptional regulation by RUNX1
Reactome:R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Reactome:R-HSA-168256 Immune System
Reactome:R-HSA-1169091 Activation of NF-kappaB in B cells
Reactome:R-HSA-168249 Innate Immune System
Reactome:R-HSA-2871837 FCERI mediated NF-kB activation
Reactome:R-HSA-8953854 Metabolism of RNA
Reactome:R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA
Reactome:R-MMU-1280218 Adaptive Immune System
Reactome:R-MMU-983705 B Cell Activation
Reactome:R-MMU-2454202 Fc epsilon receptor (FCERI) signaling
Reactome:R-MMU-1266738 Developmental Biology
Reactome:R-MMU-373752 Netrin-1 signaling
Reactome:R-MMU-109581 Apoptosis
Reactome:R-MMU-1500931 Cell-Cell communication
Reactome:R-MMU-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-MMU-1433557 Signaling by SCF-KIT
Reactome:R-MMU-372790 Signaling by GPCR
Reactome:R-MMU-157118 Signaling by NOTCH
Reactome:R-MMU-195721 Signaling by WNT
Reactome:R-MMU-9006931 Signaling by Nuclear Receptors
Reactome:R-MMU-194315 Signaling by Rho GTPases
Reactome:R-MMU-73887 Death Receptor Signaling
Reactome:R-MMU-193704 p75 NTR receptor-mediated signalling
Reactome:R-MMU-112315 Transmission across Chemical Synapses
Reactome:R-MMU-112314 Neurotransmitter receptors and postsynaptic signal transmission
Reactome:R-MMU-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity
Reactome:R-RNO-450531 Regulation of mRNA stability by proteins that bind AU-rich elements
Reactome:R-RNO-450520 HuR (ELAVL1) binds and stabilizes mRNA
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-422356 Regulation of insulin secretion
Reactome:R-RNO-416993 Trafficking of GluR2-containing AMPA receptors
Reactome:R-RNO-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-RNO-1433559 Regulation of KIT signaling
Reactome:R-RNO-157118 Signaling by NOTCH
Reactome:R-RNO-195721 Signaling by WNT
Reactome:R-RNO-5683057 MAPK family signaling cascades
Reactome:R-RNO-5625740 RHO GTPases activate PKNs
Reactome:R-RNO-1474244 Extracellular matrix organization
Reactome:R-RNO-3000170 Syndecan interactions
Reactome:R-RNO-114516 Disinhibition of SNARE formation
Reactome:R-RNO-5357801 Programmed Cell Death
Reactome:R-RNO-202403 TCR signaling
Reactome:R-RNO-202424 Downstream TCR signaling
Reactome:R-RNO-5607764 CLEC7A (Dectin-1) signaling
Reactome:R-RNO-422475 Axon guidance
Reactome:R-SCE-1168372 Downstream signaling events of B Cell Receptor (BCR)
Reactome:R-SCE-168249 Innate Immune System
Reactome:R-SCE-2454202 Fc epsilon receptor (FCERI) signaling
Reactome:R-SCE-5625740 RHO GTPases activate PKNs
Reactome:R-SCE-399997 Acetylcholine regulates insulin secretion
Reactome:R-SCE-68886 M Phase
Reactome:R-SCE-2980766 Nuclear Envelope Breakdown
Reactome:R-SPO-109582 Hemostasis
Reactome:R-SPO-76002 Platelet activation, signaling and aggregation
Reactome:R-SPO-76005 Response to elevated platelet cytosolic Ca2+
Reactome:R-XTR-168256 Immune System
Reactome:R-XTR-1169091 Activation of NF-kappaB in B cells
Reactome:R-XTR-1640170 Cell Cycle
Reactome:R-XTR-68886 M Phase
Reactome:R-XTR-5099900 WNT5A-dependent internalization of FZD4
Reactome:R-BTA-69278 Cell Cycle, Mitotic
Reactome:R-BTA-68875 Mitotic Prophase
Reactome:R-BTA-2980766 Nuclear Envelope Breakdown
Reactome:R-BTA-4419969 Depolymerization of the Nuclear Lamina
Reactome:R-BTA-76002 Platelet activation, signaling and aggregation
Reactome:R-BTA-114516 Disinhibition of SNARE formation
Reactome:R-BTA-112315 Transmission across Chemical Synapses
Reactome:R-BTA-112314 Neurotransmitter receptors and postsynaptic signal transmission
Reactome:R-BTA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity
Reactome:R-BTA-5099900 WNT5A-dependent internalization of FZD4
Reactome:R-BTA-5625740 RHO GTPases activate PKNs
Reactome:R-CEL-76005 Response to elevated platelet cytosolic Ca2+
Reactome:R-CEL-168249 Innate Immune System
Reactome:R-CEL-5607764 CLEC7A (Dectin-1) signaling
Reactome:R-CEL-2262752 Cellular responses to stress
Reactome:R-CEL-9006934 Signaling by Receptor Tyrosine Kinases
Reactome:R-CEL-372790 Signaling by GPCR
Reactome:R-CEL-416476 G alpha (q) signalling events
Reactome:R-CEL-1912408 Pre-NOTCH Transcription and Translation
Reactome:R-CEL-3858494 Beta-catenin independent WNT signaling
Reactome:R-CEL-8939211 ESR-mediated signaling
Reactome:R-CEL-5673001 RAF/MAP kinase cascade
Reactome:R-CEL-1430728 Metabolism
Reactome:R-CEL-163685 Integration of energy metabolism
Reactome:R-CEL-3000171 Non-integrin membrane-ECM interactions
Reactome:R-DRE-157118 Signaling by NOTCH
Reactome:R-DRE-4086400 PCP/CE pathway
Reactome:R-DRE-416993 Trafficking of GluR2-containing AMPA receptors
Reactome:R-DRE-421270 Cell-cell junction organization
Reactome:R-DRE-114516 Disinhibition of SNARE formation
Reactome:R-DRE-983705 B Cell Activation
Reactome:R-DME-450531 Regulation of mRNA stability by proteins that bind AU-rich elements
Reactome:R-DME-450520 HuR (ELAVL1) binds and stabilizes mRNA
Reactome:R-DME-109581 Apoptosis
Reactome:R-DME-202403 TCR signaling
Reactome:R-DME-5607764 CLEC7A (Dectin-1) signaling
Reactome:R-DME-1250196 SHC1 events in ERBB2 signaling
Reactome:R-DME-5684996 ERK1/ERK2 pathway
Reactome:R-DME-195258 RHO GTPase Effectors
Reactome:R-DME-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome:R-DME-112316 Neuronal System
Reactome:R-DME-112314 Neurotransmitter receptors and postsynaptic signal transmission
Reactome:R-DME-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity
Reactome:R-HSA-446728 Cell junction organization
Reactome:R-HSA-420029 Tight junction interactions
Reactome:R-HSA-1474244 Extracellular matrix organization
Reactome:R-HSA-3000170 Syndecan interactions
Reactome:R-HSA-114604 GPVI-mediated activation cascade
Reactome:R-HSA-76005 Response to elevated platelet cytosolic Ca2+
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-163685 Integration of energy metabolism
Reactome:R-HSA-109581 Apoptosis
Reactome:R-HSA-162582 Signaling Pathways
Reactome:R-HSA-1433557 Signaling by SCF-KIT
Reactome:R-HSA-388396 GPCR downstream signalling
Reactome:R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK
Reactome:R-HSA-1912408 Pre-NOTCH Transcription and Translation
Reactome:R-HSA-5099900 WNT5A-dependent internalization of FZD4
Reactome:R-HSA-8939211 ESR-mediated signaling
Reactome:R-HSA-5673001 RAF/MAP kinase cascade
Reactome:R-HSA-5625740 RHO GTPases activate PKNs
Reactome:R-HSA-73887 Death Receptor Signaling
Reactome:R-HSA-193704 p75 NTR receptor-mediated signalling
Reactome:R-HSA-209543 p75NTR recruits signalling complexes
Reactome:R-HSA-8953897 Cellular responses to stimuli
Reactome:R-HSA-416993 Trafficking of GluR2-containing AMPA receptors
Reactome:R-HSA-1280218 Adaptive Immune System
Reactome:R-HSA-983705 B Cell Activation
Reactome:R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
Reactome:R-MMU-202403 TCR signaling
Reactome:R-MMU-202424 Downstream TCR signaling
Reactome:R-MMU-5621481 C-type lectin receptors (CLRs)
Reactome:R-MMU-399997 Acetylcholine regulates insulin secretion
Reactome:R-MMU-3000171 Non-integrin membrane-ECM interactions
Reactome:R-MMU-109582 Hemostasis
Reactome:R-MMU-422475 Axon guidance
Reactome:R-MMU-75153 Apoptotic execution phase
Reactome:R-MMU-8953897 Cellular responses to stimuli
Reactome:R-MMU-2262752 Cellular responses to stress
Reactome:R-MMU-446728 Cell junction organization
Reactome:R-MMU-420029 Tight junction interactions
Reactome:R-MMU-1433559 Regulation of KIT signaling
Reactome:R-MMU-416476 G alpha (q) signalling events
Reactome:R-MMU-1912422 Pre-NOTCH Expression and Processing
Reactome:R-MMU-5099900 WNT5A-dependent internalization of FZD4
Reactome:R-MMU-5683057 MAPK family signaling cascades
Reactome:R-MMU-5625740 RHO GTPases activate PKNs
Reactome:R-MMU-112316 Neuronal System
Reactome:R-MMU-399719 Trafficking of AMPA receptors
Reactome:R-RNO-8953854 Metabolism of RNA
Reactome:R-RNO-1500931 Cell-Cell communication
Reactome:R-RNO-1227986 Signaling by ERBB2
Reactome:R-RNO-1912422 Pre-NOTCH Expression and Processing
Reactome:R-RNO-5099900 WNT5A-dependent internalization of FZD4
Reactome:R-RNO-5684996 ERK1/ERK2 pathway
Reactome:R-RNO-195258 RHO GTPase Effectors
Reactome:R-RNO-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome:R-RNO-193639 p75NTR signals via NF-kB
Reactome:R-RNO-76002 Platelet activation, signaling and aggregation
Reactome:R-RNO-109581 Apoptosis
Reactome:R-RNO-1168372 Downstream signaling events of B Cell Receptor (BCR)
Reactome:R-RNO-2871837 FCERI mediated NF-kB activation
Reactome:R-SCE-76005 Response to elevated platelet cytosolic Ca2+
Reactome:R-SCE-168256 Immune System
Reactome:R-SCE-202424 Downstream TCR signaling
Reactome:R-SCE-1169091 Activation of NF-kappaB in B cells
Reactome:R-SCE-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
Reactome:R-SCE-5621481 C-type lectin receptors (CLRs)
Reactome:R-SCE-5218921 VEGFR2 mediated cell proliferation
Reactome:R-SCE-372790 Signaling by GPCR
Reactome:R-SCE-416476 G alpha (q) signalling events
Reactome:R-SCE-195258 RHO GTPase Effectors
Reactome:R-SCE-69278 Cell Cycle, Mitotic
Reactome:R-SCE-68875 Mitotic Prophase
Reactome:R-XTR-109582 Hemostasis
Reactome:R-XTR-1280218 Adaptive Immune System
Reactome:R-XTR-983705 B Cell Activation
Reactome:R-XTR-68875 Mitotic Prophase
Reactome:R-XTR-2980766 Nuclear Envelope Breakdown
Reactome:R-XTR-4419969 Depolymerization of the Nuclear Lamina
Reactome:R-XTR-162582 Signaling Pathways
Reactome:R-XTR-3858494 Beta-catenin independent WNT signaling
WikiPathways:WP5381 Smith-Magenis and Potocki-Lupski syndrome copy number variation
WikiPathways:WP5121 Sphingolipid metabolism in senescence
WikiPathways:WP5200 Dravet syndrome
WikiPathways:WP5098 T-cell activation SARS-CoV-2
WikiPathways:WP5181 Roles of ceramides in development of insulin resistance
PathBank:SMP0107991 Activation of PKC Through G Protein-Coupled Receptor
PathBank:SMP0108165 Cadmium Induces DNA Synthesis and Proliferation in Macrophages
PathBank:SMP0108209 Phospholipase C Signaling Pathway
PathBank:SMP0120899 Growth Hormone Signaling Pathway
PathBank:SMP0120911 T Cell Receptor Signaling Pathway
PathBank:SMP0120923 Growth Hormone Signaling Pathway
PathBank:SMP0120935 T Cell Receptor Signaling Pathway
PathBank:SMP0120947 Growth Hormone Signaling Pathway
PathBank:SMP0120959 T Cell Receptor Signaling Pathway
PathBank:SMP0056661 Chlorphenamine H1-Antihistamine Action
PathBank:SMP0057581 Triprolidine H1-Antihistamine Action
PathBank:SMP0057585 Chloropyramine H1-Antihistamine Action
PathBank:SMP0058908 Diphenylpyraline H1-Antihistamine Action
PathBank:SMP0058916 Phenyltoloxamine H1-Antihistamine Action
PathBank:SMP0058936 Hydroxyzine H1-Antihistamine Action
PathBank:SMP0059058 Cetirizine H1-Antihistamine Action
PathBank:SMP0059110 Cinnarizine H1-Antihistamine Action
PathBank:SMP0059114 Levocetirizine H1-Antihistamine Action
PathBank:SMP0059716 Isothipendyl H1-Antihistamine Action
PathBank:SMP0059720 Mequitazine H1-Antihistamine Action
PathBank:SMP0059868 Ketotifen H1-Antihistamine Action
PathBank:SMP0059872 Doxepin H1-Antihistamine Action
PathBank:SMP0060201 Desloratadine H1-Antihistamine Action
PathBank:SMP0060741 Azelastine H1-Antihistamine Action
PathBank:SMP0062621 Tolpropamine H1-Antihistamine Action
PathBank:SMP0062625 Propiomazine H1-Antihistamine Action
PathBank:SMP0062882 Bamipine H1-Antihistamine Action
PathBank:SMP0062886 Pimethixene H1-Antihistamine Action
PathBank:SMP0062894 Thenalidine H1-Antihistamine Action
PathBank:SMP0063783 Phospholipase C Signaling Pathway
PathBank:SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages
PathBank:SMP0063810 EGF Signalling Pathway
PathBank:SMP0066977 T Cell Receptor Signaling Pathway
PathBank:SMP0108212 Cadmium Induces DNA Synthesis and Proliferation in Macrophages
PathBank:SMP0108220 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
PathBank:SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells
PathBank:SMP0108236 Nitric Oxide Signaling Pathway
PathBank:SMP0108240 Cadmium Induces DNA Synthesis and Proliferation in Macrophages
PathBank:SMP0120884 Succinate Signalling During Inflammation
PathBank:SMP0120888 Succinate Signalling During Inflammation
PathBank:SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway
PathBank:SMP0057580 Dexbrompheniramine H1-Antihistamine Action
PathBank:SMP0057584 Antazoline H1-Antihistamine Action
PathBank:SMP0058741 Methapyrilene H1-Antihistamine Action
PathBank:SMP0058769 Thonzylamine H1-Antihistamine Action
PathBank:SMP0058785 Diphenhydramine H1-Antihistamine Action
PathBank:SMP0058797 Carbinoxamine H1-Antihistamine Action
PathBank:SMP0058813 Bromodiphenhydramine H1-Antihistamine Action
PathBank:SMP0058903 Chlorphenoxamine H1-Antihistamine Action
PathBank:SMP0058923 Cyclizine H1-Antihistamine Action
PathBank:SMP0058931 Chlorcyclizine H1-Antihistamine Action
PathBank:SMP0058956 Meclizine H1-Antihistamine Action
PathBank:SMP0058964 Buclizine H1-Antihistamine Action
PathBank:SMP0059044 Oxatomide H1-Antihistamine Action
PathBank:SMP0059707 Fenethazine H1-Antihistamine Action
PathBank:SMP0060204 Ebastine H1-Antihistamine Action
PathBank:SMP0060208 Terfenadine H1-Antihistamine Action
PathBank:SMP0060224 Levocabastine H1-Antihistamine Action
PathBank:SMP0060740 Olopatadine H1-Antihistamine Action
PathBank:SMP0060744 Betahistine H1-Antihistamine Action
PathBank:SMP0061040 Emedastine H1-Antihistamine Action
PathBank:SMP0061052 Mebhydrolin H1-Antihistamine Action
PathBank:SMP0062624 Thenyldiamine H1-Antihistamine Action
PathBank:SMP0062788 Clocinizine H1-Antihistamine Action
PathBank:SMP0062881 Alcaftadine H1-Antihistamine Action
PathBank:SMP0062885 Mirtazapine H1-Antihistamine Action
PathBank:SMP0063452 Histamine H1 Receptor Activation
PathBank:SMP0108012 Activation of PKC Through G Protein-Coupled Receptor
PathBank:SMP0108162 Phospholipase C Signaling Pathway
PathBank:SMP0108186 Fc Epsilon Receptor I Signaling in Mast Cells
PathBank:SMP0108206 Nitric Oxide Signaling Pathway
PathBank:SMP0108238 Phospholipase C Signaling Pathway
PathBank:SMP0069871 BCR Signaling Pathway
PathBank:SMP0120886 Succinate Signalling During Inflammation
PathBank:SMP0120900 EGF Signalling Pathway
PathBank:SMP0120916 BCR Signaling Pathway
PathBank:SMP0120920 g-Secretase Mediated ErbB4 Signalling Pathway
PathBank:SMP0120924 EGF Signalling Pathway
PathBank:SMP0120940 BCR Signaling Pathway
PathBank:SMP0120944 g-Secretase Mediated ErbB4 Signalling Pathway
PathBank:SMP0120948 EGF Signalling Pathway
PathBank:SMP0120964 BCR Signaling Pathway
PathBank:SMP0120968 g-Secretase Mediated ErbB4 Signalling Pathway
PathBank:SMP0121018 Pancreas Function - Beta Cell
PathBank:SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
PathBank:SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells
PathBank:SMP0089975 g-Secretase Mediated ErbB4 Signalling Pathway
PathBank:SMP0056811 Dexchlorpheniramine H1-Antihistamine Action
PathBank:SMP0057579 Brompheniramine H1-Antihistamine Action
PathBank:SMP0057583 Mepyramine H1-Antihistamine Action
PathBank:SMP0057587 Tripelennamine H1-Antihistamine Action
PathBank:SMP0058732 Histapyrrodine H1-Antihistamine Action
PathBank:SMP0058808 Orphenadrine H1-Antihistamine Action
PathBank:SMP0059694 Cyproheptadine H1-Antihistamine Action
PathBank:SMP0059702 Phenbenzamine H1-Antihistamine Action
PathBank:SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action
PathBank:SMP0059730 Methdilazine H1-Antihistamine Action
PathBank:SMP0059738 Oxomemazine H1-Antihistamine Action
PathBank:SMP0060058 Bepotastine H1-Antihistamine Action
PathBank:SMP0060195 Loratadine H1-Antihistamine Action
PathBank:SMP0060235 Rupatadine H1-Antihistamine Action
PathBank:SMP0060743 Quifenadine H1-Antihistamine Action
PathBank:SMP0061047 Flunarizine H1-Antihistamine Action
PathBank:SMP0061191 Epinastine H1-Antihistamine Action
PathBank:SMP0062623 Latrepirdine H1-Antihistamine Action
PathBank:SMP0062795 Homochlorcyclizine H1-Antihistamine Action
PathBank:SMP0062880 Temelastine H1-Antihistamine Action
PathBank:SMP0062884 Quetiapine H1-Antihistamine Action
PathBank:SMP0108001 Activation of PKC Through G Protein-Coupled Receptor
PathBank:SMP0108013 Histamine H1 Receptor Activation
PathBank:SMP0108139 Fc Epsilon Receptor I Signaling in Mast Cells
PathBank:SMP0108159 Nitric Oxide Signaling Pathway
PathBank:SMP0108219 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
PathBank:SMP0120901 GnRH Signaling Pathway
PathBank:SMP0120921 Ion Channel and Phorbal Esters Signaling Pathway
PathBank:SMP0120925 GnRH Signaling Pathway
PathBank:SMP0120945 Ion Channel and Phorbal Esters Signaling Pathway
PathBank:SMP0120949 GnRH Signaling Pathway
PathBank:SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway
PathBank:SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
PathBank:SMP0000749 Activation of PKC Through G Protein-Coupled Receptor
PathBank:SMP0084634 Succinate Signalling During Inflammation
PathBank:SMP0056662 Pheniramine H1-Antihistamine Action
PathBank:SMP0057582 Dimetindene H1-Antihistamine Action
PathBank:SMP0057586 Talastine H1-Antihistamine Action
PathBank:SMP0058803 Doxylamine H1-Antihistamine Action
PathBank:SMP0058891 Clemastine H1-Antihistamine Action
PathBank:SMP0059211 Promethazine H1-Antihistamine Action
PathBank:SMP0059689 Alimemazine H1-Antihistamine Action
PathBank:SMP0059865 Azatadine H1-Antihistamine Action
PathBank:SMP0059881 Acrivastine H1-Antihistamine Action
PathBank:SMP0059897 Astemizole H1-Antihistamine Action
PathBank:SMP0060170 Bilastine H1-Antihistamine Action
PathBank:SMP0060218 Fexofenadine H1-Antihistamine Action
PathBank:SMP0060230 Mizolastine H1-Antihistamine Action
PathBank:SMP0060742 Thiazinamium H1-Antihistamine Action
PathBank:SMP0061190 Phenindamine H1-Antihistamine Action
PathBank:SMP0062622 Embramine H1-Antihistamine Action
PathBank:SMP0062883 Deptropine H1-Antihistamine Action
PathBank:SMP0062887 Pyrrobutamine H1-Antihistamine Action
PathBank:SMP0062895 Tritoqualine H1-Antihistamine Action
PathBank:SMP0063777 Nitric Oxide Signaling Pathway
PathBank:SMP0063807 Growth Hormone Signaling Pathway
PathBank:SMP0063811 GnRH Signaling Pathway